Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase

Heparanase Stimulates Chondrogenesis and Is Up-Regulated in Human Ectopic Cartilage

(2015) Julianne Huegel et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional and structural characterization of a heparanase

(2015) Lisa Bohlmann et al.   Nature Chemical Biology

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The potential of heparanase as a therapeutic target in cancer

(2014) Claudio Pisano et al.   BIOCHEMICAL PHARMACOLOGY

A Liquid Chromatography-Mass Spectrometry-based Approach to Characterize the Substrate Specificity of Mammalian Heparanase

(2014) Yang Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses

(2013) Vito Ferro   EXPERT OPINION ON THERAPEUTIC TARGETS

Heparanase: Multiple functions in inflammation, diabetes and atherosclerosis

(2013) Israel Vlodavsky et al.   MATRIX BIOLOGY

Synthesis of a Pseudo-Disaccharide Library and Its Application to the Characterisation of the Heparanase Catalytic Site

(2013) Victoria Vinader et al.   PLoS One

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

(2013) Edward Hammond et al.   FEBS Open Bio

Heparanase and Autoimmune Diabetes

(2013) Charmaine J. Simeonovic et al.   Frontiers in Immunology

Structural and Biochemical Characterization of Glycoside Hydrolase Family 79 β-Glucuronidase fromAcidobacterium capsulatum

(2012) Mari Michikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids

(2011) Nicolas Sapay et al.   BIOPOLYMERS

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-d-glucuronidase (heparanase)

(2011) Neha S Gandhi et al.   GLYCOBIOLOGY

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

Inhibition kinetics of catabolic dehydrogenases by elevated moieties of ATP and ADP - implication for a new regulation mechanism in Lactococcus lactis

(2010) Rong Cao et al.   FEBS Journal

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening

(2009) Edward Hammond et al.   ANALYTICAL BIOCHEMISTRY

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY