Ferroptosis and necroinflammation, a yet poorly explored link

An Element of Life

(2018) Douglas R. Green   CELL

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Origin and Consequences of Necroinflammation

(2018) Maysa Sarhan et al.   PHYSIOLOGICAL REVIEWS

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Lipoxygenases—Killers against Their Will?

(2018) José Pedro Friedmann Angeli et al.   ACS Central Science

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

(2017) Sonja C. Schriever et al.   NEUROSCIENCE

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

(2016) Bradley A. Carlson et al.   Redox Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

(2015) Simone Hanna Brütsch et al.   ANTIOXIDANTS & REDOX SIGNALING

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

(2015) Jung Hoon Woo et al.   CELL

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

(2015) Sho Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Necroinflammation in Kidney Disease

(2015) S. R. Mulay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity

(2015) Manuela Schneider et al.   NEOPLASIA

Cerebellar Hypoplasia in Mice Lacking Selenoprotein Biosynthesis in Neurons

(2014) Eva K. Wirth et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice

(2013) Markus Wortmann et al.   CIRCULATION RESEARCH

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

(2013) Aniruddha Sengupta et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Oxidatively Truncated Phospholipids Are Required Agents of Tumor Necrosis Factor α (TNFα)-induced Apoptosis

(2012) Calivarathan Latchoumycandane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostaglandin H Synthase-2-catalyzed Oxygenation of 2-Arachidonoylglycerol Is More Sensitive to Peroxide Tone than Oxygenation of Arachidonic Acid

(2012) Joel Musee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells

(2011) Takashi Ueta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

(2010) Pankaj Kumar Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

(2009) Eva K. Wirth et al.   FASEB JOURNAL

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Protecting Against Cerebrovascular Injury

(2008) Guang Jin et al.   STROKE