The Expanding Cell Diversity of the Brain Vasculature

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Caveolae in CNS arterioles mediate neurovascular coupling

(2020) Brian W. Chow et al.   NATURE

Perivascular spaces in the brain: anatomy, physiology and pathology

(2020) Joanna M. Wardlaw et al.   Nature Reviews Neurology

Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling

(2020) Kassandra Kisler et al.   Frontiers in Cellular Neuroscience

Precapillary sphincters maintain perfusion in the cerebral cortex

(2020) Søren Grubb et al.   Nature Communications

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

(2020) Ankit Jambusaria et al.   eLife

Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier

(2020) Marco Tjakra et al.   Frontiers in Neuroscience

Human organoids to model the developing human neocortex in health and disease

(2020) Shokoufeh Khakipoor et al.   BRAIN RESEARCH

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development

(2020) Sebastian G. Utz et al.   CELL

Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

(2020) Julien Ratelade et al.   CIRCULATION

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

(2020) Omer Ali Bayraktar et al.   NATURE NEUROSCIENCE

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia

(2020) Maiko T. Uemura et al.   Frontiers in Aging Neuroscience

Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

(2020) John DeSisto et al.   DEVELOPMENTAL CELL

Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2

(2020) Wenhui Huang et al.   Acta Neuropathologica Communications

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons

(2019) Mark S. Cembrowski et al.   NATURE REVIEWS NEUROSCIENCE

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Macrophages at CNS interfaces: ontogeny and function in health and disease

(2019) Katrin Kierdorf et al.   NATURE REVIEWS NEUROSCIENCE

Defective vascular signaling & prospective therapeutic targets in brain arteriovenous malformations

(2019) Ethan A. Winkler et al.   NEUROCHEMISTRY INTERNATIONAL

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Development and Arealization of the Cerebral Cortex

(2019) Cathryn R. Cadwell et al.   NEURON

Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas

(2019) Jaime Grutzendler et al.   TRENDS IN NEUROSCIENCES

Brain perivascular macrophages: Recent advances and implications in health and diseases

(2019) Tuo Yang et al.   CNS Neuroscience & Therapeutics

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

(2019) Alexi Nott et al.   SCIENCE

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

(2019) Madhvi Menon et al.   Nature Communications

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

(2018) Jean-François Ghersi-Egea et al.   ACTA NEUROPATHOLOGICA

Smooth muscle cells of intracranial vessels: from development to disease

(2018) Juhana Frösen et al.   CARDIOVASCULAR RESEARCH

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

(2018) David Oliveira Dias et al.   CELL

Marked Diversity of Unique Cortical Enhancers Enables Neuron-Specific Tools by Enhancer-Driven Gene Expression

(2018) Stefan Blankvoort et al.   CURRENT BIOLOGY

Bridging barriers: a comparative look at the blood–brain barrier across organisms

(2018) Natasha M. O'Brown et al.   GENES & DEVELOPMENT

Markers for human brain pericytes and smooth muscle cells

(2018) Leon C.D. Smyth et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Reductions in brain pericytes are associated with arteriovenous malformation vascular instability

(2018) Ethan A. Winkler et al.   JOURNAL OF NEUROSURGERY

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

(2018) Marisa Karow et al.   NATURE NEUROSCIENCE

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

(2018) Changsi Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers

(2018) Darin Lanjakornsiripan et al.   Nature Communications

Topographic Reorganization of Cerebrovascular Mural Cells under Seizure Conditions

(2018) Margarita Arango-Lievano et al.   Cell Reports

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

(2018) Andrée-Anne Berthiaume et al.   Cell Reports

Synchronized Astrocytic Ca 2+ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State

(2018) Xiaochun Gu et al.   Cell Reports

The evolution of modern human brain shape

(2018) Simon Neubauer et al.   Science Advances

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2

(2018) Lihui Duan et al.   NEURON

Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier

(2018) Nikolay Kutuzov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain

(2018) Stéphanie Chasseigneaux et al.   Scientific Reports

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

(2018) Mark F Sabbagh et al.   eLife

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

(2018) Liqun He et al.   Scientific Data

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

(2018) Qingyi Ma et al.   Molecular Neurodegeneration

Shared and distinct transcriptomic cell types across neocortical areas

(2018) Bosiljka Tasic et al.   NATURE

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Astrocyte Heterogeneity in the Adult Central Nervous System

