Targeting heparin and heparan sulfate protein interactions

Expanding the 3-O-Sulfate Proteome—Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity

(2016) Bryan E. Thacker et al.   ACS Chemical Biology

Reversal agents for use with direct and indirect anticoagulants

(2016) M. A. Smythe et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

De Novo Sequencing of Complex Mixtures of Heparan Sulfate Oligosaccharides

(2016) Rongrong Huang et al.   ANALYTICAL CHEMISTRY

Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA

(2016) Manu Thomas Kalathottukaren et al.   BLOOD

The toxicology of heparin reversal with protamine: past, present and future

(2016) Emilia Sokolowska et al.   Expert Opinion on Drug Metabolism & Toxicology

Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin

(2016) Jack E. Ansell et al.   THROMBOSIS RESEARCH

The Cholestanol-Conjugated Sulfated Oligosaccharide PG545 Disrupts the Lipid Envelope of Herpes Simplex Virus Particles

(2015) Joanna S. Said et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples

(2015) Boris Winterhoff et al.   EUROPEAN JOURNAL OF CANCER

Hepatocellular carcinoma treatment over sorafenib: epigenetics, microRNAs and microenvironment. Is there a light at the end of the tunnel?

(2015) Antonio Gnoni et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The sweet spot: how GAGs help chemokines guide migrating cells

(2015) Yoan Monneau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Divergent Synthesis of Heparan Sulfate Oligosaccharides

(2015) Steven B. Dulaney et al.   JOURNAL OF ORGANIC CHEMISTRY

Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells

(2015) Hooi Lim et al.   Molecular Cancer

Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions

(2015) Ryan J. Weiss et al.   Chemical Science

Inhibition of influenza H5N1 invasion by modified heparin derivatives

(2015) Mark A. Skidmore et al.   MedChemComm

De Novo Design of Self-Assembling Foldamers That Inhibit Heparin–Protein Interactions

(2014) Geronda L. Montalvo et al.   ACS Chemical Biology

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Reducing Macrophage Proteoglycan Sulfation Increases Atherosclerosis and Obesity through Enhanced Type I Interferon Signaling

(2014) Philip L.S.M. Gordts et al.   Cell Metabolism

Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development

(2014) Stephen D. Freeman et al.   DEVELOPMENTAL DYNAMICS

Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4–NF-κB signaling

(2014) Hasan Babazada et al.   JOURNAL OF CONTROLLED RELEASE

Low molecular weight protamine (LMWP): A nontoxic protamine substitute and an effective cell-penetrating peptide

(2014) Huining He et al.   JOURNAL OF CONTROLLED RELEASE

Surfen, a proteoglycan antagonist, reduces lysolecithin-induced demyelination with related effects on macrophage function

(2014) Jordan Warford et al.   JOURNAL OF NEUROIMMUNOLOGY

A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans

(2014) Che C. Colpitts et al.   JOURNAL OF VIROLOGY

A Computational Framework for Heparan Sulfate Sequencing Using High-resolution Tandem Mass Spectra

(2014) Han Hu et al.   MOLECULAR & CELLULAR PROTEOMICS

Chemoenzymatic synthesis of heparan sulfate and heparin

(2014) Jian Liu et al.   NATURAL PRODUCT REPORTS

Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants

(2014) R. A. Shenoi et al.   Science Translational Medicine

Heparan sulfate signaling in cancer

(2014) Erik H. Knelson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence

(2014) Chun-Jen Liu   WORLD JOURNAL OF GASTROENTEROLOGY

New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal

(2014) Kamil Kamiński et al.   MedChemComm

Structural features of glycol-split low-molecular-weight heparins and their heparin lyase generated fragments

(2013) Anna Alekseeva et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Tailored Design and Synthesis of Heparan Sulfate Oligosaccharide Analogues Using Sequential One-Pot Multienzyme Systems

(2013) Yi Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Peptide Inhibitor of Cytomegalovirus Infection from Human Hemofiltrate

(2013) Eva Maria Borst et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Murine T cell activation is regulated by surfen (bis-2-methyl-4-amino-quinolyl-6-carbamide)

(2013) Jordan Warford et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small molecule inhibitors of protein interaction with glycosaminoglycans (SMIGs), a novel class of bioactive agents with anti-inflammatory properties

(2013) Nicholas Harris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The accumulation of circulating histones on heparan sulphate in the capillary glycocalyx of the lungs

(2013) Craig G. Freeman et al.   BIOMATERIALS

Endosulfatases SULF1 and SULF2 limitChlamydia muridaruminfection

(2013) J. H. Kim et al.   CELLULAR MICROBIOLOGY

Heparin sensing and binding – taking supramolecular chemistry towards clinical applications

(2013) Stephen M. Bromfield et al.   CHEMICAL SOCIETY REVIEWS

Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: A mechanism likely deranged in Hereditary Multiple Exostoses

(2013) Julianne Huegel et al.   DEVELOPMENTAL BIOLOGY

Heparan sulfate in skeletal development, growth, and pathology: The case of hereditary multiple exostoses

(2013) Julianne Huegel et al.   DEVELOPMENTAL DYNAMICS

Heparan Sulfate Proteoglycans and Human Breast Cancer Epithelial Cell Tumorigenicity

(2013) Rachel K. Okolicsanyi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans

(2013) Jon C. Gonzales et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathophysiology of heparan sulphate: many diseases, few drugs

(2013) U. Lindahl et al.   JOURNAL OF INTERNAL MEDICINE

A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparin anticoagulant activity

(2013) J. Fazavana et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A 1-year drug utilization evaluation of protamine in hospitalized patients to identify possible future roles of heparin and low molecular weight heparin reversal agents

(2013) Charles E. Mahan   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Heparan sulfate in the nucleus and its control of cellular functions

(2013) Mark D. Stewart et al.   MATRIX BIOLOGY

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of human, camel, bovine and sheep lactoferrin on the hepatitis C virus cellular infectivity: comparison study

(2013) Esmail M EL-Fakharany et al.   Virology Journal

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

The Role of Syndecan-1 in Cellular Signaling and its Effects on Heparan Sulfate Biosynthesis in Mesenchymal Tumors

(2013) Tünde Szatmári et al.   Frontiers in Oncology

Top-Down Approach for the Direct Characterization of Low Molecular Weight Heparins Using LC-FT-MS

(2012) Lingyun Li et al.   ANALYTICAL CHEMISTRY

Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation

(2012) S. A. Smith et al.   BLOOD

Array-Based Functional Screening of Heparin Glycans

(2012) Tania M. Puvirajesinghe et al.   CHEMISTRY & BIOLOGY

Heparan Sulfate Dissociates Serum Amyloid A (SAA) from Acute-phase High-density Lipoprotein, Promoting SAA Aggregation

(2012) Fredrik Noborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis

(2012) Vito Ferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell Membrane–associated Heparan Sulfate Is a Receptor for Prototype Foamy Virus in Human, Monkey, and Rodent Cells

(2012) Md Nasimuzzaman et al.   MOLECULAR THERAPY

Self-Assembling Ligands for Multivalent Nanoscale Heparin Binding

(2011) Ana C. Rodrigo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Herpes Simplex Virus Type 1 and Type 2 Infections by Peptide-Derivatized Dendrimers

(2011) Anna Luganini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The effectiveness of Carraguard, a vaginal microbicide, in protecting women against high-risk human papillomavirus infection

(2011) Dianne Marais et al.   ANTIVIRAL THERAPY

Protamine reversal of low molecular weight heparin

(2011) Joost J. van Veen et al.   BLOOD COAGULATION & FIBRINOLYSIS

Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones

(2011) Beverly M. Zak et al.   BONE

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction

(2011) Yu-Peng Hu et al.   Nature Chemistry

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

(2011) Y. Xu et al.   SCIENCE

Fondaparinux – data on efficacy and safety in special situations

(2011) Michael Nagler et al.   THROMBOSIS RESEARCH

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Protamine neutralisation of low molecular weight heparins and their oligosaccharide components

(2010) Mette Schroeder et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Development of a recombinant antithrombin variant as a potent antidote to fondaparinux and other heparin derivatives

(2010) E. P. Bianchini et al.   BLOOD

In Vivo Neutralization of Unfractionated Heparin and Low-Molecular-Weight Heparin by a Novel Salicylamide Derivative

(2010) Jacqueline Kuziej et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Proteoglycans in host–pathogen interactions: molecular mechanisms and therapeutic implications

(2010) Allison H. Bartlett et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides

(2010) Renpeng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability

(2010) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

(2010) Benito Casu et al.   MATRIX BIOLOGY

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OC-07 Heparin-antagonist PMX-60056 rapidly and completely reverses heparin anticoagulation in man

(2010) R.E. McAllister   THROMBOSIS RESEARCH

The heparin-binding domain confers diverse functions of VEGF-A in development and disease: a structure–function study

(2009) Dominik Krilleke et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure–function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling

(2009) Felix S. Grünewald et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Heparin Antagonism by Polyvalent Display of Cationic Motifs on Virus-Like Particles

(2009) Andrew K. Udit et al.   CHEMBIOCHEM

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues

(2009) Scott E. Guimond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aminoquinoline Surfen Inhibits the Action of SEVI (Semen-derived Enhancer of Viral Infection)

(2009) Nadia R. Roan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types

(2009) T. R. Broutian et al.   JOURNAL OF GENERAL VIROLOGY

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage

(2009) Chun-Jen Liu et al.   JOURNAL OF HEPATOLOGY

Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies

(2009) Sailaja Arungundram et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Effect of LMWH (Nadroparin) on Tumor Progression

(2009) Zsuzsanna Nagy et al.   PATHOLOGY & ONCOLOGY RESEARCH

Sulfated K5 Escherichia coli polysaccharide derivatives: A novel class of candidate antiviral microbicides

(2009) Marco Rusnati et al.   PHARMACOLOGY & THERAPEUTICS

Polycationic calix[8]arene receptors grafted onto polymeric matrix: smart material for heparin neutralization

(2009) Tommaso Mecca et al.   POLYMERS FOR ADVANCED TECHNOLOGIES

Using a 3-O-Sulfated Heparin Octasaccharide To Inhibit the Entry of Herpes Simplex Virus Type 1†

(2008) Ronald Copeland et al.   BIOCHEMISTRY

Heparin-induced thrombocytopenia: a historical perspective

(2008) J. G. Kelton et al.   BLOOD

The story of the discovery of heparin and warfarin

(2008) Douglas Wardrop et al.   BRITISH JOURNAL OF HAEMATOLOGY

Heparin as an anticancer therapeutic

(2008) Leo R Zacharski et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

PI-88: a novel inhibitor of angiogenesis

(2008) Ragini Kudchadkar et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Surfen, a small molecule antagonist of heparan sulfate

(2008) M. Schuksz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trypanosoma cruzi heparin-binding proteins and the nature of the host cell heparan sulfate-binding domain

(2007) Francisco Odencio Rodrigues de Oliveira et al.   MICROBIAL PATHOGENESIS