On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

In vitro biomimetic engineering of a human hematopoietic niche with functional properties

(2018) Paul E. Bourgine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shwachman-Diamond Syndrome: Molecular Mechanisms and Current Perspectives

(2018) Valentino Bezzerri et al.   Molecular Diagnosis & Therapy

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

(2017) Vijay K. Singh et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

(2017) Stefan Sieber et al.   Journal of Tissue Engineering and Regenerative Medicine

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

(2017) Raphael Lis et al.   NATURE

Haematopoietic stem and progenitor cells from human pluripotent stem cells

(2017) Ryohichi Sugimura et al.   NATURE

3D models of the hematopoietic stem cell niche under steady-state and active conditions

(2017) Lisa Rödling et al.   Scientific Reports

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Therapeutic drug monitoring of 5-fluorouracil

(2016) James J. Lee et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Making sense of hematopoietic stem cell niches

(2015) P. E. Boulais et al.   BLOOD

Hematopoietic stem cells: concepts, definitions, and the new reality

(2015) C. J. Eaves   BLOOD

The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo

(2015) Hal E. Broxmeyer et al.   CURRENT OPINION IN HEMATOLOGY

Advances in umbilical cord blood stem cell expansion and clinical translation

(2015) Nicolas Pineault et al.   EXPERIMENTAL HEMATOLOGY

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

(2015) N. A. Zambetti et al.   HAEMATOLOGICA

PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

(2015) Hsiang-Ying Lee et al.   NATURE

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

(2015) N. A. Zambetti et al.   HAEMATOLOGICA

Platelet bioreactor-on-a-chip

(2014) J. N. Thon et al.   BLOOD

Variable Clinical Presentation of Shwachman–Diamond Syndrome: Update from the North American Shwachman–Diamond Syndrome Registry

(2014) Kasiani C. Myers et al.   JOURNAL OF PEDIATRICS

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

(2014) I. Fares et al.   SCIENCE

Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia

(2013) Hagop M. Kantarjian et al.   CANCER

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Hematopoietic stem cell expansion: challenges and opportunities

(2012) Marta A. Walasek et al.   Annals of the New York Academy of Sciences

Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support

(2012) Mónica S. Ventura Ferreira et al.   BIOMATERIALS

Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling

(2012) Elizabeth Csaszar et al.   Cell Stem Cell

Hematopoiesis: A Human Perspective

(2012) Sergei Doulatov et al.   Cell Stem Cell

Clinical and Molecular Pathophysiology of Shwachman–Diamond Syndrome

(2012) Kasiani C. Myers et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors

(2012) Gary K. Schwartz et al.   INVESTIGATIONAL NEW DRUGS

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

(2012) Lisa A Kohn et al.   NATURE IMMUNOLOGY

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mesenchymal stem cells from Shwachman–Diamond syndrome patients display normal functions and do not contribute to hematological defects

(2012) V André et al.   Blood Cancer Journal

Draft consensus guidelines for diagnosis and treatment of Shwachman-Diamond syndrome

(2011) Yigal Dror et al.   Annals of the New York Academy of Sciences

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome

(2011) A. J. Finch et al.   GENES & DEVELOPMENT

Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152)

(2011) Ron J. Keizer et al.   INVESTIGATIONAL NEW DRUGS

Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors

(2010) D. S. Boss et al.   ANNALS OF ONCOLOGY

Toward modeling the bone marrow niche using scaffold-based 3D culture systems

(2010) Nunzia Di Maggio et al.   BIOMATERIALS

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Shwachman-Diamond syndrome neutrophils have altered chemoattractant-induced F-actin polymerization and polarization characteristics

(2009) C. Orelio et al.   HAEMATOLOGICA

Pharmacokinetically Guided Dose Adjustment of 5-Fluorouracil: A Rational Approach to Improving Therapeutic Outcomes

(2009) M. Wasif Saif et al.   JNCI-Journal of the National Cancer Institute