Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells

To eat or not to eat — the metabolic flavor of ferroptosis

(2018) Minghui Gao et al.   CURRENT OPINION IN CELL BIOLOGY

Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18

(2018) Xiaohui Xu et al.   Cancer Research and Treatment

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Ferroptosis: bug or feature?

(2017) Scott J. Dixon   IMMUNOLOGICAL REVIEWS

The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury

(2017) Kelly McDaniel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human hepatic stellate cell isolation and characterization

(2017) Linshan Shang et al.   JOURNAL OF GASTROENTEROLOGY

Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events

(2017) Robert L. Bertrand   MEDICAL HYPOTHESES

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1

(2017) Dapeng Yu et al.   OncoTargets and Therapy

Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis

(2017) Zili Zhang et al.   Cell Death & Disease

HMGB1 Mediates Autophagy Dysfunction via Perturbing Beclin1-Vps34 Complex in Dopaminergic Cell Model

(2017) Jinsha Huang et al.   Frontiers in Molecular Neuroscience

Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells

(2017) Shihui Hao et al.   NEOPLASIA

Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell

(2017) Zili Zhang et al.   Redox Biology

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

(2017) Liwei Wu et al.   Scientific Reports

CUGBP1 and HuR regulate E-cadherin translation by altering recruitment of E-cadherin mRNA to processing bodies and modulate epithelial barrier function

(2016) Ting-Xi Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Bile Acid Analog Intercepts Liver Fibrosis

(2016) C. Daniel De Magalhaes Filho et al.   CELL

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis

(2016) Zili Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡

(2016) Kelly McDaniel et al.   HEPATOLOGY

Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-βR/ERK signaling pathway

(2016) Qin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

(2016) Xingxin Wu et al.   Nature Communications

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Targeting the Multifaceted HuR Protein, Benefits and Caveats

(2015) Chiara Zucal et al.   CURRENT DRUG TARGETS

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Melatonin attenuates carbon tetrachloride–induced liver fibrosis via inhibition of necroptosis

(2015) Hyo-Sun Choi et al.   Translational Research

Apelin-13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway-dependent upregulation of Beclin1

(2015) QIULIN HUANG et al.   Oncology Letters

Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation

(2014) Benyu Ma et al.   CELL RESEARCH

Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis

(2014) Sung-Hee Chang et al.   CURRENT OPINION IN HEMATOLOGY

Changes of cytokines in patients with liver cirrhosis and advanced hepatocellular carcinoma treated by sorafenib

(2013) Hidenari Nagai et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Beyond liver fibrosis: Hepatic stellate cell senescence links obesity to liver cancer by way of the microbiome

(2013) Nicholas A. Shackel et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

(2013) Jun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib

(2013) Yan-Ru Deng et al.   JOURNAL OF AUTOIMMUNITY

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Autophagy fuels tissue fibrogenesis

(2012) Virginia Hernández-Gea et al.   Autophagy

Autophagy: A new player in hepatic stellate cell activation

(2012) Lien F.R. Thoen et al.   Autophagy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

(2012) Yuping Chen et al.   GASTROENTEROLOGY

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

(2012) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

HuR function in disease

(2011) Subramanya Srikantan   Frontiers in Bioscience-Landmark

Hepatic stellate cell proliferation: A potential role of protein kinase R

(2011) Sara Ceccarelli et al.   HEPATOLOGY

Sorafenib inhibits transforming growth factor β1-Mediated Epithelial-Mesenchymal Transition and apoptosis in mouse hepatocytes

(2011) Yue-Lei Chen et al.   HEPATOLOGY

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis

(2011) Anthie Yiakouvaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis

(2010) Matthew M Gubin et al.   CELL CYCLE

Application of the 2010 American Association for the study of liver diseases criteria of remission to a cohort of Italian patients with autoimmune hepatitis

(2010) Luigi Muratori et al.   HEPATOLOGY

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats

(2009) Y-H Paik et al.   GUT

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL