Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity

Syndecans in Inflammation at a Glance

(2020) Sandeep Gopal   Frontiers in Immunology

Heparanase, cell signaling, and viral infections

(2020) Raghuram Koganti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Host syndecan-1 promotes listeriosis by inhibiting intravascular neutrophil extracellular traps

(2020) Rafael S. Aquino et al.   PLoS Pathogens

HS and Inflammation: A Potential Playground for the Sulfs?

(2020) Rana El Masri et al.   Frontiers in Immunology

Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase

(2019) Claire Debarnot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Roles of Heparan Sulfate 3-O-Sulfotransferases in Cancer

(2019) Agnès Denys et al.   Frontiers in Oncology

Golgi pH, Ion and Redox Homeostasis: How Much Do They Really Matter?

(2019) Sakari Kellokumpu   Frontiers in Cell and Developmental Biology

EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia

(2019) Na-wei Liu et al.   MEDICAL SCIENCE MONITOR

Role of glypicans in regulation of the tumor microenvironment and cancer progression

(2019) Sukhneeraj P. Kaur et al.   BIOCHEMICAL PHARMACOLOGY

Exosome-delivered syndecan-1 rescues acute lung injury via a FAK/p190RhoGAP/RhoA/ROCK/NF-κB signaling axis and glycocalyx enhancement

(2019) Chuankai Zhang et al.   EXPERIMENTAL CELL RESEARCH

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2- O -sulphotransferase (HS2ST) is a target for small molecule protein kinase inhibitors

(2018) Dominic P Byrne et al.   BIOCHEMICAL JOURNAL

Glycobiology of syndecan-1 in bacterial infections

(2018) Rafael S. Aquino et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heparan sulfate 3- O -sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane

(2018) Maxime Delos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Characterization of heparan sulfate N -deacetylase/ N -sulfotransferase isoform 4 using synthetic oligosaccharide substrates

(2018) Yi-Jun Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Formation of COPI-coated vesicles at a glance

(2018) Eric C. Arakel et al.   JOURNAL OF CELL SCIENCE

Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression

(2018) Israel Vlodavsky et al.   TRENDS IN BIOCHEMICAL SCIENCES

Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase

(2018) David F. Thieker et al.   Scientific Reports

Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events

(2018) Valentina Masola et al.   Cells

Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases

(2016) Yongmei Xu et al.   ACS Chemical Biology

Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation

(2016) Sean E. Gill et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Heparanase: From basic research to therapeutic applications in cancer and inflammation

(2016) Israel Vlodavsky et al.   DRUG RESISTANCE UPDATES

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

(2016) Vivien R. Sutton et al.   FEBS Journal

NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length

(2016) Audrey Deligny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the reaction mechanism of 3-O-sulfotransferase through QM/MM calculations

(2016) Rui P. Sousa et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Heparan sulfate differentially controls CXCL12 - and CXCL12 -mediated cell migration through differential presentation to their receptor CXCR4

(2016) B. J. Connell et al.   Science Signaling

Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4

(2016) Tzu-Ming Jao et al.   Oncotarget

Heparan sulfate differentially controls CXCL12 - and CXCL12 -mediated cell migration through differential presentation to their receptor CXCR4

(2016) B. J. Connell et al.   Science Signaling

Enzyme overexpression – an exercise toward understanding regulation of heparan sulfate biosynthesis

(2016) Jianping Fang et al.   Scientific Reports

C5-Epimerase and 2-O-Sulfotransferase Associate in Vitro to Generate Contiguous Epimerized and 2-O-Sulfated Heparan Sulfate Domains

(2015) Aurélie Préchoux et al.   ACS Chemical Biology

Catch Bond Interaction between Cell-Surface Sulfatase Sulf1 and Glycosaminoglycans

(2015) Alexander Harder et al.   BIOPHYSICAL JOURNAL

Role of Deacetylase Activity ofN-Deacetylase/N-Sulfotransferase 1 in FormingN-Sulfated Domain in Heparan Sulfate

(2015) Wenfang Dou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Study of d-Glucuronyl C5-epimerase

(2015) Yi Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains

(2015) Kirankumar Katta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sweet spot: how GAGs help chemokines guide migrating cells

(2015) Yoan Monneau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tissue-specificity of heparan sulfate biosynthetic machinery in cancer

(2015) Anastasia V Suhovskih et al.   Cell Adhesion & Migration

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions

(2015) Ina Kalus et al.   PLoS One

Dynamics of Sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring Sulfatase 1

