Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)

Déjà vu: Stimulating open drug discovery for SARS-CoV-2

(2020) Sean Ekins et al.   DRUG DISCOVERY TODAY

Learning from history: do not flatten the curve of antiviral research!

(2020) Tesia Bobrowski et al.   DRUG DISCOVERY TODAY

Role of heparan sulfate in the Zika virus entry, replication, and cell death

(2019) Huixin Gao et al.   VIROLOGY

Multiple Machine Learning Comparisons of HIV Cell-based and Reverse Transcriptase Data Sets

(2019) Kimberley M. Zorn et al.   MOLECULAR PHARMACEUTICS

Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

(2019) Cagno et al.   Viruses-Basel

Specific Antiviral Activity of Pyrimidinedispirotripiperazinium Alone and in Combination with Acyclovir on a Herpes-Simplex-Virus Infection Model

(2019) E. A. Novoselova et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

(2018) Thomas Lane et al.   MOLECULAR PHARMACEUTICS

Comparing Multiple Machine Learning Algorithms and Metrics for Estrogen Receptor Binding Prediction

(2018) Daniel P. Russo et al.   MOLECULAR PHARMACEUTICS

Targeting heparin and heparan sulfate protein interactions

(2017) Ryan J. Weiss et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosaminoglycans and infection

(2016) Pyong Woo Park   Frontiers in Bioscience-Landmark

Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

(2016) Karthik Sathiyamoorthy et al.   Nature Communications

Surface Proteoglycans as Mediators in Bacterial Pathogens Infections

(2016) Beatriz García et al.   Frontiers in Microbiology

Heparan sulfate proteoglycans: a sugar code for vertebrate development?

(2015) Fabienne E. Poulain et al.   DEVELOPMENT

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

(2015) Alex M. Clark et al.   Journal of Chemical Information and Modeling

Open Source Bayesian Models. 2. Mining a “Big Dataset” To Create and Validate Models with ChEMBL

(2015) Alex M. Clark et al.   Journal of Chemical Information and Modeling

A Role for 3-O-Sulfated Heparan Sulfate in Promoting Human Cytomegalovirus Infection in Human Iris Cells

(2015) John Baldwin et al.   JOURNAL OF VIROLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures

(2015) Sara M. Johnson et al.   PLoS Pathogens

DSTP-27 Prevents Entry of Human Cytomegalovirus

(2014) Rebekka Paeschke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells

(2014) A. Milewska et al.   JOURNAL OF VIROLOGY

Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion

(2013) Naohiro Takemoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Filoviruses Utilize Glycosaminoglycans for Their Attachment to Target Cells

(2013) B. Salvador et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

Inhibition of Human Respiratory Syncytial Virus Infectivity by a Dendrimeric Heparan Sulfate-Binding Peptide

(2012) Manuela Donalisio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathrin, caveolin, and flotillin

(2011) Abdul Ghafoor Khan et al.   VIROLOGY

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Antiviral drugs and antiviral drug resistance

(2011) Donald M Coen et al.   Current Opinion in Virology

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Cytomegalovirus Resistance Testing: Pitfalls and Problems for the Clinician

(2010) W. Lawrence Drew   CLINICAL INFECTIOUS DISEASES

Proteoglycans in host–pathogen interactions: molecular mechanisms and therapeutic implications

(2010) Allison H. Bartlett et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Per aspera ad astra: application of Simplex QSAR approach in antiviral research

(2010) Eugene N Muratov et al.   Future Medicinal Chemistry

Trust, But Verify: On the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research

(2010) Denis Fourches et al.   Journal of Chemical Information and Modeling

Studies of Echovirus 5 interactions with the cell surface: Heparan sulfate mediates attachment to the host cell

(2010) Stina Israelsson et al.   VIRUS RESEARCH

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth

(2009) Sayumi Yamazoe et al.   CHEMISTRY & BIOLOGY

Heparan Sulfate Proteoglycans Are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection

(2009) M. Kalia et al.   JOURNAL OF VIROLOGY

Precompetitive preclinical ADME/Tox data: set it free on the web to facilitate computational model building and assist drug development

(2009) Sean Ekins et al.   LAB ON A CHIP

Heparan Sulfate-Binding Foot-and-Mouth Disease Virus Enters Cells via Caveola-Mediated Endocytosis

(2008) V. O'Donnell et al.   JOURNAL OF VIROLOGY