Unraveling the Regulation of Hepatic Gluconeogenesis

Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice

(2018) Yanjie Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

(2018) Anila K. Madiraju et al.   NATURE MEDICINE

p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis

(2018) Weilei Yao et al.   Biomed Research International

The Role of Sirt6 in Obesity and Diabetes

(2018) Jiangying Kuang et al.   Frontiers in Physiology

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

(2018) Nadia Boudaba et al.   EBioMedicine

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis

(2017) Lu Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vasopressin: physiology, assessment and osmosensation

(2017) L. Bankir et al.   JOURNAL OF INTERNAL MEDICINE

CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis

(2017) Hyunbae Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2

(2017) Yujie Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

Fructose-1,6-bisphosphatase deficiency as a cause of recurrent hypoglycemia and metabolic acidosis: Clinical and molecular findings in Malaysian patients

(2017) Lip Hen Moey et al.   Pediatrics and Neonatology

Vasopressin, from Regulator to Disease Predictor for Diabetes and Cardiometabolic Risk

(2016) Olle Melander   ANNALS OF NUTRITION AND METABOLISM

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Insulin-inducible SMILE inhibits hepatic gluconeogenesis

(2015) Ji-Min Lee et al.   DIABETES

Metabolic roles of PGC-1α and its implications for type 2 diabetes

(2015) A. Besseiche et al.   DIABETES & METABOLISM

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

(2015) Young Suk Jo et al.   HEPATOLOGY

Exercise-induced regulation of key factors in substrate choice and gluconeogenesis in mouse liver

(2015) Jakob G. Knudsen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?

(2014) Joseph A. Baur et al.   Cell Metabolism

Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex

(2014) Shumei Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

(2014) Jia Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis

(2014) Romana Stark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Arginine Methylation of CRTC2 Is Critical in the Transcriptional Control of Hepatic Glucose Metabolism

(2014) H.-S. Han et al.   Science Signaling

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

(2014) Kashyap Patel et al.   Nature Communications

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis

(2013) Xu Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

(2013) N. Kumashiro et al.   DIABETES

Control ofFoxo1Gene Expression by Co-activator P300

(2013) Anne R. Wondisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects

(2013) Kim Ravnskjaer et al.   JOURNAL OF CLINICAL INVESTIGATION

PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis

(2013) Andrés Méndez-Lucas et al.   JOURNAL OF HEPATOLOGY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation

(2013) Dongning Pan et al.   PLoS One

SIRT1 is a Direct Coactivator of Thyroid Hormone Receptor β1 with Gene-Specific Actions

(2013) Ji Ho Suh et al.   PLoS One

PRMT5 modulates the metabolic response to fasting signals

(2013) W.-W. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yin Yang 1 Promotes Hepatic Gluconeogenesis Through Upregulation of Glucocorticoid Receptor

(2012) Y. Lu et al.   DIABETES

Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1-dependent manner

(2012) Dahee Choi et al.   HEPATOLOGY

Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis

(2012) Ming Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

The Histone Demethylase Jhdm1a Regulates Hepatic Gluconeogenesis

(2012) Dongning Pan et al.   PLoS Genetics

TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver

(2012) Kyoung-Jin Oh et al.   PLoS Genetics

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis

(2011) R. Winkler et al.   DIABETES

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

(2011) L. Norton et al.   DIABETOLOGIA

Ligand-independent actions of the orphan receptors/corepressors DAX-1 and SHP in metabolism, reproduction and disease

(2011) Anna Ehrlund et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Arginine Methylation by PRMT5 at a Naturally Occurring Mutation Site Is Critical for Liver Metabolic Regulation by Small Heterodimer Partner

(2011) D. Kanamaluru et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

(2011) Wenqing Jiang et al.   MOLECULAR CELL

New role for HDACs in glucose homeostasis

(2011) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic regulation of glucocorticoid signalling in health and disease

(2011) S. C. Biddie et al.   RHEUMATOLOGY

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

(2010) Nima Mosammaparast et al.   Annual Review of Biochemistry

The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver

(2010) Hiroshi Oiso et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

(2010) Min-Woo Lee et al.   Cell Metabolism

Histone arginine methylation

(2010) Alessandra Di Lorenzo et al.   FEBS LETTERS

Metformin Activates AMP Kinase through Inhibition of AMP Deaminase

(2010) Jiangyong Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner

(2010) Ji-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

Role of glucocorticoids and the glucocorticoid receptor in metabolism: Insights from genetic manipulations

(2010) Adam J. Rose et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells

(2010) Mahua Choudhury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy

(2010) Janice Y. Chou et al.   Nature Reviews Endocrinology

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na+-K+-ATPase

(2009) Boubacar Benziane et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

DAX-1 Acts as a Novel Corepressor of Orphan Nuclear Receptor HNF4α and Negatively Regulates Gluconeogenic Enzyme Gene Expression

(2009) Balachandar Nedumaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto–Kakizaki rats

(2009) Hiroaki Iwasaki   LIFE SCIENCES

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

(2009) Yiguo Wang et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

(2009) Yongzhan Nie et al.   NATURE CELL BIOLOGY

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

(2009) Diana A. Stavreva et al.   NATURE CELL BIOLOGY

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

(2009) D. M. Erion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Relationship between Thyroid-Stimulating Hormone and Insulin in Euthyroid Obese Men

(2008) J.C. Galofré et al.   ANNALS OF NUTRITION AND METABOLISM

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic  -Cells Results in Reduced Insulin Secretion: A New Mechanism for Fat-Induced Impairment of  -Cell Function

(2008) M. Kebede et al.   DIABETES

Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

(2008) Y. M. Cho et al.   DIABETOLOGIA

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

(2008) Daniel Moreno et al.   FEBS LETTERS

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Graves' Disease

(2008) Gregory A. Brent   NEW ENGLAND JOURNAL OF MEDICINE