The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/−Mice

The Protective Effect of Interleukin-37 on Vascular Calcification and Atherosclerosis in Apolipoprotein E-Deficient Mice with Diabetes

(2015) Meng Chai et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Amelioration of Hyperglycemia with a Sodium-Glucose Cotransporter 2 Inhibitor Prevents Macrophage-Driven Atherosclerosis through Macrophage Foam Cell Formation Suppression in Type 1 and Type 2 Diabetic Mice

(2015) Michishige Terasaki et al.   PLoS One

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

(2014) Sylvie Legrand-Poels et al.   BIOCHEMICAL PHARMACOLOGY

The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus

(2014) David ZI Cherney et al.   Cardiovascular Diabetology

Dapagliflozin as Monotherapy in Drug-Naive Asian Patients With Type 2 Diabetes Mellitus: A Randomized, Blinded, Prospective Phase III Study

(2014) Linong Ji et al.   CLINICAL THERAPEUTICS

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production

(2014) Aurora Merovci et al.   JOURNAL OF CLINICAL INVESTIGATION

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

(2014) Fei Zheng et al.   MEDIATORS OF INFLAMMATION

Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice

(2014) Naoto Terami et al.   PLoS One

Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function indb/dbmice

(2013) T Nagata et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice

(2013) E. Di Marco et al.   DIABETOLOGIA

Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice

(2013) Atsuo Tahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control

(2013) Donald E. Kohan et al.   KIDNEY INTERNATIONAL

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Effects of Dapagliflozin on Body Weight, Total Fat Mass, and Regional Adipose Tissue Distribution in Patients with Type 2 Diabetes Mellitus with Inadequate Glycemic Control on Metformin

(2012) Jan Bolinder et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Macrophage Differentiation and Function in Atherosclerosis: Opportunities for Therapeutic Intervention?

(2012) Howell J. Williams et al.   Journal of Innate Immunity

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Role of Innate Immunity in Diabetes and Metabolism: Recent Progress in the Study of Inflammasomes

(2011) Myung-Shik Lee   Immune Network

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The effect of fibrate–statin combination therapy on cardiovascular events: a retrospective cohort analysis

(2010) Anthony S. Wierzbicki et al.   CURRENT MEDICAL RESEARCH AND OPINION

Dapagliflozin Monotherapy in Type 2 Diabetic Patients With Inadequate Glycemic Control by Diet and Exercise: A randomized, double-blind, placebo-controlled, phase 3 trial

(2010) E. Ferrannini et al.   DIABETES CARE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome: A sensor of immune danger signals

(2009) Suzanne L. Cassel et al.   SEMINARS IN IMMUNOLOGY

Cytokines and atherosclerosis: a comprehensive review of studies in mice

(2008) R. Kleemann et al.   CARDIOVASCULAR RESEARCH

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS