Article
Fisheries
Mohammed A. E. Naiel, Mohamed K. Khames, Nashwa Abdel-Razek, Amany A. Gharib, Khaled A. El-Tarabily
Summary: Adding 2.5 g/kg concentration of miswak leaf powder (MLP) improves the growth performance, feed utilization, and feed efficiency of Nile tilapia. In challenge testing against Aeromonas hydrophila, a high concentration of MLP (10 g/kg) increases protein content in fish body, shows significant antibacterial and antifungal effects, and can be used to enhance resistance against the disease caused by the bacteria.
AQUACULTURE REPORTS
(2021)
Article
Chemistry, Physical
Sunil L. Dhonnar, Rahul A. More, Vishnu A. Adole, Bapu S. Jagdale, Nutan Sadgir, Santosh S. Chobe
Summary: A series of 1,3,4-oxadiazole derivatives were synthesized and characterized. The synthesized compounds exhibited significant antibacterial and antifungal activity, as well as good antioxidant properties and low cytotoxicity. Three compounds showed higher antibacterial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Food Science & Technology
Tianyu Hou, Siva Sankar Sana, Huizhen Li, Yun Xing, Anima Nanda, Vasudeva Reddy Netala, Zhijun Zhang
Summary: Essential oils are versatile and can be used as substitutes in various sectors. However, there is still a lack of comprehensive understanding about the components and molecular mechanisms of essential oils. Their bioactivity can be compared with synthetic pharmaceutical formulations, and further research is needed to explore their potential applications in nutrition or pharmaceutical companies.
Review
Food Science & Technology
Tianyu Hou, Siva Sankar Sana, Huizhen Li, Yun Xing, Anima Nanda, Vasudeva Reddy Netala, Zhijun Zhang
Summary: This article summarizes the antibacterial and antifungal properties of essential oils, their mechanisms, and ingredients, to identify areas of study that can promote implementation in various bacterial and fungal properties.
Article
Biochemistry & Molecular Biology
Denis Sudarikov, Yulia Gyrdymova, Alexander Borisov, Julia M. Lukiyanova, Roman Rumyantcev, Oksana G. Shevchenko, Diana R. Baidamshina, Nargiza D. Zakarova, Airat R. Kayumov, Ekaterina O. Sinegubova, Alexandrina S. Volobueva, Vladimir V. Zarubaev, Svetlana A. Rubtsova
Summary: New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time. The compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.
Review
Biochemistry & Molecular Biology
Magdalena Ulanowska, Beata Olas
Summary: Eugenol is a compound with various pharmacological effects, widely used in different fields. Despite its high toxicity, it is considered safe in appropriate doses. Researchers are interested in the multidirectional action of eugenol, considering it as a component of new drugs and other products with therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Corneliu Tanase, Alexandru Nicolescu, Adrian Nisca, Ruxandra Stefanescu, Mihai Babota, Anca Delia Mare, Cristina Nicoleta Ciurea, Adrian Man
Summary: This study evaluated the biological potential of red oak bark extracts, finding that they were rich in phenols and tannins, and exhibited antioxidant, anti-glucosidase, and anti-tyrosinase activity, as well as antimicrobial effects against certain bacteria and Candida species.
Article
Microbiology
Ashley L. Cunningham, Orhi Esarte Palomero, Bradley J. Voss, M. Stephen Trent, Bryan W. Davies
Summary: Otilonium bromide, a poorly absorbed oral medication used for irritable bowel syndrome, has been found to have broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. This suggests that otilonium bromide could be a new option for intestinal antimicrobial therapy targeting enteric pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tianxi Li, Lulu Li, Fangyuan Du, Lei Sun, Jichao Shi, Miao Long, Zeliang Chen
Summary: This review focuses on antifungal peptides isolated from various microorganisms, outlining their antifungal activity, toxic effects, and mechanisms of action, as well as common solutions to mitigate their toxicity. This work serves as a useful reference for further clinical research and the development of safe antifungal drugs with high efficiencies and broad application spectra.
Article
Plant Sciences
Mirela Uzelac, Barbara Sladonja, Ivana Sola, Slavica Dudas, Josipa Bilic, Ibukun M. Famuyide, Lyndy J. McGaw, Jacobus N. Eloff, Maja Mikulic-Petkovsek, Danijela Poljuha
Summary: Black locust, an invasive tree in Europe, has a rich composition of phenolic compounds with potential pharmaceutical use. The study conducted LC-MS screening of black locust from Croatia and found that the leaves had higher levels of total phenolics, flavonoids, and antioxidant capacity compared to the flowers. Ethanol extracts showed higher levels of total phenolics and non-flavonoids. A total of 64 compounds were identified, with flavonols and hydroxycinnamic acid derivatives being the most commonly represented. The extracts exhibited promising quorum sensing, biofilm prevention, and eradicating capacity.
Article
Chemistry, Physical
Nesimi Uludag, Goncagul Serdaroglu, Paramasivam Sugumar, Parthasarathi Rajkumar, Naki Colak, Erol Ercag
Summary: Efficient pathway synthesis of 6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate derivatives was achieved. The structures of the synthesized compounds were confirmed using spectroscopic methods. Antioxidant assays revealed that compound 2 exhibited the highest antioxidant capacity, followed by compound 1 and compound 3. Docking studies demonstrated that compound 1 had the strongest inhibitory activity against Escherichia coli thymidylate synthase. TD-DFT calculations and NBO analysis further supported the conclusions drawn from the antioxidant assays and docking studies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Biochemistry & Molecular Biology
Uday M. Muddapur, Sultan Alshehri, Mohammed M. Ghoneim, Mater H. Mahnashi, Mohammed Abdulrahman Alshahrani, Aejaz Abdullatif Khan, S. M. Shakeel Iqubal, Amal Bahafi, Sunil S. More, Ibrahim Ahmed Shaikh, Basheerahmed Abdulaziz Mannasaheb, Noordin Othman, Muazzam Sheriff Maqbul, Mohammad Zaki Ahmad
Summary: Bionanotechnology has revolutionized modern science and technology, with plant-mediated synthesis of gold nanoparticles overcoming the drawbacks of traditional methods and offering tunable features for the development of medical diagnostics and therapeutics.
Article
Chemistry, Multidisciplinary
Ruxandra Stefanescu, Cristina Nicoleta Ciurea, Anca Delia Mare, Adrian Man, Adrian Nisca, Alexandru Nicolescu, Andrei Mocan, Mihai Babota, Nastaca-Alina Coman, Corneliu Tanase
Summary: Processing wood leads to the accumulation of forest waste, including bark, which can be exploited for their high content of biomolecules. In this study, the histo-anatomical and phytochemical characterization of older oak bark was conducted, and the extracts obtained using microwave-assisted extraction (MAE) showed the highest polyphenol content and strongest antioxidant and antibacterial activities. These findings suggest that older oak bark could be a potential source of compounds with antibacterial, antioxidant, or antidiabetic activity.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Zuleyha Almaz
Summary: This study synthesized diverse 1,2,3-triazole compounds and investigated their activities in antioxidant, antibacterial, and antifungal aspects. Compound 4 exhibited the best antimicrobial activity and antioxidant activity close to the standard compounds.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Food Science & Technology
Liu Jiang, Kang Zheng
Summary: The cyclic voltammetry technique was used to detect the electrochemical response of 15 green tea products stored for different periods of time, and ten electrochemical feature parameters were extracted. An artificial neural network (ANN) prediction model was established to predict the changes in antioxidant activity descriptors of stored green tea. The ANN model showed good predictive accuracy with a mean absolute percentage error within 2%.
Article
Biochemistry & Molecular Biology
Nenad Zlatic, Vladimir Mihailovic, Marija Ljesevic, Vladimir Beskoski, Milan Stankovic
Summary: This study aimed to determine the qualitative variability of essential oils of mountain germander at the population level, depending on the type of geological substrate. The results showed a significant influence of the habitat geological substrate on the qualitative characteristics of the essential oil.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Chemistry, Medicinal
Jelena Popovic-Djordjevic, Cristina Quispe, Roberta Giordo, Aleksandar Kostic, Jelena S. Katanic Stankovic, Patrick Valere Tsouh Fokou, Katya Carbone, Miquel Martorell, Manoj Kumar, Gianfranco Pintus, Javad Sharifi-Rad, Anca Oana Docea, Daniela Calina
Summary: This article reviews the latest information on the anti-HIV activity of natural and synthetic compounds, including their history, mechanism of action, and the role of plants and their bioactive compounds as a source of new anti-HIV drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Asija Halilagic, Enisa Selimoviec, Jelena S. Katanic Stankovic, Nikola Sreckovc, Katarina Virijevic, Marko N. Zivanovic, Biljana Smit, Tanja Soldatovic
Summary: In this study, new heterometallic complexes were synthesized and their reactivity with biologically important nucleophiles as well as their antimicrobial and cytotoxic activities were investigated. The results showed different reactivity orders for different nucleophiles towards the complexes. The synthesized complexes exhibited moderate antimicrobial activity and significant cytotoxic effects, inducing cell death and increasing reactive radical species.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Aleksandra Minic Jancic, Jelena S. Katanic Stankovic, Nikola Sreckovic, Vladimir Mihailovic, Danijela Ilic Komatina, Dragana Stevanovic
