Heparin as a therapy for COVID-19: current evidence and future possibilities

Different signaling pathways involved in the anti-inflammatory effects of unfractionated heparin on lipopolysaccharide-stimulated human endothelial cells

(2020) Xu Li et al.   Journal of Inflammation-London

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury

(2020) W. B. LaRivière et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19

(2020) Ishan Paranjpe et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series

(2020) Janice Wang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19: A Comment

(2020) Christopher D. Barrett et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

(2020) Thomas J. Oxley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure

(2020) Katelyn Arnold et al.   Science Translational Medicine

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy

(2020) Corrado Lodigiani et al.   THROMBOSIS RESEARCH

Circulating heparan sulfate fragments mediate septic cognitive dysfunction

(2019) Joseph A. Hippensteel et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy

(2019) Jean-Louis Vincent et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

VTE Risk Profiles and Prophylaxis in Medical and Surgical Inpatients

(2018) Zhenguo Zhai et al.   CHEST

Entry of Human Coronavirus NL63 into the Cell

(2017) Aleksandra Milewska et al.   JOURNAL OF VIROLOGY

Targeting heparin and heparan sulfate protein interactions

(2017) Ryan J. Weiss et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding

(2017) Yanlin Zhang et al.   SHOCK

Is inhaled prophylactic heparin useful for prevention and Management of Pneumonia in ventilated ICU patients?

(2016) Hiran Bandeshe et al.   JOURNAL OF CRITICAL CARE

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice

(2016) S. Antoniak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Regulation of Alveolar Procoagulant Activity and Permeability in Direct Acute Lung Injury by Lung Epithelial Tissue Factor

(2015) Ciara M. Shaver et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress

(2012) Julie A Bastarache et al.   THORAX

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Evaluation of Bleeding Risk in Patients Exposed to Therapeutic Unfractionated or Low-Molecular-Weight Heparin: A Cohort Study in the Context of a Quality Improvement Initiative

(2010) B. Cossette et al.   ANNALS OF PHARMACOTHERAPY

Venous thromboembolism in critically ill patients

(2008) Mark Williams et al.   THROMBOSIS AND HAEMOSTASIS

The anti-inflammatory effects of heparin and related compounds

(2007) Edward Young   THROMBOSIS RESEARCH