Review
Plant Sciences
Zhonglei Wang, Liyan Yang
Summary: Traditional Chinese herbal medicines have shown promising potential for treating COVID-19, including active ingredients, monomer preparations, crude extracts, and formulas, all of which have potential activity against SARS-CoV-2 and have shown significant effects both in vitro and in clinical practice. As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jessica T. Mhlongo, Ayman Y. Waddad, Fernando Albericio, Beatriz G. de la Torre
Summary: Antimicrobial peptides (AMPs) are promising candidates for combating multidrug resistance due to their heterogenous structures and broad-spectrum action. The combined use of AMPs with other antimicrobial agents provides a new arsenal of drugs with synergistic action, inhibiting the development of drug resistance. This review discusses various synergies of AMPs with antimicrobials and miscellaneous agents, providing guidance for improved clinical outcomes.
Review
Microbiology
Yuanling Huang, Wenhui Wang, Zhihao Zhang, Yufeng Gu, Anxiong Huang, Junhao Wang, Haihong Hao
Summary: This article introduces the global public health issue of antimicrobial resistance and discusses the potential of phages as antibiotic alternatives as well as their applications in different fields.
Review
Biochemistry & Molecular Biology
Sebastian Walesch, Joy Birkelbach, Gwenaelle Jezequel, F. P. Jake Haeckl, Julian D. Hegemann, Thomas Hesterkamp, Anna K. H. Hirsch, Peter Hammann, Rolf Mueller
Summary: Antibacterial resistance is a significant threat to human health, and the development of new therapeutics has slowed down since the first antibiotics were approved in the 20(th) century. Most of the current drug leads are modifications of existing antibacterials, many of which come from natural products. This review highlights the challenges, advancements, and current status of the clinical and preclinical antibacterial research pipeline, and advocates for renewed investment and enthusiasm in the antibacterial discovery process.
Editorial Material
Communication
Viorela Dan, Graham N. Dixon
Summary: Actors addressing health misinformation tend to focus on correcting individual behaviors rather than societal outcomes, which can worsen societal divisions. Future research is needed to identify characteristics of corrections that can reduce false beliefs without increasing polarization.
SCIENCE COMMUNICATION
(2021)
Article
Agriculture, Dairy & Animal Science
Sam Rowe, Fidele Kabera, Simon Dufour, Sandra Godden, Jean-Philippe Roy, Daryl Nydam
Summary: The implementation of selective dry-cow therapy can enhance antibiotic stewardship on dairy farms. This study aimed to evaluate the impact of culture-guided and algorithm-guided selective dry-cow therapy on udder health and performance. The findings suggest that both culture-guided and algorithm-guided selective dry-cow therapy can be successfully implemented in cows with different milk production levels.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Infectious Diseases
Justin F. Hayes
Summary: Antimicrobial resistance is a significant global threat. A comprehensive plan, enhanced funding and regulations, incentivized drug development, strengthened One Health programs, and educational training are critical for sustainable efforts against antimicrobial resistance.
Editorial Material
Gastroenterology & Hepatology
Tejeshwar Jain, Vikas Dudeja
Summary: In 2020, significant progress was made in three major areas of pancreatic ductal adenocarcinoma (PDAC) research: risk factors, therapeutic resistance, and tumor recurrence. The pathophysiology of obesity-mediated PDAC initiation was elucidated, novel stromal mechanisms of therapeutic resistance were unveiled, and the genetic evolution of recurrent PDAC under therapeutic pressures was tracked in human samples.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Microbiology
Ekaterina Avershina, Valeria Shapovalova, German Shipulin
Summary: Antibiotic resistance is a growing global threat that may result in more deaths than all cancers combined by 2050. Research is focused on the current state of antibiotic resistance, emerging technologies, and strategies for preventing the spread of infectious diseases.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Bryan D. Lizza, Kevin D. Betthauser, David J. Ritchie, Scott T. Micek, Marin H. Kollef
Summary: C/T is primarily used as directed monotherapy at BJH, especially when Pseudomonas aeruginosa isolates show resistance to other beta-lactams. Additionally, in specific clinical situations such as the ICU, it can be used empirically at BJH before microbiological detection of antibiotic-resistant P. aeruginosa.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Chemistry, Analytical
Mariarita De Felice, Mariarosaria De Falco, Assunta Serra, Valeria Frisulli, Amina Antonacci, Rachele Isticato, Luca de Stefano, Viviana Scognamiglio
Summary: Point-of-care nucleic acid screening is crucial for addressing nosocomial infections, especially in developing countries and settings with limited centralized laboratory capabilities. It is important for timely initiation of appropriate antibiotic therapy and for resolving outbreaks while minimizing antimicrobial resistance.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jeong Yeon Kim, Yunjin Yum, Hyung Joon Joo, Hyonggin An, Young Kyung Yoon, Jong Hun Kim, Jang Wook Sohn
Summary: The study found that excessive use of antibiotics affects the prevalence of resistant organisms in the future. Therefore, controlling antibiotics with antimicrobial stewardship programs should be considered to restrict antimicrobial resistance.
SCIENTIFIC REPORTS
(2021)
Article
Ecology
Alana Palomino, Danya Gewurz, Lela DeVine, Ujana Zajmi, Jenifer Moralez, Fatima Abu-Rumman, Robert P. Smith, Allison J. Lopatkin
Summary: Previous studies have focused on antibiotic resistance genes in conjugative plasmids, neglecting the metabolic genes. This study found a high abundance of metabolic genes on conjugative plasmids and their associations with known antibiotic resistance genes at the strain level. In vitro characterization confirmed the phenotypic impact of these metabolic genes on antibiotic susceptibility.
Article
Pharmacology & Pharmacy
Alvaro Quincho-Lopez, Josmel Pacheco-Mendoza
Summary: The study reveals a significant increase in scientific research on polymyxin resistance over the past decade, with a focus on its relationship with public health, pharmacology, and genetics. China and the United States lead the scientific production in this field, while little contribution comes from central Asia, Sub-Saharan Africa, and Latin America.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Mathematics
Calvin Khor, Jose L. Rodrigo
Summary: This paper investigates a family of active scalars with a velocity field, which is a more singular version of the two-dimensional Surface Quasi-Geostrophic (SQG) equation. By studying families of almost-sharp fronts, the evolution of sharp fronts and compatible curves are analyzed, introducing the concept of a spine for improved evolution results.
JOURNAL OF DIFFERENTIAL EQUATIONS
(2021)
