Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications
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Title
Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications
Authors
Keywords
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Journal
Frontiers in Neuroscience
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-09-10
DOI
10.3389/fnins.2018.00632
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Note: Only part of the references are listed.- Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer’s Disease
- (2018) Lei Du et al. ACS Chemical Neuroscience
- Effect of ferric citrate on amyloid-beta peptides behavior
- (2018) D. Galante et al. BIOPOLYMERS
- Metal Ion Effects on Aβ and Tau Aggregation
- (2018) Anne Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms
- (2018) Darius J.R. Lane et al. JOURNAL OF ALZHEIMERS DISEASE
- Fe(II) formation after interaction of the amyloid β-peptide with iron-storage protein ferritin
- (2018) Lucia Balejcikova et al. JOURNAL OF BIOLOGICAL PHYSICS
- Hepcidin, an emerging and important player in brain iron homeostasis
- (2018) Driton Vela Journal of Translational Medicine
- Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice
- (2018) Douglas G. Peters et al. Metallomics
- The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders
- (2018) Roberta Giampietro et al. MOLECULAR PHARMACEUTICS
- Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects
- (2018) James Everett et al. Nanoscale
- Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease
- (2018) Marjolein Bulk et al. NEUROBIOLOGY OF AGING
- Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age
- (2018) J.M.G. van Bergen et al. NEUROIMAGE
- Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells
- (2018) Yoko Hirata et al. NEUROPHARMACOLOGY
- Zinc, Carnosine, and Neurodegenerative Diseases
- (2018) et al. Nutrients
- New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson’s Disease
- (2018) Huamin Xu et al. Frontiers in Molecular Neuroscience
- Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
- (2018) Moataz Abdalkader et al. Frontiers in Neuroscience
- α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice
- (2018) Yan-Hui Zhang et al. Redox Biology
- Clioquinol Reduces Zinc Accumulation in Neuritic Plaques and Inhibits the Amyloidogenic Pathway in AβPP/PS1 Transgenic Mouse Brain
- (2018) Tao Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- The Metal Theory of Alzheimer's Disease
- (2018) Ashley I. Bush JOURNAL OF ALZHEIMERS DISEASE
- Nmnat2 Attenuates Tau Phosphorylation Through Activation of PP2A
- (2018) Xiang-Shu Cheng et al. JOURNAL OF ALZHEIMERS DISEASE
- Overexpression of Heme Oxygenase 1 Causes Cognitive Decline and Affects Pathways for Tauopathy in Mice
- (2018) Dayong Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- Ferroptosis: bug or feature?
- (2017) Scott J. Dixon IMMUNOLOGICAL REVIEWS
- Cortical Iron Reflects Severity of Alzheimer’s Disease
- (2017) Sara van Duijn et al. JOURNAL OF ALZHEIMERS DISEASE
- Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study
- (2017) Scott Ayton et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases
- (2017) M. Kawahara et al. Metallomics
- Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases
- (2017) Zhi Dong Zhou et al. Molecular Neurodegeneration
- Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
- (2017) Q-z Tuo et al. MOLECULAR PSYCHIATRY
- Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load
- (2017) K Goozee et al. MOLECULAR PSYCHIATRY
- Targeting iron metabolism in drug discovery and delivery
- (2017) Bart J. Crielaard et al. NATURE REVIEWS DRUG DISCOVERY
- Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease
- (2017) J. O'Callaghan et al. NEUROIMAGE
- In vivo detection of microstructural correlates of brain pathology in preclinical and early Alzheimer Disease with magnetic resonance imaging
- (2017) Yue Zhao et al. NEUROIMAGE
- Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer’s Disease Mouse Model
- (2017) Chuang Guo et al. NEUROPSYCHOPHARMACOLOGY
- Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease
- (2017) Raed Daher et al. PRESSE MEDICALE
- Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease
- (2017) Zohara Sternberg et al. Aging and Disease
- Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
- (2017) William Sealy Hambright et al. Redox Biology
- Clioquinol Decreases Amyloid-β Burden and Reduces Working Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease
- (2017) Cristina Grossi et al. JOURNAL OF ALZHEIMERS DISEASE
- Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse
- (2016) Jessica L. Billings et al. ACS Chemical Neuroscience
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- Ferroptosis: process and function
- (2016) Y Xie et al. CELL DEATH AND DIFFERENTIATION
- Ferroptosis is an autophagic cell death process
- (2016) Minghui Gao et al. CELL RESEARCH
- Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer’s Dementia Using Quantitative Susceptibility Mapping Imaging
- (2016) Yeonsil Moon et al. JOURNAL OF ALZHEIMERS DISEASE
- Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
- (2016) Abdel A. Belaidi et al. JOURNAL OF NEUROCHEMISTRY
- Iron chelation in the treatment of neurodegenerative diseases
- (2016) Petr Dusek et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Alpha-Lipoic Acid Alleviates Acute Inflammation and Promotes Lipid Mobilization During the Inflammatory Response in White Adipose Tissue of Mice
- (2016) Jun Guo et al. LIPIDS
- Amyloid Aβ42, a promoter of magnetite nanoparticle formation in Alzheimer’s disease
- (2016) Islam Bogachan Tahirbegi et al. NANOTECHNOLOGY
- A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload
- (2016) Jirapas Sripetchwandee et al. NEUROSCIENCE
- Fe2+binding on amyloid β-peptide promotes aggregation
- (2016) Subramaniam Boopathi et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Ferroptosis: Death by Lipid Peroxidation
- (2016) Wan Seok Yang et al. TRENDS IN CELL BIOLOGY
- High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease
- (2016) Germán Plascencia-Villa et al. Scientific Reports
- Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment
- (2016) J. M. G. van Bergen et al. Scientific Reports
- Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients
- (2015) Cláudia Guerreiro et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Iron Chelation in Thalassemia Major
- (2015) Caterina Borgna-Pignatti et al. CLINICAL THERAPEUTICS
- Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- (2015) Liuji Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders
- (2015) Natalia P. Mena et al. MITOCHONDRION
- Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse
- (2015) Peng Lei et al. NEUROBIOLOGY OF DISEASE
- Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau
- (2015) Xuling Li et al. Neurotherapeutics
- Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE
- (2015) Scott Ayton et al. Nature Communications
- Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice
- (2015) Chuang Guo et al. Frontiers in Aging Neuroscience
- The Role of Tau Oligomers in the Onset of Alzheimer's Disease Neuropathology
- (2014) María del Carmen Cárdenas-Aguayo et al. ACS Chemical Neuroscience
- Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide -amyloid (1-42)
- (2014) J. Everett et al. Journal of the Royal Society Interface
- The role of iron in brain ageing and neurodegenerative disorders
- (2014) Roberta J Ward et al. LANCET NEUROLOGY
- Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats
- (2014) Fang Du et al. MOLECULAR NEUROBIOLOGY
- Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging
- (2014) Martina F. Callaghan et al. NEUROBIOLOGY OF AGING
- Multiple Mechanisms of Iron-Induced Amyloid Beta-Peptide Accumulation in SHSY5Y Cells: Protective Action of Negletein
- (2014) Priyanjalee Banerjee et al. NEUROMOLECULAR MEDICINE
- The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light
- (2014) Joanna F. Collingwood et al. Frontiers in Pharmacology
- Lactoferrin during lactation protects the immature hypoxic-ischemic rat brain
- (2014) Yohan van de Looij et al. Annals of Clinical and Translational Neurology
- Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
- (2013) Bin Zhang et al. CELL
- Alpha-lipoic acid protects oxidative stress, changes in cholinergic system and tissue histopathology during co-exposure to arsenic-dichlorvos in rats
- (2013) Nidhi Dwivedi et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Iron levels in the human brain: A post-mortem study of anatomical region differences and age-related changes
- (2013) Patrícia Ramos et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Enhanced Brain Delivery of Deferasirox–Lactoferrin Conjugates for Iron Chelation Therapy in Neurodegenerative Disorders: In Vitro and in Vivo Studies
- (2013) Golnaz Kamalinia et al. MOLECULAR PHARMACEUTICS
- Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase
- (2013) Dongsun Park et al. NEUROBIOLOGY OF AGING
- Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
- (2013) Xinxin Li et al. NEUROSCIENCE LETTERS
- Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures
- (2013) Oddvar Myhre et al. Oxidative Medicine and Cellular Longevity
- Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism
- (2013) S. I. A. Cohen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy
- (2013) Etheresia Pretorius et al. TOXICOLOGY MECHANISMS AND METHODS
- Alzheimer Mechanisms and Therapeutic Strategies
- (2012) Yadong Huang et al. CELL
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Pharmacoeconomic considerations of treating patients with advanced Parkinson's disease
- (2012) Jens P Reese et al. EXPERT OPINION ON PHARMACOTHERAPY
- Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain
- (2012) Sven O. Dahms et al. JOURNAL OF MOLECULAR BIOLOGY
- Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
- (2012) Peng Lei et al. NATURE MEDICINE
- Sting of Alzheimer's failures offset by upcoming prevention trials
- (2012) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease
- (2012) Chuang Guo et al. NEUROBIOLOGY OF AGING
- Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake
- (2012) Ling Xie et al. NEUROCHEMISTRY INTERNATIONAL
- Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
- (2012) Chuang Guo et al. NEUROCHEMISTRY INTERNATIONAL
- Preventing Alzheimer's Disease
- (2012) D. J. Selkoe SCIENCE
- The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes
- (2012) Johannes Hohenberger et al. Nature Communications
- Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice
- (2012) J. M. Fine et al. EXPERIMENTAL BRAIN RESEARCH
- Hepcidin directly inhibits transferrin receptor 1 expression in astrocytes via a cyclic AMP-protein kinase a pathway
- (2011) Fang Du et al. GLIA
- Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease
- (2011) M. D. Ikonomovic et al. NEUROLOGY
- Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation
- (2011) Markus P. Kummer et al. NEURON
- S-Nitrosylation of Critical Protein Thiols Mediates Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases
- (2010) Tomohiro Nakamura et al. ANTIOXIDANTS & REDOX SIGNALING
- Superoxide-dependent reduction of free Fe3+ and release of Fe2+ from ferritin by the physiologically-occurring Cu(I)–glutathione complex
- (2010) Margarita E. Aliaga et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
- (2010) James A. Duce et al. CELL
- Differential effects of age and history of hypertension on regional brain volumes and iron
- (2010) Karen M. Rodrigue et al. NEUROIMAGE
- Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease
- (2010) Ligang Wang et al. NEUROSCIENCE LETTERS
- Cellular iron transport
- (2009) Michael D. Garrick et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Getting the iron out: Phlebotomy for Alzheimer’s disease?
- (2009) Barney E. Dwyer et al. MEDICAL HYPOTHESES
- Lipoic Acid Increases Hippocampal Choline Acetyltransferase and Acetylcholinesterase Activities and Improvement Memory in Epileptic Rats
- (2009) Rivelilson Mendes de Freitas NEUROCHEMICAL RESEARCH
- Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases
- (2008) Catherine M. Cahill et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Distribution study of orally administered lipoic acid in rat brain tissues
- (2008) H.T. Chng et al. BRAIN RESEARCH
- RETRACTED: The Hepcidin-Binding Site on Ferroportin Is Evolutionarily Conserved
- (2008) Ivana De Domenico et al. Cell Metabolism
- Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
- (2008) Alexander Seiler et al. Cell Metabolism
- A potential pathogenetic role of iron in Alzheimer's disease
- (2008) Laura Silvestri et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- New insights into intestinal iron absorption
- (2008) W. H. Horl NEPHROLOGY DIALYSIS TRANSPLANTATION
- Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
- (2007) Tamar Amit et al. FASEB JOURNAL
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