Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

Parkinson’s disease from the gut

(2018) Rodger A. Liddle   BRAIN RESEARCH

The concept of alpha-synuclein as a prion-like protein: ten years after

(2018) Jennifer A. Steiner et al.   CELL AND TISSUE RESEARCH

Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process

(2018) Amin Karimi-Moghadam et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Biomarkers for cognitive impairment in Lewy body disorders: Status and relevance for clinical trials

(2018) Andrew Siderowf et al.   MOVEMENT DISORDERS

Cerebrospinal fluid biomarkers of central dopamine deficiency predict Parkinson's disease

(2018) David S. Goldstein et al.   PARKINSONISM & RELATED DISORDERS

miRNA-based signatures in cerebrospinal fluid as potential diagnostic tools for early stage Parkinson’s disease

(2018) Marcia Cristina T. dos Santos et al.   Oncotarget

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

(2018) Xian-Si Zeng et al.   Frontiers in Aging Neuroscience

Monoaminergic Markers Across the Cognitive Spectrum of Lewy Body Disease

(2018) Sygrid van der Zee et al.   Journal of Parkinsons Disease

Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease

(2017) Fatemeh Nouri Emamzadeh   JOURNAL OF MOLECULAR NEUROSCIENCE

Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story

(2017) Yannick Vermeiren et al.   NEUROCHEMISTRY INTERNATIONAL

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the repertoire of L-DOPA’s actions: A comprehensive review of its functional neurochemistry

(2017) Philippe De Deurwaerdère et al.   PROGRESS IN NEUROBIOLOGY

Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells

(2017) Matthias Höllerhage et al.   Scientific Reports

Parkinson’s disease is associated with DNA methylation levels in human blood and saliva

(2017) Yu-Hsuan Chuang et al.   Genome Medicine

The Proteasome Inhibition Model of Parkinson’s Disease

(2017) Eduard Bentea et al.   Journal of Parkinsons Disease

MicroRNAs and Target Genes As Biomarkers for the Diagnosis of Early Onset of Parkinson Disease

(2017) Ahmad R. Arshad et al.   Frontiers in Molecular Neuroscience

Pore-Forming Proteins as Mediators of Novel Epigenetic Mechanism of Epilepsy

(2017) Andrei Surguchov et al.   Frontiers in Neurology

Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts

(2017) Usman Saeed et al.   Translational Neurodegeneration

Molecular imaging of dopamine transporters

(2016) David J. Brooks   AGEING RESEARCH REVIEWS

The nonmotor features of Parkinsonʼs disease

(2016) Heinz Reichmann et al.   CURRENT OPINION IN NEUROLOGY

Mechanisms of deep brain stimulation

(2016) Todd M. Herrington et al.   JOURNAL OF NEUROPHYSIOLOGY

Alpha-synuclein structure, functions, and interactions

(2016) FatemehNouri Emamzadeh   Journal of Research in Medical Sciences

Aberrant CpG Methylation Mediates Abnormal Transcription of MAO-A Induced by Acute and Chronic l-3,4-Dihydroxyphenylalanine Administration in SH-SY5Y Neuronal Cells

(2016) Zhaofei Yang et al.   NEUROTOXICITY RESEARCH

TheMC1Rmelanoma risk variant p.R160W is associated with Parkinson disease

(2015) Gemma Tell-Marti et al.   ANNALS OF NEUROLOGY

Comparison of I-123 MIBG planar imaging and SPECT for the detection of decreased heart uptake in Parkinson disease

(2015) Jin-Kyoung Oh et al.   JOURNAL OF NEURAL TRANSMISSION

Quantitative Analysis of 18F-(E)-N-(3-Iodoprop-2-Enyl)-2 -Carbofluoroethoxy-3 -(4'-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease

(2015) P. Fazio et al.   JOURNAL OF NUCLEAR MEDICINE

Epigenetic mechanisms in Parkinson's disease

(2015) Ya Feng et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Longitudinal study of the substantia nigra in Parkinson disease: A high-field1H-MR spectroscopy imaging study

(2015) Navid Seraji-Bozorgzad et al.   MOVEMENT DISORDERS

Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients

(2015) Christine R. Swanson et al.   MOVEMENT DISORDERS

Relationship of orexin (hypocretin) system and astrocyte activation in Parkinson's disease with hypersomnolence

(2015) Yuya Takahashi et al.   Sleep and Biological Rhythms

Peripheral Biomarkers of Parkinson’s Disease Progression and Pioglitazone Effects

(2015) David K. Simon et al.   Journal of Parkinsons Disease

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset

(2014) Johannes Levin et al.   ACTA NEUROPATHOLOGICA

Transcranial Sonography of the Substantia Nigra: Digital Image Analysis

(2014) D. Školoudík et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

HDL and cholesterol handling in the brain

(2014) C. Vitali et al.   CARDIOVASCULAR RESEARCH

Enteric GFAP expression and phosphorylation in Parkinson's disease

(2014) Thomas Clairembault et al.   JOURNAL OF NEUROCHEMISTRY

Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism

(2014) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Glucocerebrosidase mutations in Thai patients with Parkinson's disease

(2014) Teeratorn Pulkes et al.   PARKINSONISM & RELATED DISORDERS

Alpha synuclein is transported into and out of the brain by the blood–brain barrier

(2014) Yu-Ting Sui et al.   PEPTIDES

Therapeutic induction of autophagy to modulate neurodegenerative disease progression

(2013) Warren E Hochfeld et al.   ACTA PHARMACOLOGICA SINICA

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

DNAJC13 mutations in Parkinson disease

(2013) Carles Vilariño-Güell et al.   HUMAN MOLECULAR GENETICS

The Sac1 Domain ofSYNJ1Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures

(2013) Catharine E. Krebs et al.   HUMAN MUTATION

Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study

(2013) C Warren Olanow et al.   LANCET NEUROLOGY

Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool

(2013) Vito Iacobazzi et al.   MOLECULAR GENETICS AND METABOLISM

Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy

(2013) Raymond T Bartus et al.   MOLECULAR THERAPY

Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients

(2013) R. T. Bartus et al.   NEUROLOGY

Neuromelanin of the Human Substantia Nigra: An Update

(2013) Fabio A. Zucca et al.   NEUROTOXICITY RESEARCH

Brain Imaging of Vesicular Monoamine Transporter Type 2 in Healthy Aging Subjects by 18F-FP-(+)-DTBZ PET

(2013) Kun-Ju Lin et al.   PLoS One

Functional Neuroimaging in Parkinson's Disease

(2013) M. Niethammer et al.   Cold Spring Harbor Perspectives in Medicine

Parkinson's Disease: Gene Therapies

(2013) P. G. Coune et al.   Cold Spring Harbor Perspectives in Medicine

A delicate balance: Iron metabolism and diseases of the brain

(2013) Dominic Hare et al.   Frontiers in Aging Neuroscience

The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease

(2013) Danny Estupinan et al.   Parkinsons Disease

Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?

(2012) Diogo Martins-Branco et al.   EXPERIMENTAL NEUROLOGY

Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease

(2012) Gabriele Mittermeyer et al.   HUMAN GENE THERAPY

SPECT Molecular Imaging in Parkinson's Disease

(2012) Ling Wang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Progressive dopamine and hypocretin deficiencies in Parkinson’s disease: is there an impact on sleep and wakefulness?

(2012) MIRIAM WIENECKE et al.   JOURNAL OF SLEEP RESEARCH

Review of functional/anatomical imaging in oncology

(2012) Stephanie N. Histed et al.   NUCLEAR MEDICINE COMMUNICATIONS

DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability

(2012) Çiğdem Köroğlu et al.   PARKINSONISM & RELATED DISORDERS

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

(2011) Marie-Christine Chartier-Harlin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease

(2011) Anil Kachroo et al.   ANNALS OF NEUROLOGY

Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

(2011) He-Jin Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease

(2011) Penelope G. Foulds et al.   FASEB JOURNAL

Novel variant Pro143Ala in HTRA2 contributes to Parkinson’s disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria

(2011) Chin-Hsien Lin et al.   HUMAN GENETICS

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

(2011) Brit Mollenhauer et al.   LANCET NEUROLOGY

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

PLA2G6 gene mutation in autosomal recessive early-onset parkinsonism in a Chinese cohort

(2011) C.- h. Shi et al.   NEUROLOGY

Current approaches to the treatment of Parkinson’s disease

(2011) Joseph Jankovic   Neuropsychiatric Disease and Treatment

Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease

(2010) E.-S. Wang et al.   ACTA NEUROLOGICA SCANDINAVICA

Multinuclear Magnetic Resonance Spectroscopy for in Vivo Assessment of Mitochondrial Dysfunction in Parkinson's Disease

(2010) Claire Henchcliffe et al.   Annals of the New York Academy of Sciences

Deep Brain Stimulation for Parkinson Disease

(2010) Jeff M. Bronstein et al.   ARCHIVES OF NEUROLOGY

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Urinary 8-OHdG elevations in a partial lesion rat model of parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion

(2010) Yoichiro Kikuchi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

(2010) Shin-ichi Muramatsu et al.   MOLECULAR THERAPY

The probable relation between Toxoplasma gondii and Parkinson's disease

(2010) Ozlem Miman et al.   NEUROSCIENCE LETTERS

Astrocytes and therapeutics for Parkinson’s disease

(2010) Phillip M. Rappold et al.   Neurotherapeutics

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

(2010) Lumine Matsumoto et al.   PLoS One

α-Synuclein and dopamine at the crossroads of Parkinson's disease

(2010) Lara Lourenço Venda et al.   TRENDS IN NEUROSCIENCES

Non-synonymous GIGYF2 variants in Parkinson’s disease from two Asian populations

(2009) Eng-King Tan et al.   HUMAN GENETICS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Microtubule-associated protein tau (MAPT) influences the risk of Parkinson's disease among Indians

(2009) Gautami Das et al.   NEUROSCIENCE LETTERS

Dissecting the potential molecular mechanisms underlying α-synuclein cell-to-cell transfer in Parkinson's disease

(2009) Elodie Angot et al.   PARKINSONISM & RELATED DISORDERS

Mutations in the GIGYF2 (TNRC15) Gene at the PARK11 Locus in Familial Parkinson Disease

(2008) Corinne Lautier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Characterization of PLA2G6 as a locus for dystonia-parkinsonism

(2008) Coro Paisan-Ruiz et al.   ANNALS OF NEUROLOGY

γ-Synuclein: Cell-Type-Specific Promoter Activity and Binding to Transcription Factors

(2008) Irina Surgucheva et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease

(2008) Jose A. Obeso et al.   MOVEMENT DISORDERS

Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration

(2008) Junchao Tong et al.   SYNAPSE