Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet

(2016) Alta Berger et al.   ENDOCRINOLOGY

Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner

(2016) Supachoke Mangmool et al.   MOLECULAR ENDOCRINOLOGY

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

(2016) M. Johanns et al.   Nature Communications

Beta-adrenergic blockade increases GLUT4 and improves glycemic control in insulin-treated diabetic Wistar rats

(2015) Ana Barbara Alves-Wagner et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Recent progress in the development of small-molecule glucagon receptor antagonists

(2015) Matthew F. Sammons et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Signaling pathway for adiponectin expression in adipocytes by osteocalcin

(2015) Takahito Otani et al.   CELLULAR SIGNALLING

Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance

(2015) David Ho et al.   DIABETES

Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway

(2015) Bilun Ke et al.   DIABETES

Synaptotagmin-7 phosphorylation mediates GLP-1–dependent potentiation of insulin secretion from β-cells

(2015) Bingbing Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight

(2015) Yong-Qi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic PKA regulates leptin sensitivity and adiposity

(2015) Linghai Yang et al.   Nature Communications

Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance

(2015) Emilie Blanchet et al.   Cell Reports

PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control

(2014) Kelly A. Kaihara et al.   DIABETES

Insulin Regulates Brain Function, but How Does It Get There?

(2014) S. M. Gray et al.   DIABETES

Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle

(2014) M. Sato et al.   DIABETES

Control of hepatic glucose metabolism by islet and brain

(2014) J. M. Rojas et al.   DIABETES OBESITY & METABOLISM

Differentially Regulated Protein Kinase A (PKA) Activity in Adipose Tissue and Liver Is Associated With Resistance to Diet-Induced Obesity and Glucose Intolerance in Mice That Lack PKA Regulatory Subunit Type IIα

(2014) Edra London et al.   ENDOCRINOLOGY

Role of Gsα in Central Regulation of Energy and Glucose Metabolism

(2014) L. Weinstein   HORMONE AND METABOLIC RESEARCH

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Regulation of Cardiac L-Type Ca 2+ Channel Ca V 1.2 Via the β-Adrenergic-cAMP-Protein Kinase A Pathway

(2013) Sharon Weiss et al.   CIRCULATION RESEARCH

 -Cell-Specific Protein Kinase A Activation Enhances the Efficiency of Glucose Control by Increasing Acute-Phase Insulin Secretion

(2013) K. A. Kaihara et al.   DIABETES

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease

(2013) Louisa CY Lee et al.   Future Medicinal Chemistry

Leptin Regulates KATPChannel Trafficking in Pancreatic β-Cells by a Signaling Mechanism Involving AMP-activated Protein Kinase (AMPK) and cAMP-dependent Protein Kinase (PKA)

(2013) Pei-Chun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex

(2013) Ji-Hong Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

(2013) V. E. Torres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Cooperation between brain and islet in glucose homeostasis and diabetes

(2013) Michael W. Schwartz et al.   NATURE

Hypothalamic glucagon signaling inhibits hepatic glucose production

(2013) Patricia I Mighiu et al.   NATURE MEDICINE

β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling

(2013) Robert A. Ngala et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Deficiency of the RII  subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations

(2013) R. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

(2013) Jessica L. Esseltine et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PKA regulatory subunit R2B is required for murine and human adipocyte differentiation

(2013) Erika Peverelli et al.   Endocrine Connections

cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration

(2012) Rebecca Berdeaux et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice

(2012) S. Vollert et al.   DIABETOLOGIA

Anchored phosphatases modulate glucose homeostasis

(2012) Simon A Hinke et al.   EMBO JOURNAL

Gsα Deficiency in the Paraventricular Nucleus of the Hypothalamus Partially Contributes to Obesity Associated with Gsα Mutations

(2012) Min Chen et al.   ENDOCRINOLOGY

Identification and Functional Characterization of Protein Kinase A Phosphorylation Sites in the Major Lipolytic Protein, Adipose Triglyceride Lipase

(2012) Joanne Pagnon et al.   ENDOCRINOLOGY

Prkar1a in the Regulation of Insulin Secretion

(2012) M. Hussain et al.   HORMONE AND METABOLIC RESEARCH

A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI) to the Plasma Membrane

(2012) Pepijn P. Burgers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of the Phosphodiesterase 4 Inhibitor Roflumilast on Glucose Metabolism in Patients with Treatment-Naive, Newly Diagnosed Type 2 Diabetes Mellitus

(2012) E. F. M. Wouters et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

(2012) Yiguo Wang et al.   NATURE

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

Wired on sugar: the role of the CNS in the regulation of glucose homeostasis

(2012) Bernadette E. Grayson et al.   NATURE REVIEWS NEUROSCIENCE

Glucagon regulates its own synthesis by autocrine signaling

(2012) B. Leibiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A-kinase anchoring proteins as potential drug targets

(2011) Jessica Tröger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Snapin Mediates Incretin Action and Augments Glucose-Dependent Insulin Secretion

(2011) Woo-Jin Song et al.   Cell Metabolism

Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis

(2011) Guillaume Pidoux et al.   EMBO JOURNAL

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leptin and the Central Nervous System Control of Glucose Metabolism

(2011) Gregory J. Morton et al.   PHYSIOLOGICAL REVIEWS

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

(2011) Brandon S. Willis et al.   PLoS One

Skeletal Muscle Phosphodiester Content Relates to Body Mass and Glycemic Control

(2011) Julia Szendroedi et al.   PLoS One

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

(2011) C. K. Means et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise

(2011) Jørgen Jensen et al.   Frontiers in Physiology

The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis

(2011) James DR Knight et al.   Skeletal Muscle

Gsα Deficiency in Adipose Tissue Leads to a Lean Phenotype with Divergent Effects on Cold Tolerance and Diet-Induced Thermogenesis

(2010) Min Chen et al.   Cell Metabolism

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis

(2010) E. Yehuda-Shnaidman et al.   DIABETES

Pancreas-specific Gsα deficiency has divergent effects on pancreatic α- and β-cell proliferation

(2010) Tao Xie et al.   JOURNAL OF ENDOCRINOLOGY

Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

(2010) Guillaume Pidoux et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Gsα deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency

(2009) Min Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

cAMP-response element binding protein (CREB) positively regulates mouse adiponectin gene expression in 3T3-L1 adipocytes

(2009) Hyun Bae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

Central Nervous System Imprinting of the G Protein Gsα and Its Role in Metabolic Regulation

(2009) Min Chen et al.   Cell Metabolism

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Mouse models of altered protein kinase A signaling

(2009) Lawrence S Kirschner et al.   ENDOCRINE-RELATED CANCER

AKAP 18 α and γ have opposing effects on insulin release in INS-1E cells

(2009) Knud Josefsen et al.   FEBS LETTERS

Simvastatin Suppresses Leptin Expression in 3T3-L1 Adipocytes via Activation of the Cyclic AMP–PKA Pathway Induced by Inhibition of Protein Prenylation

(2009) Toyonobu Maeda et al.   JOURNAL OF BIOCHEMISTRY

Aspects of the Control of Phosphoenolpyruvate Carboxykinase Gene Transcription

(2009) Jianqi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted Disruption of the C  Subunit of Protein Kinase A

(2009) L. C. Enns et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY

Disruption of Protein Kinase A in Mice Enhances Healthy Aging

(2009) Linda C. Enns et al.   PLoS One

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

(2009) V. T. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase A Regulatory Subunits in Human Adipose Tissue: Decreased R2B Expression and Activity in Adipocytes From Obese Subjects

(2008) G. Mantovani et al.   DIABETES

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

(2008) Teresa Coll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Specificity A-kinase Anchoring Proteins (AKAPs) Contain an Additional Binding Region That Enhances Targeting of Protein Kinase A Type I

(2008) Elisabeth Jarnæss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY

Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes

(2008) Tingting Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Characterization of the Mouse Pancreatic Islet Proteome and Comparative Analysis with Other Mouse Tissues

(2008) Vladislav A. Petyuk et al.   JOURNAL OF PROTEOME RESEARCH

Skeletal Muscle Insulin Resistance: Roles of Fatty Acid Metabolism and Exercise

(2008) Lorraine P Turcotte et al.   PHYSICAL THERAPY

Ser649 and Ser650 Are the Major Determinants of Protein Kinase A-Mediated Activation of Human Hormone-Sensitive Lipase against Lipid Substrates

(2008) Christian Krintel et al.   PLoS One

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling