Vascular Endothelial Glycocalyx Damage in COVID-19

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of age and sex on recovery from COVID-19: Analysis of 5769 Israeli patients

(2020) Irena Voinsky et al.   JOURNAL OF INFECTION

Chilblain‐like lesions during COVID‐19 epidemic: a preliminary study on 63 patients

(2020) V. Piccolo et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus

(2020) Corleone S. Delaveris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China

(2020) Juanjuan Zhang et al.   SCIENCE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

The ACE2‐deficient mouse: A model for a cytokine storm‐driven inflammation

(2020) Junyi Wang et al.   FASEB JOURNAL

Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune Dysregulation

(2020) Abby C. Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past

(2020) Dimitrios Giannis et al.   JOURNAL OF CLINICAL VIROLOGY

Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection

(2020) Hideshi Okada et al.   MICROCIRCULATION

Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: survival analysis and machine learning-based findings from the multicentre Italian CORIST Study

(2020) Augusto Di Castelnuovo et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Correlation analysis of the severity and clinical prognosis of 32 cases of patients with COVID-19

(2020) Ming Ding et al.   RESPIRATORY MEDICINE

Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19

(2020) Klaus Stahl et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Microvascular dysfunction in COVID-19: the MYSTIC study

(2020) Alexandros Rovas et al.   ANGIOGENESIS

Microcirculatory, Endothelial and Inflammatory Responses in Critically Ill Patients with COVID-19 are Distinct from those Seen in Septic Shock

(2020) Sam D. Hutchings et al.   SHOCK

Increased Plasma Heparanase Activity in COVID-19 Patients

(2020) Baranca Buijsers et al.   Frontiers in Immunology

Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19

(2020) Minako Yamaoka-Tojo   Biomedical Journal

Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition

(2019) Yandie Li et al.   Pediatric Rheumatology

Degradation of Glycocalyx and Multiple Manifestations of Endothelial Dysfunction Coincide in the Early Phase of Endothelial Dysfunction Before Atherosclerotic Plaque Development in Apolipoprotein E/Low‐Density Lipoprotein Receptor‐Deficient Mice

(2019) Anna Bar et al.   Journal of the American Heart Association

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion

(2019) Tracey L. Weissgerber et al.   Journal of the American Heart Association

Sublingual endothelial glycocalyx and atherosclerosis. A cross-sectional study

(2019) Luca Valerio et al.   PLoS One

Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease

(2019) Yuji Ohnishi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mechanobiology of the abluminal glycocalyx

(2019) Peter J. Butler et al.   BIORHEOLOGY

Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding

(2019) Jiyeon Ko et al.   FASEB JOURNAL

Multiple Soluble Components of the Glycocalyx Are Increased in Patient Plasma After Ischemic Stroke

(2019) Brian DellaValle et al.   STROKE

Hyaluronan

(2018) Maria Grandoch et al.   CIRCULATION RESEARCH

Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall

(2018) Alexander Y. Gorshkov et al.   MICROCIRCULATION

Serum Levels of Syndecan-1 in Patients with Kawasaki Disease

(2018) Li Luo et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Kawasaki Disease Shock Syndrome; A Unique and Severe Subtype of Kawasaki Disease

(2018) Luisa Berenise Gamez-Gonzalez et al.   PEDIATRICS INTERNATIONAL

High-salt intake affects sublingual microcirculation and is linked to body weight change in healthy volunteers

(2018) Nienke M.G. Rorije et al.   JOURNAL OF HYPERTENSION

Aldosterone induces albuminuria via matrix metalloproteinase–dependent damage of the endothelial glycocalyx

(2018) Matthew J. Butler et al.   KIDNEY INTERNATIONAL

Traumatic brain injury is associated with increased syndecan-1 shedding in severely injured patients

(2018) Erika Gonzalez Rodriguez et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Sublingual functional capillary rarefaction in chronic heart failure

(2017) Patricia P. Wadowski et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Early detection of left ventricular dysfunction in first-degree relatives of diabetic patients by myocardial deformation imaging: The role of endothelial glycocalyx damage

(2017) Ignatios Ikonomidis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Non-invasive assessment of microvascular dysfunction in patients with microvascular angina

(2017) Caroline Jaarsma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Association of Endothelial Glycocalyx and Tight and Adherens Junctions with Severity of Plasma Leakage in Dengue Infection

(2017) Suhendro Suwarto et al.   JOURNAL OF INFECTIOUS DISEASES

Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function

(2017) Kai B. Betteridge et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

(2017) Tommy Hing-Cheung Tang et al.   Scientific Reports

Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome

(2016) Eric P. Schmidt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evaluation of the endothelial glycocalyx damage in patients with acute coronary syndrome

(2016) Carlos Henrique Miranda et al.   ATHEROSCLEROSIS

Kawasaki disease: etiopathogenesis and novel treatment strategies

(2016) Shreya Agarwal et al.   Expert Review of Clinical Immunology

Toll-like receptors 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyx

(2016) Roma Pahwa et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

THE GLYCOCALYX AND TRAUMA

(2016) Andreia Z. Chignalia et al.   SHOCK

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

(2016) Henry Puerta-Guardo et al.   PLoS Pathogens

Vascular Glycocalyx Sodium Store - Determinant of Salt Sensitivity?

(2015) Hans Oberleithner et al.   BLOOD PURIFICATION

Characteristics and Determinants of the Sublingual Microcirculation in Populations of Different Ethnicity

(2015) Y.-M. Gu et al.   HYPERTENSION

Sympathoadrenal activation and endothelial damage in patients with varying degrees of acute infectious disease: An observational study

(2015) Sisse R. Ostrowski et al.   JOURNAL OF CRITICAL CARE

Endothelial Surface Glycocalyx Can Regulate Flow-Induced Nitric Oxide Production in Microvessels In Vivo

(2015) Wanyi Yen et al.   PLoS One

Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes

(2014) Bart B. L. Groen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease

(2014) Kazuya Shirato et al.   JOURNAL OF MEDICAL VIROLOGY

Deeper Penetration of Erythrocytes into the Endothelial Glycocalyx Is Associated with Impaired Microvascular Perfusion

(2014) Dae Hyun Lee et al.   PLoS One

Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation

(2013) Makoto Sahara et al.   CARDIOVASCULAR RESEARCH

Angiotensin (1-7) and other Angiotensin Peptides

(2013) Mitsuru Ohishi et al.   CURRENT PHARMACEUTICAL DESIGN

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

(2012) Andrew Koo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Terminal sialic acids are an important determinant of pulmonary endothelial barrier integrity

(2012) Donna L. Cioffi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus

(2010) L. N. Broekhuizen et al.   DIABETOLOGIA

ACE2–angiotensin-(1–7)–Mas axis and oxidative stress in cardiovascular disease

(2010) Luiza A Rabelo et al.   HYPERTENSION RESEARCH

Acute attenuation of glycocalyx barrier properties increases coronary blood volume independently of coronary flow reserve

(2009) Judith Brands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix

(2009) Jochen Steppan et al.   JOURNAL OF SURGICAL RESEARCH

Recognition of a Kawasaki Disease Shock Syndrome

(2009) J. T. Kanegaye et al.   PEDIATRICS

Tumor necrosis factor-α inhibition protects against endotoxin-induced endothelial glycocalyx perturbation

(2008) M. Nieuwdorp et al.   ATHEROSCLEROSIS