(2018) Sean J. Miller   Frontiers in Cellular Neuroscience

Brain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier

(2018) Yoshiaki Ando et al.   Scientific Reports

Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis

(2018) Vera Zywitza et al.   Cell Reports

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

(2017) Roger I Grant et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The vascular basement membrane in the healthy and pathological brain

(2017) Maj S Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Notch signalling limits angiogenesis via control of artery formation

(2017) Sana S. Hasan et al.   NATURE CELL BIOLOGY

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

(2017) Mara E. Pitulescu et al.   NATURE CELL BIOLOGY

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Pericytes Regulate Cerebral Blood Flow and Neuronal Health at a Capillary Level

(2017) Ethan A. Winkler et al.   NEUROSURGERY

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Brain Pericytes As Mediators of Neuroinflammation

(2017) Justin Rustenhoven et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke

(2016) Kathleen K. Kelly et al.   BMC NEUROSCIENCE

Different segments of the cerebral vasculature reveal specific endothelial specifications, while tight junction proteins appear equally distributed

(2016) Sophie Hanske et al.   Brain Structure & Function

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

(2016) Alexander Jais et al.   CELL

Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke

(2016) Rika Sakuma et al.   Journal of Neuroinflammation

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development

(2016) Tomasz J. Nowakowski et al.   NEURON

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

(2016) Antoine Louveau et al.   NEURON

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Cell type specificity of neurovascular coupling in cerebral cortex

(2016) Hana Uhlirova et al.   eLife

Characterizing spatial distributions of astrocytes in the mammalian retina

(2015) Aruna Jammalamadaka et al.   BIOINFORMATICS

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice

(2015) David A. Hartmann et al.   Neurophotonics

Brain pericytes acquire a microglial phenotype after stroke

(2014) Ilknur Özen et al.   ACTA NEUROPATHOLOGICA

The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimer's Disease?

(2014) Ethan A. Winkler et al.   BRAIN PATHOLOGY

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte Development and Heterogeneity

(2014) Omer Ali Bayraktar et al.   Cold Spring Harbor Perspectives in Biology

Arteries are formed by vein-derived endothelial tip cells

(2014) Cong Xu et al.   Nature Communications

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner

(2014) Alexander Birbrair et al.   Stem Cell Research & Therapy

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes

(2013) Georg Andreas Gundersen et al.   Brain Structure & Function

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

(2013) C. Soderblom et al.   JOURNAL OF NEUROSCIENCE

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

(2012) Ethan A. Winkler et al.   ACTA NEUROPATHOLOGICA

Diffusion Properties of Molecules at the Blood-Brain Interface: Potential Contributions of Astrocyte Endfeet to Diffusion Barrier Functions

(2012) M. Nuriya et al.   CEREBRAL CORTEX

Clonal Identity Determines Astrocyte Cortical Heterogeneity

(2012) Jorge García-Marqués et al.   CEREBRAL CORTEX

Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability

(2012) Ethan A Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of Flow-Dependent Vasomotor Mechanisms to the Autoregulation of Cerebral Blood Flow

(2012) Akos Koller et al.   JOURNAL OF VASCULAR RESEARCH

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

in vivo 3D Morphology of Astrocyte—Vasculature Interactions in the Somatosensory Cortex: Implications for Neurovascular Coupling

(2010) Addason F H McCaslin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling

(2010) Ethan A Winkler et al.   Molecular Neurodegeneration

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

(2010) F. Fernandez-Klett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The histological slides and drawings of Cajal

(2010) Garcia-Lopez   Frontiers in Neuroanatomy

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways

(2009) Tomomi Masumura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characteristics of compounds that cross the blood-brain barrier

(2009) William A Banks   BMC Neurology

Correlations of Neuronal and Microvascular Densities in Murine Cortex Revealed by Direct Counting and Colocalization of Nuclei and Vessels

(2009) P. S. Tsai et al.   JOURNAL OF NEUROSCIENCE

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code

(2008) Christian Hochstim et al.   CELL

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE