Article
Chemistry, Inorganic & Nuclear
Jungang Deng, Youru Wu, Aili Li, Weiping Pan, Lixia Hou, Daqi Wu, Zhenlei Zhang, Feng Yang, Yi Gou
Summary: Combining photodynamic therapy with chemotherapy using new dithiocarbazate-Zn(ii) complexes shows promising results for the treatment of lung cancer. The complex Zn3 exhibits good chemotherapeutic ability and generates superoxide anion radicals under light irradiation, leading to cancer cell death through photodynamic therapy. This study provides new strategies for multimodal cancer therapy.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Medicinal
Yi Gou, Xiaoying Jia, Li Xia Hou, Jun Gang Deng, Guo Jin Huang, Hao Wen Jiang, Feng Yang
Summary: Non-platinum-metal complexes have shown great potential as anticancer drugs. In this study, a series of dithiocarbazate non-Pt-metal complexes were designed and evaluated for their efficacy as antineoplastic agents. Complex 2 exhibited higher anticancer efficacy than other complexes and cisplatin, and showed comparable hemolysis with cisplatin. In vivo studies demonstrated that complex 2 effectively inhibited tumor xenograft growth with low systemic toxicity. Further investigations revealed that complex 2 suppressed cancer cells by simultaneously inhibiting mitochondria and glycolytic bioenergetics.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
P. Jyothi, V. Sumalatha, D. Rajitha
Summary: Three Co(II) complexes were synthesized and characterized, showing good DNA binding, antimicrobial, and anticancer activities.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Bhushan S. Sail, Vinod H. Naik, B. M. Prasanna, Naushad Ahmad, Mohammad Rizwan Khan, M. R. Jagadeesh, Ravikumar Cheedarala
Summary: Many Schiff bases derived from 2-hydrazinobenzothiazole and isatin have been used to form [ML2]Cl2 type Co(II) complexes. Nitrogen from azomethine, oxygen from lactonyl, and nitrogen atoms of the thiazole ring contribute to coordinating the metallic ion. The complexes consist entirely of metal and have a geometrical octahedron structure, as confirmed by analytical, magnetic, and spectroscopic investigations.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Mohammed Khaled Bin Break, Tan Yew Fung, May Zie Koh, Wan Yong Ho, Mohamed Ibrahim Mohamed Tahir, Omar Ashraf Elfar, Rahamat Unissa Syed, Weam M. A. Khojali, Turki Mubarak Alluhaibi, Bader Huwaimel, Christophe Wiart, Teng-Jin Khoo
Summary: A series of novel macroacyclic Schiff base ligands and their Cu (II) complexes were synthesized and evaluated for their anticancer and antibacterial activities. Among them, Cu1 showed the highest cytotoxic activity against breast cancer cells, while compound 3 exhibited the most potent antibacterial activity against K. rhizophila and S. aureus. The results suggested that these compounds have potential applications as anticancer and antibacterial agents.
Article
Chemistry, Inorganic & Nuclear
Rayees A. Bhat, Kaman Singh, D. Kumar, Ashok Kumar, Prashant Mishra
Summary: A new coordination compound [Zn(L)(2)] was studied for its antimicrobial potential against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. The results demonstrated effective inhibition of bacterial growth, indicating the compound's antimicrobial efficacy.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Biology
Bianka Obonova, Ladislav Habala, Miroslava Litecka, Peter Herich, Andrea Bilkova, Frantisek Bilka, Branislav Horvath
Summary: A series of Schiff base ligands were prepared by condensation and reduction reactions, which showed antimicrobial activities. The structures of the Schiff base ligands and zinc complexes were analyzed, and the antimicrobial effect of the complexes was found to be significantly higher than that of the free ligands. This suggests a synergic effect upon complexation with zinc.
Article
Chemistry, Inorganic & Nuclear
Priyanka Devi, Kiran Singh, Bhupender Kumar, Jahnavi Kumari Singh
Summary: Many pyrazoles-based Schiff bases were reported to exhibit high activity against bacterial, parasitic strains, and cancer cells. A new pyrazole based 'NO' bidentate ligand was synthesized and metal complexes with Co+2, Ni+2, Cu+2, and Zn+2 were also prepared. The characterization of the compounds and their metal complexes was performed, and the metal complexes showed enhanced activity compared to the ligand. They exhibited significant anticancer and antibacterial activity, as well as antifungal activity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Rana Muhammad Irfan, Muhammad Ashraf Shaheen, Muhammad Saleem, Muhammad Nawaz Tahir, Khurram Shahzad Munawar, Saeed Ahmad, Syeda Laila Rubab, Tehreem Tahir, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Summary: The present investigation synthesized four cadmium complexes with Schiff bases and evaluated their pharmacological activities. The complexes showed significant antibacterial potential and inhibition effects on alkaline phosphatase, indicating their potential as antimicrobial agents.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Serpil Kaya, Sultan Erkan, Duran Karakas
Summary: In this study, four-coordinated hypothetical platinum-II complexes were designed and characterized computationally. The complexes were found to have a distorted square planar geometry and the presence of an electron-donating group in the Schiff bases increased their anticancer and antibacterial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Mohamed R. Shehata, Ehab M. Abdalla
Summary: In this study, five novel metal ion complexes were synthesized and characterized, showing anticancer potential with antiproliferative effects on cancer cell lines, as well as antioxidant and antibacterial activities. The binding nature of the complexes with CT-DNA was investigated to determine intercalation or replacement mode.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Enis Nadia Md Yusof, Mohammad Azam, Siti Syaida Sirat, Thahira B. S. A. Ravoof, Alister J. Page, Abhi Veerakumarasivam, Thiruventhan Karunakaran, Mohd Rizal Razali
Summary: A novel series of transition metal complexes were synthesized using S-4-methylbenzyl-beta-N-(2-methoxybenzylmethylene)dithiocarbazate ligand. The compounds were characterized and evaluated for their cytotoxic behavior. Complex 2 showed promising results against cancer cell lines MCF-7 and MDA-MB-213.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Leonor Corte-Real, Vivien Posa, Matilde Martins, Raquel Colucas, Nora V. May, Xavier Fontrodona, Isabel Romero, Filipa Mendes, Catarina Pinto Reis, Maria Manuela Gaspar, Joao Costa Pessoa, Eva A. Enyedy, Isabel Correia
Summary: In this study, three novel Schiffbases (L1-L3) derived from the condensation of 2-carbaldehyde-8-hydroxyquinoline with amines containing morpholine or piperidine moieties were synthesized and characterized. These Schiffbases were reacted with CuCl2 and ZnCl(2) to yield six new coordination compounds, which were all characterized using various techniques. The Cu(II) complexes showed higher stability and anticancer activity than the Zn(II) complexes.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Giriraj Kalaiarasi, Pathinathan Senthilrajkapoor, Ramasamy Indumathy
Summary: Four new bivalent ruthenium(II) organometallic complexes were synthesized and characterized. The complexes showed significant antimicrobial activity and anticancer potential, exceeding that of their parent ligands and the standard drug cisplatin.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Ahmed R. E. Mahdy, Ola A. Abu Ali, Waleed M. Serag, Eman Fayad, Reda F. M. Elshaarawy, Emad M. Gad
Summary: A series of azo-functionalized Schiff base ligands containing different imidazole derivatives and their Co(II)/Zn(II) complexes were synthesized and characterized. The metal complexes exhibited higher thermal stability and showed inhibitory activity against breast carcinoma cells. The most potent and selective anti-breast cancer agent was found to be CoL3.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Engineering, Biomedical
Cesar Augusto Roque-Borda, Mauro de Mesquita Souza Saraiva, Wagner Dias Macedo Junior, Jose Carlos Estanislao Marquez Montesinos, Andreia Bagliotti Meneguin, Anna Beatriz Toledo Borges, Edson Crusca Junior, Saulo Santesso Garrido, Adriana Maria de Almeida, Reinaldo Marchetto, Marlus Chorilli, Angelo Berchieri Junior, Silvio Rainho Teixeira, Fernando Rogerio Pavan, Eduardo Festozo Vicente
Summary: The incorrect use of conventional drugs for intestinal infections has led to the spread of bacterial resistance. Antimicrobial peptide Ctx(Ile21)-Ha has shown effective antimicrobial activity against multidrug-resistant bacteria. However, direct oral application is not feasible due to gastrointestinal degradation. In this study, alginate microparticles loaded with Ctx(Ile21)-Ha peptide were designed to protect it and release it in the intestine, providing a potential solution for combating intestinal pathogens.
Article
Chemistry, Multidisciplinary
Malgorzata E. Zakrzewska, Paulo J. L. Andre, Clara S. B. Gomes, Ana V. M. Nunes, Vitor Rosa
Summary: In this study, three new neutral aryl-BIAN ZnCl2 complexes were synthesized using a green synthesis methodology. The complexes were fully characterized and tested as catalysts in the cycloaddition reaction of CO2 and epoxides. The results showed that the complexes exhibited good catalytic activity in the reaction.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Rafael R. Domeneguetti, Vanessa Y. Sakai, Gustavo F. Perotti, Isabel C. Silva, Agnieszka Tercjak, Hernane S. Barud, Fernando Pavan, Vera R. L. Constantino, Sidney J. Ribeiro
Summary: The effect of different concentrations of Laponite on the structure and properties of bacterial cellulose (BC) membranes was investigated. It was found that an appropriate amount of Laponite can improve the transparency and properties of BC membranes. This opens up new possibilities for the application of nanocomposites in the fields of medical, pharmaceutical, and cosmetics.
APPLIED CLAY SCIENCE
(2023)
Article
Chemistry, Medicinal
Guilherme F. S. Fernandes, Karyn F. Manieri, Andressa F. Bonjorno, Debora L. Campos, Camila M. Ribeiro, Fernanda M. Demarqui, Daniel A. G. Ruiz, Nailton M. Nascimento-Junior, William A. Denny, Andrew M. Thompson, Fernando R. Pavan, Jean L. Dos Santos
Summary: New carbamate derivatives showed potent antimicrobial activity against multidrug-resistant strains of M. tuberculosis with minimal toxicity to host cells and other microorganisms. Molecular docking studies indicated that these compounds may interact with the nitroreductase in a similar manner to pretomanid. These findings highlight the potential of imidazo[2,1-b][1,3]oxazine derivatives in treating multidrug-resistant tuberculosis.
Article
Biochemistry & Molecular Biology
Renan C. F. Leitao, Francisco Silva, Gabriel H. Ribeiro, Isabel C. Santos, Joana F. Guerreiro, Filipa Mendes, Alzir A. Batista, Fernando R. Pavan, Pedro Ivo da S. Maia, Antonio Paulo, Victor M. Deflon
Summary: Gallium and indium octahedral complexes with isoniazid derivative ligands were successfully synthesized. The complexes showed moderate affinity with human serum albumin through hydrophobic interactions. The complexes with H2L2 exhibited higher cytotoxicity against MCF-7 cells, as well as stronger accumulation in MCF-7 and PC-3 cells compared to the non-halogenated complexes. The ligands and metal complexes also demonstrated potent growth inhibitory effects against Mycobacterium tuberculosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wilton R. Lustri, Silmara C. Lazarini, Nayara Ap Simei Aquaroni, Flavia A. Resende, Nadia A. Aleixo, Douglas H. Pereira, Bruna Cardinali Lustri, Cristiano Gallina Moreira, Camila M. Ribeiro, Fernando R. Pavan, Douglas H. Nakahata, Adriano M. Goncalves, Nailton M. Nascimento-Junior, Pedro P. Corbi
Summary: This article describes the in vitro antibacterial activity and beta-lactamase inhibition of a novel silver(I) complex with the sulfonamide probenecid (Ag-PROB). The Ag-PROB complex showed significant growth inhibitory activity against various bacteria, including multi-drug resistant uropathogenic E. coli and ESBL-producing bacteria. Molecular docking results suggested the potential molecular mechanism of ESBL inhibition by Ag-PROB. These findings highlight the potential of Ag-PROB as a promising antibacterial agent.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sofia Friaes, Clara S. B. Gomes, Beatriz Royo
Summary: This study presents a new family of air-stable Mn and Re complexes with bidentate bis(1,2,3-triazol-5-ylidene) ligands, which can have a methylene linker or a direct link between the two triazolylidene ligands. These complexes have been used as catalysts for the N-alkylation of anilines with benzylic alcohols. The Mn complex with a bis-triazolylidene and a methylene bridge between the two triazolylidene fragments showed excellent catalytic efficiency, achieving a 92% yield of the corresponding amine with a low base loading (t-BuOK, 0.1 equiv). Comparison between Mn complexes with imidazolium- and triazolium-derived N-heterocyclic carbene ligands revealed that Mn triazolylidenes displayed higher catalytic activity under low base loading conditions.
Article
Chemistry, Physical
Rosa M. F. Baptista, Clara S. B. Gomes, Bruna Silva, Joao Oliveira, Bernardo Almeida, Cidalia Castro, Pedro V. Rodrigues, Ana Machado, Ruben B. Freitas, Manuel J. L. F. Rodrigues, Etelvina de Matos Gomes, Michael Belsley
Summary: A polymorph of glycyl-L-alanine HI.H2O is synthesized from chiral cyclo-glycyl-L-alanine dipeptide, which exhibits polar space group and shows pyroelectricity, optical second harmonic generation, thermal memory effect, and piezoelectric properties. It has a high pyroelectric coefficient and a nonlinear optical effective coefficient, making it suitable for energy harvesting applications.
Article
Chemistry, Physical
Maria S. S. Viana, Clara S. B. Gomes, Vitor Rosa
Summary: A series of nine cationic heteroleptic aryl-BIAN-copper(I) complexes were synthesized and fully characterized. The complexes showed high activity as catalysts for the copper azide-alkyne cycloaddition reaction under neat reaction conditions at 25 degrees C and in short reaction times.
Article
Chemistry, Multidisciplinary
Nadia Ribeiro, Ipek Bulut, Baris Sergi, Vivien Posa, Gabriella Spengler, Giuseppe Sciortino, Vania Andre, Liliana P. Ferreira, Tarita Biver, Valeria Ugone, Eugenio Garribba, Joao Costa-Pessoa, Eva A. Enyedy, Ceyda Acilan, Isabel Correia
Summary: This study reports the synthesis and characterization of a group of benzoylhydrazones and their Cu(II) complexes. The complexes exhibited moderate-to-strong interaction with bovine serum albumin and showed higher antiproliferative activity compared to the corresponding free ligand and cisplatin. Compound 8 demonstrated the most promising properties with low IC50 values, high induction of oxidative stress and DNA damage, resulting in high rates of apoptosis.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sofia Friaes, Candida Trigueiros, Clara S. B. Gomes, Alexandra R. Fernandes, Oscar A. Lenis-Rojas, Marta Martins, Beatriz Royo
Summary: Antimicrobial resistance is a serious health issue and lack of new antibacterial drugs is a concern. This study evaluated the antimicrobial activities of four manganese complexes and found that three of them showed good antimicrobial activities with minimal toxicity. These results are important for addressing antibiotic resistance and developing new antibacterial drugs.
Article
Pharmacology & Pharmacy
Patricia C. Pires, Mariana Fernandes, Francisca Nina, Francisco Gama, Maria F. Gomes, Lina E. Rodrigues, Sara Meirinho, Samuel Silvestre, Gilberto Alves, Adriana O. Santos
Summary: The aim of this study was to develop a nanoemulsion (NE) with good solubilization capacity for lipophilic drugs and the ability to promote the absorption of drugs with low permeability. Compositions containing two lipids were screened and characterized, and one composition showed high droplet size homogeneity without the need for high energy methods. Optimized compositions containing a high proportion of propylene glycol monocaprylate NF were able to solubilize simvastatin at high drug strength and promote faster intranasal absorption of the hydrophilic prodrug fosphenytoin.
Article
Biochemistry & Molecular Biology
Bruno M. F. Goncalves, Vanessa I. S. Mendes, Samuel M. Silvestre, Jorge A. R. Salvador
Summary: Arjunolic acid (AA) is a pentacyclic triterpenoid with promising anticancer properties. Novel AA derivatives with modifications at C-28 were designed and evaluated for their biological activity on human cancer and non-tumor cell lines. The most active derivative, compound 26, showed selectivity between malignant cells and non-malignant fibroblasts. It induced cell-cycle arrest and inhibited wound closure in PANC-1 cancer cells, and synergistically increased the cytotoxicity of Gemcitabine.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Alexandra Coimbra, Sonia Miguel, Maximiano Ribeiro, Paula Coutinho, Lucia A. Silva, Susana Ferreira, Ana Paula Duarte
Summary: This study aimed to screen the composition and bioactive properties of essential oils from Foeniculum vulgare, Helichrysum stoechas, Mentha pulegium, Pinus pinaster, Ruta graveolens, and Thymus mastichina. The essential oils showed antioxidant activity, inhibition of lipid peroxidation, and antimicrobial properties. Mentha pulegium and Thymus mastichina essential oils were found to have the strongest antimicrobial activity and potential for use in the food and pharmaceutical industries.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angelo Luis, Helena Marcelino, Fernanda Domingues, Luisa Pereira, Jose Francisco Cascalheira
Summary: Current research on resveratrol treatment for gliomas suggests that resveratrol can slow down tumor growth in animal glioma models. Combination therapy with temozolomide is more effective than temozolomide alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)