Review
Pharmacology & Pharmacy
Ling Zhou, Huiguo Liu, Kui Liu, Shuang Wei
Summary: Gold compounds have shown promising results in cancer therapy by interacting with the immune system, inducing innate immune responses and promoting adaptive immune responses to support anti-tumor immune responses. Gold nanoparticles have the potential to improve the effectiveness of immunotherapy and reduce the toxicity and side effects of treatment processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rossana Galassi, Lorenzo Luciani, Junbiao Wang, Silvia Vincenzetti, Lishan Cui, Augusto Amici, Stefania Pucciarelli, Cristina Marchini
Summary: This article reviews recent scientific findings on two classes of gold compounds containing phosphane or carbene ligands, as well as the recent developments in the application of Auranofin for breast cancers.
Article
Materials Science, Multidisciplinary
E. A. K. Nivethaa, S. Sivasankari, S. Baskar, Catherine Ann Martin, N. Sivanandham, Narayana S. Kalkura
Summary: This study focuses on synthesizing a nanocomposite of CMCS and gold (Au), loaded with 5-FU and Dox for the treatment of breast cancer. The CMCS/Au system has a better drug release performance and higher cytotoxicity compared to CMCS.
Article
Chemistry, Multidisciplinary
Jiri Schulz, Ivana Cisarova, Robert Gyepes, Petr Stepnicka
Summary: In this study, Au-I complexes combining hard oxygen and soft (diphenylphosphanyl)ferrocene (L) ligands were synthesized and structurally characterized. Unique metal complexes were obtained, including a crown-like mixed-valent Au-0/Au-I cluster. N-bridged complexes were also prepared and further studied using DFT calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Marta Redrado, Andrea Benedi, Isabel Marzo, Angel L. Garcia-Otin, Vanesa Fernandez-Moreira, M. Concepcion Gimeno
Summary: A new class of emissive cyclometallated Ir-III-Au-I complexes with a bis(diphenylphosphino) methanide bridging ligand was synthesized successfully. These complexes showed different bioactivity in A549 lung carcinoma cells versus endothelial cells, mainly affecting the mitochondrial and lysosomal distribution within the cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Dominika Radomska, Robert Czarnomysy, Dominik Radomski, Krzysztof Bielawski
Summary: This review discusses the research on the anticancer activity of selenium compounds, including the different classes of selenium compounds and their mechanisms of action, which are important for developing more effective cancer treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Inorganic & Nuclear
Yi Gou, GuoJin Huang, Jinlong Li, Feng Yang, Hong Liang
Summary: This review discusses the research progress in designing and synthesizing non-platinum metal coordination compounds, as well as the delivery methods using nanocarriers. Various types of nanocarriers, such as carbon-based, amphiphilic copolymer-based, polysaccharide-based, protein- or peptide-based nanocarriers, have been widely used for delivering compounds based on ruthenium, copper, gold, iridium, palladium, and zinc.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Lorenzo Luciani, Rossana Galassi, Junbiao Wang, Cristina Marchini, Alessia Cogo, Maria Luisa Di Paolo, Lisa Dalla Via
Summary: In the search for alternatives to platinum-based anticancer drugs, 11th group metal phosphane compounds have been considered. These compounds, particularly the tris-arylphosphane metal derivatives, have shown remarkable cytotoxic activities. By modifying the aryl moieties and phosphane ligands, the activity of the compounds can be enhanced. The resulting compounds exhibit intense emissive properties and have demonstrated significant antiproliferative effects on sensitive and cisplatin-resistant tumor cell lines.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sarah A. P. Pereira, Felix D. Bobbink, Paul J. Dyson, M. Lucia M. F. S. Saraiva
Summary: An automatic methodology using the SIA-LOV system was developed to determine the ability of metal-based anticancer compounds to inhibit COX-2 activity. The results showed the potential relevance of COX-2 inhibition to the mode of action of these compounds, especially ruthenium-based compounds. The study also confirmed the capability of the SIA-LOV system as a versatile tool for automating the determination of IC50 values of metal-based compounds.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Adam A. A. Sulaiman, Ali Alhoshani, Saeed Ahmad, Abdul Malik Puthan Peedikakkal, Ahmed K. Abogosh, Meshal Alghanem, Mohamed A. Mahmoud, W. A. Alanazi, Noura Alasmael, Muhammad Monim-ul-Mehboob, Anvarhusein A. Isab
