Article
Pharmacology & Pharmacy
Young-Sun Lee, Deepak Prasad Gupta, Sung Hee Park, Hyun-Jeong Yang, Gyun Jee Song
Summary: The study found that DMF can inhibit nitric oxide and proinflammatory cytokine production in microglia, induce microglial switching to the M2 state, increase the expression levels of autophagy markers such as LC3 and ATG7, and promote the formation of autophagosomes. These results suggest that DMF induces autophagy in microglia and its anti-inflammatory effects are partially mediated through an autophagy-dependent pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing Hu
Summary: Neuroinflammation plays a crucial role in the development of cognitive impairment. In this study, a lentiviral vector Hsp22 was used for intracerebroventricular injection pretreatment, and LPS was used to induce cognitive impairment in mice. The results showed that Hsp22 overexpression attenuated microglial activation, inflammatory responses, and apoptosis, and improved cognitive impairment in mice. These findings suggest that Hsp22 overexpression could be a potential therapeutic approach for treating cognitive impairment.
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping Gu
Summary: Research indicates that prolonged exposure to low-concentration anesthetics may induce neuroinflammation and cognitive decline, but pretreatment with metformin can alleviate these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Amanda Garcia Hoelz, Danielle Bernardes, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira
Summary: The combined treatment of dimethyl fumarate and pregabalin can effectively attenuate the glial response in mice with experimental autoimmune encephalomyelitis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anthony Fernandez-Castaneda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Michael R. O'Dea, Selena Dutton, Kiarash Shamardani, Kamsi Nwangwu, Rebecca Mancusi, Belgin Yalcin, Kathryn R. Taylor, Lehi Acosta-Alvarez, Karen Malacon, Michael B. Keough, Lijun Ni, Pamelyn J. Woo, Daniel Contreras-Esquivel, Angus Martin Shaw Toland, Jeff R. Gehlhausen, Jon Klein, Takehiro Takahashi, Julio Silva, Benjamin Israelow, Carolina Lucas, Tianyang Mao, Mario A. Pena-Hernandez, Alexandra Tabachnikova, Robert J. Homer, Laura Tabacof, Jenna Tosto-Mancuso, Erica Breyman, Amy Kontorovich, Dayna McCarthy, Martha Quezado, Hannes Vogel, Marco M. Hefti, Daniel P. Perl, Shane Liddelow, Rebecca Folkerth, David Putrino, Avindra Nath, Akiko Iwasaki, Michelle Monje
Summary: COVID survivors may experience lingering neurological symptoms similar to cognitive impairment related to cancer therapy. Research has found that respiratory SARS-CoV-2 infection can cause white-matter-selective microglial reactivity and affect neurogenesis and CCL11 levels.
Article
Environmental Sciences
Tianliang Zhang, Lijuan Sun, Tingting Wang, Chong Liu, Haoyun Zhang, Can Zhang, Li Yu
Summary: Gestational exposure to PM2.5 activates the HMGB1-NLRP3 pathway in the hippocampus of mice offspring, leading to cognitive impairment. Down-regulation of HMGB1 during pregnancy can alleviate the resulting damage, inhibit inflammation, and mitigate cognitive decline.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Endocrinology & Metabolism
Xiaoli Liao, Miao Chen, Yamin Li
Summary: The present study aimed to review evidence from postmortem brain and PET studies on the role of glia induced neuroinflammation in the pathogenesis of ASD. The findings from postmortem studies showed increased microglial number and density, as well as increased GFAP protein and mRNA expression in ASD subjects. However, the outcomes of PET studies were inconsistent, with one reporting increased TSPO expression and two reporting decreased TSPO expression in ASD subjects.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Yang Liu, Huiqun Fu, Tianlong Wang
Summary: Perioperative neurocognitive disorders (PNDs) are common complications in elderly patients, characterized by cognitive decline after anesthesia and surgery. Neuroinflammation, particularly in the elderly, has been identified as a major cause, with the activation of glial cells playing a significant role in the inflammatory responses in the central nervous system (CNS). Clinical and preclinical studies have provided evidence from various levels to understand PNDs and their potential therapeutic targets, but further research is needed to investigate the signaling pathways and their relationship with future neurocognitive dysfunction.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Sai Shi, Tianzhen Chen, Min Zhao
Summary: This article reviews the interaction between neurons and glial cells in METH-induced neuroinflammation. Neuroinflammation plays a crucial role in the brain dysfunction caused by METH abuse, and abnormal communication between neurons and glia can lead to adverse behavioral consequences.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Zhengming Tian, Xunming Ji, Jia Liu
Summary: Vascular cognitive impairment and dementia (VCID) is the second most common type of dementia worldwide, caused by long-term chronic low perfusion. Neuroinflammation plays an important role in the development of VCID, but due to unclear classification and diagnostic criteria, there is no clear treatment strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: Neuroinflammation is implicated in various CNS disorders, and the activation of astrocytes and microglia plays a crucial role in defense mechanisms. However, their activation can trigger neuroinflammation, exacerbating or inducing CNS injury. Non-coding RNAs are highly expressed in astrocytes and microglia and may be mediators of neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Roberta J. Ward, David T. Dexter, Robert R. Crichton
Summary: Disturbance of brain homeostasis leads to inflammation and cell death. Inflammation and iron metabolism interact, leading to iron deposition in brain cells. Reactive oxygen and nitrogen species play a role in inflammation and iron metabolism. Mechanisms to regulate iron homeostasis are important, and therapeutic approaches include N-acetyl cysteine, anti-inflammatory compounds, and iron chelation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Ming Cai, Yuanqi Zhang, Si Chen, Zhan Wu, Lei Zhu
Summary: The study established a visual model map of articles in the field of neuroinflammation-induced mild cognitive impairment (MCI) over the past 11 years to analyze research hotspots and predict future trends. The research on neuroinflammation-induced MCI is rapidly growing, with significant collaboration among different countries and institutions. The current research hotspots mainly focus on the effects of various metabolites on microglial activation. Future studies should aim to regulate the phenotypes of microglia and astrocytes to reduce neuroinflammation and treat MCI.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Zsuzsanna Barad, Joana Augusto, Aine M. Kelly
Summary: Optimal performance of the central nervous system depends on communication between different cell types. Ageing is associated with CNS disequilibrium, but endurance exercise can have a positive impact on neuroimmune communications. Regular aerobic exercise provides an adaptive advantage against perturbations to homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Immunology
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Dennis A. Brown, Pei-Yu Wang, I-Chen Yu, Jui-Hung Yen
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Neurosciences
Hallel C. Paraiso, Xueqian Wang, Ping-Chang Kuo, Destin Furnas, Barbara A. Scofield, Fen-Lei Chang, Jui-Hung Yen, I-Chen Yu
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Hematology
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Destin Furnas, Hallel C. Paraiso, Alexander J. Intriago, Kristopher D. Bosi, I-Chen Yu, Jui-Hung Yen
Article
Immunology
Wen-Tsan Weng, Ping-Chang Kuo, Dennis A. Brown, Barbara A. Scofield, Destin Furnas, Hallel C. Paraiso, Pei-Yu Wang, I-Chen Yu, Jui-Hung Yen
Summary: This study demonstrated that 4-EG has therapeutic effects in EAE by modulating neuroinflammation, inhibiting Th1 and Th17 differentiation, and suppressing inflammatory immune responses in the CNS and periphery. This suggests that 4-EG, a natural compound found in foods, could potentially be developed as a therapeutic agent for the treatment of MS/EAE.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Lee-Wei Chen, Pei-Hsuan Chen, Jui-Hung Yen
Summary: This study reveals that diabetes induces increased M1 cytokine expression but decreased M2 cytokine expression in adipose tissue, while non-diabetic plasma can reverse this trend and reduce DPP4 activity, potentially improving liver inflammation and insulin resistance.
Article
Cell & Tissue Engineering
Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang, Jui-Hung Yen
Summary: This study examines the effects of adipose-derived stromal cells on diabetes-induced insulin resistance and M1 cytokine expression. The results show that adipose stromal cells treated with nondiabetic plasma can inhibit M1 cytokine expression and increase M2 cytokine expression, thereby alleviating insulin resistance and liver inflammation caused by diabetes. These findings suggest that adipose stromal cell-based therapy could be a promising therapeutic strategy for the treatment of diabetes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Wen-Tsan Weng, Ping-Chang Kuo, Barbara A. Scofield, Hallel C. Paraiso, Dennis A. Brown, I-Chen Yu, Jui-Hung Yen
Summary: In this study, it was found that 4-EG has a protective effect against ischemic stroke by inducing the Nrf2/HO-1 pathway. 4-EG can reduce infarct size and neurological deficits, alleviate blood-brain barrier disruption, and suppress inflammatory responses and changes in endothelial cell adhesion molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A. Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen Abckl
Summary: Targeting Nrf2 with D3T may alleviate psoriasis symptoms by reducing hyperkeratosis and scaling, inhibiting IL-17A-secreting γδ T cells in IMQ-induced psoriatic mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Paul Bojrab, Brandon Kimes, I-Chen Ivorine Yu, Jui-Hung Jimmy Yen
Summary: This study found that interferon beta (IFN beta) extends the therapeutic window of tissue plasminogen activator (tPA) and alleviates its adverse effects in ischemic stroke. IFN beta modulates microglia (MG) phenotypes, suppressing inflammatory MG and promoting anti-inflammatory MG, which leads to reduced brain injury and blood-brain barrier disruption.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Destin Furnas, Hallel C. Paraiso, I-Chen Yu, Jui-Hung Yen
Summary: The induction of immunoresponsive gene 1 in microglia following ischemic stroke acts as an endogenous protective mechanism to reduce brain injury by up-regulating heme oxygenase-1. Targeting immunoresponsive gene 1 may represent a novel therapeutic approach for the treatment of ischemic stroke, as observed in animal models with exacerbated brain injury and improved outcomes with the administration of dimethyl itaconate.
BRAIN COMMUNICATIONS
(2021)