Article
Biochemistry & Molecular Biology
Orsolya Domotor, Ricardo G. Teixeira, Gabriella Spengler, Fernando Avecilla, Fernanda Marques, Oscar A. Lenis-Rojas, Cristina P. Matos, Rodrigo F. M. de Almeida, Eva A. Enyedy, Ana Isabel Tomaz
Summary: In this study, two Ru(II)-polypyridyl compounds were prepared and characterized. The solid-state structure was confirmed by X-ray diffraction analysis. The solubility, stability, and lipophilicity of the complexes were investigated under physiological mimetic conditions, as well as their potential uptake by passive diffusion. The complexes exhibited cytotoxicity on ovarian and colon cancer cells and induced late apoptosis and necrosis. They showed weak binding to human serum albumin but significant binding to calf thymus DNA.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Livio Racane, Ivo Zlatar, Natasa Perin, Maja Cindric, Vedrana Radovanovic, Mihailo Banjanac, Suresh Shanmugam, Marijana Radic Stojkovic, Karmen Brajsa, Marijana Hranjec
Summary: Newly designed and synthesized compounds with benzimidazole/benzothiazole structures showed potential antitumor activity by inhibiting proliferation of human lung cancer cell lines. Benzothiazole derivatives exhibited higher activity compared to benzimidazole derivatives. Some compounds also demonstrated antimicrobial activity.
Article
Chemistry, Physical
Kritika Laxmikeshav, Pooja Sharma, Manisurya Palepu, Pravesh Sharma, Ashutosh Mahale, Joel George, Regur Phanindranath, Manoj P. Dandekar, Onkar Prakash Kulkarni, Narayana Nagesh, Nagula Shankaraiah
Summary: A new series of carboxamide-bearing benzimidazole derivatives have been investigated for their cytotoxicity on selected human tumor cells. Compounds 10g and 10m showed selective cytotoxicity towards SK-Mel-28 skin cancer cells and were safe for human non-cancerous lung epithelial cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Hasan Kucukbay, Mustafa Uckun, Elif Apohan, Ozfer Yesilada
Summary: New benzimidazole derivatives were synthesized and tested for their cytotoxic properties against lung cancer cell line A549 and healthy lung epithelial cell line BEAS-2B. Compound 12 showed the highest cytotoxicity against A549 cells and comparable cytotoxicity to cisplatin against BEAS-2B cells. Additionally, compounds 7, 8, and 11 exhibited high antimicrobial activity against various microorganisms, with yeasts being particularly sensitive to these compounds.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Medicinal
Mei Chen, Xuemei Tang, Tingting Liu, Feng Peng, Qing Zhou, Hui Luo, Ming He, Wei Xue
Summary: A series of novel myricetin derivatives containing benzimidazole skeleton were constructed, with compound 4q showing the best inhibitory activities against Xanthomonas oryzae pv. Oryzae. In vivo experiments demonstrated the potential of compound 4q in treating rice bacterial leaf blight. Scanning electron microscopy studies revealed the antimicrobial mechanism of compounds 4l and 4q, suggesting their potential as antibacterial reagents.
Article
Chemistry, Medicinal
Merve Saylam, Fadime Aydin Kose, Aysun Pabuccuoglu, Duygu Barut Celepci, Muhittin Aygun, Varol Pabuccuoglu
Summary: Myeloperoxidase (MPO) is a key factor in the human antimicrobial system, oxidizing microorganisms through the production of hypochlorous acid. However, MPO can also be released outside cells and cause tissue damage. It has been associated with inflammatory diseases and is considered a potential therapeutic target. In this study, various derivatives were designed and tested for their inhibitory activity on MPO. Among them, C19 was found to be the most active inhibitor on both chlorination and peroxidation cycles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Elham Alterhoni, Aydin Tavman, Mayram Hacioglu, Onur Sahin, A. Seher Birteksoz Tan
Summary: New Schiff bases and benzimidazolylphenol derivatives were synthesized and characterized in this study, as well as their metal complexes. Some metal complexes exhibited higher antimicrobial activity compared to the ligands, with Co(II) complexes showing a wide range of antimicrobial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Medicinal
Eman M. E. Dokla, Nader S. Abutaleb, Sandra N. Milik, Ezzat A. E. A. Kandil, Omar M. Qassem, Yehia Elgammal, Maha Nasr, Martin J. McPhillie, Khaled A. M. Abouzid, Mohamed N. Seleem, Peter Imming, Mai Adel
Summary: Antibiotic-resistant bacteria pose a serious threat to modern medicine and human life. A study has found that compound 25d, a novel benzimidazole derivative, exhibits potent antibacterial activity against tolC-mutant Escherichia coli without significant cytotoxicity to mammalian cells. Formulation of compound 25d as lipidic nanoparticles further enhances its antibacterial activity against Gram-negative bacterial strains.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Spectroscopy
Esra Oguzcan, Zeynep Koksal, Tugba Taskin-Tok, Ayse Uzgoren-Baran, Nuriye Akbay
Summary: The interaction type between modafinil and calf thymus DNA was examined using various methods, and the results suggest that modafinil can quench the fluorescence of DNA through both static and dynamic mechanisms. The binding of modafinil with DNA was found to be intercalation, and the docking studies showed that R-modafinil interacts better with DNA. The thermodynamic analysis indicated that the driving forces for the interaction are likely hydrogen bonding or van der Waals forces.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Yusif S. El-Sayed, Mohamed Gaber, Marwa N. El-Nahass
Summary: Three novel chelates derived from HL have been designed, with detailed structural and spectral analyses showing their potential as optical sensors for metal ions. All compounds interact with CT-DNA through intercalative mode, with evaluated binding constants confirming strong intercalation between the investigated ligand and metal complexes with the CT-DNA, indicating their potential use as therapeutic drugs. The metal complexes also exhibited antimicrobial activities upon screening.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Multidisciplinary Sciences
Nerea Escala, Laura M. Pineda, Michelle G. Ng, Lorena M. Coronado, Carmenza Spadafora, Esther del Olmo
Summary: Malaria cases and deaths remain high, mainly due to increased resistance to antimalarials. The search for new molecules to replace current drugs is essential. This study presents the synthesis of benzimidazole derivatives and evaluates their activity against P. falciparum HB3 strain. Compounds with electron donating groups on ring A and pyridine type structure on ring B show favorable activity. Two molecules display high nanomolar range antiplasmodial activity and selectivity indexes above 10. They seem to use a different pathway than chloroquine and most antimalarials.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Florin Aonofriesei, Irinel-Gratiela Manescu, Gabriela Stanciu, Simona Lupsor, Manuela Ghica, Magdalena Mititelu
Summary: Benzimidazoles are compounds widely used in clinical and pharmacological applications. There is ongoing research on synthesizing new derivatives and exploring their properties, particularly as potential antimicrobial agents. The study found that benzimidazole derivatives with photoprotective properties had significant inhibitory activity against Gram-positive bacteria and Candida strains.
Review
Chemistry, Multidisciplinary
Maria Letizia Di Pietro, Giuseppina La Ganga, Francesco Nastasi, Fausto Puntoriero
Summary: The paragraph discusses the importance of transition metal complexes with dppz-type ligands in studying the structure of DNA helix and their role as DNA light-switches. It also provides a brief overview of the binding mechanism of Ru-dppz complexes with DNA and their effects on structural modifications and biological applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Dian H. O. Howan, Sandor Jenei, Janos Szolomajer, Gabriella Endre, Eva Kondorosi, Gabor K. Toth
Summary: Medicago truncatula in symbiosis with its rhizobial bacterium partner produces a diverse range of nodule-specific cysteine-rich (NCR) peptides, many of which have antimicrobial activity and the potential to combat antimicrobial resistance. This study focuses on the antibacterial activity of NCR169 peptide derivatives, specifically the C-terminal sequence of NCR169 (NCR169C(17-38)), which has been shown to have antifungal activity. The results demonstrate that NCR169C(17-38) and its substituted derivatives are capable of killing ESKAPE pathogens, and the presence of modified fluorotryptophans can enhance their antimicrobial activity without notable hemolytic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Decheng Liu, Chen Tian, Meixia Shan, Junyong Zhu, Yatao Zhang
Summary: Benzimidazole-linked polymers (BILPs) are porous organic frameworks with high microporosity and exceptional thermal and chemical stabilities. The microstructure and separation capability of BILPs membranes can be controlled by synthetic parameters. The optimized composite membrane exhibits high water permeance, selectivity, and antimicrobial activity.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Applied
Ponnukalai Ponya Utthra, Ganesan Kumaravel, Raju Senthilkumar, Natarajan Raman
APPLIED ORGANOMETALLIC CHEMISTRY
(2017)
Article
Chemistry, Applied
Seemon Packianathan, Ganesan Kumaravel, Natarajan Raman
APPLIED ORGANOMETALLIC CHEMISTRY
(2017)
Article
Chemistry, Applied
Alagarraj Arunadevi, Natarajan Raman
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Article
Chemistry, Applied
Alagarraj Arunadevi, Rajakkani Paulpandiyan, Natarajan Raman
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Ganesan Kumaravel, Ponnukalai Ponya Utthra, Natarajan Raman
BIOORGANIC CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Ganesan Kumaravel, Ponya Utthra Ponnukalai, Dharmasivam Mahendiran, Natarajan Raman
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Chemistry, Inorganic & Nuclear
Michael Samuel, Rajamanickam Rajasekar, Porkodi Jeyaraman, Selvaganapathy Muthusamy, Vellaichamy Muniyandi, Natarajan Raman
Summary: The study describes the synthesis of novel Knoevenagel condensed copper(II) complexes from Schiff bases of thiosemicarbazide derivatives, characterized using analytical and spectral techniques. DFT calculations confirmed the stability and biological approachability of these compounds, with pharmacokinetic properties suggesting oral administration and intercalative binding with CTDNA.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Samuel Michael, Porkodi Jeyaraman, Bhuvaneswari Marimuthu, Rajamanickam Rajasekar, Radha Thanasamy, Karuppiah Arunsunai Kumar, Natarajan Raman
Summary: Novel Cu(II) and Zn(II) complexes [ML(dppz)]Cl2, where L is Schiff bases derived from the condensation of (E)-3-(2-mercaptovinyl)-pentane-2,4-dione and para-substituted anilines, were successfully synthesized and characterized. These complexes exhibited monomeric and cationic properties with square-planar geometry. The compounds showed strong DNA nuclease activity via intercalative binding mechanism, with [CuL1(dppz)]Cl2 demonstrating the highest binding efficacy among all the complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Karuppaiya Palpandi, Chellapandi Bhuvaneswari, Sundaram Ganesh Babu, Natarajan Raman
Summary: A novel metal stannate (Mn2SnO4) nanocube electrocatalyst with outstanding sensing capability and electrochemical properties was synthesized using an ultrasonic-assisted technique. The electrocatalyst exhibited higher cathodic current response, lower detection limit, and good sensitivity for the determination of chloramphenicol.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Karuppaiya Palpandi, Natarajan Raman
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Applied
Natarajan Raman, Thiravidamani Chandrasekar, Ganesan Kumaravel, Liviu Mitu
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Article
Chemistry, Applied
Ganesan Kumaravel, Ponnukalai Ponya Utthra, Natarajan Raman
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Article
Chemistry, Applied
Jeyaraman Porkodi, Natarajan Raman
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)