Summary: Four new phosphanegold(I) complexes were synthesized and characterized, showing excellent cytotoxicity against human cancer cell lines, with one complex inducing apoptosis in A549 cells in a concentration-dependent manner.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Carlo Marotta, Ester Giorgi, Francesca Binacchi, Damiano Cirri, Chiara Gabbiani, Alessandro Pratesi
Summary: The discovery of cisplatin's antineoplastic properties in 1965 renewed the interest in metal complexes for medicinal applications. Researchers have been studying safer and more effective alternatives to cisplatin, including platinum(IV)-based compounds. These compounds have attracted attention because they can be reduced in cells to activate the platinum center and offer advantages such as reducing side effects. This review summarizes the recent achievements in the field of Pt(IV) prodrugs.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Motahareh Mortazavi, Masoumeh Divar, Tahereh Damghani, Fatemeh Moosavi, Luciano Saso, Somayeh Pirhadi, Mehdi Khoshneviszadeh, Najmeh Edraki, Omidreza Firuzi
Summary: In this study, a series of novel quinazolinone hydrazide triazole derivatives were designed and synthesized as MET receptor tyrosine kinase inhibitors. Compound CM9 showed significant antiproliferative effect and apoptosis induction in lung cancer cells, and also inhibited several other protein kinases.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Pierre Picchetti, Angela Casini
Summary: The discovery of medicinal properties of gold complexes has led to the development of new anticancer drugs, which are unique in their modes of action. Current research focuses on designing drug leads with enhanced pharmacological activities and improving physicochemical properties of gold compounds. Encapsulation of gold compounds in nanocarriers or their grafting onto targeted delivery vectors may lead to new nanomedicines for clinical applications. This article provides an overview of gold anticancer compounds and a detailed review of nanoparticle-based delivery systems for gold chemotherapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Marco Zuccolo, Noemi Arrighetti, Paola Perego, Diego Colombo
Summary: Platinum drugs are widely used for treating solid tumors, but their side effects and drug resistance are major limitations. The development of Pt(II) and Pt(IV) complexes with bioactive ligands shows promising anticancer activities and improved pharmacological profiles.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Suxing Jin, Yan Guo, Zijian Guo, Xiaoyong Wang
Summary: Monofunctional platinum(II) complexes are a class of non-traditional anticancer agents hopeful to overcome the defects of current platinum drugs, with designs aiming to visualize cellular distribution, reduce side effects, improve tumor selectivity, or inhibit cancer cells through non-DNA targets.
Article
Instruments & Instrumentation
Rossana Galassi, Christian Contini, Matteo Pucci, Ennio Gambi, Gabriele Manca
Summary: The remote, timely and in-field detection of sulfured additives in natural gas pipelines is challenging for various reasons. A customized ultraviolet spectrophotometer, named Spectra, was developed for the in-field detection of odorants in pipelines, providing continuous analysis and quantitative determination. The experimental and theoretical datasets showed good matches, validating the reliability of the collected data and making the instrument suitable for various purposes.
APPLIED SPECTROSCOPY
(2021)
Article
Cell Biology
Sonia Silvestri, Ilenia Cirilli, Fabio Marcheggiani, Phiwayinkosi Dludla, Giulio Lupidi, Riccardo Pettinari, Fabio Marchetti, Corrado Di Nicola, Giancarlo Falcioni, Cristina Marchini, Patrick Orlando, Luca Tiano, Augusto Amici
Summary: Platinum-based compounds are widely used anticancer drugs, but their toxicity and chemoresistance issues have driven the study of other compounds, such as ruthenium-based compounds. UNICAM-1, tested in vitro, showed a clear mitochondrial target and cytotoxic dose-dependent response, potentially serving as an effective alternative for chemotherapy treatment of breast cancer.
