Canine Cognitive Dysfunction and Alzheimer’s Disease – Two Facets of the Same Disease?

Canine Cognitive Dysfunction

(2019) Curtis Wells Dewey et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Alzheimer's disease, cellular prion protein, and dolphins

(2018) Giovanni Di Guardo   Alzheimers & Dementia

Networks of tau distribution in Alzheimer’s disease

(2018) Merle C Hoenig et al.   BRAIN

(-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer’s Disease

(2018) Robert E. Becker et al.   Current Alzheimer Research

Clinical Trials for Disease-Modifying Therapies in Alzheimer’s Disease: A Primer, Lessons Learned, and a Blueprint for the Future

(2018) Jeffrey Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease

(2018) Carlo Condello et al.   NEUROBIOLOGY OF DISEASE

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers

(2018) Clare Rusbridge et al.   Frontiers in Aging Neuroscience

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies

(2018) Alice Bittar et al.   npj Vaccines

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

(2018) Ulf Neumann et al.   EMBO Molecular Medicine

Cholinesterase Inhibitors Improve Both Memory and Complex Learning in Aged Beagle Dogs

(2018) Joseph A. Araujo et al.   JOURNAL OF ALZHEIMERS DISEASE

Expression of p75NTR, a Marker for Basal Forebrain Cholinergic Neurons, in Young and Aged Dogs with or without Cognitive Dysfunction Syndrome

(2018) Daniel Insua et al.   JOURNAL OF ALZHEIMERS DISEASE

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

(2018) Mathias Jucker et al.   NATURE NEUROSCIENCE

Rodent models for Alzheimer disease

(2018) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Stereotypic horses (Equus caballus) are not cognitively impaired

(2018) Sabrina Briefer Freymond et al.   ANIMAL COGNITION

Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis

(2018) Osman Shabir et al.   BMC NEUROSCIENCE

Multiple infarcts and hemorrhages in the central nervous system of a dog with cerebral amyloid angiopathy: a case report

(2018) Laís Limeira Rodrigues et al.   BMC Veterinary Research

A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease

(2018) Justyna A Dobrowolska Zakaria et al.   EMBO Molecular Medicine

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

(2018) Cody Wolfe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: A Path toward Precision Medicine

(2018) Sarah M. Neuner et al.   NEURON

Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer’s disease: a network meta-analysis of 41 randomized controlled trials

(2018) Kai-Xin Dou et al.   Alzheimers Research & Therapy

Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead

(2018) Petr Novak et al.   Frontiers in Neuroscience

APP Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and a Literature Review

(2017) François Sellal et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

(2017) Stephanie Villarreal et al.   JOURNAL OF ALZHEIMERS DISEASE

Young to Middle-Aged Dogs with High Amyloid-β Levels in Cerebrospinal Fluid are Impaired on Learning in Standard Cognition tests

(2017) Herman Borghys et al.   JOURNAL OF ALZHEIMERS DISEASE

Dissociating Normal Aging from Alzheimer’s Disease: A View from Cognitive Neuroscience

(2017) Max Toepper   JOURNAL OF ALZHEIMERS DISEASE

Recent Progress in Alzheimer’s Disease Research, Part 3: Diagnosis and Treatment

(2017) Francis T. Hane et al.   JOURNAL OF ALZHEIMERS DISEASE

Is sporadic Alzheimer′s disease a developmental disorder?

(2017) Thomas Arendt et al.   JOURNAL OF NEUROCHEMISTRY

Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy

(2017) Yui Kobatake et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages

(2017) Paulina R. Davis et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease markers in the aged sheep ( Ovis aries )

(2017) Suzanne J. Reid et al.   NEUROBIOLOGY OF AGING

The Exceptional Vulnerability of Humans to Alzheimer’s Disease

(2017) Lary C. Walker et al.   TRENDS IN MOLECULAR MEDICINE

Evaluation of interthalamic adhesion size as an indicator of brain atrophy in dogs with and without cognitive dysfunction

(2017) Daji Noh et al.   VETERINARY RADIOLOGY & ULTRASOUND

Signs and symptoms preceding the diagnosis of Alzheimer’s disease: a systematic scoping review of literature from 1937 to 2016

(2017) Fidelia Bature et al.   BMJ Open

Merck ends trial of potential Alzheimer’s drug verubecestat

(2017) Nigel Hawkes   BMJ-British Medical Journal

Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease

(2017) Tingting Zheng et al.   Frontiers in Aging Neuroscience

Merck ends trial of potential Alzheimer’s drug verubecestat

(2017) Nigel Hawkes   BMJ-British Medical Journal

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

(2017) Sarah C. Kelly et al.   Acta Neuropathologica Communications

Amyloid-β Peptide and Oligomers in the Brain and Cerebrospinal Fluid of Aged Canines

(2017) Elizabeth Head et al.   JOURNAL OF ALZHEIMERS DISEASE

Phenserine Efficacy in Alzheimer's Disease

(2017) Bengt Winblad et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Genetics of Frontotemporal Dementia

(2016) Diana A. Olszewska et al.   Current Neurology and Neuroscience Reports

Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer’s Disease: A Translational Study of Neuropathological and Inflammatory Markers

(2016) Trine Schütt et al.   JOURNAL OF ALZHEIMERS DISEASE

The Relation between canine cognitive dysfunction and age-related brain lesions

(2016) Makiko OZAWA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Early Alzheimer's disease–type pathology in the frontal cortex of wild mountain gorillas ( Gorilla beringei beringei )

