The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies

Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis

(2017) Song Chen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

CCL2 nitration is a negative regulator of chemokine-mediated inflammation

(2017) Catriona E. Barker et al.   Scientific Reports

Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy

(2016) Yingjie Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3

(2016) Wenguang G. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

(2016) Kirti V. Sawant et al.   Scientific Reports

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

Heparan Sulphate as a Regulator of Leukocyte Recruitment in Inflammation

(2015) Archana Kumar et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation

(2015) Liat Stoler-Barak et al.   FASEB JOURNAL

CXCL1/MGSA Is a Novel Glycosaminoglycan (GAG)-binding Chemokine

(2015) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction of Heparin Tetrasaccharides with Chemokine CCL5 Is Modulated by Sulfation Pattern and pH

(2015) Arunima Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Role of Heparanase-Driven Inflammatory Cascade in Pathogenesis of Diabetic Nephropathy

(2014) R. Goldberg et al.   DIABETES

Glycobiology of leukocyte trafficking in inflammation

(2014) R. D. Wright et al.   GLYCOBIOLOGY

Transendothelial migration of effector T cells across inflamed endothelial barriers does not require heparan sulfate proteoglycans

(2014) Liat Stoler-Barak et al.   INTERNATIONAL IMMUNOLOGY

Multiple Glycosaminoglycan-binding Epitopes of Monocyte Chemoattractant Protein-3/CCL7 Enable It to Function as a Non-oligomerizing Chemokine

(2014) Catherina L. Salanga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fucosylated Chondroitin Sulfates from the Body Wall of the Sea Cucumber Holothuria forskali

(2014) Charalampos G. Panagos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis

(2014) Angelique LWMM Rops et al.   KIDNEY INTERNATIONAL

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

(2014) Katharine J. Goodall et al.   PLoS One

Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice

(2013) Immanuel Lerner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heparanase in inflammation and inflammation-associated cancer

(2013) Amichay Meirovitz et al.   FEBS Journal

Molecular Basis of Glycosaminoglycan Heparin Binding to the Chemokine CXCL1 Dimer

(2013) Krishna Mohan Poluri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Effects of Fucoidan, a P- and L-Selectin Inhibitor, in Murine Acute Pancreatitis

(2013) Ana C.S. Carvalho et al.   PANCREAS

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain

(2012) Xiao Zhang et al.   ACTA NEUROPATHOLOGICA

Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression

(2012) Miry Blich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice

(2012) J. Axelsson et al.   BLOOD

Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients

(2012) Milka Sarris et al.   CURRENT BIOLOGY

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome

(2011) B. Shao et al.   BLOOD

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

(2011) Andrew F. Ziolkowski et al.   JOURNAL OF CLINICAL INVESTIGATION

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

(2011) Pavani Gangavarapu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Urinary heparanase activity in patients with Type 1 and Type 2 diabetes

(2011) Angelique L.W.M.M. Rops et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels

(2011) Itay Shafat et al.   PLoS One

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

(2010) Xingfeng Bao et al.   IMMUNITY

Controlled release of 2, 3 desulfated heparin exerts its anti-inflammatory activity by effectively inhibiting E-selectin

(2010) T. S. Ramyaa Lakshmi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Kinetics of Chemokine–Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs

(2010) Yoshi Tanino et al.   JOURNAL OF IMMUNOLOGY

A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis

(2010) Judilyn Fuentes-Duculan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Monomeric and Dimeric CXCL8 Are Both Essential for In Vivo Neutrophil Recruitment

(2010) Sandhya Thulasi Das et al.   PLoS One

Locally available heparin modulates inflammatory cell recruitment in a manner independent of anticoagulant activity

(2009) Rebecca Lever et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chemokine patterning by glycosaminoglycans and interceptors

(2009) Antal Rot   Frontiers in Bioscience-Landmark

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

(2009) Eyal Zcharia et al.   PLoS One

Comparison of Anticoagulant and Anti-Inflammatory Responses Using Enoxaparin Versus Unfractionated Heparin for Transesophageal Echocardiography-Guided Cardioversion of Atrial Fibrillation††A list of participating clinical sites appears in the Appendix.

(2008) Debra Hoppensteadt et al.   AMERICAN JOURNAL OF CARDIOLOGY

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

(2008) Rachel W. Li et al.   ARTHRITIS AND RHEUMATISM

Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking

(2007) A.L. Rops et al.   KIDNEY INTERNATIONAL