Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time

Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9

(2016) S. Antony Ceasar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Small Maf proteins (MafF, MafG, MafK): History, structure and function

(2016) Fumiki Katsuoka et al.   GENE

Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice

(2016) Fumiki Katsuoka et al.   GENES TO CELLS

Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish

(2016) Vu Thanh Nguyen et al.   Oxidative Medicine and Cellular Longevity

Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane

(2016) Li Yang et al.   SEMINARS IN ONCOLOGY

Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish

(2016) Yuji Fuse et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio)

(2015) Michelle E. Rousseau et al.   AQUATIC TOXICOLOGY

Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention

(2015) Magdalena Bugno et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish ( Danio rerio )

(2015) Mark E. Hahn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms and functions of Nrf2 signaling in Drosophila

(2015) Andrew Pitoniak et al.   FREE RADICAL BIOLOGY AND MEDICINE

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy inDrosophilaAre Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB

(2015) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

(2015) Ryota Saito et al.   MOLECULAR AND CELLULAR BIOLOGY

Connecting genotypes, phenotypes and fitness: harnessing the power of CRISPR/Cas9 genome editing

(2015) Jeremy M. Bono et al.   MOLECULAR ECOLOGY

The octopus genome and the evolution of cephalopod neural and morphological novelties

(2015) Caroline B. Albertin et al.   NATURE

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

(2013) B. E. Hast et al.   CANCER RESEARCH

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

(2013) Eleni N. Tsakiri et al.   FASEB JOURNAL

The African coelacanth genome provides insights into tetrapod evolution

(2013) Chris T. Amemiya et al.   NATURE

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf

(2013) Kira M. Glover-Cutter et al.   PLoS Genetics

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function

(2012) J. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic Evidence of an Evolutionarily Conserved Role for Nrf2 in the Protection against Oxidative Stress

(2012) K. Mukaigasa et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

(2012) T Yamadori et al.   ONCOGENE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture

(2012) Nirmalya Chatterjee et al.   PLoS One

NFE2L3 (NRF3): the Cinderella of the Cap‘n’Collar transcription factors

(2011) Grégory Chevillard et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptional regulation of xenobiotic detoxification in Drosophila

(2011) J. R. Misra et al.   GENES & DEVELOPMENT

Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2)

(2011) Alicia R. Timme-Laragy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

The genome of the green anole lizard and a comparative analysis with birds and mammals

(2011) Jessica Alföldi et al.   NATURE

Tissue-Restricted Expression of Nrf2 and Its Target Genes in Zebrafish with Gene-Specific Variations in the Induction Profiles

(2011) Hitomi Nakajima et al.   PLoS One

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Critical Role of Nitric Oxide Signaling, via ProteinS-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

(2010) Shigemoto Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome

(2010) K. B. Grimberg et al.   MOLECULAR AND CELLULAR BIOLOGY

The dynamic genome of Hydra

(2010) Jarrod A. Chapman et al.   NATURE

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Yap family and its role in stress response

(2010) Claudina Rodrigues-Pousada et al.   YEAST

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

(2009) K. P. Choe et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence

(2008) Yiguo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY