Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

Role of heparan sulfate in the Zika virus entry, replication, and cell death

(2019) Huixin Gao et al.   VIROLOGY

Glycosaminoglycan Compositional Analysis of Relevant Tissues in Zika Virus Pathogenesis and in Vitro Evaluation of Heparin as an Antiviral against Zika Virus Infection

(2019) So Young Kim et al.   BIOCHEMISTRY

Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and is Shed During Lung Injury

(2018) Sarah M Haeger et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Efficacy of a Carrageenan gel Against Transmission of Cervical HPV (CATCH): interim analysis of a randomized, double-blind, placebo-controlled, phase 2B trial

(2018) S. Magnan et al.   CLINICAL MICROBIOLOGY AND INFECTION

The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection

(2018) Michihito Sasaki et al.   JOURNAL OF INFECTIOUS DISEASES

Extracellular Conformational Changes in the Capsid of Human Papillomaviruses Contribute to Asynchronous Uptake into Host Cells

(2018) Miriam Becker et al.   JOURNAL OF VIROLOGY

VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection

(2018) Ken Fujii et al.   JOURNAL OF VIROLOGY

The generation and characterisation of neutralising antibodies against the Theiler’s murine encephalomyelitis virus (TMEV) GDVII capsid reveals the potential binding site of the host cell co-receptor, heparan sulfate

(2018) Nicole Upfold et al.   VIRUS RESEARCH

Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells

(2018) James Hopkins et al.   JOURNAL OF VIROLOGY

The emergence of Zika virus and its new clinical syndromes

(2018) Theodore C. Pierson et al.   NATURE

A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism

(2018) Eirini D. Tseligka et al.   PLoS Pathogens

Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses

(2017) Shin Murakami et al.   JOURNAL OF VIROLOGY

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

(2017) Ting Shi et al.   LANCET

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

(2017) Valeria Cagno et al.   NATURE MATERIALS

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses

(2017) Eileen M. Geoghegan et al.   Cell Reports

Quasispecies composition and evolution of a typical Zika virus clinical isolate from Suriname

(2017) Sander van Boheemen et al.   Scientific Reports

The AGMA1 poly(amidoamine) inhibits the infectivity of herpes simplex virus in cell lines, in human cervicovaginal histocultures, and in vaginally infected mice

(2016) Manuela Donalisio et al.   BIOMATERIALS

A Slow Maturation Process Renders Hepatitis B Virus Infectious

(2016) Stefan Seitz et al.   Cell Host & Microbe

Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues

(2016) Edita M. Klimyte et al.   JOURNAL OF VIROLOGY

Mutations in VP1 and 3A proteins improve binding and replication of rhinovirus C15 in HeLa-E8 cells

(2016) Yury A. Bochkov et al.   VIROLOGY

Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses

(2016) Maria Dolores Fernandez-Garcia et al.   mBio

Emergence of a Large-Plaque Variant in Mice Infected with Coxsackievirus B3

(2016) Yao Wang et al.   mBio

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

Merkel cell polyomavirus infection and Merkel cell carcinoma

(2016) Wei Liu et al.   Current Opinion in Virology

Role of Heparan Sulfate in Cellular Infection of Integrin-Binding Coxsackievirus A9 and Human Parechovirus 1 Isolates

(2016) Pirjo Merilahti et al.   PLoS One

The Agmatine-Containing Poly(Amidoamine) Polymer AGMA1 Binds Cell Surface Heparan Sulfates and Prevents Attachment of Mucosal Human Papillomaviruses

(2015) Valeria Cagno et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses

(2015) Gabriel L. Hendricks et al.   ANTIVIRAL RESEARCH

Cell entry mechanisms of HSV: what we have learned in recent years

(2015) Alex M Agelidis et al.   Future Virology

Interaction of human papillomavirus type 16 particles with heparan sulfate and syndecan-1 molecules in the keratinocyte extracellular matrix plays an active role in infection

(2015) Zurab Surviladze et al.   JOURNAL OF GENERAL VIROLOGY

CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells

(2015) Tatiana Chirkova et al.   JOURNAL OF GENERAL VIROLOGY

Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo

(2015) Anne K. Zaiss et al.   JOURNAL OF VIROLOGY

Characterization of Hepatitis C Virus Interaction with Heparan Sulfate Proteoglycans

(2015) Yan Xu et al.   JOURNAL OF VIROLOGY

Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry

(2015) Aileen O'Hearn et al.   JOURNAL OF VIROLOGY

Cell Surface Nucleolin Facilitates Enterovirus 71 Binding and Infection

(2015) Pei-Yi Su et al.   JOURNAL OF VIROLOGY

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection

(2015) Amber M. Riblett et al.   JOURNAL OF VIROLOGY

Diversity of Heparan Sulfate and HSV Entry: Basic Understanding and Treatment Strategies

(2015) Vaibhav Tiwari et al.   MOLECULES

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

(2015) Yury A. Bochkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan Sulfate-Dependent Enhancement of Henipavirus Infection

(2015) Cyrille Mathieu et al.   mBio

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

(2015) Satvik R. Hadigal et al.   Nature Communications

Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures

(2015) Sara M. Johnson et al.   PLoS Pathogens

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

(2015) Morgan S. A. Gilman et al.   PLoS Pathogens

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Highly Sulfated K5 Escherichia coli Polysaccharide Derivatives Inhibit Respiratory Syncytial Virus Infectivity in Cell Lines and Human Tracheal-Bronchial Histocultures

(2014) Valeria Cagno et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Agmatine-Containing Poly(amidoamine)s as a Novel Class of Antiviral Macromolecules: Structural Properties andIn VitroEvaluation of Infectivity Inhibition

(2014) Manuela Donalisio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition

(2014) Aixa Rodríguez et al.   ANTIVIRAL RESEARCH

The variations of VP1 protein might be associated with nervous system symptoms caused by enterovirus 71 infection

(2014) Bao Zhang et al.   BMC INFECTIOUS DISEASES

Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells

(2014) A. Milewska et al.   JOURNAL OF VIROLOGY

Cell Surface Vimentin Is an Attachment Receptor for Enterovirus 71

(2014) N. Du et al.   JOURNAL OF VIROLOGY

Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection

(2014)   PEDIATRICS

Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells

(2014) Eliana G. Acosta et al.   VIRUS RESEARCH

Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

(2014) Christina L. Gardner et al.   PLoS Neglected Tropical Diseases

The Evolving Field of Human Papillomavirus Receptor Research: a Review of Binding and Entry

(2013) A. B. Raff et al.   JOURNAL OF VIROLOGY

A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization

(2013) L. A. Silva et al.   JOURNAL OF VIROLOGY

Filoviruses Utilize Glycosaminoglycans for Their Attachment to Target Cells

(2013) B. Salvador et al.   JOURNAL OF VIROLOGY

Multiple Heparan Sulfate Binding Site Engagements Are Required for the Infectious Entry of Human Papillomavirus Type 16

(2013) K. F. Richards et al.   JOURNAL OF VIROLOGY

Human Papillomavirus Types 16, 18, and 31 Share Similar Endocytic Requirements for Entry

(2013) G. Spoden et al.   JOURNAL OF VIROLOGY

The extostosin family: Proteins with many functions

(2013) Marta Busse-Wicher et al.   MATRIX BIOLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

A cornucopia of human polyomaviruses

(2013) James A. DeCaprio et al.   NATURE REVIEWS MICROBIOLOGY

Proteoglycans Act as Cellular Hepatitis Delta Virus Attachment Receptors

(2013) Oscar Lamas Longarela et al.   PLoS One

Sulfated Escherichia coli K5 Polysaccharide Derivatives Inhibit Dengue Virus Infection of Human Microvascular Endothelial Cells by Interacting with the Viral Envelope Protein E Domain III

(2013) Peter Vervaeke et al.   PLoS One

Peptide-Derivatized SB105-A10 Dendrimer Inhibits the Infectivity of R5 and X4 HIV-1 Strains in Primary PBMCs and Cervicovaginal Histocultures

(2013) Isabella Bon et al.   PLoS One

The papillomavirus major capsid protein L1

(2013) Christopher B. Buck et al.   VIROLOGY

Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles

(2013) Charlermchai Artpradit et al.   VIRUS RESEARCH

Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction

(2013) Yorihiro Nishimura et al.   PLoS Pathogens

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

Inhibition of Human Respiratory Syncytial Virus Infectivity by a Dendrimeric Heparan Sulfate-Binding Peptide

(2012) Manuela Donalisio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prevention of human enterovirus 71 infection by kappa carrageenan

(2012) Ya-Huang Chiu et al.   ANTIVIRAL RESEARCH

Heparan Sulfate Biosynthesis

(2012) Johan Kreuger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Human Metapneumovirus (HMPV) Binding and Infection Are Mediated by Interactions between the HMPV Fusion Protein and Heparan Sulfate

(2012) A. Chang et al.   JOURNAL OF VIROLOGY

Heparan Sulfate Facilitates Rift Valley Fever Virus Entry into the Cell

(2012) S. M. de Boer et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Uses Cell Surface Heparan Sulfate Glycosaminoglycan as an Attachment Receptor

(2012) C. W. Tan et al.   JOURNAL OF VIROLOGY

The microbiology of asthma

(2012) Michael R. Edwards et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Site-Specific Adaptations Conferring Increased Neural Cell Tropism during Human Enterovirus 71 Infection

(2012) Samuel Cordey et al.   PLoS Pathogens

The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1

(2011) Vanessa Pirrone et al.   ANTIVIRAL RESEARCH

The effectiveness of Carraguard, a vaginal microbicide, in protecting women against high-risk human papillomavirus infection

(2011) Dianne Marais et al.   ANTIVIRAL THERAPY

Progressive Multifocal Leukoencephalopathy (PML) Development Is Associated With Mutations in JC Virus Capsid Protein VP1 That Change Its Receptor Specificity

(2011) Leonid Gorelik et al.   JOURNAL OF INFECTIOUS DISEASES

Productive Dengue Virus Infection of Human Endothelial Cells Is Directed by Heparan Sulfate-Containing Proteoglycan Receptors

(2011) N. Dalrymple et al.   JOURNAL OF VIROLOGY

Annexin II Binds to Capsid Protein VP1 of Enterovirus 71 and Enhances Viral Infectivity

(2011) S.-L. Yang et al.   JOURNAL OF VIROLOGY

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus

(2011) Farnoosh Tayyari et al.   NATURE MEDICINE

Rhinovirus Genome Variation during Chronic Upper and Lower Respiratory Tract Infections

(2011) Caroline Tapparel et al.   PLoS One

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

(2011) Clare F. Price et al.   PLoS One

Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence

(2011) C. L. Gardner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathrin, caveolin, and flotillin

(2011) Abdul Ghafoor Khan et al.   VIROLOGY

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Glycosaminoglycans and Sialylated Glycans Sequentially Facilitate Merkel Cell Polyomavirus Infectious Entry

(2011) Rachel M. Schowalter et al.   PLoS Pathogens

Identification of a Dendrimeric Heparan Sulfate-Binding Peptide That Inhibits Infectivity of Genital Types of Human Papillomaviruses

(2010) M. Donalisio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sulfated Derivatives of Escherichia coli K5 Capsular Polysaccharide Are Potent Inhibitors of Human Cytomegalovirus

(2010) B. Mercorelli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate

(2010) Anna Luganini et al.   ANTIVIRAL RESEARCH

Structure-Function Analysis of the Human JC Polyomavirus Establishes the LSTc Pentasaccharide as a Functional Receptor Motif

(2010) Ursula Neu et al.   Cell Host & Microbe

Upper-Respiratory Viral Infection, Biomarkers, and COPD Exacerbations

(2010) Omar Kherad et al.   CHEST

Role of N-Linked Glycosylation of the 5-HT2A Receptor in JC Virus Infection

(2010) M. S. Maginnis et al.   JOURNAL OF VIROLOGY

The ABCs of Rhinoviruses, Wheezing, and Asthma

(2010) J. E. Gern   JOURNAL OF VIROLOGY

Clinical features, diagnosis, and management of enterovirus 71

(2010) Mong How Ooi et al.   LANCET NEUROLOGY

Mechanisms of cell entry by human papillomaviruses: an overview

(2010) Caroline AJ Horvath et al.   Virology Journal

Studies of Echovirus 5 interactions with the cell surface: Heparan sulfate mediates attachment to the host cell

(2010) Stina Israelsson et al.   VIRUS RESEARCH

Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry

(2009) Jihan Akhtar et al.   FEBS Journal

Heparan Sulfate Proteoglycans Are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection

(2009) M. Kalia et al.   JOURNAL OF VIROLOGY

Scavenger receptor B2 is a cellular receptor for enterovirus 71

(2009) Seiya Yamayoshi et al.   NATURE MEDICINE

Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71

(2009) Yorihiro Nishimura et al.   NATURE MEDICINE

Sulfated K5 Escherichia coli polysaccharide derivatives: A novel class of candidate antiviral microbicides

(2009) Marco Rusnati et al.   PHARMACOLOGY & THERAPEUTICS

Sialylated glycans as receptor and inhibitor of enterovirus 71 infection to DLD-1 intestinal cells

(2009) Betsy Yang et al.   Virology Journal

Target Cell Cyclophilins Facilitate Human Papillomavirus Type 16 Infection

(2009) Malgorzata Bienkowska-Haba et al.   PLoS Pathogens

Inhibition of Herpes Simplex Virus Types 1 and 2 In Vitro Infection by Sulfated Derivatives of Escherichia coli K5 Polysaccharide

(2008) D. Pinna et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sulfated K5 Escherichia coli Polysaccharide Derivatives as Wide-Range Inhibitors of Genital Types of Human Papillomavirus

(2008) D. Lembo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Heparan Sulfate in Attachment to and Infection of the Murine Female Genital Tract by Human Papillomavirus

(2008) K. M. Johnson et al.   JOURNAL OF VIROLOGY

Role of Cellular Glycosaminoglycans and Charged Regions of Viral G Protein in Human Metapneumovirus Infection

(2008) S. Thammawat et al.   JOURNAL OF VIROLOGY

A Mouse-Passaged Dengue Virus Strain with Reduced Affinity for Heparan Sulfate Causes Severe Disease in Mice by Establishing Increased Systemic Viral Loads

(2008) T. R. Prestwood et al.   JOURNAL OF VIROLOGY

Cleavage of Group 1 Coronavirus Spike Proteins: How Furin Cleavage Is Traded Off against Heparan Sulfate Binding upon Cell Culture Adaptation

(2008) C. A. M. de Haan et al.   JOURNAL OF VIROLOGY

E Protein Domain III Determinants of Yellow Fever Virus 17D Vaccine Strain Enhance Binding to Glycosaminoglycans, Impede Virus Spread, and Attenuate Virulence

(2008) E. Lee et al.   JOURNAL OF VIROLOGY

Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial

(2008) Stephanie Skoler-Karpoff et al.   LANCET

Enterovirus 71 infection: a new threat to global public health?

(2008) Jane Qiu   LANCET NEUROLOGY

Enterovirus 71 in Taiwan

(2008) Luan-Yin Chang   Pediatrics and Neonatology

Effectiveness of Cellulose Sulfate Vaginal Gel for the Prevention of HIV Infection: Results of a Phase III Trial in Nigeria

(2008) Vera Halpern et al.   PLoS One