Journal
BIOCHEMISTRY
Volume 57, Issue 11, Pages 1673-1680Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.7b01305
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Funding
- National Science Foundation [CHE-1352132]
- National Institutes of Health [R01GM118695]
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The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This Perspective highlights recent advances in the Zn(II) coordination chemistry of these three proteins, as well as select studies that evaluate Zn(II) sequestration as an antimicrobial mechanism.
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