Article
Oncology
Stefania C. Pinto, Thiago Acunha, Janio M. Santurio, Laura B. Denardi, Bernardo A. Iglesias
Summary: This study reported enhanced antimicrobial photoinactivation using tetra-cationic porphyrins with peripheral platinum(II) and palladium(II) complexes against fungal dermatophyte strains. Among the six different positively charged porphyrins tested in antimicrobial photodynamic therapy experiments, the most effective PS meta isomer 3PtP significantly reduced the concentration of viable fungal colony under white-light irradiation for 120 min. Tetra-cationic porphyrins containing platinum(II)-bipyridyl complexes may be promising fungicidal aPDT agents with potential applications in future clinical cases.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Grazille Guidolin Rossi, Kevim Bordignon Guterres, Kelly Schneider Moreira, Thiago Augusto Lima Burgo, Marli Matiko Anraku de Campos, Bernardo Almeida Iglesias
Summary: Antimicrobial photodynamic therapy has shown potential in treating noninvasive infections, with positively charged porphyrins, especially the 3-PdTPyP derivative, demonstrating the most efficient bactericidal activity against fast-growing mycobacterial strains.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Dariane Clerici Jornada, Rafael de Queiroz Garcia, Carolina Hahn da Silveira, Lino Misoguti, Cleber Renato Mendonca, Roberto Christ Vianna Santos, Leonardo De Boni, Bernardo Almeida Iglesias
Summary: This manuscript investigates the photophysical properties of tetra-cisplatin porphyrin derivatives and their antimicrobial photoinactivation effects against Gram + and Gram - bacterial strains. The results suggest that the compound substituted at the meta position is the most efficient photosensitizer against bacterial cultures, indicating potential applications of tetra-cationic porphyrins containing cisplatin derivatives in clinical infections.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Chemistry, Physical
Yanyan Li, Guichen Li, Qian Zhang, Yuxia Li, Qifan Jia, Wenyuan Zhang, Xiaoxia Feng, Weibing Xu, Jiacheng Liu
Summary: Three water-soluble porphyrins containing halogen atoms (F, Cl, Br) were synthesized, with P3 showing the highest singlet oxygen generation capacity. MTT assay confirmed good phototoxicity and high selectivity of P1-P3, while fluorescence imaging and intracellular reactive oxygen species demonstrated cell apoptosis and ROS production. The high ROS production and excellent phototoxicity make the photosensitizers potential candidates for PDT drugs.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Chemistry, Multidisciplinary
D. Chakraborty, D. Musib, R. Saha, A. Das, M. K. Raza, V Ramu, S. Chongdar, K. Sarkar, A. Bhaumik
Summary: This research demonstrates the synthesis of a stable phosphonate ligand-based fluorescent copper-MOF with excellent photocytotoxic effect against lung cancer cells and antibacterial efficacy against both Gram-positive and Gram-negative microorganisms. This MOF also shows good fluorescence properties for cancer cell imaging.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shanshan Liu, Bingnan Wang, Yuewen Yu, Yubo Liu, Zeyan Zhuang, Zujin Zhao, Guangxue Feng, Anjun Qin, Ben Zhong Tang
Summary: This article introduces a molecular cationization approach to enhance the generation of reactive oxygen species (ROS) by aggregation-induced emission (AIE) photosensitizers, especially type I ROS, for photodynamic treatment of drug-resistant bacteria.
Article
Oncology
Kevim Bordignon Guterres, Grazielle Guidolin Rossi, Marli Matiko Anraku de Campos, Kelly Schneider Moreira, Thiago Augusto Lima Burgo, Bernardo Almeida Iglesias
Summary: In this study, the photoinactivation evaluation of Ag(II) porphyrins in the antimicrobial photodynamic therapy of rapidly growing mycobacterial strains was reported. The results showed that Ag(II) porphyrins significantly reduced the concentration of viable mycobacteria and induced potential structural damage.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Inorganic & Nuclear
Maxwell I. Martin, Trong-Nhan Pham, Kaytlin N. Ward, Anthony T. Rice, Phoebe R. Hertler, Glenn P. A. Yap, Philip H. Gilmartin, Joel Rosenthal
Summary: Photodynamic therapy (PDT) is a promising treatment for certain cancers, but traditional macrocyclic tetrapyrrole ligands have limitat
ions due to adverse biological side effects. However, non-traditional oligotetrapyrrole ligands metalated with palladium (Pd[DMBil1]) have shown excellent biocompatibility. In this study, a new family of Pd[DMBil2-R] complexes with extended conjugation was synthesized and characterized, indicating their potential for PDT applications. The electronic nature of the phenylalkynyl appendages greatly influenced the photophysics of the Pd-II biladiene.
DALTON TRANSACTIONS
(2023)
Article
Engineering, Biomedical
Zheng Wang, Chao Sun, Yifeng Yu, Dong Zhang, Baiwen Qi, Zonghuan Li, Xinzeyu Yi, Aixi Yu
Summary: This study evaluated the therapeutic potential of a near-infrared probe (WL-808) mediated photodynamic therapy for traumatic heterotopic ossification (HO). In vitro experiments showed that WL-808 could induce chondrocyte apoptosis and inhibit cell viability. In vivo experiments demonstrated that WL-808 could specifically target HO and inhibit bone formation under near-infrared excitation.
MATERIALS TODAY BIO
(2023)
Article
Microbiology
Zhanjuan Zhao, Jinduo Ma, Yiyi Wang, Zehua Xu, Lu Zhao, Jianxi Zhao, Ge Hong, Tianjun Liu
Summary: The cationic porphyrin conjugate PPIX-MED has a potent photosensitive antibacterial effect on a variety of clinically isolated bacteria. Combining antimicrobial photodynamic therapy (aPDT) with antibiotics enhances the healing of infected third-degree burns in rats. PPIX-MED-aPDT shows promising bactericidal effects both in vitro and in vivo.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Viviana Teresa Orlandi, Eleonora Martegani, Fabrizio Bolognese, Nicola Trivellin, Francesco Garzotto, Enrico Caruso
Summary: Antimicrobial photodynamic therapy (aPDT) is gaining attention as a promising tool for treating microbial infections and sanitizing environments. A study on a panel of photosensitizers found that dicationic diaryl-porphyrins show potential in efficiently photoinactivating Pseudomonas aeruginosa, including inhibiting biofilm formation. These findings suggest the potential applicability of dicationic diaryl-porphyrins in different fields for combating difficult-to-treat microbes like P. aeruginosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ticiane da Rosa Pinheiro, Gabrielle Aguiar Dantas, Jean Lucas Gutknecht da Silva, Daniela Bitencourt Rosa Leal, Ricardo Barreto da Silva, Thiago Augusto de Lima Burgo, Roberto Christ Vianna Santos, Bernardo Almeida Iglesias
Summary: This study evaluated the in vitro activity of cationic porphyrins with platinum(II) complexes against Candida albicans. The results showed that 3PtTPyP exhibited excellent antifungal activity and reduced preformed biofilms effectively.
Article
Oncology
Ticiane da Rosa Pinheiro, Carolina Gonzalez Urquhart, Thiago Vargas Acunha, Roberto Christ Vianna Santos, Bernardo Almeida Iglesias
Summary: This manuscript presents the first report on antimicrobial photo-inactivation in vitro using tetra-cationic porphyrins with peripheral platinum(II) bipyridyl complexes against Gram-positive bacteria. Two isomeric tetracationic porphyrins (3TPyP and 4TPyP) were tested against clinically important bacterial species. The antimicrobial activity assays were performed at specific photosensitizer (PS) concentrations under dark and white-light LED irradiation conditions for 120 min.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Solmaz Saghebasl, Hassan Amini, Abbas Nobakht, Sanya Haiaty, Hesam Saghaei Bagheri, Parisa Hasanpour, Morteza Milani, Sepideh Saghati, Ozra Naturi, Mehrdad Farhadi, Reza Rahbarghazi
Summary: This study investigated a nanofibrous matrix for promoting wound healing, which showed good cytocompatibility, antibacterial activity, and enhanced healing potential. The addition of an antibacterial agent and a drug release system improved the therapeutic effect of the matrix.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vanya N. Mantareva, Vesselin Kussovski, Petya Orozova, Lyudmila Dimitrova, Irem Kulu, Ivan Angelov, Mahmut Durmus, Hristo Najdenski
Summary: PhotoDynamic Therapy (PDT) is an effective strategy to combat antimicrobial multidrug resistance (AMR) in pathogenic bacteria. This study demonstrates the efficacy of new Pd(II)- and Zn(II)-phthalocyanine complexes in inactivating Gram-negative bacteria, independent of their antibiotic sensitivity.
