Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine

Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis

(2019) Seth A. Sharp et al.   DIABETES CARE

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

(2019) Juan Fernández-Tajes et al.   Genome Medicine

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Polygenic Risk Scores That Predict Common Diseases Using Millions of Single Nucleotide Polymorphisms: Is More, Better?

(2019) A. Cecile J.W. Janssens et al.   CLINICAL CHEMISTRY

The Genetic Basis of Metabolic Disease

(2019) Inês Barroso et al.   CELL

Clinical relevance of genome‐wide polygenic score may be less than claimed

(2019) David Curtis   ANNALS OF HUMAN GENETICS

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

(2019) Jason Flannick et al.   NATURE

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data

(2019) John M Dennis et al.   Lancet Diabetes & Endocrinology

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

(2018) Natalie R. van Zuydam et al.   DIABETES

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes

(2018) Matthew B. Johnson et al.   DIABETOLOGIA

Evaluation of polygenic risk models using multiple performance measures: a critical assessment of discordant results

(2018) Forike K. Martens et al.   GENETICS IN MEDICINE

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

(2018) Kerrin S. Small et al.   NATURE GENETICS

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

(2018) Fredrick R. Schumacher et al.   NATURE GENETICS

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

(2018) Soren K. Thomsen et al.   NATURE GENETICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Cost-effectiveness analyses of genetic and genomic diagnostic tests

(2018) Katherine Payne et al.   NATURE REVIEWS GENETICS

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children

(2018) Ezio Bonifacio et al.   PLOS MEDICINE

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

(2018) Matthias Thurner et al.   eLife

Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

(2018) Nicholas J Thomas et al.   Lancet Diabetes & Endocrinology

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

(2018) Miriam S. Udler et al.   PLOS MEDICINE

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

(2018) Nasim Mavaddat et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody–Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

(2018) Anita L. Grubb et al.   DIABETES CARE

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families

(2018) Chang-Fu Kuo et al.   Clinical Epidemiology

Genetics of type 1 diabetes

(2017) Maria J Redondo et al.   PEDIATRIC DIABETES

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

(2017) Arushi Varshney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are Data Sharing and Privacy Protection Mutually Exclusive?

(2016) Yann Joly et al.   CELL

Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes

(2016) Kashyap A. Patel et al.   DIABETES

Precision Medicine in Diabetes: Is It Time?: Table 1

(2016) Jose C. Florez   DIABETES CARE

The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell–Centric Classification Schema

(2016) Stanley S. Schwartz et al.   DIABETES CARE

The Genetic Landscape of Renal Complications in Type 1 Diabetes

(2016) Niina Sandholm et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Intolerable secretion and diabetes in tolerant transgenic mice, revisited

(2016) John A Todd   NATURE GENETICS

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

(2016) Luca A Lotta et al.   NATURE GENETICS

Developing and evaluating polygenic risk prediction models for stratified disease prevention

(2016) Nilanjan Chatterjee et al.   NATURE REVIEWS GENETICS

Exposing the exposures responsible for type 2 diabetes and obesity

(2016) P. W. Franks et al.   SCIENCE

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

(2016) Johannes Kettunen et al.   Nature Communications

The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis

(2016) Gareth J Hollands et al.   BMJ-British Medical Journal

The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis

(2016) Gareth J Hollands et al.   BMJ-British Medical Journal

A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults

(2015) Richard A. Oram et al.   DIABETES CARE

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Identification of type 2 diabetes subgroups through topological analysis of patient similarity

(2015) Li Li et al.   Science Translational Medicine

The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium

(2015) Gonneke Willemsen et al.   Twin Research and Human Genetics

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

(2015) Martijn van de Bunt et al.   PLoS Genetics

Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

(2014) H. Yaghootkar et al.   DIABETES

Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

(2014) R. A. Scott et al.   DIABETES

Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection

(2014) Jason L. Vassy et al.   DIABETES

Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes

(2014) Christiane Winkler et al.   DIABETOLOGIA

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

(2013) Antigone S. Dimas et al.   DIABETES

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

(2013) Jason Flannick et al.   NATURE GENETICS

Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies

(2013) Nilanjan Chatterjee et al.   NATURE GENETICS

Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers

(2013) Andrea K Steck et al.   PEDIATRIC DIABETES

Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial

(2012) R. W. Grant et al.   DIABETES CARE

Automatic Relevance Determination in Nonnegative Matrix Factorization with the /spl beta/-Divergence

(2012) V. Y. F. Tan et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

(2011) R. J. Strawbridge et al.   DIABETES

Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program

(2011) M.-F. Hivert et al.   DIABETES

Genetic Syndromes of Severe Insulin Resistance

(2011) Robert K. Semple et al.   ENDOCRINE REVIEWS

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Maturity-onset diabetes of the young (MODY): how many cases are we missing?

(2010) B. M. Shields et al.   DIABETOLOGIA

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes

(2009) H. Lango Allen et al.   DIABETES

Preservation of  -Cell Function in Autoantibody-Positive Youth With Diabetes

(2009) C. J. Greenbaum et al.   DIABETES CARE

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

(2008) H. Lango et al.   DIABETES

Ser1369Ala Variant in Sulfonylurea Receptor Gene ABCC8 Is Associated With Antidiabetic Efficacy of Gliclazide in Chinese Type 2 Diabetic Patients

(2008) Y. Feng et al.   DIABETES CARE

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

(2008) Itsik Pe'er et al.   GENETIC EPIDEMIOLOGY

Concordance for Islet Autoimmunity among Monozygotic Twins

(2008) Maria J. Redondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

(2008) James B. Meigs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE