Natural product and natural product derived drugs in clinical trials
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Title
Natural product and natural product derived drugs in clinical trials
Authors
Keywords
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Journal
NATURAL PRODUCT REPORTS
Volume 31, Issue 11, Pages 1612-1661
Publisher
Royal Society of Chemistry (RSC)
Online
2014-09-10
DOI
10.1039/c4np00064a
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- (2007) Ajay Goel et al. BIOCHEMICAL PHARMACOLOGY
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