CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII

Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors

(2021) Yue Liu et al.   Science Translational Medicine

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

(2020) Yuchi Honaker et al.   Science Translational Medicine

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

(2020) Nicholas A. J. Dawson et al.   Science Translational Medicine

CD4+ T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice

(2020) Richard Y. Fu et al.   CELLULAR IMMUNOLOGY

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

(2019) Billur Akkaya et al.   NATURE IMMUNOLOGY

An immunoproteomic approach to characterize the CAR interactome and signalosome

(2019) Maria C. Ramello et al.   Science Signaling

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

(2019) Patrick A. Baeuerle et al.   Nature Communications

Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy

(2018) Shivani Srivastava et al.   JOURNAL OF IMMUNOLOGY

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function

(2018) Alexander I. Salter et al.   Science Signaling

Prevention of the anti-factor VIII memory B-cell response by inhibition of the Bruton's tyrosine kinase in experimental hemophilia A

(2018) Sandrine Delignat et al.   HAEMATOLOGICA

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Treg cells—the next frontier of cell therapy

(2018) Jeffrey A. Bluestone et al.   SCIENCE

Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus

(2018) Maria Dall'Era et al.   Arthritis & Rheumatology

Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression

(2018) Elena Gianchecchi et al.   Frontiers in Immunology

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release

(2018) Yiyang Xu et al.   Cell Discovery

TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs

(2017) William F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Combination therapy for inhibitor reversal in haemophilia A using monoclonal anti-CD20 and rapamycin

(2017) Alexandra Sherman et al.   THROMBOSIS AND HAEMOSTASIS

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

(2016) Jeongheon Yoon et al.   BLOOD

AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease

(2016) Alexandra Kitz et al.   EMBO REPORTS

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

The Allostery Model of TCR Regulation

(2016) Wolfgang W. A. Schamel et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-PlasmodiumHumoral Immunity

(2016) Jenna J. Guthmiller et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor SignalingIn Vivo

(2016) Peter A. Thill et al.   MOLECULAR AND CELLULAR BIOLOGY

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade

(2016) Tessa Gargett et al.   MOLECULAR THERAPY

Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy

(2015) Ankit Saxena et al.   CYTOKINE

TIGIT predominantly regulates the immune response via regulatory T cells

(2015) Sema Kurtulus et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1

(2015) Peter Hsu et al.   JOURNAL OF IMMUNOLOGY

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

(2015) Dapeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD

(2015) A. Kunkele et al.   Cancer Immunology Research

Functional Comparison of Engineered T Cells Carrying a Native TCR versus TCR-like Antibody–Based Chimeric Antigen Receptors Indicates Affinity/Avidity Thresholds

(2014) Ravit Oren et al.   JOURNAL OF IMMUNOLOGY

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

(2014) Debalina Sarkar et al.   Molecular Therapy-Methods & Clinical Development

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

High TCR Stimuli Prevent Induced Regulatory T Cell Differentiation in a NF- B-Dependent Manner

(2011) L. L. Molinero et al.   JOURNAL OF IMMUNOLOGY

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

(2010) J. N. Kochenderfer et al.   BLOOD

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion

(2009) M. S. Turner et al.   JOURNAL OF IMMUNOLOGY

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

(2009) Y. Zhao et al.   JOURNAL OF IMMUNOLOGY

Role of regulatory T cells in tolerance to coagulation factors

(2009) O. CAO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B

(2009) Ou Cao et al.   MOLECULAR THERAPY

The Treg/Th17 Cell Balance: A New Paradigm for Autoimmunity

(2009) Eli M Eisenstein et al.   PEDIATRIC RESEARCH

Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3

(2007) Sarah E Allan et al.   MOLECULAR THERAPY