Inflammatory Response in the CNS: Friend or Foe?

TREM2 Function in Alzheimer’s Disease and Neurodegeneration

(2016) Jason D. Ulrich et al.   ACS Chemical Neuroscience

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

(2016) Somayyeh Hamzei Taj et al.   BIOMATERIALS

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Euflammation attenuates peripheral inflammation-induced neuroinflammation and mitigates immune-to-brain signaling

(2016) Xiaoyu Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasomes as polyvalent cell death platforms

(2016) Nathalia M. de Vasconcelos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

(2016) Jerzy Leszek et al.   CNS & Neurological Disorders-Drug Targets

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review

(2016) Marlies Weltevrede et al.   EXPERIMENTAL GERONTOLOGY

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina

(2016) Xu Wang et al.   JOURNAL OF NEUROSCIENCE

The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence

(2016) Moisés Evandro Bauer et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study

(2016) Se-Hong Kim et al.   Diabetology & Metabolic Syndrome

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

(2016) Cong Zheng et al.   Translational Neurodegeneration

p53, ROS and senescence in the control of aging

(2016) Arnaud Vigneron et al.   Aging-US

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?

(2016) Serena Stanga et al.   Aging-US

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 enables amyloid β clearance by microglia

(2015) Serge Rivest   CELL RESEARCH

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

(2015) Allyson K. Palmer et al.   DIABETES

Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease

(2015) Jae K Ryu et al.   Journal of Neuroinflammation

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

(2015) Clare H Latta et al.   Journal of Neuroinflammation

MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination

(2015) Z. Yu et al.   JOURNAL OF NEUROSCIENCE

Innate and adaptive immune responses in the CNS

(2015) Ari Waisman et al.   LANCET NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Infection, systemic inflammation, and Alzheimer's disease

(2015) Siok Lam Lim et al.   MICROBES AND INFECTION

TREM2 in CNS homeostasis and neurodegenerative disease

(2015) Meghan M. Painter et al.   Molecular Neurodegeneration

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Development and functions of the choroid plexus–cerebrospinal fluid system

(2015) Melody P. Lun et al.   NATURE REVIEWS NEUROSCIENCE

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

Dealing with Danger in the CNS: The Response of the Immune System to Injury

(2015) Sachin P. Gadani et al.   NEURON

Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy

(2015) C.H. Latta et al.   NEUROSCIENCE

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Serum Interleukin (IL)-15 as a Biomarker of Alzheimer's Disease

(2015) Ram J. Bishnoi et al.   PLoS One

The resolution of inflammation: Principles and challenges

(2015) Sarah E. Headland et al.   SEMINARS IN IMMUNOLOGY

Immune Surveillance of the CNS following Infection and Injury

(2015) Matthew V. Russo et al.   TRENDS IN IMMUNOLOGY

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Origin of Microglia: Current Concepts and Past Controversies

(2015) Florent Ginhoux et al.   Cold Spring Harbor Perspectives in Biology

Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia

(2015) Insaf Bahrini et al.   Scientific Reports

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

(2015) Douglas G. Walker et al.   Alzheimers Research & Therapy

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Does Infection-Induced Immune Activation Contribute to Dementia?

(2015) Tatiana Barichello et al.   Aging and Disease

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

(2015) Gertjan van Dijk et al.   Frontiers in Neuroscience

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes

(2015) Luca Steardo et al.   Frontiers in Neuroscience

Central Nervous System and Peripheral Inflammatory Processes in Alzheimer’s Disease: Biomarker Profiling Approach

(2015) Constance Delaby et al.   Frontiers in Neurology

The role of inflammasome in Alzheimer's disease

(2014) Li Liu et al.   AGEING RESEARCH REVIEWS

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Kinetic characteristics of euflammation: The induction of controlled inflammation without overt sickness behavior

(2014) Andrew J. Tarr et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting microglia for the treatment of Alzheimer’s disease

(2014) Patrick L McGeer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Aging with HIV infection: A journey to the center of inflammAIDS, immunosenescence and neuroHIV

(2014) Milena Nasi et al.   IMMUNOLOGY LETTERS

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases

(2014) Hugo González et al.   Journal of Neuroinflammation

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Adipokines: a link between obesity and dementia?

(2014) Amanda J Kiliaan et al.   LANCET NEUROLOGY

The role of microglial activation in disease progression

(2014) Jorge Correale   Multiple Sclerosis Journal

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

(2014) D. M. Pegtel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microglial diversity by responses and responders

(2014) Ulla Gertig et al.   Frontiers in Cellular Neuroscience

miR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization

(2013) Craig S. Moore et al.   ANNALS OF NEUROLOGY

Exosomes: the future of biomarkers in medicine

(2013) Francesca Properzi et al.   Biomarkers in Medicine

Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy

(2013) Marta Sochocka et al.   CNS & Neurological Disorders-Drug Targets

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

(2013) Michal Schwartz et al.   EMBO JOURNAL

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease

(2013) Marina A. Lynch   IMMUNOLOGY

Glia Maturation Factor Induces Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases

(2013) Duraisamy Kempuraj et al.   Journal of Neuroimmune Pharmacology

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

TNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice

(2013) Marie Lou Camara et al.   PSYCHONEUROENDOCRINOLOGY

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression

(2013) L Buizza et al.   Cell Death & Disease

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Adaptation or Malignant Transformation: The Two Faces of Epigenetically Mediated Response to Stress

(2013) Aleksandar Vojta et al.   Biomed Research International

Microglia Control Neuronal Network Excitability via BDNF Signalling

(2013) Francesco Ferrini et al.   NEURAL PLASTICITY

Microglia Activation as a Biomarker for Traumatic Brain Injury

(2013) Diana G. Hernandez-Ontiveros et al.   Frontiers in Neurology

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer’s disease

(2012) Francesca Salani et al.   CYTOKINE

The Role of Visceral Fat

(2012) Arvind Batra et al.   DIGESTIVE DISEASES

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

(2012) Elina M Sutinen et al.   Journal of Neuroinflammation

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Neuron-Astrocyte-Microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus

(2012) Francesca Cerbai et al.   PLoS One

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

(2012) Dongsheng Cai   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Microglial microvesicle secretion and intercellular signaling

(2012) Elena Turola   Frontiers in Physiology

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

The changing phenotype of microglia from homeostasis to disease

(2012) Xiao-Guang Luo et al.   Translational Neurodegeneration

The role of IL-15 in central nervous system disorders

(2011) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Mechanisms of Resolution of Inflammation

(2011) Benjamin H. Maskrey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Production and functions of IL-33 in the central nervous system

(2011) Satoko Yasuoka et al.   BRAIN RESEARCH

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Therapeutic Approaches to the Challenge of Neuronal Ceroid Lipofuscinoses

(2011) R. Kohan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Metabolic regulation by p53

(2011) Oliver D. K. Maddocks et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inflammation in the early stages of neurodegenerative pathology

(2011) Preeti J. Khandelwal et al.   JOURNAL OF NEUROIMMUNOLOGY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Peripheral blood mono-nuclear cells derived from Alzheimer's disease patients show elevated baseline levels of secreted cytokines but resist stimulation with β-amyloid peptide

(2011) Natália Pessoa Rocha et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of p53 in Neurodegenerative Diseases

(2011) J. Robert Chang et al.   Neurodegenerative Diseases

A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death

(2011) Roman Fischer et al.   PLoS One

IL-3 Control Tau Modifications and Protects Cortical Neurons from Neurodegeneration

(2010) A. Zambrano et al.   Current Alzheimer Research

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Dynamics of microRNA biogenesis: crosstalk between p53 network and microRNA processing pathway

(2010) Hiroshi I. Suzuki et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tumor Necrosis Factor-  Signaling Maintains the Ability of Cortical Synapses to Express Synaptic Scaling

(2010) C. C. Steinmetz et al.   JOURNAL OF NEUROSCIENCE

MicroRNA Functions in Stress Responses

(2010) Anthony K.L. Leung et al.   MOLECULAR CELL

Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

(2010) M Schwartz et al.   MOLECULAR PSYCHIATRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Alternative fuel--another role for p53 in the regulation of metabolism

(2010) K. H. Vousden   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

(2009) Yukiko Doi et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of neuronal apoptosis by expression of Hes6 via p53-dependent pathway

(2009) Bokkee Eun et al.   BRAIN RESEARCH

Inflammation and Anti-Inflammatory Strategies for Alzheimer’s Disease – A Mini-Review

(2009) Benjamin Brian Alexander McNaull et al.   GERONTOLOGY

Life and Death of Microglia

(2009) Wolfgang J. Streit et al.   Journal of Neuroimmune Pharmacology

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

(2009) H. Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Activated astroglia during chronic inflammation in Alzheimer's disease—Do they neglect their neurosupportive roles?

(2009) Stacey Fuller et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Evidence for a cytokine model of cognitive function

(2008) J. McAfoose et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The immune system in extreme longevity

(2007) P. Sansoni et al.   EXPERIMENTAL GERONTOLOGY