Article
Chemistry, Inorganic & Nuclear
Akin Mumcu, Mert Olgun Karatas, Namik Ozdemir, Ali Erdogan, Hasan Kucukbay
Summary: In this study, complexes [Ru(NHC)(p-cymene)Cl-2], [MCl(NHC)(cod)] (M=Rh or Ir), and [RhCl(NHC)(CO)(2)] have been synthesized and characterized. The catalytic activity of these complexes in hydrosilylation of terminal alkynes has been investigated. Among them, Ir-NHC exhibited high conversion rate and β-(Z) selectivity, while Rh-NHC showed β-(Z) selectivity initially but isomerized to β-(E) isomer after 24 hours. The results indicate the potential application of these complexes in catalytic reactions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Kuntal Pal, Chandra M. R. Volla
Summary: Alpha-imino carbenoids generated via transition metal catalyzed denitrogenative ring-opening of N-sulfonyl-1,2,3-triazoles have found extensive applications in synthetic organic chemistry over the past decade. In addition, 3-diazoindolin-2-imines have been successfully used as alternative sources of alpha-imino carbenoid precursors for the development of methodologies to access diverse indole derivatives. This review summarizes the insertion reactions of alpha-imino metal carbenes derived from N-sulfonyl-1,2,3-triazoles and 3-diazoindolin-2-imines.
Article
Biochemistry & Molecular Biology
Jahanzaib Arshad, Kelvin K. H. Tong, Sanam Movassaghi, Tilo Sohnel, Stephen M. F. Jamieson, Muhammad Hanif, Christian G. Hartinger
Summary: Complexes of Ru derivatives with pyridinecarbothioamides exhibit potential as orally active anticancer metallodrugs with high selectivity towards the molecular target plectin. The metal center significantly impacts the anticancer activity of the compound class, with Ru derivatives showing the most potent activity regardless of the halido leaving group. Rh derivatives are more active than Ir analogues in terms of in vitro anticancer activity.
Article
Chemistry, Inorganic & Nuclear
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Sohnel, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: In this study, organometallic complexes with a piano-stool structure and di- or tridentate ligand systems were reported, showing improved biological activity and impact on cytotoxic activity.
INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Liza Roos, P. Malan Frederick, Marile Landman
Summary: The review provides an overview of 82 N-heterocyclic carbene metal complexes containing a naphthalimide-NHC moiety, which have diverse applications. These complexes may exhibit notable conformations in the solid state, and play important roles in catalysis and biology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Organic
Haiman Zhang, Zhongyi Zeng, Yurong Yang, Junyuan Tang, Silin Zhang, Wei Yi, Zhi Zhou
Summary: This article describes a unique rhodium-catalyzed site-selective carbene transfer reaction, leading to the synthesis of 2-alkylated benzofurans. The reaction exhibits simple operation, mild conditions, and good functional group tolerance. The obtained benzofuran derivatives show potential as tyrosinase inhibitors.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Mohammad Kaikhosravi, Alexander D. Boeth, Michael J. Sauer, Robert M. Reich, Fritz E. Kuehn
Summary: The heterobimetallic N-heterocyclic dicarbene (NHDC) rhodium ruthenium complex was synthesized via transmetallation and tested as a catalyst in the transfer hydrogenation reaction of acetophenone. The complex exhibited high turnover frequency and good catalytic performance.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Estefan van Vuuren, Frederick P. Malan, Marile Landman
Summary: The incorporation of N-tethers into N-heterocyclic carbene ligands has led to the development of a powerful class of multidentate, responsive ligand frameworks that have shown success and usefulness in various applications, particularly in homogeneous catalysis. These NHC complexes of group IX transition metals exhibit a wide range of accessible oxidation states, favorable stabilities, and reactivities, and have been the subject of significant research interest in the past two decades. The inclusion of carbon as a secondary binding atom has enabled these metal complexes to undergo complex C-H activation, small molecule fixation and activation, and unusual migratory insertion reactions.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Inorganic & Nuclear
Sourav De, Sabnaz Kazi, Sabyasachi Banerjee, Subhasis Banerjee, Nandan Sarkar, Suraj Kumar Shah, Yung-Chih Kuo, S. K. Ashok Kumar
Summary: This article reviews the literature on the cytotoxic effects and cellular uptake of metal complexes such as ruthenium, iridium, rhodium, and rhenium, with a particular focus on recently developed metal-based complexes. These complexes primarily target DNA and mitochondria, inducing cancer cell apoptosis to reduce adverse drug reactions.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yanling Liang, Chuanan Liao, Xinqi Guo, Guanhua Li, Xin Yang, Jing Yu, Jingping Zhong, Ying Xie, Li Zheng, Jinmin Zhao
Summary: In this study, 2D titanium carbide (Ti3C2Tx)-supported RhRu alloy nanoclusters (RhRu/Ti3C2Tx) were prepared and used for synergistic therapy of osteosarcoma. The nanoclusters showed excellent catalase and peroxidase-like activities, as well as the ability to convert light into heat and catalyze the production of singlet oxygen. In vitro and in vivo experiments confirmed the synergistic chemodynamic therapy, photodynamic therapy, and photothermal therapy effect of RhRu/Ti3C2Tx on osteosarcoma.
Article
Chemistry, Organic
Yifeng Ni, Jiangtao Sun
Summary: A rhodium-catalyzed dearomative 1,4-acyl migratory rearrangement reaction of 2-oxypyridines has been developed for the direct synthesis of 2-alkylated pyridones under mild reaction conditions. Different carbene precursors were used, and a range of N-alkylated pyridones were prepared in acceptable yields with good functional group tolerance.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Araceli Martinez, Daniel Zarate-Saldana, Joel Vargas, Arlette A. Santiago
Summary: The synthesis and properties of copolyesters with different molar ratios of HDL and NB were investigated, with Ru1 catalyst showing higher activity and stability. The copolymer HDN-NB exhibited good thermal stability and increased stress values as the NB content increased.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Fang Li, Chao Pei, Calogero Quaranta, Rene M. Koenigs
Summary: This study reports a rhodium-catalyzed reaction of triazoles with acyl selenides, resulting in high yields and stereoselectivity of functionalized compounds. Computational calculations suggest a direct pathway to achieve 1,3-difunctionalization without the formation of ylide intermediates.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Nikita M. Ankudinov, Denis A. Chusov, Yulia Nelyubina, Dmitry S. Perekalin
Summary: A new method for synthesizing chiral diene rhodium catalysts has been introduced, with one catalyst showing efficient asymmetric insertion of diazoesters into B-H and Si-H bonds with high yields and enantiomeric purity. The stereoselectivity of separation and catalytic reaction can be predicted by DFT calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt, Dan Gibson
Summary: Au-I-carbene and Pt-IV-Au-I-carbene prodrugs exhibit low to sub-mu M activity against various cancer cell lines and overcome cisplatin resistance. The most potent prodrug is achieved by linking a cisplatin-derived Pt-IV(phenylbutyrate) complex to an Au-I-phenylimidazolylidene complex 2. In vivo tests on Lewis Lung Carcinoma demonstrate that the prodrug Pt-IV(phenylbutyrate)-Au-I-carbene (7) and the co-administration of cisplatin:phenylbutyrate:2 efficiently inhibit tumor growth (approximately 95%), surpassing the effectiveness of 2 (75%) or cisplatin (84%), while only causing 5% body weight loss compared to 14% for 2, 20% for cisplatin, and >30% for the co-administration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Tom Miclot, Aurane Froux, Luisa D'Anna, Emmanuelle Bignon, Stephanie Grandemange, Giampaolo Barone, Antonio Monari, Alessio Terenzi
Summary: In this review, the important studies on the interactions between G4s and peptides are examined, and the strengths and limitations of current analytic approaches are highlighted. It is found that the combined use of high-level molecular simulation techniques and experimental spectroscopy is the best way to design specifically tuned and selective peptides, thus controlling important biological functions.
Article
Chemistry, Inorganic & Nuclear
Luisa D'Anna, Simona Rubino, Candida Pipitone, Graziella Serio, Carla Gentile, Antonio Palumbo Piccionello, Francesco Giannici, Giampaolo Barone, Alessio Terenzi
Summary: Five metal complexes were synthesized and characterized for their interactions with DNA G-quadruplex structures. The copper complex showed the highest selectivity towards G-quadruplexes and exhibited dose-dependent cytotoxic activity in cancer cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Paramita Sarkar, Kathakali De, Malvika Modi, Geetika Dhanda, Richa Priyadarshini, Julia E. Bandow, Jayanta Haldar
Summary: Resistance to vancomycin requires developing alternative therapeutics. In this study, vancomycin derivatives with mechanisms beyond d-Ala-d-Ala binding were reported. The lead molecule, VanQAmC(10), inhibits bacterial cell division, which is a previously unknown property for glycopeptide antibiotics.
Article
Chemistry, Medicinal
Irina Kollmorgen, Nathalie Bachmann, Michael Dal Molin, Carsten Degenhart, Eldar Zent, Vikram Pareek, Uwe Koch, Jan Rybniker, Nils Metzler-Nolte, Raphael Stoll, Bert Klebl, Julia Elisabeth Bandow, Jurgen Scherkenbeck
Summary: Due to increasing resistances, there is a need for antibacterial compounds with unique modes of action. One such compound, moiramide B, shows strong activity against gram-positive bacteria but weaker activity against gram-negative bacteria. The structure-activity relationship of moiramide B presents a challenge for optimization strategies, while the fatty acid tail is considered as a transport vehicle. However, the sorbic acid unit is found to be relevant for ACC inhibition and allows the development of moiramide derivatives with altered antibacterial profiles.
Article
Chemistry, Physical
Emmanuelle Bignon, Angelo Spinello, Tom Miclot, Luisa D'Anna, Cosimo Ducani, Stephanie Grandemange, Giampaolo Barone, Antonio Monari, Alessio Terenzi
Summary: This article investigates the interplay among three G4 sequences in the c-KIT proto-oncogene promoter and finds that their structural linkage favors the formation of a parallel structure for WSP. Using molecular dynamics simulations and enhanced sampling methods, they provide the first computationally resolved structure of a well-organized G4 cluster in the promoter of a crucial gene involved in cancer development. The study suggests that neighboring G4s influence their mutual three-dimensional arrangement and provide a powerful tool for predicting and interpreting complex DNA structures, which can be used as a starting point for drug discovery.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Correction
Oncology
Mathea Sophia Galanski, Bernhard K. K. Keppler
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Monika Caban, Bettina Koblmueller, Diana Groza, Hemma H. Schueffl, Alessio Terenzi, Alexander Tolios, Thomas Mohr, Marlene Mathuber, Kushtrim Kryeziu, Carola Jaunecker, Christine Pirker, Bernhard K. Keppler, Walter Berger, Christian R. Kowol, Petra Heffeter
Summary: Through chemical modifications, KP2187 has similar activity and action as other clinically used EGFR inhibitors, without interfering with EGFR binding. In vitro and in vivo experiments have shown that KP2187 can significantly inhibit tumor cell proliferation and activate the EGFR signaling pathway. Moreover, KP2187 has a high synergistic effect with VEGFR inhibitors, indicating its potential as a hypoxia-activated prodrug.
Article
Chemistry, Applied
Alexia Tialiou, Zahraa H. Athab, Robert T. Woodward, Veronika Biegler, Bernhard K. Keppler, Ahmed F. Halbus, Michael R. Reithofer, Jia Min Chin
Summary: A novel hydroxypropyl cellulose (gHPC) hydrogel with graded porosity was successfully synthesized by cross-linking different parts of the hydrogel at different temperatures. The pore size in the hydrogel decreased from top to bottom. The hydrogel also showed graded mechanical properties, with the top layer being able to withstand 50% compression before fracture, while the middle and bottom layers could withstand 80% compression.
CARBOHYDRATE POLYMERS
(2023)
Correction
Biochemistry & Molecular Biology
Mathea Sophia Galanski, Michael A. Jakupec, Bernhard K. Keppler
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Angelo Spinello, Luisa D'Anna, Emmanuelle Bignon, Tom Miclot, Stephanie Grandemange, Alessio Terenzi, Giampaolo Barone, Florent Barbault, Antonio Monari
Summary: The human enzyme TMPRSS2 is involved in protein maturation and post-translation and plays a crucial role in viral infections, particularly SARS-CoV-2. Through molecular modeling, we investigated the structure and dynamics of TMPRSS2 and its interaction with a lipid bilayer. We also studied the mechanism of action of a potential inhibitor and its effect on the enzyme. This study provides important insights for rational design of antiviral strategies targeting transmembrane proteases.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Biochemical Research Methods
Melissa Vazquez-Hernandez, Stephanie L. Leedom, Kenneth C. Keiler, Julia Elisabeth Bandow
Summary: Trans-translation is the most effective ribosome rescue system in bacteria, but Bacillus subtilis possesses two alternative ribosome rescue mechanisms. In this study, the proteomes of B. subtilis 168 and a ssrA mutant were compared using quantitative proteomics. The mutant strain showed lower growth rate and protein synthesis rates, altered motility and chemotaxis phenotype, and alterations in the abundance of ribosomal proteins and proteins related to amino acid biosynthesis, reflecting slow ribosome recycling.
Article
Polymer Science
M. Ali Aboudzadeh, Vanessa Rodriguez-Fanjul, Alessio Terenzi, Estibaliz Gonzalez de San Roman, Jose I. Miranda, Ana M. Pizarro, Luca Salassa, Fabienne Barroso-Bujans
Summary: We synthesized a macrocyclic poly(ethyleneoxide) (PEO) connected with a [Ru(bpy)(3)](2+) unit, which is a photoactive metal complex with potential biomedical applications. The PEO chain provides biocompatibility, water solubility, and topological play. The macrocycles were successfully synthesized by copper-free click cycloaddition and exhibited higher fluorescence lifetime compared to their linear analogues.
Article
Multidisciplinary Sciences
Tim Dirks, Marco Krewing, Katharina Vogel, Julia E. Bandow
Summary: Cold atmospheric pressure plasmas have a significant impact on protein aggregation, and Hsp33 plays an important role in preventing protein aggregation. It has been found that over-production of Hsp33 can increase bacterial resistance to cold plasmas.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Multidisciplinary Sciences
Tim Dirks, Abdulkadir Yayci, Sabrina Klopsch, Marco Krewing, Wuyuan Zhang, Frank Hollmann, Julia E. Bandow
Summary: This study demonstrates that immobilization universally protects enzymes under plasma-operating conditions and improves their activity, opening up new possibilities for emerging applications.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
