Discovery of metal-based complexes as promising antimicrobial agents

Multi-Targeted Anticancer Activity of Imidazolate Phosphane Gold(I) Compounds by Inhibition of DHFR and TrxR in Breast Cancer Cells

(2021) Rossana Galassi et al.   Frontiers in Chemistry

The Lancet Infectious Diseases Commission on antimicrobial resistance: 6 years later

(2020) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Zinc(II) Complexes with Amino Acids for Potential Use in Dermatology: Synthesis, Crystal Structures, and Antibacterial Activity

(2020) Michał Abendrot et al.   MOLECULES

Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands

(2020) Sonja Ž. Đurić et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments

(2020) Prinessa Chellan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antimicrobial Resistance in ESKAPE Pathogens

(2020) David M. P. De Oliveira et al.   CLINICAL MICROBIOLOGY REVIEWS

Thiosemicarbazone-metal complexes exhibiting cytotoxicity in colon cancer cell lines through oxidative stress

(2020) Raquel Alcaraz et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Resisting antimicrobial resistance

(2020) Carl Nathan   NATURE REVIEWS MICROBIOLOGY

Manganese complex [Mn(CO)3(tpa-κ3N)]Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae

(2020) Apostolos Liakopoulos et al.   Journal of Global Antimicrobial Resistance

Zinc-Containing Metalloenzymes: Inhibition by Metal-Based Anticancer Agents

(2020) Ruirong Ye et al.   Frontiers in Chemistry

Human Antimicrobial Peptide Hepcidin 25-Induced Apoptosis in Candida albicans

(2020) Ruei-Ching Chen et al.   Microorganisms

Di-2-pyridylketone-N1-substituted thiosemicarbazone derivatives of copper(II): Biosafe antimicrobial potential and high anticancer activity against immortalized L6 rat skeletal muscle cells

(2020) Tarlok S. Lobana et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity

(2020) Dumitrela Diaconu et al.   MOLECULES

Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

(2020) Katarzyna Gałczyńska et al.   MOLECULES

Transmission of Antibiotic Resistant Bacteria and Genes: Unveiling the Jigsaw Pieces of a One Health Problem

(2020) Carla Novais et al.   Pathogens

An Investigation on DNA Binding, Cleavage and Antimicrobial Properties of Mononuclear Co(II), Ni(II) and Cu(II) Complexes Derived from N, O Donor Schiff Bases

(2020) Aveli Rambabu et al.   JOURNAL OF FLUORESCENCE

Synergistic effect of combined imipenem and photodynamic treatment with the cationic Ir(III) complexes to polypyridine ligand on carbapenem-resistant Klebsiella pneumoniae

(2020) Manuel Valenzuela-Valderrama et al.   Photodiagnosis and Photodynamic Therapy

Investigation of isomeric tetra-cationic porphyrin activity with peripheral [Pd(bpy)Cl]+ units by antimicrobial photodynamic therapy

(2020) Carolina Hahn da Silveira et al.   Photodiagnosis and Photodynamic Therapy

Zn(II) Complex of Plant Phenolic Chlorogenic Acid: Antioxidant, Antimicrobial and Structural Studies

(2020) Monika Kalinowska et al.   Materials

Gallium Porphyrin and Gallium Nitrate Synergistically Inhibit Mycobacterial Species by Targeting Different Aspects of Iron/Heme Metabolism

(2020) Seoung-ryoung Choi et al.   ACS Infectious Diseases

Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

(2020) Shuofeng Yuan et al.   Nature Microbiology

The discrete breast cancer stem cell mammosphere activity of Group 10‐bis(azadiphosphine) metal complexes

(2020) Zhiyin Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

4-Oxycoumarinyl linked acetohydrazide Schiff bases as potent urease inhibitors

(2020) Fouzia Naz et al.   BIOORGANIC CHEMISTRY

Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures

(2020) Kyle J. Sommers et al.   ChemMedChem

Investigating the antibacterial activity of salen/salophene metal complexes: Induction of ferroptosis as part of the mode of action

(2020) Daniel Baecker et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fe(III) Complexes Based on Mono- and Bis-pyrazolyl-s-triazine Ligands: Synthesis, Molecular Structure, Hirshfeld, and Antimicrobial Evaluations

(2020) Saied M. Soliman et al.   MOLECULES

New Cobalt (II) Complexes with Imidazole Derivatives: Antimicrobial Efficiency against Planktonic and Adherent Microbes and In Vitro Cytotoxicity Features

(2020) Alina Fudulu et al.   MOLECULES

Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes

(2020) Filipa Ramilo-Gomes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis

(2019) Luca Mazzei et al.   ACS Medicinal Chemistry Letters

Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws

(2019) Lorenzo Giacani et al.   PLoS Neglected Tropical Diseases

Iridium(III)-based chemosensors for the detection of metal ions

(2019) Dik-Lung Ma et al.   METHODS

Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling

(2019) Ningning Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cu-ATCUN Derivatives of Sub5 Exhibit Enhanced Antimicrobial Activity via Multiple Modes of Action

(2019) Jessica L. Alexander et al.   ACS Chemical Biology

Studies on the Interaction between Poly-Phosphane Gold(I) Complexes and Dihydrofolate Reductase: An Interplay with Nicotinamide Adenine Dinucleotide Cofactor

(2019) Stefania Pucciarelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent

(2019) Dimitris Matiadis et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Binary Effect on Methicillin‐Resistant Staphylococcus aureus of Polymeric Nanovesicles Appended by Proline‐Rich Amino Acid Sequences and Inorganic Nanoparticles

(2019) Nicole J. Bassous et al.   Small

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

(2019) Xiaonan Zhang et al.   BIOCHIMIE

Probing the antibacterial and anticancer potential of tryptamine based mixed ligand Schiff base Ruthenium(III) complexes

(2019) Manzoor Ahmad Malik et al.   BIOORGANIC CHEMISTRY

Macrobrachium rosenbergii Cu/Zn superoxide dismutase (Cu/Zn SOD) expressed in Saccharomyces cerevisiae and evaluation of the immune function to Vibrio parahaemolyticus

(2019) Jie Du et al.   FISH & SHELLFISH IMMUNOLOGY

Heme, Heme Oxygenase, and Endoplasmic Reticulum Stress—A New Insight into the Pathophysiology of Vascular Diseases

(2019) Gáll et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Inhibition of Klebsiella pneumoniae and Pseudomonas aeruginosa Iron Metabolism Using Gallium Porphyrin and Gallium Nitrate

(2019) Seoung-ryoung Choi et al.   ACS Infectious Diseases

Selective photoinactivation of methicillin‐resistant Staphylococcus aureus by highly positively charged Ru(II) complexes

(2019) Yang Feng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biologically active novel N, N, O donor tridentate water soluble hydrazide based O-carboxymethyl chitosan Schiff base Cu (II) metal complexes: Synthesis and characterisation

(2019) Murugaiyan Manimohan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antibacterial and transfection activities of nebulized formulations incorporating long n-alkyl chain silver N-heterocyclic carbene complexes

(2019) Angélique Mottais et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthesis and Structure–Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens

(2019) Bin Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crisis of Antimicrobial Resistance in China: Now and the Future

(2019) Junyan Qu et al.   Frontiers in Microbiology

Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa

(2019) Yu Guo et al.   ACS Infectious Diseases

Economic burden of antibiotic resistance in ESKAPE organisms: a systematic review

(2019) Xuemei Zhen et al.   Antimicrobial Resistance and Infection Control

A novel and green cellulose-based Schiff base-Cu (II) complex and its excellent antibacterial activity

(2019) Yongjian Xu et al.   CARBOHYDRATE POLYMERS

Synthesis and characterization of new Cr(III), Fe(III) and Cu(II) complexes incorporating multi-substituted aryl imidazole ligand: Structural, DFT, DNA binding, and biological implications

(2019) Ahmed M. Abu-Dief et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery

(2019) Marcin Makowski et al.   Pharmaceutics

Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects

(2019) Raj Kumar Thapa et al.   Acta Biomaterialia

Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors

(2019) Merve Gökşin Karaaslan et al.   BIOORGANIC CHEMISTRY

On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities

(2019) Sílvia A. Sousa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Urease inhibition studies of six Ni(II), Co(II) and Cu(II) complexes with two sexidentate N2O4-donor bis-Schiff base ligands: An experimental and DFT computational study

(2019) Hu Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies

(2019) Chioma Festus et al.   Frontiers in Chemistry

Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins

(2018) Lisa S. Cunden et al.   BIOCHEMISTRY

Synthesis, structural determination and antimicrobial evaluation of two novel CoII and ZnII halogenometallates as efficient catalysts for the acetalization reaction of aldehydes

(2018) Assila Maatar Ben Salah et al.   Chemistry Central Journal

The structure of urease inactivated by Ag(i): a new paradigm for enzyme inhibition by heavy metals

(2018) Luca Mazzei et al.   DALTON TRANSACTIONS

Synthesis and characterization of nitrile functionalized silver(I)- N -heterocyclic carbene complexes: DNA binding, cleavage studies, antibacterial properties and mosquitocidal activity against the dengue vector, Aedes albopictus

(2018) Patrick O. Asekunowo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

(2018) Wojciech Streciwilk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations

(2018) Muhammad Sirajuddin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Study of Anti-/Pro-Oxidant, Lipophilic, Microbial and Spectroscopic Properties of New Alkali Metal Salts of 5-O-Caffeoylquinic Acid

(2018) Monika Kalinowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Physicochemical, antioxidant, DNA cleaving properties and antimicrobial activity of fisetin-copper chelates

(2018) Elżbieta Łodyga-Chruscińska et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, structural and antimicrobial studies of type II topoisomerase-targeted copper(II) complexes of 1,3-disubstituted thiourea ligands

(2018) Anna Bielenica et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Antitubercular Bis-Substituted Cyclam Derivatives: Structure–Activity Relationships and in Vivo Studies

(2018) Malcolm Spain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, spectroscopic, thermal and molecular modeling studies of Zn 2+ , Cd 2+ and UO 2 2+ complexes of Schiff bases containing triazole moiety. Antimicrobial, anticancer, antioxidant and DNA binding studies

(2018) Mohamed Gaber et al.   Materials Science & Engineering C-Materials for Biological Applications

Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine

(2018) Gina Vasile Scăețeanu et al.   MOLECULES

Is the chlorophyll derivative Zn(II)e 6 Me a good photosensitizer to be used in root canal disinfection?

(2018) Patrícia Diogo et al.   Photodiagnosis and Photodynamic Therapy

Synthesis, spectral and antimicrobial studies of amino acid derivative Schiff base metal (Co, Mn, Cu, and Cd) complexes

(2018) Muhammad Pervaiz et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Antimicrobial and anti-biofilm activity of hexadentated macrocyclic complex of copper (II) derived from thiosemicarbazide against Staphylococcus aureus

(2018) Umarani Brahma et al.   Scientific Reports

Antifungal Activity and Mechanism of Action of the Co(III) Coordination Complexes With Diamine Chelate Ligands Against Reference and Clinical Strains of Candida spp.

(2018) Katarzyna Turecka et al.   Frontiers in Microbiology

Schiff bases and their metal complexes as urease inhibitors – A brief review

(2018) Ângelo de Fátima et al.   Journal of Advanced Research

Auranofin and its Analogues Show Potent Antimicrobial Activity Covering Multiresistant Pathogens: Structure-Activity Relationships

(2018) Tiziano Marzo et al.   ChemMedChem

Syntheses, Structures, and Antimicrobial Activities of Gold(I)– and Copper(I)–N-Heterocyclic Carbene (NHC) Complexes Derived from Basket-Shaped Dinuclear Ag(I)–NHC Complex

(2018) Kenji Nomiya et al.   INORGANIC CHEMISTRY

Design, Synthesis, Photophysical Properties, Biological Estimation and Molecular Docking Studies of Novel Schiff Base Derivatives as Potential Urease Inhibitors

(2018) Balasaheb D. Vanjare et al.   JOURNAL OF FLUORESCENCE

Ferrocene-containing tetrahydropyrazolopyrazolones: Antioxidant and antimicrobial activity

(2018) J.P. Bugarinović et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Antimicrobial Activity of Gallium Compounds on ESKAPE Pathogens

(2018) Sarah Hijazi et al.   Frontiers in Cellular and Infection Microbiology

Rhamnolipid from a Lysinibacillus sphaericus strain IITR51 and its potential application for dissolution of hydrophobic pesticides

(2018) Vivek Kumar Gaur et al.   BIORESOURCE TECHNOLOGY

X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives

(2018) Ioana Vlaicu et al.   MOLECULES

DNA binding, prominent photonuclease activity and antibacterial PDT of cobalt(II) complexes of phenanthroline based photosensitizers

(2018) Chittanahalli N. Sudhamani et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Synthesis and structural characterization of antimicrobial binuclear copper(II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid

(2018) Hana Buchtelova et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Structures and biochemical evaluation of silver(I) 5,5-diethylbarbiturate complexes with bis(diphenylphosphino)alkanes as potential antimicrobial and anticancer agents