Article
Chemistry, Inorganic & Nuclear
Zhou Lu, Alfredo Burini, Roy N. McDougald, Simone Ricci, Lorenzo Luciani, Vladimir N. Nesterov, Abdel-Monem M. Rawashdeh, Mohammad A. Omary, Rossana Galassi
Summary: The formation of heterobimetallic complexes from cyclic trinuclear complexes (CTCs) of gold(I) is a straightforward strategy that leads to strengthened bonding and improved optoelectronic properties. This study investigates a new gold(I)-vinylimidazolate CTC and its highly emissive sandwich adducts with soft metal cations. The research provides valuable insights for designing and synthesizing metal complexes with unique optoelectronic properties.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Rossana Galassi, Lorenzo Luciani, Claudia Graiff, Gabriele Manca
Summary: Coinage metal cyclic trinuclear compounds (CTCs) are a valuable class of metal coordination compounds for optoelectronic applications. This study investigates the effect of different substituents on the chemistry of Au(I) CTCs with imidazolate ligands. Experimental and computational results provide insights into the addition/oxidation reactions and propose a new interpretation of Au(I)-ligand bonding in the oxidized CTCs.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Rossana Galassi, Christian Contini, Matteo Pucci, Ennio Gambi
Summary: The presence of benzene and similar aromatic compounds in civil environments is influenced by human activities and natural sources. It is crucial to detect these compounds in natural gas pipelines and ensure their concentration remains within legal limits. An optical device designed for the measurement of sulfured odorizing agents in natural gas pipelines can provide in-field detections of benzene, toluene, and xylenes (BTX) through continuous remote check.
Review
Biochemistry & Molecular Biology
Rossana Galassi, Lorenzo Luciani, Junbiao Wang, Silvia Vincenzetti, Lishan Cui, Augusto Amici, Stefania Pucciarelli, Cristina Marchini
Summary: This article reviews recent scientific findings on two classes of gold compounds containing phosphane or carbene ligands, as well as the recent developments in the application of Auranofin for breast cancers.
Article
Chemistry, Multidisciplinary
Lorenzo Luciani, Rossana Galassi, Junbiao Wang, Cristina Marchini, Alessia Cogo, Maria Luisa Di Paolo, Lisa Dalla Via
Summary: In the search for alternatives to platinum-based anticancer drugs, 11th group metal phosphane compounds have been considered. These compounds, particularly the tris-arylphosphane metal derivatives, have shown remarkable cytotoxic activities. By modifying the aryl moieties and phosphane ligands, the activity of the compounds can be enhanced. The resulting compounds exhibit intense emissive properties and have demonstrated significant antiproliferative effects on sensitive and cisplatin-resistant tumor cell lines.
FRONTIERS IN CHEMISTRY
(2022)
Article
Oncology
Junbiao Wang, Alessia Lamolinara, Laura Conti, Mara Giangrossi, Lishan Cui, Maria Beatrice Morelli, Consuelo Amantini, Maurizio Falconi, Caterina Bartolacci, Cristina Andreani, Fiorenza Orlando, Mauro Provinciali, Francesco Domenico Del Pizzo, Francesca Russo, Barbara Belletti, Federica Riccardo, Elisabetta Bolli, Elena Quaglino, Federica Cavallo, Augusto Amici, Manuela Iezzi, Cristina Marchini
Summary: This study demonstrates that phage-based HER2 vaccines can delay the onset and progression of breast cancer and generate anti-HER2 antibodies, providing a new approach for the treatment of HER2-positive breast cancer.