Proteoglycans in brain development and pathogenesis

Glial cell responses in a murine multifactorial perinatal brain injury model

(2018) Miriam Domowicz et al.   BRAIN RESEARCH

Chondroitin Sulfate Impairs Neural Stem Cell Migration Through ROCK Activation

(2017) Layla T. Galindo et al.   MOLECULAR NEUROBIOLOGY

Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes

(2017) Zhendong Su et al.   Oncotarget

Glycan susceptibility factors in autism spectrum disorders

(2016) Chrissa A. Dwyer et al.   MOLECULAR ASPECTS OF MEDICINE

Anti-inflammatory properties of the glial scar

(2016) VivienJ Coulson-Thomas et al.   Neural Regeneration Research

Neuroblastoma: Molecular Pathogenesis and Therapy

(2015) Chrystal U. Louis et al.   Annual Review of Medicine

Neurological Aspects of Human Glycosylation Disorders

(2015) Hudson H. Freeze et al.   Annual Review of Neuroscience

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission

(2015) Ji Seung Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteoglycans and neuronal migration in the cerebral cortex during development and disease

(2015) Nobuaki Maeda   Frontiers in Neuroscience

Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions

(2015) Ina Kalus et al.   PLoS One

Novel Therapeutic Targets in the Brain Tumor Microenvironment

(2015) Joanna J. Phillips   Oncotarget

NDST1missense mutations in autosomal recessive intellectual disability

(2014) Miriam S. Reuter et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth

(2014) Erik H. Knelson et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex

(2014) C. Levy et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Defective Initiation of Glycosaminoglycan Synthesis due to B3GALT6 Mutations Causes a Pleiotropic Ehlers-Danlos-Syndrome-like Connective Tissue Disorder

(2013) Fransiska Malfait et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structure and function of midkine as the basis of its pharmacological effects

(2013) T Muramatsu   BRITISH JOURNAL OF PHARMACOLOGY

Perilesional Treatment with Chondroitinase ABC and Motor Training Promote Functional Recovery After Stroke in Rats

(2013) L. Gherardini et al.   CEREBRAL CORTEX

Glycosaminoglycans are functional ligands for receptor for advanced glycation end-products in tumors

(2013) Shuji Mizumoto et al.   FEBS Journal

Proteoglycans and their roles in brain cancer

(2013) Anna Wade et al.   FEBS Journal

The missing “link”: an autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation

(2013) Julia Schreml et al.   HUMAN GENETICS

Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease

(2013) Hao Cui et al.   IUBMB LIFE

Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

(2013) Erik H. Knelson et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex

(2013) C. Romberg et al.   JOURNAL OF NEUROSCIENCE

Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan receptors in mouse visual cortex

(2013) Qian Ye et al.   MATRIX BIOLOGY

The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain

(2013) Tam Vo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Unbiased Discovery of Glypican as a Receptor for LRRTM4 in Regulating Excitatory Synapse Development

(2013) Joris de Wit et al.   NEURON

An LRRTM4-HSPG Complex Mediates Excitatory Synapse Development on Dentate Gyrus Granule Cells

(2013) Tabrez J. Siddiqui et al.   NEURON

Review: Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair

(2013) E. R. Burnside et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gliosis-specific transcription factor OASIS coincides with proteoglycan core protein genes in the glial scar and inhibits neurite outgrowth

(2012) Ken Iseki et al.   BIOMEDICAL RESEARCH-TOKYO

Targeted Disruption of Heparan Sulfate Interaction with Hepatocyte and Vascular Endothelial Growth Factors Blocks Normal and Oncogenic Signaling

(2012) Fabiola Cecchi et al.   CANCER CELL

The perineuronal net and the control of CNS plasticity

(2012) Difei Wang et al.   CELL AND TISSUE RESEARCH

ConditionalSox9ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury

(2012) William M. McKillop et al.   GLIA

Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines

(2012) Shuji Mizumoto et al.   GLYCOCONJUGATE JOURNAL

Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

(2012) Hao Cui et al.   JOURNAL OF NEUROCHEMISTRY

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

(2012) Travis L Dickendesher et al.   NATURE NEUROSCIENCE

Increased Microglia/Macrophage Gene Expression in a Subset of Adult and Pediatric Astrocytomas

(2012) Jane R. Engler et al.   PLoS One

The Niche Factor Syndecan-1 Regulates the Maintenance and Proliferation of Neural Progenitor Cells during Mammalian Cortical Development

(2012) Qingjie Wang et al.   PLoS One

Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

(2012) Thomas W. Mühleisen et al.   SCHIZOPHRENIA RESEARCH

The Long and the Short of it: Gene and Environment Interactions During Early Cortical Development and Consequences for Long-Term Neurological Disease

(2012) Helen Stolp et al.   Frontiers in Psychiatry

Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder

(2011) Sven Cichon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Astrocyte precursor response to embryonic brain injury

(2011) Miriam S. Domowicz et al.   BRAIN RESEARCH

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors

(2011) Sista Sugiarto et al.   CANCER CELL

Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition

(2011) Lohitash Karumbaiah et al.   GLIA

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin

(2011) Maxim M. Bespalov et al.   JOURNAL OF CELL BIOLOGY

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

6-Sulphated Chondroitins Have a Positive Influence on Axonal Regeneration

(2011) Rachel Lin et al.   PLoS One

Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches

(2011) C. J. Rogers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temtamy Preaxial Brachydactyly Syndrome Is Caused by Loss-of-Function Mutations in Chondroitin Synthase 1, a Potential Target of BMP Signaling

(2010) Yun Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of CHSY1, a Secreted FRINGE Enzyme, Causes Syndromic Brachydactyly in Humans via Increased NOTCH Signaling

(2010) Jing Tian et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

(2010) Daniela Carulli et al.   BRAIN

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

(2010) Achilleas D. Theocharis et al.   FEBS Journal

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans

(2010) Renato V. Iozzo et al.   FEBS Journal

Musculocontractural Ehlers-Danlos Syndrome (former EDS type VIB) and adducted thumb clubfoot syndrome (ATCS) represent a single clinical entity caused by mutations in the dermatan-4-sulfotransferase 1 encoding CHST14 gene

(2010) Fransiska Malfait et al.   HUMAN MUTATION

Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome

(2010) Noriko Miyake et al.   HUMAN MUTATION

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

(2010) Ken D. Johnstone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer’s disease

(2010) David W. Klaver et al.   JOURNAL OF NEUROCHEMISTRY

Role of proteoglycans and glycosaminoglycans in the pathogenesis of Alzheimer's disease and related disorders: Amyloidogenesis and therapeutic strategies-A review

(2010) Toshio Ariga et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Genome-wide association study of recurrent early-onset major depressive disorder

(2010) J Shi et al.   MOLECULAR PSYCHIATRY

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

O-Mannosyl Phosphorylation of Alpha-Dystroglycan Is Required for Laminin Binding

(2010) T. Yoshida-Moriguchi et al.   SCIENCE

Loss of Dermatan-4-Sulfotransferase 1 Function Results in Adducted Thumb-Clubfoot Syndrome

(2009) Munis Dündar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88

(2009) Md Motarab Hossain et al.   GLYCOBIOLOGY

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage

(2009) Chun-Jen Liu et al.   JOURNAL OF HEPATOLOGY

Administration of Chondroitinase ABC Rostral or Caudal to a Spinal Cord Injury Site Promotes Anatomical but Not Functional Plasticity

(2009) Veronica J. Tom et al.   JOURNAL OF NEUROTRAUMA

Common genetic variants on 5p14.1 associate with autism spectrum disorders

(2009) Kai Wang et al.   NATURE

Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis

(2009) Yi-Huei Jen et al.   Neural Development

Gene-Network Analysis Identifies Susceptibility Genes Related to Glycobiology in Autism

(2009) Bert van der Zwaag et al.   PLoS One

Solution Structure of Synbindin Atypical PDZ Domain and Interaction with Syndecan-2

(2009) Shilong Fan et al.   PROTEIN AND PEPTIDE LETTERS

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

PTP  Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

(2009) Y. Shen et al.   SCIENCE

Aggrecan is expressed by embryonic brain glia and regulates astrocyte development

(2008) Miriam S. Domowicz et al.   DEVELOPMENTAL BIOLOGY

Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation

(2008) Francesca Properzi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord

(2008) Clare M. Galtrey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Heparan sulfate regulates ephrin-A3/EphA receptor signaling

(2008) F. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

(2007) Dustin J. Donnelly et al.   EXPERIMENTAL NEUROLOGY

Expression of Multiple Chondroitin/Dermatan Sulfotransferases in the Neurogenic Regions of the Embryonic and Adult Central Nervous System Implies That Complex Chondroitin Sulfates Have a Role in Neural Stem Cell Maintenance

(2007) Kaoru Akita et al.   STEM CELLS