Article
Chemistry, Applied
Vanessa Schopf Machado, Camila Marina Verdi, Sabrina Somacal, Grazielle Guidolin Rossi, Marina Lopes Machado, Bruna Klein, Vitor Corteline Roos, Carolina Gonzalez Urquhart, Ionara Irion Dalcol, Michele Rorato Sagrillo, Alencar Kolinsk Machado, Marli Matiko Campos, Roger Wagner, Roberto Christ Vianna Santos
Summary: The essential oil of Achyrocline flaccida is composed mainly of alpha-pinene and caryophyllene, demonstrating significant antioxidant capacity and no genotoxicity. Additionally, it showed inhibitory effects on the growth of various mycobacterium strains, indicating potential for treating mycobacteriosis.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Maiara Callegaro Velho, Luciana Filippin Cossetin, Samantha Nunes de Godoi, Roberto Christ Vianna Santos, Andre Gundel, Silvia Gonzalez Monteiro, Aline Ferreira Ourique
Summary: This study focused on the preparation, characterization, and exploration of the insecticidal activity of nanoemulsions containing lemongrass or eucalyptus essential oil against adult flies. The nanoemulsions, prepared using high-energy method, exhibited a potential insecticidal effect of lemongrass oil at certain concentrations against Musca domestica and Lucilia cuprina, with further enhancement when nanoemulsified specifically against L. cuprina.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Camila Marina Verdi, Vanessa Schopf Machado, Alencar Kolinsk Machado, Bruna Klein, Pauline Cordenonsi Bonez, Eduardo Nascimento Correa de Andrade, Grazielle Rossi, Marli Matiko Campos, Roger Wagner, Michele Rorato Sagrillo, Roberto Christ Vianna Santos
Summary: This study is the first to relate cytogenotoxicity with oxidative metabolism and antimicrobial activity of Gaultheria procumbens essential oil. The results showed that the essential oil has promising potential for developing future formulations to treat infections caused by microorganisms, as it exhibited effective inhibition and killing of various microorganisms.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Carolina H. Silveira, Mariana G. Fronza, Renata A. Balaguez, Allya M. E. Larroza, Lucielli Savegnago, Davi F. Back, Bernardo A. Iglesias, Diego Alves
Summary: In this study, three new 4,7-bis((arylselanyeethynyebenzo[c][1,2,5]thiadiazoles were successfully synthesized using silver-catalyzed direct selanylation. The photophysical properties of the alkynyl derivatives were examined through UV-Vis and steady-state emission fluorescence, and the experimental and theoretical DNA/HSA binding properties were assessed. The results demonstrate the effective synthesis and characterization of the new compounds with potential applications in biological systems.
Article
Biotechnology & Applied Microbiology
Fallon dos Santos Siqueira, Camilla Filippi dos Santos Alves, Alencar Kolinski Machado, Josieli Demetrio Siqueira, Thiago dos Santos, Caren Rigon Mizdal, Kelly Schneider Moreira, Diogo Teixeira Carvalho, Pauline Codernonsi Bonez, Carolina Gonzalez Urquhart, Roberto Christ Vianna Santos, Michele Rorato Sagrillo, Lenice de Lourenco Marques, Davi Fernando Back, Marli Matiko Anraku de Campos
Summary: This study evaluated the anti-biofilm action and safety profile of a sulfamethoxazole-Ag complex, showing potential anti-biofilm activity through QS inhibition against Pseudomonas aeruginosa. In silico tests demonstrated the compound acts on key regulators of biofilm formation in P. aeruginosa and was found to be safe for human peripheral blood mononuclear cells.
Article
Chemistry, Applied
Vanessa Schopf Machado, Camila Marina Verdi, Grazielle Guidolin Rossi, Larissa Ilha de Souza, Cristiane Antunes Teixeira, Marina Lopes Machado, Tassia Limana da Silveira, Michele Rorato Sagrillo, Alencar Kolinski Machado, Rafaela Castro Dornelles, Marli Matiko Campos, Eliseu Rodrigues, Tatiana Emanuelli, Sabrina Somacal, Roberto Christ Vianna Santos
Summary: Achyrocline flaccida aqueous extract contains mainly flavonoids, which exhibit protective effects against oxidative stress and antimycobacterial activity without toxicity. The study suggests that this extract has potential as a new phytotherapeutic drug against clinically relevant mycobacteria.
NATURAL PRODUCT RESEARCH
(2022)
Article
Oncology
Dariane Clerici Jornada, Rafael de Queiroz Garcia, Carolina Hahn da Silveira, Lino Misoguti, Cleber Renato Mendonca, Roberto Christ Vianna Santos, Leonardo De Boni, Bernardo Almeida Iglesias
Summary: This manuscript investigates the photophysical properties of tetra-cisplatin porphyrin derivatives and their antimicrobial photoinactivation effects against Gram + and Gram - bacterial strains. The results suggest that the compound substituted at the meta position is the most efficient photosensitizer against bacterial cultures, indicating potential applications of tetra-cationic porphyrins containing cisplatin derivatives in clinical infections.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Polymer Science
Franciele da Silva Bruckmann, Altevir Rossato Viana, Leonardo Quintana Soares Lopes, Roberto Christ Vianna Santos, Edson Irineu Muller, Sergio Roberto Mortari, Cristiano Rodrigo Bohn Rhoden
Summary: This study successfully achieved the magnetite-functionalization of eugenol using the co-precipitation method, showing promising biocompatibility and antibacterial activity in vitro. It exhibited strong selectivity against cancer cells and has the potential to be a candidate for drug delivery in the treatment of cancer and bacterial infections in the future.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2022)
Article
Instruments & Instrumentation
Veronica Ferrari Cervi, Camila Parcianello Saccol, Ticiane da Rosa Pinheiro, Roberto Christ Vianna Santos, Marcel Henrique Marcondes Sari, Leticia Cruz
Summary: Nanocapsule-loaded Pullulan films for the treatment of vulvovaginal candidiasis demonstrated promising stability, controlled drug release, and antifungal activity against Candida albicans.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Parasitology
Samantha Nunes de Godoi, Lucas Trevisan Gressler, Antonio Francisco Igor Magalhaes de Matos, Andre Gundel, Silvia Gonzalez Monteiro, Roberto Christ Vianna Santos, Alencar Kolinski Machado, Michele Rorato Sagrillo, Aline Ferreira Ourique
Summary: This study evaluated the cytotoxicity of nanoemulsions containing Eucalyptus globulus essential oil against the blood of healthy sheep and their activity against the parasite H. contortus. The results showed that the nanoemulsion had suitable nanotechnological characteristics and demonstrated potential anthelmintic action in inhibiting parasite development.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Chemistry, Physical
Thaissa S. Beck, Mara de Mattos, Carlos R. T. Jortieke, Jean C. B. Vieira, Camila M. Verdi, Roberto C. V. Santos, Michele R. Sagrillo, Aline Rossato, Larissa da Silva Silveira, Clarissa P. Frizzo
Summary: Amino acid-based ionic liquids exhibit specific properties in thermal stability, heat capacity, antimicrobial activity, and cytotoxicity. It was found in the study that amino acid-based anions can reduce the thermal stability of mono and dicationic AAILs, and AAILs with more carbon chains have lower glass transition temperature.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Immunology
Dariane Jornada Clerici, Carolina Hahn da Silveira, Bernardo Almeida Iglesias, Roberto Christ Vianna Santos
Summary: Biofilms are responsible for a large majority of antimicrobial-resistant nosocomial infections, especially those associated with medical devices like urinary catheters. This study focused on evaluating the antimicrobial and antibiofilm effects of cationic porphyrins on Proteus mirabilis, the most prevalent microorganism causing these infections. The findings suggest that antimicrobial photodynamic therapy and cationic porphyrins can be promising alternatives to treat P. mirabilis biofilms.
MICROBIAL PATHOGENESIS
(2023)
Article
Infectious Diseases
Fabiana de Cassia Romanha Sturmer, Paulo Ricardo Moreira, Juliana Felipetto Cargnelutti, Leonardo Quintana Soares Lopes, Ezequiel Lorenzett, Thiago Augusto de Lima Burgo, Roberto Christ Vianna Santos
Summary: This study demonstrates the persistence of B. cereus in the hemodialysis system, highlighting its ability to form biofilms, produce virulence factors, and exhibit resistance to antimicrobial drugs.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2022)
Article
Fisheries
Elisia Gomes da Silva, Guerino Bandeira Junior, Juliana Felipetto Cargnelutti, Roberto Christ Vianna Santos, Andre Gundel, Bernardo Baldisserotto
Summary: This study found that limonene has high antibiofilm activity against Aeromonas hydrophila and can be an alternative treatment in fish farming industry. When combined with florfenicol, it showed an additive effect against the treatment of A. hydrophila, offering a potential therapeutic strategy in controlling bacterial diseases in fish farming.
Article
Infectious Diseases
Pauline Cordenonsi Bonez, Vanessa Albertina Agertt, Grazielle Guidolin Rossi, Fallon dos Santos Siqueira, Josieli Demetrio Siqueira, Lenice Lorenco Marques, Gelson Noe Manzoni de Oliveira, Roberto Christ Vianna Santos, Marli Matiko Anraku de Campos
Summary: Sulfonamide metal complexes were evaluated for their activity against RGM biofilm, showing effective inhibition of adhesion and biofilm formation. The anti-biofilm capacity is likely due to the inhibition of c-di-GMP synthesis, a crucial signal for RGM biofilm formation.
JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES
(2021)
