Emerging Targets in Type 2 Diabetes and Diabetic Complications

Epigenetic Mechanisms in Diabetic Vascular Complications and Metabolic Memory: The 2020 Edwin Bierman Award Lecture

(2021) Rama Natarajan   DIABETES

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

(2021) Robert Wagner et al.   NATURE MEDICINE

Inceptor counteracts insulin signalling in β-cells to control glycaemia

(2021) Ansarullah et al.   NATURE

Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy

(2020) Jie‐hong Wu et al.   EMBO Molecular Medicine

Mechanisms of Cardiorenal Effects of Sodium-Glucose Cotransporter 2 Inhibitors

(2020) Thomas A. Zelniker et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

(2020) Peng Zhao et al.   SCIENCE

Metabolic transcriptional memory

(2020) Poonam Bheda   Molecular Metabolism

Role of gut microbiota in type 2 diabetes pathophysiology

(2020) Manoj Gurung et al.   EBioMedicine

Compromised DNA repair is responsible for diabetes‐associated fibrosis

(2020) Varun Kumar et al.   EMBO JOURNAL

Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes

(2020) Alina Kuryłowicz et al.   MOLECULES

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

(2020) Ji A Seo et al.   Nature Communications

Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength

(2020) Daniel Schwarz et al.   Scientific Reports

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation

(2020) Thoufiqul Alam Riaz et al.   Cells

Transforming Growth Factor-Beta1 in Diabetic Kidney Disease

(2020) Lijun Zhao et al.   Frontiers in Cell and Developmental Biology

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition

(2020) Issei Tomita et al.   Cell Metabolism

Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

(2020) Lance A. Thielen et al.   Cell Metabolism

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

(2020) Christin Krause et al.   DIABETOLOGIA

Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction

(2020) Qin Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting QKI-7 in vivo restores endothelial cell function in diabetes

(2020) Chunbo Yang et al.   Nature Communications

Diabetes mellitus exacerbates post‐myocardial infarction heart failure by reducing sarcolipin promoter methylation

(2020) Zhongwei Liu et al.   ESC Heart Failure

Gut microbiota and diabetes: From correlation to causality and mechanism

(2020) Wei-Zheng Li et al.   World Journal of Diabetes

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

(2020) José A. Nicolás-Ávila et al.   CELL

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect

(2020) Joana Almaça et al.   DIABETOLOGIA

Intestinal microbial metabolites in human metabolism and type 2 diabetes

(2020) Hilde Herrema et al.   DIABETOLOGIA

Association of SGLT2 Inhibitors With Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes

(2020) Darren K. McGuire et al.   JAMA Cardiology

How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling

(2020) Naomi R. Latorraca et al.   CELL

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

(2020) Amir Tirosh et al.   Cell Metabolism

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism

(2020) Yi Fu et al.   Cell Metabolism

Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

(2020) Pierre-Alexandre Just et al.   Nature Communications

Role of Gut Microbiota on Onset and Progression of Microvascular Complications of Type 2 Diabetes (T2DM)

(2020) Daniela Maria Tanase et al.   Nutrients

K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice

(2020) Jing Xie et al.   Scientific Reports

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

Unraveling the Regulation of Hepatic Gluconeogenesis

(2019) Xueping Zhang et al.   Frontiers in Endocrinology

Targeting pericyte–endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction

(2019) Chang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy

(2019) Khalil Miloudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies

(2019) Magdalena Koziczak-Holbro et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc

(2019) Stefano Ciciliot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Energy metabolism in cachexia

(2019) Maria Rohm et al.   EMBO REPORTS

Gut microbiome and its role in obesity and insulin resistance

(2019) Clare J. Lee et al.   Annals of the New York Academy of Sciences

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression

(2019) Melissa L. Hancock et al.   CELL

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia

(2019) Anfang Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration

(2019) Sarah I. Lindstrom et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart from Failure

(2019) Mariya Kronlage et al.   CIRCULATION

Glucagon Receptor Signaling and Glucagon Resistance

(2019) Janah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thirty sweet years of GLUT4

(2019) Amira Klip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

The role of inflammation in diabetic eye disease

(2019) Marina Mesquida et al.   Seminars in Immunopathology

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

(2019) A. Mitrofanova et al.   Nature Communications

Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship

(2019) Jakub Mesinovic et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine

(2019) Miriam S Udler et al.   ENDOCRINE REVIEWS

Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice

(2019) Ying Zhou et al.   HEPATOLOGY

Probing Effective Out‐of‐Plane Piezoelectricity in van der Waals Layered Materials Induced by Flexoelectricity

(2019) Xiang Wang et al.   Small

Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential

(2019) Michael Whitehead et al.   Journal of Diabetes Research

Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

(2019) Elizabeth M. Rhea et al.   Frontiers in Neuroscience

SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis

(2019) Brendon L Neuen et al.   Lancet Diabetes & Endocrinology

Renal lipid metabolism and lipotoxicity in diabetes

(2019) Laongdao Thongnak et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training

(2019) Parker L. Evans et al.   Nutrients

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

(2019) Søren L Kristensen et al.   Lancet Diabetes & Endocrinology

Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells

(2019) Hayat Aljaibeji et al.   Frontiers in Endocrinology

Role of Grb10 in mTORC1-dependent regulation of insulin signaling and action in human skeletal muscle cells

(2019) Ashlin M. Edick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammageing and metaflammation: The yin and yang of type 2 diabetes

(2018) Francesco Prattichizzo et al.   AGEING RESEARCH REVIEWS

Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

(2018) Thomas R. Einarson et al.   Cardiovascular Diabetology

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

(2018) Alexandra Moraru et al.   Cell Metabolism

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

(2018) Wenshan Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation

(2018) Weiwei Dai et al.   FASEB JOURNAL

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

(2018) Nirupa D. Jayaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1

(2018) Yeji Kim et al.   JOURNAL OF MEDICINAL FOOD

Sodium–glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice

(2018) Shinji Tanaka et al.   KIDNEY INTERNATIONAL

Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes

(2018) W. Timothy Garvey et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial

(2018) Katherine R Tuttle et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes

(2018) Stefan Kopf et al.   RESPIRATION

Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer’s Disease

(2018) Lan Cao et al.   Frontiers in Neuroscience

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

Endoplasmic Reticulum Stress in Metabolic Disorders

(2018) Rose Ghemrawi et al.   Cells

Anti-angiogenic effects of the DPP-4 inhibitor linagliptin via inhibition of VEGFR signalling in the mouse model of oxygen-induced retinopathy

(2018) Matthias Kolibabka et al.   DIABETOLOGIA

Diabetic Pulmopathy: A New Clinical Challenge for Diabetology

(2018) Stefan Kopf et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes

(2018) Dagmar Schumacher et al.   Molecular Metabolism

Bioactive lipids and pathological retinal angiogenesis

(2018) Khaled Elmasry et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes

(2018) Man Wang et al.   DIABETOLOGIA

The many secret lives of adipocytes: implications for diabetes

(2018) Philipp E. Scherer   DIABETOLOGIA

Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model

(2018) Andrea Schlotterer et al.   FASEB JOURNAL

Anti-inflammatory effects of empagliflozin in patients with type 2 diabetes and insulin resistance

(2018) Sachiko Hattori   Diabetology & Metabolic Syndrome

From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions

(2017) Tiziana Caputo et al.   FEBS LETTERS

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Absence of IQGAP1 Protein Leads to Insulin Resistance

(2017) Bhavna Chawla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic β-arrestin 2 is essential for maintaining euglycemia

(2017) Lu Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

(2017) Wei Ying et al.   JOURNAL OF CLINICAL INVESTIGATION

Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress

(2017) Baran A. Ersoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

(2017) Mohammed Bensellam et al.   JOURNAL OF ENDOCRINOLOGY

The β-cell assassin: IAPP cytotoxicity

(2017) Daniel Raleigh et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pharmacologic Blockade of α v β 1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo

(2017) Yongen Chang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fast renal decline to end-stage renal disease: an unrecognized feature of nephropathy in diabetes

(2017) Andrzej S. Krolewski et al.   KIDNEY INTERNATIONAL

Neuropathies and diabetes in Jules Verne

(2017) Antonio Perciaccante et al.   LANCET NEUROLOGY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

(2017) Yan Zheng et al.   Nature Reviews Endocrinology

Schwann cell interactions with axons and microvessels in diabetic neuropathy

(2017) Nádia P. Gonçalves et al.   Nature Reviews Neurology

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

(2017) Eva L. Feldman et al.   NEURON

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

(2017) Bruce Neal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair

(2017) Varun Kumar et al.   NUCLEIC ACIDS RESEARCH

Pericytes, an overlooked player in vascular pathobiology

(2017) David Ferland-McCollough et al.   PHARMACOLOGY & THERAPEUTICS

The effect of sodium/glucose cotransporter 2 (SGLT2) inhibition on the urinary proteome

(2017) David Cherney et al.   PLoS One

Hyperpolarization-activated cyclic nucleotide–gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy

(2017) Christoforos Tsantoulas et al.   Science Translational Medicine

Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out

(2017) Ragadeepthi Tunduguru et al.   Frontiers in Endocrinology

Interactions of Notch1 and TLR4 signaling pathways in DRG neurons of in vivo and in vitro models of diabetic neuropathy

(2017) Tianhua Chen et al.   Scientific Reports

Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504Significance

(2016) Marpadga A. Reddy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics

(2016) Charles Affourtit   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Clinical Update: Cardiovascular Disease in Diabetes Mellitus

(2016) Cecilia C. Low Wang et al.   CIRCULATION

Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion

(2016) Jessica Houtz et al.   DEVELOPMENTAL CELL

JAK inhibition in the treatment of diabetic kidney disease

(2016) Frank C. Brosius et al.   DIABETOLOGIA

Investigational insulin secretagogues for type 2 diabetes

(2016) André J. Scheen   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells

(2016) Jakob Morgenstern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

(2016) Haihua Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/−Mice

(2016) Weiling Leng et al.   MEDIATORS OF INFLAMMATION

Fatty acid induced metabolic memory involves alterations in renal histone H3K36me2 and H3K27me3

(2016) Sandeep Kumar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway

(2016) JINSHENG WU et al.   ONCOLOGY REPORTS

“Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes

(2016) Francesco Prattichizzo et al.   Oxidative Medicine and Cellular Longevity

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

(2016) João-Paulo G. Camporez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Control of diabetic hyperglycaemia and insulin resistance through TSC22D4

(2016) Bilgen Ekim Üstünel et al.   Nature Communications

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

(2016) Naoto Kubota et al.   Nature Communications

Insulin receptor substrate 1 is a substrate of the Pim protein kinases

(2016) Jin H. Song et al.   Oncotarget

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity

(2016) Xiaoting Luo et al.   Aging and Disease

A Role for Insulin in Diabetic Neuropathy

(2016) Caleb W. Grote et al.   Frontiers in Neuroscience

Magnetic resonance neurography detects diabetic neuropathy early and with Proximal Predominance

(2015) Mirko Pham et al.   ANNALS OF NEUROLOGY

Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin–angiotensin system blockade

(2015) Michael A. Weber et al.   BLOOD PRESSURE

Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues

(2015) J Dong et al.   INTERNATIONAL JOURNAL OF OBESITY

Targeting endoplasmic reticulum stress in insulin resistance

(2015) Laia Salvadó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Involvement of advanced glycation end-products in ‘hyperglycemic memory’

(2015) Takeshi Nishikawa et al.   Journal of Diabetes Investigation

TGF-β/Smad signaling in renal fibrosis

(2015) Xiao-Ming Meng et al.   Frontiers in Physiology

Identifying Common Genetic Risk Factors of Diabetic Neuropathies

(2015) Ini-Isabée Witzel et al.   Frontiers in Endocrinology

Key Glycolytic Enzyme Activities of Skeletal Muscle Are Decreased under Fed and Fasted States in Mice with Knocked Down Levels of Shc Proteins

(2015) Kevork Hagopian et al.   PLoS One

Shc depletion stimulates brown fat activityin vivoandin vitro

(2014) Alexey Tomilov et al.   AGING CELL

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

β-Cell Telomere Attrition in Diabetes: Inverse Correlation Between HbA1c and Telomere Length

(2014) Yoshiaki Tamura et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

(2014) T.-H. Yoo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Methylglyoxal Evokes Pain by Stimulating TRPA1

(2013) David A. Andersson et al.   PLoS One

Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus

(2012) Steven G. Coca et al.   ARCHIVES OF INTERNAL MEDICINE

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

(2012) Amanda R Martins et al.   Lipids in Health and Disease

Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis

(2012) Kevork Hagopian et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

The identification of gene expression profiles associated with progression of human diabetic neuropathy

(2011) Junguk Hur et al.   BRAIN

The central role of calcium in the effects of cytokines on beta-cell function: Implications for type 1 and type 2 diabetes

(2011) James W. Ramadan et al.   CELL CALCIUM

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

Proximal Neuropathic Lesions in Distal Symmetric Diabetic Polyneuropathy: Findings of high-resolution magnetic resonance neurography

(2011) M. Pham et al.   DIABETES CARE

Dual Mode of glucagon receptor internalization: Role of PKCα, GRKs and β-arrestins

(2011) Lada Krilov et al.   EXPERIMENTAL CELL RESEARCH

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

(2011) B. Ekim et al.   MOLECULAR AND CELLULAR BIOLOGY

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Glycated Hemoglobin and the Risk of Kidney Disease and Retinopathy in Adults With and Without Diabetes

(2010) E. Selvin et al.   DIABETES

Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms

(2010) Stephen Tonna et al.   Nature Reviews Nephrology

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

(2009) Fuye Yang et al.   HYPERTENSION

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys

(2009) H. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The activation of NF-κB and AP-1 in peripheral blood mononuclear cells isolated from patients with diabetic nephropathy

(2008) Ji Sun Nam et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Role of TSC–mTOR pathway in diabetic nephropathy

(2008) Ken Inoki   DIABETES RESEARCH AND CLINICAL PRACTICE

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

(2008) Peter Gæde et al.   NEW ENGLAND JOURNAL OF MEDICINE

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE