Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells

(2020) Huan-huan Lv et al.   ACTA PHARMACOLOGICA SINICA

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

(2020) Enyong Dai et al.   Autophagy

AIFM2 blocks ferroptosis independent of ubiquinol metabolism

(2020) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

(2020) Yuqing Wu et al.   Molecular Cancer

Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (S)-Butin

(2020) Liu et al.   MOLECULES

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

(2020) Azhaar Ashraf et al.   Redox Biology

Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells

(2020) Xican Li et al.   Antioxidants

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

The osteoprotective effects of artemisinin compounds and the possible mechanisms associated with intracellular iron: A review of in vivo and in vitro studies

(2020) Jian Zhang   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking

(2020) Zarith Nameyrra Md Nesran et al.   Evidence-based Complementary and Alternative Medicine

Ferroptosis inhibitory constituents from the fruits of Cullen corylifolium

(2020) Aftab Yaseen et al.   NATURAL PRODUCT RESEARCH

Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement

(2020) Vaishali Aggarwal et al.   SEMINARS IN CANCER BIOLOGY

The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer’s Disease, a Case Made With the Genus Eriodictyon

(2020) Pamela Maher et al.   Frontiers in Pharmacology

Kaempferol Protects Against Cerebral Ischemia Reperfusion Injury Through Intervening Oxidative and Inflammatory Stress Induced Apoptosis

(2020) Jing Wang et al.   Frontiers in Pharmacology

Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma

(2020) Bhavishya Sarma et al.   Cancers

Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities

(2020) Lingrong Wen et al.   FOOD CHEMISTRY

Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis

(2020) Saber Ghazizadeh Darband et al.   LIFE SCIENCES

Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent

(2020) Surya Kant Tripathi et al.   PHARMACOLOGICAL RESEARCH

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

(2020) Laura Mahoney-Sánchez et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice

(2020) Xi Zhao et al.   TOXICOLOGY

Ferroptosis in Neurological Diseases

(2020) Jia-Xin Ren et al.   Frontiers in Cellular Neuroscience

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

(2020) Jennifer Michel et al.   Frontiers in Pharmacology

An insight into the therapeutic applications of coumarin compounds and their mechanisms of action

(2020) Sourbh Suren Garg et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

N-acetylglycoside of oleanolic acid (aridanin) displays promising cytotoxicity towards human and animal cancer cells, inducing apoptotic, ferroptotic and necroptotic cell death

(2020) Armelle T. Mbaveng et al.   PHYTOMEDICINE

Oxidative Damage and Antioxidant Defense in Ferroptosis

(2020) Feimei Kuang et al.   Frontiers in Cell and Developmental Biology

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

(2019) Sita Sharan Patel et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Emerging Roles of Ferroptosis in Huntington’s Disease

(2019) Yajing Mi et al.   NEUROMOLECULAR MEDICINE

Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy

(2019) Armelle T. Mbaveng et al.   PHYTOMEDICINE

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

The release and activity of HMGB1 in ferroptosis

(2019) Qirong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

(2019) Guo-Qing Chen et al.   CELL DEATH AND DIFFERENTIATION

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

(2019) Melania Guerrero-Hue et al.   FASEB JOURNAL

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

(2019) Evijola Llabani et al.   Nature Chemistry

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits bladder cancer cell growth via the mitochondrial apoptosis and JNK pathways

(2019) Qiyu Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System

(2019) Brent R. Stockwell et al.   Cell Metabolism

Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells

(2019) Giuseppe Antonio Malfa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells

(2019) Kang Wang et al.   Drug Design Development and Therapy

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

(2019) Qin Li et al.   Frontiers in Pharmacology

Interactions between iron and α-synuclein pathology in Parkinson's disease

(2019) Bingbing Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

(2019) Yibing Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy

(2019) Gaofei Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms explaining the efficacy of psoralidin in cancer and osteoporosis, a review

(2019) Zhenlong Xin et al.   PHARMACOLOGICAL RESEARCH

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells

(2019) Madoka Takashima et al.   FOOD AND CHEMICAL TOXICOLOGY

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective

(2019) Paul J. Derry et al.   PROGRESS IN NEUROBIOLOGY

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

(2019) Wijdan M. Dabeek et al.   Nutrients

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

(2019) Hua Luo et al.   Chinese Medicine

7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

(2019) Sandra Gunesch et al.   Redox Biology

Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins

(2019) Qiongtao Song et al.   BIOMEDICINE & PHARMACOTHERAPY

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

(2018) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Prevention of carcinogenesis and metastasis by Artemisinin-type drugs

(2018) Mohammed L. Abba et al.   CANCER LETTERS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The application of natural products in cancer therapy by targeting apoptosis pathways

(2018) Yan Wang et al.   CURRENT DRUG METABOLISM

Structures, bioactivities and future prospective of polysaccharides from Morus alba (white mulberry): A review

(2018) Xirui He et al.   FOOD CHEMISTRY

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isothiocyanates: Translating the Power of Plants to People

(2018) Dushani L. Palliyaguru et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Compound of icariin, astragalus, and puerarin mitigates iron overload in the cerebral cortex of Alzheimer's disease mice

(2018) Xi-Qing Chai et al.   Neural Regeneration Research

The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews

(2018) Ester Pagano et al.   PHARMACOLOGICAL RESEARCH

A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

(2018) Armelle T. Mbaveng et al.   PHYTOMEDICINE

New highlights on the health-improving effects of sulforaphane

(2018) Alfredo Briones-Herrera et al.   Food & Function

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Selenium-Encoded Isotopic Signature Targeted Profiling

(2018) Jinjun Gao et al.   ACS Central Science

Radiation protection and mitigation by natural antioxidants and flavonoids; implications to radiotherapy and radiation disasters

(2018) Rasoul Yahyapour et al.   Current Molecular Pharmacology

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells

(2018) Zili Zhang et al.   Autophagy

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

(2018) Muneeb U Rehman et al.   Current Neuropharmacology

Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

(2018) Gaofei Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis

(2018) Tetsuro Ishii et al.   FREE RADICAL BIOLOGY AND MEDICINE

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

(2018) Changmin Kim et al.   Nutrients

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

(2018) Jun-Lin Liu et al.   Frontiers in Neuroscience

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation

(2018) Eui Ho Kim et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

(2018) Ling Wang et al.   IUBMB LIFE

Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Che-Lin Hu et al.   JOURNAL OF NEUROCHEMISTRY

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

(2018) Muhammad Imran et al.   PHYTOTHERAPY RESEARCH

Iron Status and Risk of Stroke

(2018) Dipender Gill et al.   STROKE

Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

(2018) Wolfgang Fischer et al.   Redox Biology

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

(2018) Jing Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

(2017) Biswanath Dinda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis

(2017) Shinya Toyokuni et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer

(2017) Shasha Tao et al.   MOLECULAR CARCINOGENESIS

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer

(2017) Armelle T. Mbaveng et al.   PHYTOMEDICINE

Butein in health and disease: A comprehensive review

(2017) Ganesan Padmavathi et al.   PHYTOMEDICINE

Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1

(2017) Hyun Jeong Kwak et al.   PLoS One

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

(2017) Chunguang Yang et al.   Drug Design Development and Therapy

Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

(2017) Mustapha Imam et al.   Nutrients

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9

(2017) Jonathan M. Goodwin et al.   Cell Reports

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

(2016) Yangchun Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective role of epigallocatechin-3-gallate in health and disease: A perspective

(2016) Animesh Chowdhury et al.   BIOMEDICINE & PHARMACOTHERAPY

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

(2016) Renyu Lin et al.   CANCER LETTERS

Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

(2016) Anna L. Greenshields et al.   MOLECULAR CARCINOGENESIS

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells

(2016) Takashi Kasukabe et al.   ONCOLOGY REPORTS

Role of Antioxidants and Natural Products in Inflammation

(2016) Palanisamy Arulselvan et al.   Oxidative Medicine and Cellular Longevity

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erianin induces G2/M-phase arrest, apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo

(2016) H Wang et al.   Cell Death & Disease

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

(2015) Pravat K. Mandal et al.   BIOLOGICAL PSYCHIATRY

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

(2015) O. Canli et al.   BLOOD

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

(2015) Milla Kibble et al.   NATURAL PRODUCT REPORTS

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

(2015) Edna Ooko et al.   PHYTOMEDICINE

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Epunctanone, a New Benzophenone, and Further Secondary Metabolites fromGarcinia epunctataStapf(Guttiferae)

(2014) Ghislain W. Fotso et al.   HELVETICA CHIMICA ACTA

Natural product and natural product derived drugs in clinical trials

(2014) Mark S. Butler et al.   NATURAL PRODUCT REPORTS

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells

(2014) Gaofei Wei et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke

(2013) Rachel E. Speer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases

(2013) Christian Guerra-Araiza et al.   FREE RADICAL RESEARCH

Pooled analysis of iron-related genes in Parkinson's disease: Association with transferrin

(2013) Shannon L. Rhodes et al.   NEUROBIOLOGY OF DISEASE

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Puerarin: A Review of Pharmacological Effects

(2013) Yan-Xi Zhou et al.   PHYTOTHERAPY RESEARCH

Alterations in Brain Transition Metals in Huntington Disease

(2012) H. Diana Rosas et al.   ARCHIVES OF NEUROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Systematic review of β-Elemene injection as adjunctive treatment for lung cancer

(2012) Bin Wang et al.   Chinese Journal of Integrative Medicine

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis

(2012) Kosuke Okada et al.   JOURNAL OF GASTROENTEROLOGY

Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases

(2011) Laura Casu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin Inhibits Growth of Saccharomyces cerevisiae through Iron Chelation

(2011) Steven Minear et al.   EUKARYOTIC CELL

Iron as a target of chemoprevention for longevity in humans

(2011) Shinya Toyokuni   FREE RADICAL RESEARCH

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

(2010) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

Chemical study and medical application of saponins as anti-cancer agents

(2010) Shuli Man et al.   FITOTERAPIA

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

The complexity of neurobiological processes in acute ischemic stroke

(2009) R. Brouns et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator

(2008) Y. Jiao et al.   BLOOD