Quinazolinone azolyl ethanols: potential lead antimicrobial agents with dual action modes targeting methicillin-resistantStaphylococcus aureusDNA

Heterocyclic Naphthalimides as New Skeleton Structure of Compounds with Increasingly Expanding Relational Medicinal Applications

(2016) Huo-Hui Gong et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism

(2016) Sheng-Feng Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coumarin-derived azolyl ethanols: synthesis, antimicrobial evaluation and preliminary action mechanism

(2016) Xin-Mei Peng et al.   Science China-Chemistry

Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu2+ mediated DNA-targeting antibacterial agents

(2015) Ling Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Antimicrobial Evaluation of Novel Quinolone Imidazoles and Interactions with MRSA DNA

(2015) Ling Zhang et al.   Chemical Biology & Drug Design

Target-based molecular modeling strategies for schistosomiasis drug discovery

(2015) Leonardo G Ferreira et al.   Future Medicinal Chemistry

Novel benzimidazole derived naphthalimide triazoles: synthesis, antimicrobial activity and interactions with calf thymus DNA

(2015) Yun-Lei Luo et al.   Science China-Chemistry

Design, synthesis, and antibacterial evaluation of novel azolylthioether quinolones as MRSA DNA intercalators

(2015) Ling Zhang et al.   MedChemComm

Synthesis and biological evaluation of a new class of quinazolinoneazoles as potential antimicrobial agents and their interactions with calf thymus DNA and human serum albumin

(2015) Li-Ping Peng et al.   MedChemComm

Mechanism of Quinolone Action and Resistance

(2014) Katie J. Aldred et al.   BIOCHEMISTRY

Design, synthesis, and biological evaluation of dihydroartemisinin–fluoroquinolone conjugates as a novel type of potential antitubercular agents

(2014) Fu-Wei Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel hybrids of metronidazole and quinolones: Synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin

(2014) Sheng-Feng Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

(2014) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and antibacterial activity of novel Schiff base derivatives of quinazolin-4(3H)-one

(2014) Xiang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The synthesis and activities of novel mononuclear or dinuclear cyclen complexes bearing azole pendants as antibacterial and antifungal agents

(2014) Shuo Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA

(2013) Sheng-Feng Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives

(2013) Li-Ping Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Current Developments of Coumarin Compounds in Medicinal Chemistry

(2013) Xin-Mei Peng et al.   CURRENT PHARMACEUTICAL DESIGN

Recent Developments in Azole Compounds as Antibacterial and Antifungal Agents

(2013) Xin-Mei Peng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nonclassical antifolates, part 3: Synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones

(2013) Fatmah A.M. Al-Omary et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin

(2013) Ben-Tao Yin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, DNA binding, hemolysis assays and anticancer studies of copper(II), nickel(II) and iron(III) complexes of a pyrazoline-based ligand

(2013) Kishwar Saleem et al.   Future Medicinal Chemistry

Two Novel Ternary Dicopper(II) μ-Guanazole Complexes with Aromatic Amines Strongly Activated by Quantum Dots for DNA Cleavage

(2013) Javier Hernández-Gil et al.   INORGANIC CHEMISTRY

A new hybrid approach and in vitro antimicrobial evaluation of novel 4(3H)-quinazolinones and thiazolidinone motifs

(2013) N.C. Desai et al.   JOURNAL OF FLUORINE CHEMISTRY

Discovery of Selective Small Molecule Type III Phosphatidylinositol 4-Kinase Alpha (PI4KIIIα) Inhibitors as Anti Hepatitis C (HCV) Agents

(2013) Anna L. Leivers et al.   JOURNAL OF MEDICINAL CHEMISTRY

DFT Computational Study of the Methanolytic Cleavage of DNA and RNA Phosphodiester Models Promoted by the Dinuclear Zn(II) Complex of 1,3-Bis(1,5,9-triazacyclododec-1-yl)propane

(2013) Christopher I. Maxwell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

(2013) Ling Zhang et al.   MEDICINAL RESEARCH REVIEWS

Synthesis, spectroscopic characterisation, DNA cleavage, superoxidase dismutase activity and antibacterial properties of some transition metal complexes of a novel bidentate Schiff base derived from isatin and 2-aminopyrimidine

(2013) L.P. Nitha et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Molecular Spectroscopy Evidence of Berberine Binding to DNA: Comparative Binding and Thermodynamic Profile of Intercalation

(2012) Xiao-Ling Li et al.   BIOMACROMOLECULES

Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents

(2012) Yan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Researches in Triazole Compounds as Medicinal Drugs

(2012) C. -H. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides

(2012) Caterina Carmi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents

(2012) QingPeng Wang et al.   Science China-Chemistry

Structural analysis of DNA and RNA interactions with antioxidant flavonoids

(2012) C. D. Kanakis et al.   SPECTROSCOPY-AN INTERNATIONAL JOURNAL

Quinazolinone Analogs as Potential Therapeutic Agents

(2011) P. C. Sharma et al.   CURRENT MEDICINAL CHEMISTRY

Molecular Spectroscopic Studies of Farrerol Interaction with Calf Thymus DNA

(2011) Guowen Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of theS. aureusNorA Efflux Pump

(2011) Stefano Sabatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents

(2010) Yuan Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances in structure-based drug design of novel bacterial topoisomerase inhibitors

(2010) Katherine Widdowson et al.   Future Medicinal Chemistry

Novel fused quinazolinones: further studies on the anticonvulsant activity of 1,2,9,11-tetrasubstituted-7H-thieno[2´,3´:4,5]pyrimido[6,1-b]-quinazolin-7-one and 1,3,10,12-tetrasubstituted-8H-pyrido[2´,3´:4,5]pyrimido[6,1-b]quinazolin-8-one

(2010) Sachin S Laddha et al.   Future Medicinal Chemistry

Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

(2009) Koichiro Harada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorescence Interaction and Determination of Calf Thymus DNA with Two Ethidium Derivatives

(2009) Nuriye Akbay et al.   JOURNAL OF FLUORESCENCE

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY