PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s Disease
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s Disease
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 5, Pages 1772
Publisher
MDPI AG
Online
2020-03-06
DOI
10.3390/ijms21051772
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL
- (2019) Fumika Koyano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson’s disease
- (2019) Dajana Grossmann et al. ANTIOXIDANTS & REDOX SIGNALING
- Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons
- (2019) J. Key et al. NEUROBIOLOGY OF DISEASE
- Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
- (2019) Fumika Koyano et al. EMBO REPORTS
- The ADP/ATP translocase drives mitophagy independent of nucleotide exchange
- (2019) Atsushi Hoshino et al. NATURE
- DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1
- (2019) Yi Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
- (2019) Souvik Modi et al. Nature Communications
- The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells
- (2019) M. Jacoupy et al. Scientific Reports
- PTENα Regulates Mitophagy and Maintains Mitochondrial Quality Control
- (2018) Yuxin Yin et al. Autophagy
- PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol
- (2018) Shiori Sekine et al. BMC BIOLOGY
- PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy
- (2018) Liming Wang et al. CELL RESEARCH
- Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives
- (2018) Jin-Sung Park et al. Current Neurology and Neuroscience Reports
- Cargo recognition and degradation by selective autophagy
- (2018) Damián Gatica et al. NATURE CELL BIOLOGY
- Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions
- (2018) György Csordás et al. TRENDS IN CELL BIOLOGY
- Mitofusin 2: from functions to disease
- (2018) Riccardo Filadi et al. Cell Death & Disease
- The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update
- (2018) Jennifer Rieusset Cell Death & Disease
- Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy
- (2018) Gian-Luca McLelland et al. eLife
- Association Between Autophagy and Neurodegenerative Diseases
- (2018) Nobuhiro Fujikake et al. Frontiers in Neuroscience
- Reduction of PINK1 or DJ-1 impair mitochondrial motility in neurites and alter ER-mitochondria contacts
- (2018) Cristina Parrado-Fernández et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
- (2018) Konstantinos Palikaras et al. NATURE CELL BIOLOGY
- Regulation of Endoplasmic Reticulum-Mitochondria contacts by Parkin via Mfn2
- (2018) Valentina Basso et al. PHARMACOLOGICAL RESEARCH
- Parkin-dependent regulation of the MCU complex component MICU1
- (2018) Alessandra Matteucci et al. Scientific Reports
- Miro proteins prime mitochondria for Parkin translocation and mitophagy
- (2018) Dzhamilja Safiulina et al. EMBO JOURNAL
- Advances in Parkinson’s Disease: 200 Years Later
- (2018) Natalia López-González Del Rey et al. Frontiers in Neuroanatomy
- Autophagy impairment in Parkinson’s disease
- (2017) Cansu Karabiyik et al. Essays in Biochemistry
- Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia
- (2017) Nordine Helassa et al. HUMAN MOLECULAR GENETICS
- PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
- (2017) En Huang et al. Nature Communications
- Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination
- (2017) YouJin Lee et al. Cell Reports
- PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?
- (2017) Dominika Truban et al. Journal of Parkinsons Disease
- Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
- (2017) Atul Kumar et al. eLife
- Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter
- (2016) Cristina Mammucari et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons inpink1−/−zebrafish
- (2016) Smijin Soman et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations
- (2016) Clément A. Gautier et al. HUMAN MOLECULAR GENETICS
- Mechanisms of Selective Autophagy
- (2016) Gabriele Zaffagnini et al. JOURNAL OF MOLECULAR BIOLOGY
- There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases
- (2016) Sebastien Paillusson et al. TRENDS IN NEUROSCIENCES
- Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease
- (2016) I Celardo et al. Cell Death & Disease
- Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter
- (2016) Juan Shao et al. Scientific Reports
- PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane
- (2015) Stephan Gehrke et al. Cell Metabolism
- Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
- (2015) A. Kazlauskaite et al. EMBO REPORTS
- Parkin structure and function
- (2015) Marjan Seirafi et al. FEBS Journal
- Phosphorylated ubiquitin chain is the genuine Parkin receptor
- (2015) Kei Okatsu et al. JOURNAL OF CELL BIOLOGY
- The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
- (2015) Jin-Mi Heo et al. MOLECULAR CELL
- MDS clinical diagnostic criteria for Parkinson's disease
- (2015) Ronald B. Postuma et al. MOVEMENT DISORDERS
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy
- (2015) Victor S. Van Laar et al. NEUROBIOLOGY OF DISEASE
- Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling
- (2015) Riccardo Filadi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RBR E3 ubiquitin ligases: new structures, new insights, new questions
- (2014) Donald E. Spratt et al. BIOCHEMICAL JOURNAL
- Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
- (2014) Agne Kazlauskaite et al. BIOCHEMICAL JOURNAL
- Self and Nonself: How Autophagy Targets Mitochondria and Bacteria
- (2014) Felix Randow et al. Cell Host & Microbe
- USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin
- (2014) T. M. Durcan et al. EMBO JOURNAL
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- -Synuclein Is Localized to Mitochondria-Associated ER Membranes
- (2014) C. Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity
- (2014) Maria Patron et al. MOLECULAR CELL
- Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
- (2014) Alban Ordureau et al. MOLECULAR CELL
- Ubiquitin is phosphorylated by PINK1 to activate parkin
- (2014) Fumika Koyano et al. NATURE
- Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
- (2014) Giuseppina Amadoro et al. Frontiers in Aging Neuroscience
- Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
- (2014) Kahori Shiba-Fukushima et al. PLoS Genetics
- Ataxin-3 Is a Multivalent Ligand for the Parkin Ubl Domain
- (2013) Jane J. Bai et al. BIOCHEMISTRY
- Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics
- (2013) Tito Calì et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner
- (2013) A Bononi et al. CELL DEATH AND DIFFERENTIATION
- MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter
- (2013) György Csordás et al. Cell Metabolism
- Structure of the human Parkin ligase domain in an autoinhibited state
- (2013) Tobias Wauer et al. EMBO JOURNAL
- The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering
- (2013) D. Ottolini et al. HUMAN MOLECULAR GENETICS
- Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
- (2013) Masahiro Iguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
- (2013) Michael Lazarou et al. JOURNAL OF CELL BIOLOGY
- MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2
- (2013) Ayumu Sugiura et al. MOLECULAR CELL
- Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
- (2013) Shireen A. Sarraf et al. NATURE
- The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
- (2013) E. S. Vincow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome
- (2013) D. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism
- (2013) David M. Duda et al. STRUCTURE
- Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
- (2013) B.E. Riley et al. Nature Communications
- The Ubiquitin Code
- (2012) David Komander et al. Annual Review of Biochemistry
- Mitophagy: mechanisms, pathophysiological roles, and analysis
- (2012) Wen-Xing Ding et al. BIOLOGICAL CHEMISTRY
- Na+/K+-ATPase 2-isoform preferentially modulates Ca2+ transients and sarcoplasmic reticulum Ca2+ release in cardiac myocytes
- (2012) S. Despa et al. CARDIOVASCULAR RESEARCH
- MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival
- (2012) Karthik Mallilankaraman et al. CELL
- Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
- (2012) Michael Lazarou et al. DEVELOPMENTAL CELL
- Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
- (2012) Andrew W Greene et al. EMBO REPORTS
- α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions
- (2012) Tito Calì et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
- (2012) C. Kondapalli et al. Open Biology
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
- (2011) Xinnan Wang et al. CELL
- VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria
- (2011) D De Stefani et al. CELL DEATH AND DIFFERENTIATION
- Autoregulation of Parkin activity through its ubiquitin-like domain
- (2011) Viduth K Chaugule et al. EMBO JOURNAL
- The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
- (2011) Wendou Yu et al. HUMAN MOLECULAR GENETICS
- Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
- (2011) Nickie C. Chan et al. HUMAN MOLECULAR GENETICS
- Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
- (2011) Saori R. Yoshii et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
- (2011) B. Heeman et al. JOURNAL OF CELL SCIENCE
- Parkin Interacts with Ambra1 to Induce Mitophagy
- (2011) C. Van Humbeeck et al. JOURNAL OF NEUROSCIENCE
- UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
- (2011) Dawn M. Wenzel et al. NATURE
- Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
- (2011) Ravi S. Akundi et al. PLoS One
- The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
- (2010) S Michiorri et al. CELL DEATH AND DIFFERENTIATION
- Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
- (2010) Atsushi Tanaka et al. JOURNAL OF CELL BIOLOGY
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
- (2010) Noriyuki Matsuda et al. JOURNAL OF CELL BIOLOGY
- Eaten alive: a history of macroautophagy
- (2010) Zhifen Yang et al. NATURE CELL BIOLOGY
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
- (2010) Sven Geisler et al. NATURE CELL BIOLOGY
- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
- (2010) E. Ziviani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
- (2009) Vanessa A. Morais et al. EMBO Molecular Medicine
- Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling
- (2009) Anna Sandebring et al. FEBS Journal
- Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair
- (2009) Oliver Rothfuss et al. HUMAN MOLECULAR GENETICS
- Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux
- (2009) Roberta Marongiu et al. JOURNAL OF NEUROCHEMISTRY
- PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
- (2009) Sonia Gandhi et al. MOLECULAR CELL
- SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination
- (2009) Jean-François Trempe et al. MOLECULAR CELL
- Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter
- (2009) D. Jiang et al. SCIENCE
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation