The genetics of multiple sclerosis: an up-to-date review

Uncoupling the Roles of HLA-DRB1 and HLA-DRB5 Genes in Multiple Sclerosis

(2014) S. J. Caillier et al.   JOURNAL OF IMMUNOLOGY

DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)

(2012) Nathali Kaushansky et al.   Journal of Neuroinflammation

Implication of the toll-like receptor 4 pathway in the response to interferon-β in multiple sclerosis

(2011) Marta F. Bustamante et al.   ANNALS OF NEUROLOGY

Rare variants in the CYP27B1 gene are associated with multiple sclerosis

(2011) Sreeram V. Ramagopalan et al.   ANNALS OF NEUROLOGY

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

iCTNet: A Cytoscape plugin to produce and analyze integrative complex traits networks

(2011) Lili Wang et al.   BMC BIOINFORMATICS

Computational classifiers for predicting the short-term course of Multiple sclerosis

(2011) Bartolome Bejarano et al.   BMC Neurology

The major histocompatibility complex and multiple sclerosis: a smoking gun?

(2011) Stephen Sawcer et al.   BRAIN

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

(2011) N. Couturier et al.   BRAIN

Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis

(2011) Anna Karin Hedström et al.   BRAIN

Natural killer cell phenotype and clinical response to interferon-beta therapy in multiple sclerosis

(2011) J.E. Martínez-Rodríguez et al.   CLINICAL IMMUNOLOGY

Challenges in Obtaining Adequate Genetic Sample Sets in Clinical Trials: The Perspective of the Industry Pharmacogenomics Working Group

(2011) A W Warner et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis

(2011) Marie-Claude Babron et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide association study of severity in multiple sclerosis

(2011)   GENES AND IMMUNITY

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA–CLEC16A–SOCS1 gene complex

(2011) Rebecca L. Zuvich et al.   HUMAN MOLECULAR GENETICS

The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation

(2011) D. M. Kofler et al.   JOURNAL OF IMMUNOLOGY

Shared genetics in coeliac disease and other immune-mediated diseases

(2011) J. Gutierrez-Achury et al.   JOURNAL OF INTERNAL MEDICINE

Association of HLA class I markers with multiple sclerosis in the Italian and UK population: evidence of two independent protective effects

(2011) L. Bergamaschi et al.   JOURNAL OF MEDICAL GENETICS

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Predictive, personalized, preventive, participatory (P4) cancer medicine

(2011) Leroy Hood et al.   Nature Reviews Clinical Oncology

The sociobiology of molecular systems

(2011) Kevin R. Foster   NATURE REVIEWS GENETICS

Determinants of interferon β efficacy in patients with multiple sclerosis

(2011) Joep Killestein et al.   Nature Reviews Neurology

Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse

(2011) Markus R Meyer et al.   PHARMACOGENOMICS

Pharmacogenetics, Pharmacogenomics, and Individualized Medicine

(2011) Q. Ma et al.   PHARMACOLOGICAL REVIEWS

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis

(2011) Haik Mkhikian et al.   Nature Communications

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

(2010) Eveliina Jakkula et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Bayes factors in complex genetics

(2010) Stephen Sawcer   EUROPEAN JOURNAL OF HUMAN GENETICS

HLA-DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population

(2010) L. Romero-Pinel et al.   EUROPEAN JOURNAL OF NEUROLOGY

A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution

(2010) S. V. Ramagopalan et al.   GENOME RESEARCH

Refining the association of MHC with multiple sclerosis in African Americans

(2010) Joseph P. McElroy et al.   HUMAN MOLECULAR GENETICS

Role of Differential Expression of Interferon Receptor Isoforms on the Response of Multiple Sclerosis Patients to Therapy with Interferon Beta

(2010) Francesca Gilli   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Two HLA class I genes independently associated with multiple sclerosis

(2010) Jenny Link et al.   JOURNAL OF NEUROIMMUNOLOGY

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

(2010) Sandra Nischwitz et al.   JOURNAL OF NEUROIMMUNOLOGY

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

(2010) Sergio E. Baranzini et al.   NATURE

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

(2010) Serena Sanna et al.   NATURE GENETICS

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

HLA B*44: Protective effects in MS susceptibility and MRI outcome measures

(2010) B. C. Healy et al.   NEUROLOGY

A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01

(2010) Bruce A. C. Cree et al.   PLoS One

Multiple Sclerosis: Association with HL-A3

(2010) S. NAITO et al.   TISSUE ANTIGENS

Predictive, preventive, personalized and participatory medicine: back to the future

(2010) Charles Auffray et al.   Genome Medicine

Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis

(2009) Åslaug R. Lorentzen et al.   ANNALS OF NEUROLOGY

Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA

(2009) Bruce A. C. Cree et al.   ARCHIVES OF NEUROLOGY

Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses

(2009) J. P.A. Ioannidis   CANADIAN MEDICAL ASSOCIATION JOURNAL

Prediction of Cardiovascular Disease Outcomes and Established Cardiovascular Risk Factors by Genome-Wide Association Markers

(2009) John P.A. Ioannidis   Circulation-Cardiovascular Genetics

The genetics of autoimmune diseases: a networked perspective

(2009) Sergio E Baranzini   CURRENT OPINION IN IMMUNOLOGY

Identification of new sensitive biomarkers for thein vivoresponse to interferon-β treatment in multiple sclerosis using DNA-array evaluation

(2009) F. Sellebjerg et al.   EUROPEAN JOURNAL OF NEUROLOGY

HLA-DRB1⁎15 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis

(2009) Kerstin Imrell et al.   JOURNAL OF NEUROIMMUNOLOGY

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

(2009) Melanie Bahlo et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

A network view of disease and compound screening

(2009) Eric E. Schadt et al.   NATURE REVIEWS DRUG DISCOVERY

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility

(2009) M. R. Lincoln et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Norwegian Sami differs significantly from other Norwegians according to their HLA profile

(2009) H. F. Harbo et al.   TISSUE ANTIGENS

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

(2009) Lisa M. Maier et al.   PLoS Genetics

Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

(2009) Sreeram V. Ramagopalan et al.   PLoS Genetics

Genotype–Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures

(2008) D. T. Okuda et al.   BRAIN

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS

Gene expression analysis of interferon-β treatment in multiple sclerosis

(2008) F Sellebjerg et al.   Multiple Sclerosis Journal

Detecting shared pathogenesis from the shared genetics of immune-related diseases

(2008) Alexandra Zhernakova et al.   NATURE REVIEWS GENETICS

Interferon-beta responders and non-responders. A biological approach

(2008) Antonio Bertolotto et al.   NEUROLOGICAL SCIENCES

Pharmacogenomics of Interferon-ß Therapy in Multiple Sclerosis: Baseline IFN Signature Determines Pharmacological Differences between Patients

(2008) Lisa G. M. van Baarsen et al.   PLoS One

Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms

(2008) Manuel Comabella et al.   PLoS One

Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

(2008) J.-C. Corvol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA