Article
Neurosciences
Francisca Acuna-Hinrichsen, Adriana Covarrubias-Pinto, Yuta Ishizuka, Maria Francisca Stolzenbach, Carolina Martin, Paula Salazar, Maite A. Castro, Clive R. Bramham, Carola Otth
Summary: HSV-1 infection may induce structural disassembly and functional deregulation in early stages, leading to altered glutamate response, increased accumulation of Arc protein within somata, and decreased expression of dendritic spine scaffolding proteins.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Meritxell Pons-Espinal, Lucas Blasco-Agell, Antonella Consiglio
Summary: Parkinson's disease is an incurable neurodegenerative disease characterized by movement impairments due to the loss of dopamine neurons. Recent advances in iPSC technology have allowed for the recreation of PD-related pathological phenotypes, shedding light on early disease mechanisms.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Kai Jiang, Jing Feng, Xia Qi, Lili Ran, Lixin Xie
Summary: This study validated the inhibitory effect of oridonin on herpes simplex virus type 1 and demonstrated its potential in alleviating herpes simplex keratitis infection in mice.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Immunology
Meng-Shan Tsai, Shun-Hua Chen, Chih-Peng Chang, Yi-Ling Hsiao, Li-Chiu Wang
Summary: ILK reduces the accumulation of H3K9me3 on HSV-1 DNA by reducing SUV39H1 and TRIM28 binding, enhancing virus replication. ILK knockdown decreases TRIM28 phosphorylation, weakening its inhibition on lytic gene transcription. ILK inhibitor suppresses HSV-1 replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Luisa F. Duarte, Sebastian Gatica, Almendra Castillo, Alexis M. Kalergis, Susan M. Bueno, Claudia A. Riedel, Pablo A. Gonzalez
Summary: Numerous studies have linked the onset and severity of multiple sclerosis (MS) with viral infections. Herpes simplex virus type 1 (HSV-1), which is neurotropic and commonly found in the brains of healthy individuals, has been suggested to be associated with MS. This review discusses the reported connections between HSV-1 and MS.
MICROBES AND INFECTION
(2023)
Review
Biochemistry & Molecular Biology
Matylda Barbara Mielcarska, Katarzyna Skowronska, Zbigniew Wyzewski, Felix Ngosa Toka
Summary: Current data strongly indicate that herpes simplex virus type 1 (HSV-1) infection is a contributing factor to Alzheimer's disease (AD). HSV-1 infection causes damage to neurons and glial cells, as well as modifications in their environment, leading to impaired signal transmission and homeostatic and immune functions. This review discusses the pathological alterations in central nervous system (CNS) cells following HSV-1 infection, including inflammatory responses, oxidative damage, and cellular dysfunctions associated with AD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zipora Tietel, Sarit Melamed, Noy Eretz-Kdosha, Ami Guetta, Raanan Gvirtz, Navit Ogen-Shtern, Arnon Dag, Guy Cohen
Summary: Jojoba wax does not affect the growth of Staphylococcus aureus, Staphylococcus epidermidis, and Malassezia furfur, but significantly attenuates HSV-1 plaque formation. Different varieties of Jojoba wax show a high potency anti-viral effect against HSV-1 infection.
Article
Biochemistry & Molecular Biology
Harald Frankowski, Fred Yeboah, Bonnie J. Berry, Chizuru Kinoshita, Michelle Lee, Kira Evitts, Joshua Davis, Yoshito Kinoshita, Richard S. Morrison, Jessica E. Young
Summary: This study reveals that levels of HDAC2 decrease while neuron-specific isoforms of Endophilin-B1 increase during hiPSC differentiation, potentially related to mitochondrial dynamics and neuronal development. Manipulation of HDAC2 and Endophilin-B1 in hiPSC-Ns affects mitochondrial morphology, cytotoxic stress response, and gene expression related to mitochondrial dynamics and synaptogenesis, highlighting the role of HDAC2 in regulating key neuronal and mitochondrial pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Amanda L. Verzosa, Lea A. McGeever, Shun-Je Bhark, Tracie Delgado, Nicole Salazar, Erica L. Sanchez
Summary: This article discusses the transmission and lifecycle of alphaherpesviruses, with a focus on the impact of HSV-1 on host cell innate immune responses. It highlights how HSV-1 suppresses immune responses through various mechanisms, primarily in neuronal and epithelial cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Christine Johnston
Summary: This article discusses the management of genital herpes infection and provides recommendations based on a systematic literature review, serving as a basis for updating the treatment guidelines.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Noemie Berry, Rodolphe Suspene, Vincent Caval, Pierre Khalfi, Guillaume Beauclair, Stephane Rigaud, Herve Blanc, Marco Vignuzzi, Simon Wain-Hobson, Jean-Pierre Vartanian
Summary: HSV-1 impairs the mitochondrial network and releases mtDNA, leading to the upregulation of type I interferon and APOBEC3A expression. The RNA polymerase III/RIG-I pathway is crucial for interferon production. Released mtDNA causes mutations induced by APOBEC3A, resulting in DNA catabolism.
Article
Virology
Anita Felicitas Meier, Kurt Tobler, Kevin Michaelsen, Bernd Vogt, Els Henckaerts, Cornel Fraefel
Summary: The study shows that HSV-1 modulates AAV genome end recombination, potentially through mechanisms involving the ICP8 protein. Despite changes in the type of end recombination, no significant alteration in circular AAV genome abundance was observed.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Nabil El Bilali, Bita Khadivjam, Eric Bonneil, Pierre Thibault, Roger Lippe
Summary: The study investigated the composition of HSV-1 A, B, and C nuclear capsids, identifying host proteins specific to C-capsids. By purifying viral particles using a novel method, it aims to uncover the differences and functional relevance of these viral capsids. This innovative approach opens up new research avenues to clarify the biology of herpesviruses.
JOURNAL OF VIROLOGY
(2021)
Article
Cell Biology
Jie Han, Leslie A. Goldstein, Wen Hou, Simon C. Watkins, Hannah Rabinowich
Summary: The study reveals that the non-apoptotic activity of endosomal CASP9 promotes the retrograde transport of IGF2R and is involved in endosomal sorting and lysosomal biogenesis. CASP9 deficiency leads to missorting of proteins, accumulation of late endosomes, and disruption of protein degradation. The findings suggest a novel cell survival function for CASP9 at the endosomal membrane.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eric E. Abrahamson, Jeffrey S. Stehouwer, Alberto L. Vazquez, Guo-Feng Huang, N. Scott Mason, Brian J. Lopresti, William E. Klunk, Chester A. Mathis, Milos D. Ikonomovic
Summary: A candidate CAA-selective compound was synthesized and showed affinity to A beta fibrils and lipophilicity, with selectivity for CAA versus parenchymal plaque deposits assessed. The compound demonstrated in-vivo preferential labeling of CM in living mice and displayed characteristics of Ali binding dyes in histological sections.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Article
Virology
Eric E. Abrahamson, Wenxiao Zheng, Vaishali Muralidaran, Milos D. Ikonomovic, David C. Bloom, Vishwajit L. Nimgaonkar, Leonardo D'Aiuto
Summary: The study suggests that HSV-1 infection in the brain may lead to the accumulation of A beta 42, thus contributing to the onset of Alzheimer's disease. Additionally, by comparing 2D and 3D neuronal cultures, different patterns of accumulation were observed, emphasizing the importance of 3D cultures in modeling host-pathogen interactions.
JOURNAL OF VIROLOGY
(2021)
Article
Cell Biology
Sachin Surve, Simon C. Watkins, Alexander Sorkin
Summary: The study demonstrated that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and do not colocalize with endosomal EGFR upon EGF stimulation. It was suggested that a small pool of surface EGFRs sustain signaling within the RAS-ERK1/2 pathway.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Mireia Perez Verdaguer, Tian Zhang, Joao A. Paulo, Steven Gygi, Simon C. Watkins, Hiroaki Sakurai, Alexander Sorkin
Summary: This study dissects the mechanisms of p38-induced endocytosis of EGFR using a pH-sensitive model, proposing a unifying model of crosstalk between multiple endocytosis pathways. The research reveals that p38-dependent EGFR endocytosis is essential for the interaction with the sigma 2 subunit of clathrin adaptor AP2, and is additive to CME induced by cytokines but constrained to internalizing ligand-free EGFRs due to Grb2 recruitment by ligand-activated EGFRs.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Geriatrics & Gerontology
Violetta N. Pivtoraiko, Tamara Racic, Eric E. Abrahamson, Victor L. Villemagne, Benjamin L. Handen, Ira T. Lott, Elizabeth Head, Milos D. Ikonomovic
Summary: Individuals with Down syndrome (DS) have a different molecular profile of A beta forms compared to late-onset Alzheimer's disease (AD) cases, with a higher preponderance of pyroglutamate-modified A beta NpE3-40 and unmodified A beta 40 forms. Despite greater vascular amyloidosis in DS cases, cortical H-3-PiB binding does not distinguish between diagnostic groups at an advanced level of amyloid plaque pathology.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Article
Cell Biology
Jonathan Barroso-Gonzalez, Laura Garcia-Exposito, Pablo Galaviz, Michelle Lee Lynskey, Joshua A. M. Allen, SongMy Hoang, Simon C. Watkins, Hilda A. Pickett, Roderick J. O'Sullivan
Summary: Alternative lengthening of telomeres (ALT) is a telomere-elongation mechanism observed in 15% of cancer subtypes. Disruption of the MutSa DNA mismatch repair complex leads to striking telomere hyperextension in ALT cells. MutSa is specifically recruited to telomeres in ALT cells by associating with the PCNA subunit of the replisome, counteracting the role of BLM helicase in stabilizing hyper-extended telomeres and maintaining the survival of MutSa-deficient ALT cancer cells.
Article
Neurosciences
Alexander T. Clark, Eric E. Abrahamson, Matthew M. Harper, Milos D. Ikonomovic
Summary: In this study, the chronic effects of blast-induced traumatic brain injury (bTBI) and amyloid-beta (Aβ) on cellular components of the neurovascular unit (NVU) and capillary network were investigated using transgenic mice. The results showed that bTBI exposure led to reduced AQP4 expression and chronic capillary proliferation in the presence of high brain concentrations of human Aβ. These long-term microvascular changes may increase the risk for developing chronic neurodegenerative disease later in life.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Immunology
Clifford Guy, Diana M. Mitrea, Po-Chien Chou, Jamshid Temirov, Kate M. Vignali, Xueyan Liu, Hui Zhang, Richard Kriwacki, Marcel P. Bruchez, Simon C. Watkins, Creg J. Workman, Dario A. A. Vignali
Summary: This study reveals that the inhibitory receptor LAG3 interferes with TCR signaling and T cell activation by lowering the pH at the immune synapse, providing insights into the mechanism of action of LAG3 in inhibiting T cell function.
Article
Microbiology
Jacqueline D. Corry, Gwenddolen Kettenburg, Amit A. Upadhyay, Megan Wallace, Michelle M. Marti, Elizabeth R. Wonderlich, Stephanie J. Bissel, Kyndal Goss, Timothy J. Sturgeon, Simon C. Watkins, Douglas S. Reed, Steven E. Bosinger, Simon M. Barratt-Boyes
Summary: This study used a novel model of lethal avian influenza in nonhuman primates to investigate the mechanism of severe pneumonia caused by the virus. The researchers found that a potent innate immune response, including high-level production of interferons and inflammatory factors, drives severe disease by recruiting inflammatory cells and leading to the release of neutrophil extracellular traps. They also observed a specific form of cell death known as pyroptosis during lethal influenza. These findings shed light on the mechanisms driving severe influenza and could be targeted for therapeutic interventions to prevent acute lung injury in patients with severe influenza.
Article
Oncology
Huda I. Atiya, Leonard Frisbie, Ester Goldfeld, Taylor Orellana, Nicole Donnellan, Francesmary Modugno, Michael Calderon, Simon Watkins, Rugang Zhang, Esther Elishaev, Thing Rinda Soong, Anda Vlad, Lan Coffman
Summary: This study reveals that a subset of endometriosis-derived mesenchymal stem cells (enMSCs), characterized by loss of CD10 expression, support the growth of ovarian clear cell carcinoma (OCCC) through iron donation. This iron donation is essential for cancer growth and also confers sensitivity to ferroptosis-inducing therapy.
Article
Biochemistry & Molecular Biology
Eric E. Abrahamson, Robert F. Padera, Julie Davies, Gill Farrar, Victor L. Villemagne, Sharmila Dorbala, Milos D. Ikonomovic
Summary: This study demonstrates the high selectivity of cyano-flutemetamol binding to myocardial amyloid in patients with cardiac amyloidosis, supporting the diagnostic utility of [F-18]flutemetamol PET imaging in ATTR and AL types of cardiac amyloidosis.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2023)
Article
Neurosciences
Zhiping Mi, Eric E. Abrahamson, Angela Y. Ryu, Michael Malek-Ahmadi, Julia K. Kofler, Kenneth N. Fish, Robert A. Sweet, Victor L. Villemagne, Julie A. Schneider, Elliott J. Mufson, Milos D. Ikonomovic
Summary: Altered glutamatergic neurotransmission may contribute to impaired default mode network function in Alzheimer's disease (AD). The frontal cortex (FC) may undergo a glutamatergic plasticity response in prodromal AD, while the status of glutamatergic synapses in the precuneus (PreC) during clinical-neuropathological AD progression is not known.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Hematology
Lillian Tran, Bowen Xie, Edwyn Assaf, Ricardo Ferrari, Iraklis I. Pipinos, George P. Casale, Roberto Ivan Mota Alvidrez, Simon Watkins, Ulka Sachdev
Summary: This study found that genes related to ferroptosis are differentially expressed in skeletal muscle affected by PAD. Targeting ferroptosis may be a new therapeutic strategy to reduce PAD myopathy.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)