Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

(2020) Jin-jin Zhang et al.   ALLERGY

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

(2020) Sundy N.Y. Yang et al.   ANTIVIRAL RESEARCH

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus

(2020) Weicheng Liang et al.   GUT

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

COVID-19 and the cardiovascular system

(2020) Ying-Ying Zheng et al.   Nature Reviews Cardiology

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential

(2020) Jimin Xu et al.   ACS Infectious Diseases

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Amiodarone: A Comprehensive Guide for Clinicians

(2020) David Hamilton et al.   American Journal of Cardiovascular Drugs

Can spironolactone be used to prevent COVID-19-induced acute respiratory distress syndrome in patients with hypertension?

(2020) Flávio A. Cadegiani   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

(2020) Sangeun Jeon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

(2020) Markus Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Convalescent plasma in Covid-19: Possible mechanisms of action

(2020) Manuel Rojas et al.   AUTOIMMUNITY REVIEWS

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

(2020) Meijuan Zheng et al.   Cellular & Molecular Immunology

Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China

(2020) Yan Deng et al.   CHINESE MEDICAL JOURNAL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China

(2020) Wen Zhang et al.   CLINICAL IMMUNOLOGY

Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study

(2020) Andrea Giacomelli et al.   CLINICAL INFECTIOUS DISEASES

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study

(2020) N. Lian et al.   CLINICAL MICROBIOLOGY AND INFECTION

COVID-19 treatment by repurposing drugs until the vaccine is in sight

(2020) Mrudula Phadke et al.   DRUG DEVELOPMENT RESEARCH

Repurposing chlorpromazine to treat COVID-19: The reCoVery study

(2020) M. Plaze et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

Pulmonary embolism in patients with Covid-19 pneumonia

(2020) Florian Bompard et al.   EUROPEAN RESPIRATORY JOURNAL

Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review

(2020) Nicholas E. Ingraham et al.   EUROPEAN RESPIRATORY JOURNAL

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

(2020) Julie Helms et al.   INTENSIVE CARE MEDICINE

Camostat mesilate therapy for COVID-19

(2020) Yoshiharu Uno   Internal and Emergency Medicine

Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein

(2020) Naveen Vankadari   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

(2020) Christian A. Devaux et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine

(2020) Zahra Sahraei et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Three cases of treatment with Nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy

(2020) Sukbin Jang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?

(2020) Samir Jawhara   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Convalescent Plasma to Treat COVID-19

(2020) John D. Roback et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State

(2020) Eli S. Rosenberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression

(2020) Dan Zhou et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy

(2020) Angela Ceribelli et al.   JOURNAL OF AUTOIMMUNITY

The convalescent sera option for containing COVID-19

(2020) Arturo Casadevall et al.   JOURNAL OF CLINICAL INVESTIGATION

Deployment of convalescent plasma for the prevention and treatment of COVID-19

(2020) Evan M. Bloch et al.   JOURNAL OF CLINICAL INVESTIGATION

Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact

(2020) Fabrizio Cantini et al.   JOURNAL OF INFECTION

Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19

(2020) Zhen Zhu et al.   JOURNAL OF INFECTION

Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19

(2020) Yun Xie et al.   JOURNAL OF INFECTION

Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study

(2020) Lisi Deng et al.   JOURNAL OF INFECTION

Treatment with convalescent plasma for COVID-19 patients in Wuhan, China

(2020) Mingxiang Ye et al.   JOURNAL OF MEDICAL VIROLOGY

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated

(2020) Carlos Gustavo Wambier et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

(2020) Behnood Bikdeli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cutaneous manifestations in COVID‐19: a first perspective

(2020) S. Recalcati   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19: A Comment

(2020) Christopher D. Barrett et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia

(2020) Songping Cui et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome

(2020) Marco Ranucci et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Acute limb ischemia in patients with COVID-19 pneumonia

(2020) Raffaello Bellosta et al.   JOURNAL OF VASCULAR SURGERY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

(2020) Giuseppe Mancia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

(2020) Harmony R. Reynolds et al.   NEW ENGLAND JOURNAL OF MEDICINE

ST-Segment Elevation in Patients with Covid-19 — A Case Series

(2020) Sripal Bangalore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

(2020) Joshua Geleris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

(2020) Thomas J. Oxley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

(2020) Tianxiao Liu et al.   PHARMACOLOGY & THERAPEUTICS

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses

(2020) Shibo Jiang et al.   TRENDS IN IMMUNOLOGY

Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection

(2020) David S. Fedson et al.   mBio

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France

(2020) Matthieu Million et al.   Travel Medicine and Infectious Disease

Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

(2020) Philippe Gautret et al.   Travel Medicine and Infectious Disease

Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin

(2020) José Millán-Oñate et al.   Annals of Clinical Microbiology and Antimicrobials

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial

(2020) Wei Tang et al.   BMJ-British Medical Journal

Amiodarone as a possible therapy for coronavirus infection

(2020) Alberto Aimo et al.   European Journal of Preventive Cardiology

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China

(2020) Ping Wu et al.   JAMA Ophthalmology

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019

(2020) Wei Cao et al.   Open Forum Infectious Diseases

Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19

(2020) Sebastiano Bruno Solerte et al.   ACTA DIABETOLOGICA

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

Reply to Gautret et al: hydroxychloroquine sulfate and azithromycin for COVID-19: what is the evidence and what are the risks?

(2020) Julian D Machiels et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

(2020) Ling Li et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Effects of ARBs, ACEis, and Statins on Clinical Outcomes of COVID-19 Infection Among Nursing Home Residents

(2020) Anton De Spiegeleer et al.   Journal of the American Medical Directors Association

No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection

(2020) J.M. Molina et al.   MEDECINE ET MALADIES INFECTIEUSES

Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19

(2020) Sai Kiran S.S. Pindiprolu et al.   MEDICAL HYPOTHESES

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

(2020) David R. Boulware et al.   NEW ENGLAND JOURNAL OF MEDICINE

Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection

(2020) Roberto Maggio et al.   PHARMACOLOGICAL RESEARCH

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

(2020) Hong-Long Ji et al.   PHYSIOLOGICAL REVIEWS

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

(2020) Johanna Hansen et al.   SCIENCE

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels

(2020) P. Demelo-Rodríguez et al.   THROMBOSIS RESEARCH

Coagulation abnormalities and thrombosis in patients with COVID-19

(2020) Marcel Levi et al.   Lancet Haematology

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

(2020) Mayla Gabriela Silva Borba et al.   JAMA Network Open

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Arbidol and other Low Molecular Weight Drugs That Inhibit Lassa and Ebola Viruses

(2019) C. E. Hulseberg et al.   JOURNAL OF VIROLOGY

Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells

(2019) Huimin Zou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process

(2019) Dat Huu Tran et al.   JOURNAL OF ANTIBIOTICS

The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication

(2019) Morgan R. Herod et al.   JOURNAL OF GENERAL VIROLOGY

Antimalarial activity of primaquine operates via a two-step biochemical relay

(2019) Grazia Camarda et al.   Nature Communications

Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses

(2019) Chunfeng Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial

(2019) Morihisa Hirota et al.   JOURNAL OF GASTROENTEROLOGY

A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC)

(2019) Mitchell L. Ramsey et al.   Trials

Lipophilic statins inhibit Zika virus production in Vero cells

(2019) Erica Españo et al.   Scientific Reports

Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib

(2019) Elena Maria Elli et al.   Frontiers in Oncology

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells

(2019) Kim et al.   Biomolecules

Classics in Chemical Neuroscience: Chlorpromazine

(2018) Debra Boyd-Kimball et al.   ACS Chemical Neuroscience

Niclosamide: Beyond an antihelminthic drug

(2018) Wei Chen et al.   CELLULAR SIGNALLING

Hydroxychloroquine: An old drug with new relevance

(2018) E. A. SHIPPEY et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Drugs in Development for Malaria

(2018) Elizabeth A. Ashley et al.   DRUGS

Antiviral activity of arbidol hydrochloride against herpes simplex virus I in vitro and in vivo

(2018) Min-ke Li et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Adjunctive therapy with azithromycin for moderate and severe acute respiratory distress syndrome: a retrospective, propensity score-matching analysis of prospectively collected data at a single center

(2018) Kodai Kawamura et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses

(2018) Jan Haviernik et al.   Viruses-Basel

Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing

(2018) Punya Shrivastava-Ranjan et al.   mBio

Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope

(2018) Romulo L. S. Neris et al.   Scientific Reports

The Antiviral Drug Arbidol Inhibits Zika Virus

(2018) Susan L. Fink et al.   Scientific Reports

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

(2017) Andy Crump   JOURNAL OF ANTIBIOTICS

Doxycycline as an anti-inflammatory agent: updates in dermatology

(2017) M. Henehan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion

(2017) Judith M. Phillips et al.   JOURNAL OF VIROLOGY

PharmGKB summary

(2017) Alison E. Fohner et al.   Pharmacogenetics and Genomics

Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study

(2017) Kodai Kawamura et al.   BMC Pulmonary Medicine

A reappraisal of the mucoactive activity and clinical efficacy of bromhexine

(2017) Alessandro Zanasi et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Discovery and Development of Calcium Channel Blockers

(2017) Théophile Godfraind   Frontiers in Pharmacology

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay

(2016) Mizuki Yamamoto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigational hemagglutinin-targeted influenza virus inhibitors

(2016) Li-Yan Zeng et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Heparin and anticoagulation

(2016) Robert J Linhardt   Frontiers in Bioscience-Landmark

Inactivation of Dengue and Yellow Fever viruses by heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX

(2016) I. Assunção-Miranda et al.   JOURNAL OF APPLIED MICROBIOLOGY

Use of Antipsychotics for the Treatment of Behavioral Symptoms of Dementia

(2016) H. Karl Greenblatt et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses

(2016) Eve-Isabelle Pécheur et al.   JOURNAL OF VIROLOGY

The anti-dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression

(2016) Owen Lloyd Bryan-Marrugo et al.   Molecular Medicine Reports

Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision)

(2016) Michael F. Marmor et al.   OPHTHALMOLOGY

Tetrandrine – A molecule of wide bioactivity

(2016) N. Bhagya et al.   PHYTOCHEMISTRY

Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol

(2016) Rameshwar U. Kadam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

(2016) Hanna Retallack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory and immunomodulatory effects of antibiotics and their use in dermatology

(2016) Bhushan Madke et al.   INDIAN JOURNAL OF DERMATOLOGY

Prescribing azithromycin

(2015) Brendan K McMullan et al.   Australian Prescriber

Nafamostat Mesilate Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production

(2015) Min-Woong Kang et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Ruxolitinib versus Standard Therapy for the Treatment of Polycythemia Vera

(2015) Alessandro M. Vannucchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Statins May Decrease the Fatality Rate of Middle East Respiratory Syndrome Infection: FIG 1 

(2015) Shu Yuan   mBio

Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

(2015) Wahyu N. Wulan et al.   Frontiers in Microbiology

Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process

(2015) Cristiano Salata et al.   Pathogens and Disease

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

(2015) Peter B. Madrid et al.   ACS Infectious Diseases

Arbidol as a broad-spectrum antiviral: An update

(2014) Julie Blaising et al.   ANTIVIRAL RESEARCH

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

(2014) Gerrit Gehring et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis

(2014) John Mair-Jenkins et al.   JOURNAL OF INFECTIOUS DISEASES

An Investigational Antiviral Drug, DAS181, Effectively Inhibits Replication of Zoonotic Influenza A Virus Subtype H7N9 and Protects Mice From Lethality

(2014) Henju Marjuki et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, for the Treatment of Rheumatoid Arthritis in Open-label, Longterm Extension Studies

(2014) J. Wollenhaupt et al.   JOURNAL OF RHEUMATOLOGY

Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells

(2014) A. Milewska et al.   JOURNAL OF VIROLOGY

Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders

(2014) Rami A. Al-Horani et al.   MEDICINAL RESEARCH REVIEWS

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

(2014) J. M. Lucas et al.   Cancer Discovery

Meta-Analysis of the Adverse Effects of Long-Term Azithromycin Use in Patients with Chronic Lung Diseases

(2013) Hui Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking

(2013) Julie Blaising et al.   ANTIVIRAL RESEARCH

Inhibitory effect of doxycycline against dengue virus replication in vitro

(2013) Hussin A. Rothan et al.   ARCHIVES OF VIROLOGY

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle

(2013) Yuan-Lung Cheng et al.   CLINICAL SCIENCE

Hemozoin and antimalarial drug discovery

(2013) Kim Y Fong et al.   Future Medicinal Chemistry

Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis

(2013) Josje Altenburg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oseltamivir resistance during treatment of H7N9 infection

(2013) Alan J Hay et al.   LANCET

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Imbalance Between Pulmonary Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Activity in Acute Respiratory Distress Syndrome

(2013) Roelie M. Wösten-van Asperen et al.   Pediatric Critical Care Medicine

Practical management of patients with myelofibrosis receiving ruxolitinib

(2013) Claire Harrison et al.   Expert Review of Hematology

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance

(2012) Jennifer L. McKimm-Breschkin   Influenza and Other Respiratory Viruses

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

Macrolide Therapy in Respiratory Viral Infections

(2012) Jin-Young Min et al.   MEDIATORS OF INFLAMMATION

Ruxolitinib

(2012) Ruben A. Mesa et al.   NATURE REVIEWS DRUG DISCOVERY

Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

(2012) Jing-Xuan Pan et al.   Chinese Journal of Cancer

Linagliptin

(2011) Lesley J. Scott   DRUGS

Nafamostat Mesilate as an Anticoagulant during Continuous Veno-Venous Hemodialysis: A Three-Year Retrospective Cohort Study

(2011) Yukio Maruyama et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Regulation of the inflammatory response by tin protoporphyrin IX in the rat anterior cruciate ligament transection model of osteoarthritis

(2011) Aitana Braza-Boïls et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol

(2011) Elodie Teissier et al.   PLoS One

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature

(2010) Michael O. Griffin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Azithromycin Alters Macrophage Phenotype and Pulmonary Compartmentalization during Lung Infection with Pseudomonas

(2010) D. J. Feola et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azithromycin induces anti-viral responses in bronchial epithelial cells

(2010) V. Gielen et al.   EUROPEAN RESPIRATORY JOURNAL

Up-Regulation of the Inflammatory Response by Ovariectomy in Collagen-Induced Arthritis. Effects of Tin Protoporphyrin IX

(2010) Lidia Ibáñez et al.   INFLAMMATION

A Recombinant Sialidase Fusion Protein Effectively Inhibits Human Parainfluenza Viral Infection In Vitro and In Vivo

(2010) Anne Moscona et al.   JOURNAL OF INFECTIOUS DISEASES

DAS181 Inhibits H5N1 Influenza Virus Infection of Human Lung Tissues

(2009) R. W. Y. Chan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis

(2009) Gallen B. Triana-Baltzer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease

(2009) K. Coote et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine fromStephaniae tetrandrae

(2009) Lijin Zhang et al.   JOURNAL OF SEPARATION SCIENCE

An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the Parasitic Nematode Haemonchus contortus

(2009) S. McCavera et al.   MOLECULAR PHARMACOLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Inhibition of Neuraminidase Inhibitor-Resistant Influenza Virus by DAS181, a Novel Sialidase Fusion Protein

(2009) Gallen B. Triana-Baltzer et al.   PLoS One

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrolides for the treatment of severe respiratory illness caused by novel H1N1 swine influenza viral strains

(2009) Jesus F. Bermejo-Martin et al.   Journal of Infection in Developing Countries

Amiodarone Alters Late Endosomes and Inhibits SARS Coronavirus Infection at a Post-Endosomal Level

(2008) Konrad Stadler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

(2008) Bijan Zakeri et al.   Biochemistry and Cell Biology

Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension

(2008) Ai Maekawa et al.   JOURNAL OF HYPERTENSION

Mouse Hepatitis Virus Type 2 Enters Cells through a Clathrin-Mediated Endocytic Pathway Independent of Eps15

(2008) Y. Pu et al.   JOURNAL OF VIROLOGY

The anti-inflammatory effects of heparin and related compounds

(2007) Edward Young   THROMBOSIS RESEARCH