Summary: A small library of ferrocenes containing six-membered cyclic ureas ring were synthesized and characterized. The electrochemical properties of the compounds were studied. The compounds showed lower antimicrobial activity but some exhibited strong antioxidant activity.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Plant Sciences
Tijana Micovic, Jelena S. Katanic Stankovic, Rudolf Bauer, Xuehong Nost, Zoran Markovic, Dejan Milenkovic, Vladimir Jakovljevic, Marina Tomovic, Jovana Bradic, Danijela Stesevic, Danilo Stojanovic, Zoran Maksimovic
Summary: The study found that hyssop herb has anti-inflammatory properties, making it a potential treatment option for inflammatory diseases. The extracts from hyssop herb showed significant inhibition of COX-2 enzyme in in vitro testing and demonstrated anti-inflammatory effects in in vivo testing. Preliminary in silico testing also showed that the organic acids in hyssop herb had better inhibitory activity against COX-1 and COX-2 enzymes compared to common non-steroidal anti-inflammatory drugs.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Agricultural Engineering
Nikola Sreckovic, Danijela Misic, Uros Gasic, Sanja Lj. Matic, Jelena S. Katanic Stankovic, Nevena R. Mihailovic, Daria Maria Monti, Luigi D'Elia, Vladimir Mihailovic
Summary: Salvia pratensis, especially its root, contains valuable phenolic compounds and shows significant antioxidant, antibacterial, and anticancer activities.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Jelena Katanic S. Stankovic, Jelena Dorovic Jovanovic, Danijela Misic, Uros Gasic, Stefanie Nikles, Zoran Markovic, Rudolf Bauer
Summary: R. holostea is a medicinal plant with antioxidant, antimicrobial, and anti-inflammatory properties. It contains phenolic acids, flavonoids, and flavonoid glucosides as its main constituents. It is widely distributed in Europe, Western Asia, and North Africa, and was previously used in salads or for the treatment of inflammatory disorders.
Article
Biochemistry & Molecular Biology
Nikola Z. Sreckovic, Zoran P. Nedic, Daria Maria Monti, Luigi D'Elia, Silvana B. Dimitrijevic, Nevena R. Mihailovic, Jelena Katanic S. Stankovic, Vladimir B. Mihailovic
Summary: The aim of this study was to synthesize silver nanoparticles using aqueous extracts of Salvia pratensis L., and to evaluate their biological and catalytic activity. Characterization of the nanoparticles was done using various techniques, and the phenolic and flavonoid contents as well as antioxidant activity of the extracts were determined. The synthesized nanoparticles showed higher activity compared to the extracts and exhibited strong antimicrobial activity against bacteria and fungi, as well as biocompatibility and catalytic activity.
Editorial Material
Chemistry, Medicinal
Jelena B. B. Popovic-Djordjevic, Jelena S. Katanic Stankovic
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Review
Horticulture
Sandra Vukovic, Jelena B. Popovic-Djordjevic, Aleksandar Z. Kostic, Nebojsa Dj. Pantelic, Nikola Sreckovic, Muhammad Akram, Umme Laila, Jelena S. Katanic S. Stankovic
Summary: Allium species, including onion, garlic, leek, chives, Welsh onion, and wild garlic, have been widely used in human diet, traditional medicine, and officinal medicine. This review focuses on the major metabolites, antioxidant and antimicrobial properties of alliums, particularly those found in the Balkan region. The Balkan region is considered the genocenter of alliums due to its richness in endemic species, with 56 recorded Allium species and 17 of them being endemic. These plants are valued for their pungent taste and smell, attributed to various organosulfur compounds. Additionally, phytochemicals such as organosulfur compounds, phenolics, fatty acids, and saponins contribute to their antioxidant and antimicrobial properties.
Article
Chemistry, Multidisciplinary
Katarina D. Virijevic, Petar B. Stanic, Jovana M. Muskinja, Jelena S. Katanic Stankovic, Nikola Sreckovic, Marko N. Zivanovic, Biljana M. Smit
Summary: A series of zingerone-thiohydantoin hybrids were synthesized and characterized. These compounds showed potential bioactivity and exhibited antimicrobial and in vitro anticancer activities.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