(2017) Veysel T. Yilmaz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

(2017) Anas Allam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Spectral Characterization, SEM, Antimicrobial, Antioxidative Activity Evaluation, DNA Binding and DNA Cleavage Investigation of Transition Metal(II) Complexes Derived from a tetradentate Schiff base bearing thiophene moiety

(2017) Ayman A. Abdel Aziz et al.   JOURNAL OF FLUORESCENCE

Silver complexes of ligands derived from adamantylamines: Water-soluble silver-donating compounds with antibacterial properties

(2017) Jorge Jimenez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

DNA interaction, antimicrobial, antioxidant and anticancer studies on Cu(II) complexes of Luotonin A

(2017) M.P. Kesavan et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

A treatise on benzimidazole based Schiff base metal(II) complexes accentuating their biological efficacy: Spectroscopic evaluation of DNA interactions, DNA cleavage and antimicrobial screening

(2017) Ganesan Kumaravel et al.   Materials Science & Engineering C-Materials for Biological Applications

Synthesis, characterization and antimicrobial study of polymeric transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)

(2017) Shamim Ahmad Khan et al.   MICROBIAL PATHOGENESIS

The therapeutic potential of iron-targeting gallium compounds in human disease: From basic research to clinical application

(2017) Christopher R. Chitambar   PHARMACOLOGICAL RESEARCH

Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy

(2017) Khazna Alenezi et al.   Photodiagnosis and Photodynamic Therapy

At the Nexus of Antibiotics and Metals: The Impact of Cu and Zn on Antibiotic Activity and Resistance

(2017) Keith Poole   TRENDS IN MICROBIOLOGY

Fighting antimicrobial resistance on all fronts

(2017) The Lancet Global Health   Lancet Global Health

Synthesis, characterization and antimicrobial activities of novel silver(I) complexes with coumarin substituted N-heterocyclic carbene ligands

(2016) Mert Olgun Karataş et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agents

(2016) Murat Kaloğlu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Some new nano-sized Fe(II), Cd(II) and Zn(II) Schiff base complexes as precursor for metal oxides: Sonochemical synthesis, characterization, DNA interaction, in vitro antimicrobial and anticancer activities

(2016) Laila H. Abdel-Rahman et al.   BIOORGANIC CHEMISTRY

Quinazolinone azolyl ethanols: potential lead antimicrobial agents with dual action modes targeting methicillin-resistantStaphylococcus aureusDNA

(2016) Xin-Mei Peng et al.   Future Medicinal Chemistry

Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity

(2016) Yakup Sarı et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

In vitroantimicrobial studies of new benzimidazolium salts and silverN-heterocyclic carbene complexes

(2016) Yetkin Gök et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Influence of Amino Acid-Nucleobase Hybrid Ligand in Binding and Biological Activity of Co(II) and Zn(II) Complexes

(2016) V. Violet Dhayabaran et al.   JOURNAL OF FLUORESCENCE

Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis

(2016) Legna Colina-Vegas et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Pharmacological investigations and Petra/Osiris/Molinspiration (POM) analyses of newly synthesized potentially bioactive organotin(IV) carboxylates

(2016) Muhammad Tariq et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Alkali metal salts of rutin – Synthesis, spectroscopic (FT-IR, FT-Raman, UV–VIS), antioxidant and antimicrobial studies

(2015) M. Samsonowicz et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis, DNA interactions and antibacterial PDT of Cu(II) complexes of phenanthroline based photosensitizers via singlet oxygen generation

(2015) C.N. Sudhamani et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition

(2015) Lin Wang et al.   Frontiers in Microbiology

Silver in medicine: The basic science

(2014) David E. Marx et al.   BURNS

Convenient syntheses of cyanuric chloride-derived NHC ligands, their Ag(i) and Au(i) complexes and antimicrobial activity

(2013) Foteini Almalioti et al.   DALTON TRANSACTIONS

Spectroscopic (FT-IR, FT-Raman, 1H, 13C NMR, UV/VIS), thermogravimetric and antimicrobial studies of Ca(II), Mn(II), Cu(II), Zn(II) and Cd(II) complexes of ferulic acid

(2013) M. Kalinowska et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes

(2009) Yutaka Yoshikawa et al.   BIOCHIMIE

Inhibition ofSchistosoma mansoniThioredoxin-glutathione Reductase by Auranofin

(2009) Francesco Angelucci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY