The Placental Barrier: the Gate and the Fate in Drug Distribution

Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin

(2017) Kaveri Arora et al.   FASEB JOURNAL

Drug Safety and Risk of Adverse Outcomes for Pregnant Patients With Inflammatory Bowel Disease

(2017) Uma Mahadevan et al.   GASTROENTEROLOGY

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells

(2017) Ayako Furugen et al.   REPRODUCTIVE TOXICOLOGY

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

(2016) John V. Ilekis et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse

(2016) Christopher J. Endres et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Effects of valproic acid on the placental barrier in the pregnant mouse: Optical imaging and transporter expression studies

(2016) Michal Meir et al.   EPILEPSIA

Detectable Drug Levels in Infants Exposed to Biologics: So What?

(2016) Priya Kathpalia et al.   GASTROENTEROLOGY

Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

(2016) Mette Julsgaard et al.   GASTROENTEROLOGY

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

(2016) Huldrych F. Günthard et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Certolizumab pegol does not bind the neonatal Fc receptor (FcRn): Consequences for FcRn-mediated in vitro transcytosis and ex vivo human placental transfer

(2016) Charlene Porter et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

A microphysiological model of the human placental barrier

(2016) Cassidy Blundell et al.   LAB ON A CHIP

Placental ABC Transporters: Biological Impact and Pharmaceutical Significance

(2016) Anand A. Joshi et al.   PHARMACEUTICAL RESEARCH

Maternal–fetal transfer of indocyanine green across the perfused human placenta

(2016) Miriam Rubinchik-Stern et al.   REPRODUCTIVE TOXICOLOGY

Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier

(2016) Jeyan S. Kumar et al.   Scientific Reports

The Role of Megalin in the Transport of Gentamicin Across BeWo Cells, an In Vitro Model of the Human Placenta

(2015) Amal A. Akour et al.   AAPS Journal

What is the placenta?

(2015) Graham J. Burton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Placenta: The Forgotten Organ

(2015) Emin Maltepe et al.   Annual Review of Cell and Developmental Biology

Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy

(2015) Amanda G. Wood et al.   EPILEPSIA

Valproate in the treatment of epilepsy in girls and women of childbearing potential

(2015) Torbjörn Tomson et al.   EPILEPSIA

Antiepileptic drugs alter the expression of placental carriers: An in vitro study in a human placental cell line

(2015) Miriam Rubinchik-Stern et al.   EPILEPSIA

Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells

(2015) Bin He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Near Infrared Imaging of Indocyanine Green Distribution in Pregnant Mice and Effects of Concomitant Medications

(2015) Ameer Bishara et al.   MOLECULAR PHARMACEUTICS

Therapeutic and safety considerations of nanoparticle-mediated drug delivery in pregnancy

(2015) Jeffrey A Keelan et al.   Nanomedicine

Dose-dependent teratogenicity of valproate in mono- and polytherapy

(2015) Torbjörn Tomson et al.   NEUROLOGY

Brief report novel mechanism for valproate-induced teratogenicity

(2014) Kristin Fathe et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Protecting the Fetus Against HIV Infection: A Systematic Review of Placental Transfer of Antiretrovirals

(2014) Shelley A. McCormack et al.   CLINICAL PHARMACOKINETICS

Associations Between ABCG2 Gene Polymorphisms and Isolated Septal Defects in a Han Chinese Population

(2014) Chuan Wang et al.   DNA AND CELL BIOLOGY

Synthetic Glucocorticoid Reduces Human Placental System A Transport in Women Treated With Antenatal Therapy

(2014) Melanie C. Audette et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Human Placenta Project: Placental structure, development, and function in real time

(2014) A.E. Guttmacher et al.   PLACENTA

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier

(2013) Petr Pavek et al.   DRUG METABOLISM REVIEWS

Targeted Nanoparticle Delivery of Doxorubicin Into Placental Tissues to Treat Ectopic Pregnancies

(2013) Tu'uhevaha J. Kaitu'u-Lino et al.   ENDOCRINOLOGY

Fetal antiepileptic drug exposure: Adaptive and emotional/behavioral functioning at age 6years

(2013) Morris J. Cohen et al.   EPILEPSY & BEHAVIOR

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

(2013) Jakob Christensen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Modeling Cyclosporine A Inhibition of the Distribution of a P-Glycoprotein PET Ligand, 11C-Verapamil, into the Maternal Brain and Fetal Liver of the Pregnant Nonhuman Primate: Impact of Tissue Blood Flow and Site of Inhibition

(2013) A. B. Ke et al.   JOURNAL OF NUCLEAR MEDICINE

Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study

(2013) Kimford J Meador et al.   LANCET NEUROLOGY

Receptor-Mediated Endocytosis across Human Placenta: Emphasis on Megalin

(2013) Amal A. Akour et al.   MOLECULAR PHARMACEUTICS

Kinetics of silica nanoparticles in the human placenta

(2013) Marie Sønnegaard Poulsen et al.   Nanotoxicology

Placental P-glycoprotein is unaffected by timing of antenatal glucocorticoid therapy but reduced in SGA preterm infants

(2013) N.A. Hodyl et al.   PLACENTA

Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2

(2013) J. Bakhsheshian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrauterine Inflammation Increases Materno-Fetal Transfer of Gold Nanoparticles in a Size-Dependent Manner in Murine Pregnancy

(2013) Xin Tian et al.   Small

Placental serotonin: implications for the developmental effects of SSRIs and maternal depression

(2013) Juan C. Velasquez et al.   Frontiers in Cellular Neuroscience

Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease

(2012) Uma Mahadevan et al.   Clinical Gastroenterology and Hepatology

The UCSF-FDA TransPortal: A Public Drug Transporter Database

(2012) K M Morrissey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure

(2012) Frantisek Staud et al.   JOURNAL OF DRUG TARGETING

Teratogenic effects of antiepileptic drugs

(2012) Torbjörn Tomson et al.   LANCET NEUROLOGY

ABC drug transporter and nuclear receptor expression in human cytotrophoblasts: Influence of spontaneous syncytialization and induction by glucocorticoids

(2012) S. Manceau et al.   PLACENTA

Placental transfer and metabolism: An overview of the experimental models utilizing human placental tissue

(2012) Päivi Myllynen et al.   TOXICOLOGY IN VITRO

Drug Interactions at the Human Placenta: What is the Evidence?

(2012) Miriam Rubinchik-Stern et al.   Frontiers in Pharmacology

The Expression and Function of Organic Anion Transporting Polypeptides in Normal Tissues and in Cancer

(2011) Amanda Obaidat et al.   Annual Review of Pharmacology and Toxicology

Is heparin a placental anticoagulant in high-risk pregnancies?

(2011) J. C. P. Kingdom et al.   BLOOD

Exposing Fetal Drug Exposure

(2011) L DeVane et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Human Placental Perfusion Model: A Systematic Review and Development of a Model to Predict In Vivo Transfer of Therapeutic Drugs

(2011) J R Hutson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

ATP-Binding Cassette Efflux Transporters in Human Placenta

(2011) Zhanglin Ni et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs)

(2011) Kristiina Tertti et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier

(2011) Masatoshi Tomi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

(2011) Torbjörn Tomson et al.   LANCET NEUROLOGY

Glucocorticoid Regulation of Placental Breast Cancer Resistance Protein (Bcrp1) in the Mouse

(2011) Sophie Petropoulos et al.   Reproductive Sciences

Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Nuclear Translocator Expression in Human and Rat Placentas and Transcription Activity in Human Trophoblast Cultures

(2011) Lucie Stejskalova et al.   TOXICOLOGICAL SCIENCES

The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies

(2010) C. Prouillac et al.   DRUG METABOLISM AND DISPOSITION

Modulation of endocrine and transport functions in human trophoblasts by saquinavir and nelfinavir

(2010) Delphine Beghin et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Transfer of PAMAM dendrimers across human placenta: Prospects of its use as drug carrier during pregnancy

(2010) Anupa R. Menjoge et al.   JOURNAL OF CONTROLLED RELEASE

Drugs of abuse and human placenta

(2010) Vadivel Ganapathy   LIFE SCIENCES

Placental P-glycoprotein and breast cancer resistance protein: Influence of polymorphisms on fetal drug exposure and physiology

(2010) J.R. Hutson et al.   PLACENTA

Effect of glucocorticoids on regulation of placental multidrug resistance phosphoglycoprotein (P-gp) in the mouse

(2010) S. Petropoulos et al.   PLACENTA

Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide

(2009) Olga L. Zharikova et al.   BIOCHEMICAL PHARMACOLOGY

Drug transporters in the human blood-placental barrier

(2009) Kirsi Vähäkangas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Multidrug resistance phosphoglycoprotein (ABCB1) expression in the guinea pig placenta: developmental changes and regulation by betamethasone

(2009) Grazyna M. Kalabis et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Barrier Capacity of Human Placenta for Nanosized Materials

(2009) Peter Wick et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta

(2009) Kristiina Tertti et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues

(2009) Päivi Myllynen et al.   Expert Opinion on Drug Metabolism & Toxicology

Receptor-mediated uptake and transport of macromolecules in the human placenta

(2009) Henning Schneider et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Simultaneous PET Imaging of P-Glycoprotein Inhibition in Multiple Tissues in the Pregnant Nonhuman Primate

(2009) S. Eyal et al.   JOURNAL OF NUCLEAR MEDICINE

Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs

(2009) Kimford J. Meador et al.   NEW ENGLAND JOURNAL OF MEDICINE

Folic acid uptake by the human syncytiotrophoblast: Interference by pharmacotherapy, drugs of abuse and pathological conditions

(2009) Elisa Keating et al.   REPRODUCTIVE TOXICOLOGY

Placental Transport of Immunoglobulins: A Clinical Review for Gastroenterologists Who Prescribe Therapeutic Monoclonal Antibodies to Women During Conception and Pregnancy

(2008) Sunanda V Kane et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Nutritional supplements, foods, and epilepsy: Is there a relationship?

(2008) Ali A. Asadi-Pooya et al.   EPILEPSIA

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The anatomy of the normal placenta

(2008) B Huppertz   JOURNAL OF CLINICAL PATHOLOGY

Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta

(2008) Bernhard Ugele et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Role of Placental Breast Cancer Resistance Protein in the Efflux of Glyburide across the Human Placenta

(2008) E. Pollex et al.   PLACENTA

Carrier-mediated transport of metformin across the human placenta determined by using theex vivo perfusion of the placental cotyledon model

(2008) Michal Kovo et al.   PRENATAL DIAGNOSIS

The inhibitory effects of fluoroquinolones on l-carnitine transport in placental cell line BeWo

(2007) T HIRANO et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS