Regulatory T cells and their roles in immune dysregulation and allergy

XCL1 Enhances Regulatory Activities of CD4+CD25highCD127low/- T Cells in Human Allergic Asthma

(2014) K. D. Nguyen et al.   JOURNAL OF IMMUNOLOGY

Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

(2014) Rosa Bacchetta et al.   Frontiers in Immunology

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Prevention of Graft-versus-Host Disease by Adoptive T Regulatory Therapy Is Associated with Active Repression of Peripheral Blood Toll-Like Receptor 5 mRNA Expression

(2013) Birgit Sawitzki et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation

(2013) D. Schneidawind et al.   BLOOD

Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells

(2013) Y. Zhang et al.   BLOOD

Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

(2013) Kevin Goudy et al.   CLINICAL IMMUNOLOGY

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells

(2013) Jennifer A. Jenks et al.   CLINICAL IMMUNOLOGY

FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells

(2013) Dewan Md Sakib Hossain et al.   IMMUNITY

Food allergy diagnosis and therapy: where are we now?

(2013) Aleena Syed et al.   Immunotherapy

Forkhead box P3:The Peacekeeper of the Immune System

(2013) Laura Passerini et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation

(2013) Roshi Afshar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma

(2013) Takashi Kinoshita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

CD4+ T Cells from IPEX Patients Convert into Functional and Stable Regulatory T Cells by FOXP3 Gene Transfer

(2013) L. Passerini et al.   Science Translational Medicine

Cell-Based Therapeutics: The Next Pillar of Medicine

(2013) M. A. Fischbach et al.   Science Translational Medicine

Immunodeficiency with Autoimmunity: Beyond the Paradox

(2013) R. Bacchetta et al.   Frontiers in Immunology

Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells

(2012) T. Kinnunen et al.   BLOOD

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Oral Immunotherapy and Anti-IgE Antibody-Adjunctive Treatment for Food Allergy

(2012) Kari C. Nadeau et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome

(2012) F. Barzaghi et al.   JOURNAL OF AUTOIMMUNITY

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease

(2012) SuJin Hwang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

(2012) Grazia Andolfi et al.   MOLECULAR THERAPY

Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection

(2012) J Loebbermann et al.   Mucosal Immunology

Asthma Discordance in Twins Is Linked to Epigenetic Modifications of T Cells

(2012) R. Scott Runyon et al.   PLoS One

T-Cell Tolerance: Central and Peripheral

(2012) Y. Xing et al.   Cold Spring Harbor Perspectives in Biology

The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

(2012) Silvia Gregori et al.   Frontiers in Immunology

Autoimmunity in Wiskott–Aldrich Syndrome: An Unsolved Enigma

(2012) Marco Catucci et al.   Frontiers in Immunology

Autoimmune Dysregulation and Purine Metabolism in Adenosine Deaminase Deficiency

(2012) Aisha Vanessa Sauer et al.   Frontiers in Immunology

Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A Paradigm of Immunodeficiency with Autoimmunity

(2012) Federica Barzaghi et al.   Frontiers in Immunology

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

(2012) Ashish K. Marwaha et al.   Frontiers in Immunology

Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts

(2011) C. G. Brunstein et al.   BLOOD

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

(2011) Sebastian F. M. Häusler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome

(2011) Laura Passerini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells

(2011) Chiara F. Magnani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The rs3761548 polymorphism of FOXP3 is a protective genetic factor against allergic rhinitis in the Hungarian female population

(2011) Eszter Fodor et al.   HUMAN IMMUNOLOGY

CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease

(2011) Helen Martin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Making sense of regulatory T cell suppressive function

(2011) Itay Shalev et al.   SEMINARS IN IMMUNOLOGY

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

Increased Airway T Regulatory Cells in Asthmatic Subjects

(2010) Lucy J.C. Smyth et al.   CHEST

Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis

(2010) Yong Min Kim et al.   CLINICAL IMMUNOLOGY

Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy

(2010) R. Bacchetta et al.   HAEMATOLOGICA

Adenosine and Prostaglandin E2Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells

(2010) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

(2010) S. Hanabuchi et al.   JOURNAL OF IMMUNOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts

(2009) R. W. B. Bottema et al.   ALLERGY

Allergen provocation increases TH2-cytokines and FOXP3 expression in the asthmatic lung

(2009) S. Thunberg et al.   ALLERGY

In Situ Activation and Expansion of Host Tregs: A New Approach to Enhance Donor Chimerism and Stable Engraftment in Major Histocompatibility Complex-Matched Allogeneic Hematopoietic Cell Transplantation

(2009) Alwi Shatry et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Selective engraftment of donor CD4+25high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation

(2009) M. G. Seidel et al.   BLOOD

Wild-type FOXP3 is selectively active in CD4+CD25hi regulatory T cells of healthy female carriers of different FOXP3 mutations

(2009) S. Di Nunzio et al.   BLOOD

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

(2009) G. Wieczorek et al.   CANCER RESEARCH

Plasticity of CD4+ FoxP3+ T cells

(2009) Xuyu Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Genetic association study of FOXP3 polymorphisms in allergic rhinitis in a Chinese population

(2009) Luo Zhang et al.   HUMAN IMMUNOLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Clinical efficacy and immune regulation with peanut oral immunotherapy

(2009) Stacie M. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cell Suppression Is Potentiated by Target T Cells in a Cell Contact, IL-35- and IL-10-Dependent Manner

(2009) Lauren W. Collison et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequencies of circulating CD4+CD25+CD127low cells in atopics are altered by bronchial allergen challenge

(2008) M. Moniuszko et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

(2008) Xuyu Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3

(2007) Sarah E Allan et al.   MOLECULAR THERAPY