The Effects of Environmental Adversities on Human Neocortical Neurogenesis Modeled in Brain Organoids

An early cell shape transition drives evolutionary expansion of the human forebrain

(2021) Silvia Benito-Kwiecinski et al.   CELL

One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure

(2020) Zheng Ao et al.   ANALYTICAL CHEMISTRY

Cell stress in cortical organoids impairs molecular subtype specification

(2020) Aparna Bhaduri et al.   NATURE

Chromatin accessibility dynamics in a model of human forebrain development

(2020) Alexandro E. Trevino et al.   SCIENCE

Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain

(2020) Yoshiaki Tanaka et al.   Cell Reports

Visualization of SARS-CoV-2 virus invading the human placenta using electron microscopy

(2020) Gabriela N. Algarroba et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Human organoids to model the developing human neocortex in health and disease

(2020) Shokoufeh Khakipoor et al.   BRAIN RESEARCH

Herpes simplex virus: global infection prevalence and incidence estimates, 2016

(2020) Charlotte James et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development

(2020) Sebastian G. Utz et al.   CELL

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

(2020) Xuyu Qian et al.   Cell Stem Cell

Expression of P-gp in Glioblastoma: What we can Learn from Brain Development

(2020) Ignazio de Trizio et al.   CURRENT PHARMACEUTICAL DESIGN

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

SARS-CoV-2 infects human neural progenitor cells and brain organoids

(2020) Bao-Zhong Zhang et al.   CELL RESEARCH

Human CNS barrier-forming organoids with cerebrospinal fluid production

(2020) Laura Pellegrini et al.   SCIENCE

Human fetal microglia acquire homeostatic immune-sensing properties early in development

(2020) L. Kracht et al.   SCIENCE

Glucocorticoids as Mediators of Adverse Outcomes of Prenatal Stress

(2020) Anthi C. Krontira et al.   TRENDS IN NEUROSCIENCES

Convolutional Neural Networks Can Predict Retinal Differentiation in Retinal Organoids

(2020) Evgenii Kegeles et al.   Frontiers in Cellular Neuroscience

Transplacental transmission of SARS-CoV-2 infection

(2020) Alexandre J. Vivanti et al.   Nature Communications

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

(2020) Roger Pique-Regi et al.   eLife

Neuropathogenesis of SARS-CoV-2 infection

(2020) Shumayila Khan et al.   eLife

Human Neural Stem Cell Systems to Explore Pathogen-Related Neurodevelopmental and Neurodegenerative Disorders

(2020) Matteo Baggiani et al.   Cells

Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia

(2020) Enrrico Bloise et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

(2020) Fadi Jacob et al.   Cell Stem Cell

SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

(2020) Laura Pellegrini et al.   Cell Stem Cell

SARS ‐CoV‐2 targets neurons of 3D human brain organoids

(2020) Anand Ramani et al.   EMBO JOURNAL

SARS–CoV-2 infection of the placenta

(2020) Hillary Hosier et al.   JOURNAL OF CLINICAL INVESTIGATION

Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

(2020) Lei Xing et al.   NEURON

Species-specific pace of development is associated with differences in protein stability

(2020) Teresa Rayon et al.   SCIENCE

Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis

(2020) John Allotey et al.   BMJ-British Medical Journal

Herpes simplex virus type 1 infection leads to neurodevelopmental disorder-associated neuropathological changes

(2020) Haowen Qiao et al.   PLoS Pathogens

Review of Artificial Intelligence Applications and Algorithms for Brain Organoid Research

(2020) Jiayidaer Badai et al.   Interdisciplinary Sciences-Computational Life Sciences

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids

(2020) Thiago Arzua et al.   Translational Psychiatry

Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2

(2020) Nancy Ashary et al.   Frontiers in Cell and Developmental Biology

Maternal immune activation in mice disrupts proteostasis in the fetal brain

(2020) Brian T. Kalish et al.   NATURE NEUROSCIENCE

Generation and long-term culture of advanced cerebral organoids for studying later stages of neural development

(2020) Stefano L. Giandomenico et al.   Nature Protocols

Multiscale 3D phenotyping of human cerebral organoids

(2020) Alexandre Albanese et al.   Scientific Reports

The Expanding Cell Diversity of the Brain Vasculature

(2020) Jayden M. Ross et al.   Frontiers in Physiology

Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex

(2019) Simone Mayer et al.   NEURON

Modeling HSV-1 infections in human CNS neuronal cells using two-dimensional and three- dimensional cultures derived from induced pluripotent stem cells

(2019) Leonardo D'Aiuto et al.   JOURNAL OF VIROLOGY

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

(2019) Yan-Peng Xu et al.   CELL RESEARCH

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Human 3D cellular model of hypoxic brain injury of prematurity

(2019) Anca M. Pașca et al.   NATURE MEDICINE

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

(2019) L. Telley et al.   SCIENCE

Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids

(2019) Erin M. Boisvert et al.   Cell Death & Disease

Human Cytomegalovirus Compromises Development of Cerebral Organoids

(2019) Rebecca M. Brown et al.   JOURNAL OF VIROLOGY

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic Injury

(2019) Nicolas Daviaud et al.   Frontiers in Cellular Neuroscience

Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons

(2019) Martina Donadoni et al.   Cell Death & Disease

Molecular and cellular evolution of corticogenesis in amniotes

(2019) Adrián Cárdenas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation

(2019) Urs Meyer   TRENDS IN NEUROSCIENCES

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

(2018) Ian T. Fiddes et al.   CELL

Cortical progenitor biology: key features mediating proliferation versus differentiation

(2018) Ana Uzquiano et al.   JOURNAL OF NEUROCHEMISTRY

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

The Placental Barrier: the Gate and the Fate in Drug Distribution

(2018) Nino Tetro et al.   PHARMACEUTICAL RESEARCH

The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B

(2018) Jillian C. Carmichael et al.   PLoS Pathogens

Engineering Brain Organoids to Probe Impaired Neurogenesis Induced by Cadmium

(2018) Fangchao Yin et al.   ACS Biomaterials-Science & Engineering

Engineering Brain Organoids to Probe Impaired Neurogenesis Induced by Cadmium

(2018) Fangchao Yin et al.   ACS Biomaterials Science & Engineering

Can we better understand how Zika leads to microcephaly? A systematic review of the effects of the Zika virus on human brain organoids

(2018) Bayu Sutarjono   JOURNAL OF INFECTIOUS DISEASES

Generation and assembly of human brain region–specific three-dimensional cultures

(2018) Steven A. Sloan et al.   Nature Protocols

Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC–Derived Neural 3D Cultures

(2018) Oksana Sirenko et al.   TOXICOLOGICAL SCIENCES

Congenital Viral Infection: Traversing the Uterine-Placental Interface

(2018) Lenore Pereira   Annual Review of Virology

Transcriptome and epigenome landscape of human cortical development modeled in organoids

(2018) Anahita Amiri et al.   SCIENCE

Probing impaired neurogenesis in human brain organoids exposed to alcohol

(2017) Yujuan Zhu et al.   Integrative Biology

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Review: The blood-brain barrier; protecting the developing fetal brain

(2017) Kate Goasdoué et al.   PLACENTA

Prevalence and correlates of alcohol and tobacco use among pregnant women in the United States: Evidence from the NSDUH 2005–2014

(2017) Sehun Oh et al.   PREVENTIVE MEDICINE

Sex-specific gene–environment interactions underlying ASD-like behaviors

(2017) Sara M. Schaafsma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

(2017) Tomasz J. Nowakowski et al.   SCIENCE

Dynamic behaviour of human neuroepithelial cells in the developing forebrain

(2017) Lakshmi Subramanian et al.   Nature Communications

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

(2017) D Mattei et al.   Translational Psychiatry

Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility

(2017) Abiola A. Ayanlaja et al.   Frontiers in Molecular Neuroscience

Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis

(2017) Svetlana Popova et al.   Lancet Global Health

First estimates of the global and regional incidence of neonatal herpes infection

(2017) Katharine J Looker et al.   Lancet Global Health

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

(2017) Vanja Dakic et al.   Scientific Reports

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

(2016) Béla Z. Schmidt et al.   ARCHIVES OF TOXICOLOGY

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fetal programming of neuropsychiatric disorders

(2016) Gavino Faa et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes

(2016) Ying Pei et al.   BRAIN RESEARCH

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection

(2016) Michael F. Wells et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

(2016) Elke Gabriel et al.   EMBO JOURNAL

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

(2016) Christian Lange et al.   EMBO JOURNAL

A microphysiological model of the human placental barrier

(2016) Cassidy Blundell et al.   LAB ON A CHIP

A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment

(2016) Carina Muoth et al.   Nanoscale

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development

(2016) Tomasz J. Nowakowski et al.   NEURON

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit

(2016) Chun-Ting Lee et al.   NEUROPSYCHOPHARMACOLOGY

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

(2016) Hanna Retallack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study

(2016) Maria de Fatima Vasco Aragao et al.   BMJ-British Medical Journal

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

(2016) Marco Onorati et al.   Cell Reports

Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study

(2016) Maria de Fatima Vasco Aragao et al.   BMJ-British Medical Journal

Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

(2016) Felipe Mora-Bermúdez et al.   eLife

Human three-dimensional engineered neural tissue reveals cellular and molecular events following cytomegalovirus infection

(2015) Érika Cosset et al.   BIOMATERIALS

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex

(2015) Yuki Aoyama et al.   NEUROPSYCHOPHARMACOLOGY

The ontogeny of P-glycoprotein in the developing human blood–brain barrier: implication for opioid toxicity in neonates

(2015) Jessica Lam et al.   PEDIATRIC RESEARCH

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inner CSF–brain barrier: developmentally controlled access to the brain via intercellular junctions

(2015) Sophie Whish et al.   Frontiers in Neuroscience

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Cannabis use during pregnancy in France in 2010

(2014) M-J Saurel-Cubizolles et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

It's Not Your Mother's Marijuana

(2014) Tamara D. Warner et al.   CLINICS IN PERINATOLOGY

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

(2014) Emily J Ross et al.   NEUROPSYCHOPHARMACOLOGY

Minocycline alleviates behavioral deficits and inhibits microglial activation in the offspring of pregnant mice after administration of polyriboinosinic–polyribocytidilic acid

(2014) Furong Zhu et al.   PSYCHIATRY RESEARCH

Risk architecture of schizophrenia

(2013) Dragan M. Svrakic et al.   CURRENT OPINION IN PSYCHIATRY

Gene-Environment Interactions and Epigenetic Pathways in Autism: The Importance of One-Carbon Metabolism

(2013) L. R. Schaevitz et al.   ILAR JOURNAL

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Physiology of Blood–Brain Interfaces in Relation to Brain Disposition of Small Compounds and Macromolecules

(2013) N. Strazielle et al.   MOLECULAR PHARMACEUTICS

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate

(2013) Marion Betizeau et al.   NEURON

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prenatal cannabis exposure and infant outcomes: Overview of studies

(2013) A.C. Huizink   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Prenatal programing: At the intersection of maternal stress and immune activation

(2012) Christopher L. Howerton et al.   HORMONES AND BEHAVIOR

Maternal Stress in Pregnancy: Considerations for Fetal Development

(2012) Janet A. DiPietro   JOURNAL OF ADOLESCENT HEALTH

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development

(2012) J. Diaz-Alonso et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sertraline Alters Multidrug Resistance Phosphoglycoprotein Activity in the Mouse Placenta and Fetal Blood–Brain Barrier

(2012) Manzerul Bhuiyan et al.   Reproductive Sciences

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age

(2011) Gisela Enders et al.   JOURNAL OF CLINICAL VIROLOGY

A new subtype of progenitor cell in the mouse embryonic neocortex

(2011) Xiaoqun Wang et al.   NATURE NEUROSCIENCE

The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells

(2011) Maria K. Lehtinen et al.   NEURON

Barriers in the developing brain and Neurotoxicology

(2011) C. Joakim Ek et al.   NEUROTOXICOLOGY

Developmental expression of multidrug resistance phosphoglycoprotein (P-gp) in the mouse fetal brain and glucocorticoid regulation

(2010) Sophie Petropoulos et al.   BRAIN RESEARCH

A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex

(2010) Isabel Reillo et al.   CEREBRAL CORTEX

Gas chromatography–mass spectrometry assay for the simultaneous quantification of drugs of abuse in human placenta at 12th week of gestation

(2010) Xavier Joya et al.   FORENSIC SCIENCE INTERNATIONAL

Building a human cortex: the evolutionary differentiation of Cajal-Retzius cells and the cortical hem

(2010) Gundela Meyer   JOURNAL OF ANATOMY

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Cocaine causes deficits in radial migration and alters the distribution of glutamate and GABA neurons in the developing rat cerebral cortex

(2010) Chun-Ting Lee et al.   SYNAPSE

ABC Transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) Expression in the Developing Human CNS

(2009) M. Daood et al.   NEUROPEDIATRICS

Neurological Complications of Herpes Simplex Virus Type 2 Infection

(2008) Joseph R. Berger et al.   ARCHIVES OF NEUROLOGY

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

(2008) B. R. Mueller et al.   JOURNAL OF NEUROSCIENCE

A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine

(2008) Chun-Ting Lee et al.   PLOS MEDICINE