(2014) A. A. Oustah et al.   DEVELOPMENT

Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development

(2014) Stephen D. Freeman et al.   DEVELOPMENTAL DYNAMICS

Structural Abnormalities of Corpus Callosum and Cortical Axonal Tracts Accompanied by Decreased Anxiety-Like Behavior and Lowered Sociability inSpock3-Mutant Mice

(2014) Ayako Yamamoto et al.   DEVELOPMENTAL NEUROSCIENCE

Novel de novo SPOCK1 mutation in a proband with developmental delay, microcephaly and agenesis of corpus callosum

(2014) Radhika Dhamija et al.   European Journal of Medical Genetics

Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture 13C-glucose metabolic labeling

(2014) Mathieu Pegeot et al.   GLYCOBIOLOGY

PAPST1 regulates sulfation of heparan sulfate proteoglycans in epithelial MDCK II cells

(2014) G. Dick et al.   GLYCOBIOLOGY

Molecular Mechanism of Substrate Specificity for Heparan Sulfate 2-O-Sulfotransferase

(2014) Chunhui Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Phosphatase That Dephosphorylates Xylose in the Glycosaminoglycan-Protein Linkage Region of Proteoglycans

(2014) Toshiyasu Koike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Containing Unsubstituted Glucosamine Residues

(2014) Satomi Nadanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basement Membrane Zone Collagens XV and XVIII/Proteoglycans Mediate Leukocyte Influx in Renal Ischemia/Reperfusion

(2014) Azadeh Zaferani et al.   PLoS One

Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis

(2014) J. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer

(2014) Romain R. Vivès et al.   Frontiers in Oncology

The Drosophila GOLPH3 homolog regulates the biosynthesis of heparan sulfate proteoglycans by modulating the retrograde trafficking of exostosins

(2013) Wei-Ling Chang et al.   DEVELOPMENT

HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity

(2013) Amal Seffouh et al.   FASEB JOURNAL

Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains

(2013) Tina Manon-Jensen et al.   FEBS Journal

The many routes of Golgi-dependent trafficking

(2013) Gaelle Boncompain et al.   HISTOCHEMISTRY AND CELL BIOLOGY

EXTL2, a Member of theEXTFamily of Tumor Suppressors, Controls Glycosaminoglycan Biosynthesis in a Xylose Kinase-dependent Manner

(2013) Satomi Nadanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Testican-3: a brain-specific proteoglycan member of the BM-40/SPARC/osteonectin family

(2013) Ursula Hartmann et al.   JOURNAL OF NEUROCHEMISTRY

The extostosin family: Proteins with many functions

(2013) Marta Busse-Wicher et al.   MATRIX BIOLOGY

Heparan sulfate 3-O-sulfation: A rare modification in search of a function

(2013) Bryan E. Thacker et al.   MATRIX BIOLOGY

Border patrol: Insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders

(2013) Mary C. Farach-Carson et al.   MATRIX BIOLOGY

Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells

(2013) Angeliki Korpetinou et al.   PLoS One

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

Serglycin in Health and Diseases

(2012) Olivia J. Scully et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach

(2012) Jian Liu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate

(2012) E. H. Pempe et al.   GLYCOBIOLOGY

Roles of Heparan Sulfate Sulfation in Dentinogenesis

(2012) Satoru Hayano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncovering Biphasic Catalytic Mode of C5-epimerase in Heparan Sulfate Biosynthesis

(2012) Juzheng Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Biosynthesis

(2012) Hinke A. B. Multhaupt et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Heparan Sulfate Biosynthesis

(2012) Johan Kreuger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Correction: Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

(2012) Wendy A. Boivin et al.   PLoS One

Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies

(2011) Zheng Wei et al.   GLYCOCONJUGATE JOURNAL

Differential characterization and classification of tissue specific glycosaminoglycans by tandem mass spectrometry and statistical methods

(2011) Nancy Leymarie et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

The Dominating Role ofN-Deacetylase/N-Sulfotransferase 1 in Forming Domain Structures in Heparan Sulfate

(2011) Juzheng Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Organization of GolgiN- andO-Glycosylation Pathways Involves pH-dependent Complex Formation That Is Impaired in Cancer Cells

(2011) Antti Hassinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serglycin: A Structural and Functional Chameleon with Wide Impact on Immune Cells

(2011) Svein O. Kolset et al.   JOURNAL OF IMMUNOLOGY

TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

(2011) Hamid Akbarshahi et al.   Journal of Translational Medicine

Betaglycan: A multifunctional accessory

(2011) Maree Bilandzic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Architecture of the Mammalian Golgi

(2011) J. Klumperman   Cold Spring Harbor Perspectives in Biology

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation

(2010) Adam Kleinschmit et al.   DEVELOPMENTAL BIOLOGY

Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate

(2010) Steven D Rosen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Proteoglycans in health and disease: the multiple roles of syndecan shedding

(2010) Tina Manon-Jensen et al.   FEBS Journal

Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche

(2010) Aliete Langsdorf et al.   GLYCOBIOLOGY

Serglycin Is a Major Proteoglycan in Polarized Human Endothelial Cells and Is Implicated in the Secretion of the Chemokine GROα/CXCL1

(2010) Astri J. Meen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COPII-mediated vesicle formation at a glance

(2010) D. Jensen et al.   JOURNAL OF CELL SCIENCE

A Novel Mechanism of Sequestering Fibroblast Growth Factor 2 by Glypican in Lipid Rafts, Allowing Skeletal Muscle Differentiation

(2010) J. Gutierrez et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of the Basement Membrane Heparan Sulfate Proteoglycan Type XVIII Collagen Causes Hypertriglyceridemia in Mice and Humans

(2010) Joseph R. Bishop et al.   PLoS One

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New role for Agrin in T cells and its potential importance in immune system regulation

(2010) Elizabeth C Jury et al.   ARTHRITIS RESEARCH & THERAPY

FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan–protein linkage region

(2009) Toshiyasu Koike et al.   BIOCHEMICAL JOURNAL

The emerging role of TGF-β superfamily coreceptors in cancer

(2009) Carmelo Bernabeu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines

(2009) K. Hayashida et al.   BLOOD

Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression

(2009) Viktoriya Nikolova et al.   CARCINOGENESIS

Characterization of the Human Sulfatase Sulf1 and Its High Affinity Heparin/Heparan Sulfate Interaction Domain

(2009) Marc-André Frese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Consequences of the Subdomain Organization of the Sulfs

(2009) Renhong Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack ofl-Iduronic Acid in Heparan Sulfate Affects Interaction with Growth Factors and Cell Signaling

(2009) Juan Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics

(2009) Sophie M. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating the Elusive Mechanism of Glycosaminoglycan Biosynthesis

(2009) Xylophone V. Victor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Journeys through the Golgi—taking stock in a new era

(2009) Scott Emr et al.   JOURNAL OF CELL BIOLOGY

Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

(2009) David R. Taylor et al.   PLoS Pathogens

Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface

(2008) Alexandra Traister et al.   BIOCHEMICAL JOURNAL

Membrane Type 1 Matrix Metalloproteinase-Mediated Stromal Syndecan-1 Shedding Stimulates Breast Carcinoma Cell Proliferation

(2008) G. Su et al.   CANCER RESEARCH

The heparanome and regulation of cell function: structures, functions and challenges

(2008) Alessandro Ori   Frontiers in Bioscience-Landmark

Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan

(2008) Maria Ringvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered Heparan Sulfate Structure in Mice with DeletedNDST3Gene Function

(2008) Srinivas R. Pallerla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor-β1 Induces Heparan Sulfate 6-O-Endosulfatase 1 Expressionin Vitroandin Vivo

(2008) Xinping Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Follicular Fluid Heparan Sulfate Contains Abundant 3-O-Sulfated Chains with Anticoagulant Activity

(2008) Ariane I. de Agostini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-O-Phosphorylation of Xylose and 6-O-Sulfation of Galactose in the Protein Linkage Region of Glycosaminoglycans Influence the Glucuronyltransferase-I Activity Involved in the Linkage Region Synthesis

(2008) Yuko Tone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin/Heparan Sulfate Biosynthesis

(2008) Pernilla Carlsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity

(2008) Ina Kalus et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lack of collagen XVIII accelerates cutaneous wound healing, while overexpression of its endostatin domain leads to delayed healing

(2008) Lotta Seppinen et al.   MATRIX BIOLOGY

Opposing roles for glypicans in Hedgehog signalling

(2008) Dong Yan et al.   NATURE CELL BIOLOGY

Engineering sulfotransferases to modify heparan sulfate

(2008) Ding Xu et al.   Nature Chemical Biology

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

(2008) J. Presto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glypicans

(2008) Jorge Filmus et al.   GENOME BIOLOGY

Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice

(2007) D. S. Woulfe et al.   BLOOD

Fine-tuning of cell signaling by glypicans

(2007) A. Fico et al.   CELLULAR AND MOLECULAR LIFE SCIENCES