The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

(2016) Brandon Zimmerman et al.   CELL

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

(2016) Alexandra C. Walls et al.   NATURE

Pre-fusion structure of a human coronavirus spike protein

(2016) Robert N. Kirchdoerfer et al.   NATURE

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

(2016) Jung-Eun Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mouse model for MERS coronavirus-induced acute respiratory distress syndrome

(2016) Adam S. Cockrell et al.   Nature Microbiology

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Differential effect of cholesterol on type I and II feline coronavirus infection

(2015) Tomomi Takano et al.   ARCHIVES OF VIROLOGY

Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9

(2015) Quoc-Tuan Le et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronavirus and Influenza Virus Proteolytic Priming Takes Place in Tetraspanin-Enriched Membrane Microdomains

(2015) James T. Earnest et al.   JOURNAL OF VIROLOGY

Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity

(2014) S. Gierer et al.   JOURNAL OF INFECTIOUS DISEASES

Receptor Variation and Susceptibility to Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. Barlan et al.   JOURNAL OF VIROLOGY

Mouse Dipeptidyl Peptidase 4 Is Not a Functional Receptor for Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. S. Cockrell et al.   JOURNAL OF VIROLOGY

Evidence for Camel-to-Human Transmission of MERS Coronavirus

(2014) Esam I. Azhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD9 Negatively Regulates CD26 Expression and Inhibits CD26-Mediated Enhancement of Invasive Potential of Malignant Mesothelioma Cells

(2014) Toshihiro Okamoto et al.   PLoS One

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD81 and Hepatitis C Virus (HCV) Infection

(2014) Lucie Fénéant et al.   Viruses-Basel

IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms

(2014) Florian Wrensch et al.   Viruses-Basel

The Tetraspanin CD151 in Papillomavirus Infection

(2014) Konstanze Scheffer et al.   Viruses-Basel

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model

(2013) C. M. Rosenberger et al.   JOURNAL OF GENERAL VIROLOGY

Tetraspanin CD151 Mediates Papillomavirus Type 16 Endocytosis

(2013) K. D. Scheffer et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

(2013) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

(2013) S. Bertram et al.   JOURNAL OF VIROLOGY

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

(2013) S. Gierer et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

High-Content Analysis of Sequential Events during the Early Phase of Influenza A Virus Infection

(2013) Indranil Banerjee et al.   PLoS One

Dual Function of CD81 in Influenza Virus Uncoating and Budding

(2013) Jiang He et al.   PLoS Pathogens

Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

(2013) Tijana Ivanovic et al.   eLife

The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9

(2011) Maria Dolores Gutiérrez-López et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional interplay between tetraspanins and proteases

(2011) María Yáñez-Mó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interacting Regions of CD81 and Two of Its Partners, EWI-2 and EWI-2wint, and Their Effect on Hepatitis C Virus Infection

(2011) Claire Montpellier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines

(2010) Michael A. Whitt   JOURNAL OF VIROLOGICAL METHODS

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

HIV-1 Assembly Differentially Alters Dynamics and Partitioning of Tetraspanins and Raft Components

(2010) Dimitry N. Krementsov et al.   TRAFFIC

Lateral organization of membrane proteins: tetraspanins spin their web

(2009) Stéphanie Charrin et al.   BIOCHEMICAL JOURNAL

Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-Claudin-1 associations

(2009) Sophie E. Krieger et al.   HEPATOLOGY

Type II Transmembrane Serine Proteases

(2009) Thomas H. Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of Syncytia Is Repressed by Tetraspanins in Human Immunodeficiency Virus Type 1-Producing Cells

(2009) J. Weng et al.   JOURNAL OF VIROLOGY

Two-Step Conformational Changes in a Coronavirus Envelope Glycoprotein Mediated by Receptor Binding and Proteolysis

(2009) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating the Stoichiometry of Human Immunodeficiency Virus Entry

(2008) C. Magnus et al.   JOURNAL OF VIROLOGY

Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

(2008) B. J. Bosch et al.   JOURNAL OF VIROLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2

(2008) Joerg Glende et al.   VIROLOGY