Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats

Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling

(2020) Leon G. Coleman et al.   Journal of Neuroinflammation

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

(2020) Rebecca J. Henry et al.   JOURNAL OF NEUROSCIENCE

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

(2020) Seiko Ikezu et al.   MOLECULAR PSYCHIATRY

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

The role of microglia in the second and third postnatal weeks of life in rat hippocampal development and memory

(2020) Alita Soch et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia senescence occurs in both substantia nigra and ventral tegmental area

(2020) Fatemeh Shaerzadeh et al.   GLIA

Neuronal gamma oscillations and activity‐dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue

(2020) Andrea Lewen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence

(2020) Jolie Barter et al.   MOLECULAR NEUROBIOLOGY

Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ

(2019) Thuy-Truc Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity

(2019) Xiaoning Han et al.   MOLECULAR NEUROBIOLOGY

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

(2019) Olivia Sheppard et al.   Journal of Neuroinflammation

The behavioral sequelae of social defeat require microglia and are driven by oxidative stress in mice

(2019) Michael L. Lehmann et al.   JOURNAL OF NEUROSCIENCE

Microglial Cells Depletion Increases Inflammation and Modifies Microglial Phenotypes in an Animal Model of Severe Sepsis

(2019) Monique Michels et al.   MOLECULAR NEUROBIOLOGY

Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

(2019) Silvia Marinelli et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging

(2019) Ashok Kumar et al.   Aging-US

Microglia and the Aging Brain: Are Senescent Microglia the Key to Neurodegeneration?

(2019) Dafina M. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Depletion of Microglia Attenuates Dendritic Spine Loss and Neuronal Apoptosis in the Acute Stage of Moderate Traumatic Brain Injury in Mice

(2019) Chuan-fang Wang et al.   JOURNAL OF NEUROTRAUMA

Effect of Systemic Inflammation on Rat Attentional Function and Neuroinflammation: Possible Protective Role for Food Restriction

(2019) Brittney Yegla et al.   Frontiers in Aging Neuroscience

Progression from Feature-Specific Brain Activity to Hippocampal Binding during Episodic Encoding

(2019) Rose A. Cooper et al.   JOURNAL OF NEUROSCIENCE

Redox Signaling in Neurotransmission and Cognition During Aging

(2018) Ashok Kumar et al.   ANTIOXIDANTS & REDOX SIGNALING

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain

(2018) SeungHwan Lee et al.   Molecular Pain

Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals

(2018) Ashok Kumar et al.   NEUROBIOLOGY OF AGING

Stereological Analysis of Microglia in Aged Male and Female Fischer 344 Rats in Socially Relevant Brain Regions

(2018) Amy E. Perkins et al.   NEUROSCIENCE

Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex

(2018) Thomas E. Chan et al.   Frontiers in Aging Neuroscience

How to reprogram microglia toward beneficial functions

(2018) Marta Fumagalli et al.   GLIA

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence

(2018) Ashok Kumar et al.   NEUROCHEMICAL RESEARCH

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Partial reduction of microglia does not affect tau pathology in aged mice

(2018) Rachel E. Bennett et al.   Journal of Neuroinflammation

Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains

(2018) Kwang-Min Kim et al.   JOURNAL OF NEUROSCIENCE

Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

(2018) Shane M. O’Neil et al.   Acta Neuropathologica Communications

Microglial repopulation resolves inflammation and promotes brain recovery after injury

(2017) Rachel A. Rice et al.   GLIA

Old Maids: Aging and Its Impact on Microglia Function

(2017) Edward Koellhoffer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia Are Irrelevant for Neuronal Degeneration and Axon Regeneration after Acute Injury

(2017) Alexander M. Hilla et al.   JOURNAL OF NEUROSCIENCE

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

(2017) K E Hopperton et al.   MOLECULAR PSYCHIATRY

Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex

(2017) Oded Klavir et al.   NATURE NEUROSCIENCE

Brain interference: Revisiting the role of IFNγ in the central nervous system

(2017) S. Monteiro et al.   PROGRESS IN NEUROBIOLOGY

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Dynamic microglial modulation of spatial learning and social behavior

(2016) Luisa Torres et al.   BRAIN BEHAVIOR AND IMMUNITY

Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage

(2016) Minshu Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina

(2016) Xu Wang et al.   JOURNAL OF NEUROSCIENCE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Microglia Priming with Aging and Stress

(2016) Anzela Niraula et al.   NEUROPSYCHOPHARMACOLOGY

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Systemic lipopolysaccharide administration impairs retrieval of context–object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation

(2015) Jennifer Czerniawski et al.   BRAIN BEHAVIOR AND IMMUNITY

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Re-Opening the Critical Window for Estrogen Therapy

(2015) L. A. Bean et al.   JOURNAL OF NEUROSCIENCE

Prefrontal NMDA receptors expressed in excitatory neurons control fear discrimination and fear extinction

(2015) Philip A. Vieira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer

(2015) Michelle L. Thompson et al.   PAIN

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses

(2014) Ashok Kumar et al.   HIPPOCAMPUS

Medial Temporal Lobe Coding of Item and Spatial Information during Relational Binding in Working Memory

(2014) L. A. Libby et al.   JOURNAL OF NEUROSCIENCE

An organization of visual and auditory fear conditioning in the lateral amygdala

(2014) Hadley C. Bergstrom et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Homeostatic and injury-induced microglia behavior in the aging brain

(2013) Jasmin K. Hefendehl et al.   AGING CELL

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Microglial Senescence

(2013) Wolfgang Streit et al.   CNS & Neurological Disorders-Drug Targets

Rare contacts between synapses and microglial processes containing high levels of Iba1 and actin - a postembedding immunogold study in the healthy rat brain

(2013) Carl J. L. Sogn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease

(2013) Marina A. Lynch   IMMUNOLOGY

Delayed Bone Regeneration Is Linked to Chronic Inflammation in Murine Muscular Dystrophy

(2013) Rana Abou-Khalil et al.   JOURNAL OF BONE AND MINERAL RESEARCH

KIT oncogene inhibition drives intratumoral macrophage M2 polarization

(2013) Michael J. Cavnar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Linking Redox Regulation of NMDAR Synaptic Function to Cognitive Decline during Aging

(2013) A. Kumar et al.   JOURNAL OF NEUROSCIENCE

Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats

(2013) Wei-Hua Lee et al.   NEUROBIOLOGY OF AGING

Investigations into the involvement of NMDA mechanisms in recognition memory

(2013) E. Clea Warburton et al.   NEUROPHARMACOLOGY

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition

(2012) Carlos E. Prada et al.   ACTA NEUROPATHOLOGICA

Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor

(2012) B.L. Brim et al.   BEHAVIOURAL BRAIN RESEARCH

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

(2012) Marie-Ève Tremblay et al.   GLIA

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

(2012) X. Liu et al.   NEUROSCIENCE

Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity

(2012) Thomas C. Foster   PROGRESS IN NEUROBIOLOGY

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Double Dissociation between Hippocampal and Parahippocampal Responses to Object-Background Context and Scene Novelty

(2011) L. R. Howard et al.   JOURNAL OF NEUROSCIENCE

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology

(2011) Ashok Kumar et al.   NEUROBIOLOGY OF AGING

CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment

(2011) Laura Maggi   Frontiers in Cellular Neuroscience

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Carbachol-Induced Long-Term Synaptic Depression Is Enhanced During Senescence at Hippocampal CA3–CA1 Synapses

(2010) Ashok Kumar   JOURNAL OF NEUROPHYSIOLOGY

Redox Sensitive Calcium Stores Underlie Enhanced After Hyperpolarization of Aged Neurons: Role for Ryanodine Receptor Mediated Calcium Signaling

(2010) Karthik Bodhinathan et al.   JOURNAL OF NEUROPHYSIOLOGY

Interferon-γ Produced by Microglia and the Neuropeptide PACAP Have Opposite Effects on the Viability of Neural Progenitor Cells

(2010) Johanna Mäkelä et al.   PLoS One

Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala

(2009) Ingie Hong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immune and behavioral consequences of microglial reactivity in the aged brain

(2009) A. M. Wynne et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Human Fear Conditioning and Extinction in Neuroimaging: A Systematic Review

(2009) Christina Sehlmeyer et al.   PLoS One

Dissociable Roles for the Hippocampus and the Amygdala in Human Cued versus Context Fear Conditioning

(2008) A. Marschner et al.   JOURNAL OF NEUROSCIENCE

Contextual Fear Conditioning in Humans: Cortical-Hippocampal and Amygdala Contributions

(2008) R. P. Alvarez et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders

(2008) Massimiliano Di Filippo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES