Heparan Sulfate Proteoglycans in Viral Infection and Treatment: A Special Focus on SARS-CoV-2

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

(2021) Shuai Wang et al.   CELL RESEARCH

Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design

(2021) Xuhua Xia   Viruses-Basel

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

(2021) Hin Chu et al.   Nature Communications

Herpes Simplex Virus Cell Entry Mechanisms: An Update

(2021) Krishnaraju Madavaraju et al.   Frontiers in Cellular and Infection Microbiology

Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins—An Important Strategy for Developing Novel Therapeutics for the COVID-19 Pandemic

(2021) Mingjia Yu et al.   Frontiers in Molecular Biosciences

Contribution of Syndecans to the Cellular Entry of SARS-CoV-2

(2021) Anett Hudák et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury

(2020) W. B. LaRivière et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

(2020) Sangeun Jeon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses

(2020) Sean Ekins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heparanase, cell signaling, and viral infections

(2020) Raghuram Koganti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing

(2020) Oleg O. Glebov   FEBS Journal

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

(2020) Wenling Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19: A Comment

(2020) Christopher D. Barrett et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The versatile heparin in COVID‐19

(2020) Jecko Thachil   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiorgan and Renal Tropism of SARS-CoV-2

(2020) Victor G. Puelles et al.   NEW ENGLAND JOURNAL OF MEDICINE

A myosin-7B–dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos

(2020) Qi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

(2020) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria

(2020) Douglas B. Kell et al.   Frontiers in Immunology

Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy

(2020) Valeria De Pasquale et al.   Cells

Heparin as a therapy for COVID-19: current evidence and future possibilities

(2020) Joseph A. Hippensteel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle

(2020) Clarisse Salgado-Benvindo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

COVID-19 and pneumonia: a role for the uPA/uPAR system

(2020) Daniele D’Alonzo et al.   DRUG DISCOVERY TODAY

Discovering small-molecule therapeutics against SARS-CoV-2

(2020) Vaibhav Tiwari et al.   DRUG DISCOVERY TODAY

Lactoferrin as potential preventative and adjunct treatment for COVID-19

(2020) Raymond Chang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials

(2020) Rami A. Al-Horani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past

(2020) Dimitrios Giannis et al.   JOURNAL OF CLINICAL VIROLOGY

Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression

(2020) Sunil Rangarajan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Detection profile of SARS‐CoV‐2 using RT‐PCR in different types of clinical specimens: A systematic review and meta‐analysis

(2020) George M. Bwire et al.   JOURNAL OF MEDICAL VIROLOGY

Structure of Merkel cell polyomavirus capsid and interaction with its glycosaminoglycan attachment receptor

(2020) Niklas J. Bayer et al.   JOURNAL OF VIROLOGY

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

Hepatitis B Virus Entry into Cells

(2020) Charline Herrscher et al.   Cells

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

(2020) So Young Kim et al.   ANTIVIRAL RESEARCH

Endothelial dysfunction in COVID-19: Current findings and therapeutic implications

(2020) Matthias P. Nägele et al.   ATHEROSCLEROSIS

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19

(2020) Carina Conzelmann et al.   CLINICAL MEDICINE

Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment

(2020) Valeria De Pasquale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heparin-binding Peptides as Novel Therapies to Stop SARS-CoV-2 Cellular Entry and Infection

(2020) Omid Tavassoly et al.   MOLECULAR PHARMACOLOGY

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity

(2020) Thibault Annaval et al.   MOLECULES

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Mechanisms of SARS-CoV-2 transmission and pathogenesis

(2020) Andrew G. Harrison et al.   TRENDS IN IMMUNOLOGY

Virus–Host Cell Interplay during Hepatitis E Virus Infection

(2020) Michael H. Wißing et al.   TRENDS IN MICROBIOLOGY

Characterization of accessory genes in coronavirus genomes

(2020) Christian Jean Michel et al.   Virology Journal

Tick-Borne Encephalitis Virus Adaptation in Different Host Environments and Existence of Quasispecies

(2020) Renata Helmová et al.   Viruses-Basel

A molecular understanding of alphavirus entry

(2020) Autumn C. Holmes et al.   PLoS Pathogens

Increased Plasma Heparanase Activity in COVID-19 Patients

(2020) Baranca Buijsers et al.   Frontiers in Immunology

Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

(2020) Baranca Buijsers et al.   EBioMedicine

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

(2020) Erik Volz et al.   CELL

Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer

(2020) Nourhan Hassan et al.   CELLULAR SIGNALLING

Vascular Endothelial Glycocalyx Damage in COVID-19

(2020) Minako Yamaoka-Tojo   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emergence of a Highly Fit SARS-CoV-2 Variant

(2020) Ralph S. Baric   NEW ENGLAND JOURNAL OF MEDICINE

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

(2020) Courtney J. Mycroft-West et al.   THROMBOSIS AND HAEMOSTASIS

COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?

(2020) Serena Del Turco et al.   THROMBOSIS RESEARCH

Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)

(2020) Anna Egorova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Degradation of Glycocalyx and Multiple Manifestations of Endothelial Dysfunction Coincide in the Early Phase of Endothelial Dysfunction Before Atherosclerotic Plaque Development in Apolipoprotein E/Low‐Density Lipoprotein Receptor‐Deficient Mice

(2019) Anna Bar et al.   Journal of the American Heart Association

Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry

(2019) Michela Mazzon et al.   Viruses-Basel

Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

(2019) Ruben J. G. Hulswit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating heparan sulfate fragments mediate septic cognitive dysfunction

(2019) Joseph A. Hippensteel et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation

(2019) Shravan Morla   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early events in rabies virus infection—Attachment, entry, and intracellular trafficking

(2019) Yidi Guo et al.   VIRUS RESEARCH

Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors

(2019) Artur Szczepanski et al.   Viruses-Basel

Membrane protein of HCoV-NL63 is responsible for interaction with the adhesion receptor.

(2019) Antonina Naskalska et al.   JOURNAL OF VIROLOGY

The pleiotropic role of proteoglycans in extracellular vesicle mediated communication in the tumor microenvironment

(2019) M. Cerezo-Magaña et al.   SEMINARS IN CANCER BIOLOGY

Molecular Mechanism of HIV-1 Entry

(2019) Bing Chen   TRENDS IN MICROBIOLOGY

Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

(2019) Cagno et al.   Viruses-Basel

Heparan sulfate proteoglycans: The sweet side of development turns sour in mucopolysaccharidoses

(2019) Valeria De Pasquale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Preliminary Phase 1 Data on the Safety and Efficacy of a Novel PET Radiotracer, 124I-p5+14, for Imaging Systemic Amyloidosis

(2019) Jonathan S. Wall et al.   BLOOD

Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau

(2019) Anett Hudák et al.   Scientific Reports

The human coronavirus HCoV‐229E S‐protein structure and receptor binding

(2019) Zhijie Li et al.   eLife

Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress

(2019) Satvik Hadigal et al.   JOURNAL OF VIROLOGY

Proteoglycans in brain development and pathogenesis

(2018) Nancy B. Schwartz et al.   FEBS LETTERS

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

(2018) Hin Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies

(2018) Brooke L. Farrugia et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation

(2018) Paul O’Callaghan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection

(2018) Michihito Sasaki et al.   JOURNAL OF INFECTIOUS DISEASES

Extracellular Conformational Changes in the Capsid of Human Papillomaviruses Contribute to Asynchronous Uptake into Host Cells

(2018) Miriam Becker et al.   JOURNAL OF VIROLOGY

Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice

(2018) Kyousuke Kobayashi et al.   JOURNAL OF VIROLOGY

EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB

(2018) Valeria De Pasquale et al.   Cell Death & Disease

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus

(2018) Jinliang Wang et al.   PLoS Pathogens

Targeting Heparan Sulfate Proteoglycans as a Novel Therapeutic Strategy for Mucopolysaccharidoses

(2018) Valeria De Pasquale et al.   Molecular Therapy-Methods & Clinical Development

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

(2018) Nikos K. Karamanos et al.   CHEMICAL REVIEWS

A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism

(2018) Eirini D. Tseligka et al.   PLoS Pathogens

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Sulfotransferase and Heparanase: Remodeling Engines in Promoting Virus Infection and Disease Development

(2018) Dominik D. Kaltenbach et al.   Frontiers in Pharmacology

Heparan sulfate proteoglycan – A common receptor for diverse cytokines

(2018) Meng Xie et al.   CELLULAR SIGNALLING

Antiviral activity of cationic amphiphilic drugs

(2017) Cristiano Salata et al.   Expert Review of Anti-Infective Therapy

Heparan sulfate as a receptor for poxvirus infections and as a target for antiviral agents

(2017) Mayank Khanna et al.   JOURNAL OF GENERAL VIROLOGY

Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche

(2017) Taihei Yamada et al.   JOURNAL OF NEUROCHEMISTRY

Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling

(2017) R.S. Ghadiali et al.   MATRIX BIOLOGY

Targeting heparin and heparan sulfate protein interactions

(2017) Ryan J. Weiss et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding

(2017) Yanlin Zhang et al.   SHOCK

Beyond attachment: Roles of DC-SIGN in dengue virus infection

(2017) Ping Liu et al.   TRAFFIC

The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

(2017) James T. Earnest et al.   PLoS Pathogens

Heparan Sulfate in the Developing, Healthy, and Injured Lung

(2016) Sarah M. Haeger et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The D-form of a novel heparan binding peptide decreases cytomegalovirus infection in vivo and in vitro

(2016) Elisabeth A. Pitt et al.   ANTIVIRAL RESEARCH

Evaluation of the endothelial glycocalyx damage in patients with acute coronary syndrome

(2016) Carlos Henrique Miranda et al.   ATHEROSCLEROSIS

Syndecans - key regulators of cell signaling and biological functions

(2016) Nikolaos A. Afratis et al.   FEBS Journal

Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase

(2016) Daniele Pala et al.   GLYCOBIOLOGY

Early events in hepatitis B virus infection: From the cell surface to the nucleus

(2016) C Nelson Hayes et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues

(2016) Edita M. Klimyte et al.   JOURNAL OF VIROLOGY

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

(2016) Che-Man Chan et al.   JOURNAL OF VIROLOGY

TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection

(2016) Jing Wang et al.   JOURNAL OF VIROLOGY

Mutations in VP1 and 3A proteins improve binding and replication of rhinovirus C15 in HeLa-E8 cells

(2016) Yury A. Bochkov et al.   VIROLOGY

Cellular uptake of hepatitis B virus envelope L particles is independent of sodium taurocholate cotransporting polypeptide, but dependent on heparan sulfate proteoglycan

(2016) Masaharu Somiya et al.   VIROLOGY

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

(2016) Henry Puerta-Guardo et al.   PLoS Pathogens

The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis

(2016) Dustin R. Glasner et al.   Annual Review of Virology

Acute Degradation of the Endothelial Glycocalyx in Infants Undergoing Cardiac Surgical Procedures

(2015) Dirk Bruegger et al.   ANNALS OF THORACIC SURGERY

Design, Synthesis, and Evaluation of Genistein Analogues as Anti-Cancer Agents

(2015) Pahoua Xiong et al.   Anti-Cancer Agents in Medicinal Chemistry

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases

(2015) Bernhard F. Becker et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Syndecan-1 in Acute Decompensated Heart Failure　– Association With Renal Function and Mortality –

(2015) Fernanda Macedo de Oliveira Neves et al.   CIRCULATION JOURNAL

Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries

(2015) Paul C. Billings et al.   CONNECTIVE TISSUE RESEARCH

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

(2015) Eloi R. Verrier et al.   HEPATOLOGY

Sympathoadrenal activation and endothelial damage in patients with varying degrees of acute infectious disease: An observational study

(2015) Sisse R. Ostrowski et al.   JOURNAL OF CRITICAL CARE

Interaction of human papillomavirus type 16 particles with heparan sulfate and syndecan-1 molecules in the keratinocyte extracellular matrix plays an active role in infection

(2015) Zurab Surviladze et al.   JOURNAL OF GENERAL VIROLOGY

Acidosis Increases MHC Class II–Restricted Presentation of a Protein Endowed with a pH-Dependent Heparan Sulfate–Binding Ability

(2015) Delphine Knittel et al.   JOURNAL OF IMMUNOLOGY

A Role for 3-O-Sulfated Heparan Sulfate in Promoting Human Cytomegalovirus Infection in Human Iris Cells

(2015) John Baldwin et al.   JOURNAL OF VIROLOGY

Characterization of Hepatitis C Virus Interaction with Heparan Sulfate Proteoglycans

(2015) Yan Xu et al.   JOURNAL OF VIROLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Diversity of Heparan Sulfate and HSV Entry: Basic Understanding and Treatment Strategies

(2015) Vaibhav Tiwari et al.   MOLECULES

Novel Heparan Sulfate-Binding Peptides for Blocking Herpesvirus Entry

(2015) Pranay Dogra et al.   PLoS One

The tyrosine kinase inhibitor genistein induces the detachment of rotavirus particles from the cell surface

(2015) Tomás López et al.   VIRUS RESEARCH

Serum Syndecan-1 Levels and Its Relationship to Disease Activity in Patients with Crohn’s Disease

(2015) Cem Çekiç et al.   Gastroenterology Research and Practice

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

(2015) Satvik R. Hadigal et al.   Nature Communications

Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids

(2015) Marta Moskot et al.   Scientific Reports

Damage of the endothelial glycocalyx in chronic kidney disease

(2014) Jan-Sören Padberg et al.   ATHEROSCLEROSIS

The Circulating Glycosaminoglycan Signature of Respiratory Failure in Critically Ill Adults

(2014) Eric P. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells

(2014) A. Milewska et al.   JOURNAL OF VIROLOGY

Syndecan 4 Is Involved in Mediating HCV Entry through Interaction with Lipoviral Particle-Associated Apolipoprotein E

(2014) Mathieu Lefèvre et al.   PLoS One

Cysteine Cathepsin Activity Regulation by Glycosaminoglycans

(2014) Marko Novinec et al.   Biomed Research International

Glycosaminoglycans in infectious disease

(2013) Eyal Kamhi et al.   BIOLOGICAL REVIEWS

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

Early Microvascular Changes with Loss of the Glycocalyx in Children with Type 1 Diabetes

(2013) Claudia Nussbaum et al.   JOURNAL OF PEDIATRICS

The Evolving Field of Human Papillomavirus Receptor Research: a Review of Binding and Entry

(2013) A. B. Raff et al.   JOURNAL OF VIROLOGY

Syndecan-1 Serves as the Major Receptor for Attachment of Hepatitis C Virus to the Surfaces of Hepatocytes

(2013) Q. Shi et al.   JOURNAL OF VIROLOGY

Multiple Heparan Sulfate Binding Site Engagements Are Required for the Infectious Entry of Human Papillomavirus Type 16

(2013) K. F. Richards et al.   JOURNAL OF VIROLOGY

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

αvβ6- and αvβ8-Integrins Serve As Interchangeable Receptors for HSV gH/gL to Promote Endocytosis and Activation of Membrane Fusion

(2013) Tatiana Gianni et al.   PLoS Pathogens

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

Adjuvant therapy options following curative treatment of hepatocellular carcinoma: A systematic review of randomized trials

(2012) J.-H. Zhong et al.   EJSO

A conformational heparan sulfate binding site essential to infectivity overlaps with the conserved hepatitis B virus A-determinant

(2012) Camille Sureau et al.   HEPATOLOGY

Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

(2012) Satoshi Nagamine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Metapneumovirus (HMPV) Binding and Infection Are Mediated by Interactions between the HMPV Fusion Protein and Heparan Sulfate

(2012) A. Chang et al.   JOURNAL OF VIROLOGY

HSULF-1 inhibits ERK and AKT signaling and decreases cell viability in vitro in human lung epithelial cells

(2012) Huiying Zhang et al.   RESPIRATORY RESEARCH

Herpes Simplex Virus Type-1 (HSV-1) Entry into Human Mesenchymal Stem Cells Is Heavily Dependent on Heparan Sulfate

(2011) Samiksha Choudhary et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Progressive Multifocal Leukoencephalopathy (PML) Development Is Associated With Mutations in JC Virus Capsid Protein VP1 That Change Its Receptor Specificity

(2011) Leonid Gorelik et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus

(2011) Farnoosh Tayyari et al.   NATURE MEDICINE

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Glycosaminoglycans and Sialylated Glycans Sequentially Facilitate Merkel Cell Polyomavirus Infectious Entry

(2011) Rachel M. Schowalter et al.   PLoS Pathogens

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus

(2010) Maria Ekblad et al.   ANTIVIRAL RESEARCH

Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection

(2010) S. Bacsa et al.   JOURNAL OF GENERAL VIROLOGY

Directional Spread of Surface-Associated Retroviruses Regulated by Differential Virus-Cell Interactions

(2010) N. M. Sherer et al.   JOURNAL OF VIROLOGY

GAG-binding variants of tick-borne encephalitis virus

(2010) L.I. Kozlovskaya et al.   VIROLOGY

Heparin sulphate d-glucosaminyl 3-O-sulfotransferase 3B1 plays a role in HBV replication

(2010) Zhenzhen Zhang et al.   VIROLOGY

Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry

(2009) Jihan Akhtar et al.   FEBS Journal

Heparan Sulfate Proteoglycans Are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection

(2009) M. Kalia et al.   JOURNAL OF VIROLOGY

The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection

(2008) Shinji Kakimoto et al.   BIOMATERIALS

Structural proteomics of dengue virus

(2008) Rushika Perera et al.   CURRENT OPINION IN MICROBIOLOGY

The Binding Properties of Minimal Oligosaccharides Reveal a Common Heparan Sulfate/Dermatan Sulfate-binding Site in Hepatocyte Growth Factor/Scatter Factor That Can Accommodate a Wide Variety of Sulfation Patterns

(2008) Jon A. Deakin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Major Histocompatibility Complex Class I C Molecule as an Attachment Factor That Facilitates Coronavirus HKU1 Spike-Mediated Infection

(2008) C. M. Chan et al.   JOURNAL OF VIROLOGY