(2016) Sylvia E. Perez et al.   NEUROBIOLOGY OF AGING

Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy

(2016) Emma L. Ivansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS  -amyloid in animal models and in Alzheimers disease patients

(2016) M. E. Kennedy et al.   Science Translational Medicine

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

(2016) S. A. Youssef et al.   VETERINARY PATHOLOGY

Histological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogs

(2016) Slađan Nešić et al.   VETERINARY QUARTERLY

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset

(2016) Juan D. Rodriguez-Callejas et al.   Frontiers in Aging Neuroscience

Immununochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases

(2016) Ulises Gómez-Pinedo et al.   Frontiers in Neurology

Plasma β-amyloid in Alzheimer’s disease and vascular disease

(2016) Shorena Janelidze et al.   Scientific Reports

Regional mosaic genomic heterogeneity in the elderly and in Alzheimer’s disease as a correlate of neuronal vulnerability

(2015) Thomas Arendt et al.   ACTA NEUROPATHOLOGICA

Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES)

(2015) Aladar Madari et al.   APPLIED ANIMAL BEHAVIOUR SCIENCE

IBS: an illustrator for the presentation and visualization of biological sequences: Fig. 1.

(2015) Wenzhong Liu et al.   BIOINFORMATICS

Accelerating Alzheimerʼs research through ‘natural’ animal models

(2015) Nady Braidy et al.   CURRENT OPINION IN PSYCHIATRY

Developing therapeutic vaccines against Alzheimer’s disease

(2015) Thomas Wisniewski et al.   Expert Review of Vaccines

Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment

(2015) Tomas Smolek et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines

(2015) Franziska Schmidt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A  Pharmacodynamic Responses in Mice, Dogs, and Humans

(2015) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Genetically modified pig models for neurodegenerative disorders

(2015) Ida E Holm et al.   JOURNAL OF PATHOLOGY

Cognitive Function, Progression of Age-related Behavioral Changes, Biomarkers, and Survival in Dogs More Than 8 Years Old

(2015) T. Schütt et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

APOE and cerebral amyloid angiopathy in community-dwelling older persons

(2015) Lei Yu et al.   NEUROBIOLOGY OF AGING

Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy

(2015) S. Nakamae et al.   NEUROSCIENCE

Spontaneous Pathology and Routine Clinical Pathology Parameters in Aging Beagle Dogs

(2015) J. Barnes et al.   VETERINARY PATHOLOGY

The domestic cat as a natural animal model of Alzheimer’s disease

(2015) James K. Chambers et al.   Acta Neuropathologica Communications

Alzheimer's disease under strain

(2014) Adriano Aguzzi   NATURE

Amyloid-� Immunotherapy Reduces Amyloid Plaques and Astroglial Reaction in Aged Domestic Dogs

(2014) Maria Neus Bosch et al.   Neurodegenerative Diseases

Aging in the Canine and Feline Brain

(2014) Charles H. Vite et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla)

(2013) Sylvia E. Perez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

An Observational Study with Long-Term Follow-Up of Canine Cognitive Dysfunction: Clinical Characteristics, Survival, and Risk Factors

(2013) R. Fast et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

PiB Fails to Map Amyloid Deposits in Cerebral Cortex of Aged Dogs with Canine Cognitive Dysfunction

(2013) Rikke Fast et al.   Frontiers in Aging Neuroscience

Dogs with Cognitive Dysfunction Syndrome: A Natural Model of Alzheimer’s Disease

(2012) Maria Neus Bosch et al.   Current Alzheimer Research

Where, when, and in what form does sporadic Alzheimerʼs disease begin?

(2012) Heiko Braak et al.   CURRENT OPINION IN NEUROLOGY

White matter myelin loss in the brains of aged dogs

(2012) James Kenn Chambers et al.   EXPERIMENTAL GERONTOLOGY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

(2012) Niklas Mattsson et al.   PLoS One

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Cognitive Dysfunction Syndrome

(2012) Gary M. Landsberg et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Effect of age and severity of cognitive dysfunction on spontaneous activity in pet dogs – Part 1: Locomotor and exploratory behaviour

(2012) B. Rosado et al.   VETERINARY JOURNAL

Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker

(2012) Iqbal El-Assaad et al.   VETERINARY RESEARCH COMMUNICATIONS

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Characterization of AβpN3 deposition in the brains of dogs of various ages and other animal species

(2011) James K. Chambers et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Antioxidants in the canine model of human aging

(2011) Amy L.S. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model

(2011) Sarah B. Martin et al.   Current Neuropharmacology

Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease

(2011) Ángela González-Martínez et al.   EXPERIMENTAL GERONTOLOGY

Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer’s Disease and the Brain of Aged Dogs with Cognitive Dysfunction

(2011) C.-H. Yu et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease

(2011) Eugenio Barone et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain

(2011) S. Snigdha et al.   NEUROSCIENCE

Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density

(2011) Joseph A. Araujo et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Dietary and Behavioral Interventions Protect against Age Related Activation of Caspase Cascades in the Canine Brain

(2011) Shikha Snigdha et al.   PLoS One

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

(2011) S. Serizawa et al.   VETERINARY PATHOLOGY

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

(2010) Thomas Arendt et al.   AMERICAN JOURNAL OF PATHOLOGY

Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

(2010) Orso Bugiani et al.   ARCHIVES OF NEUROLOGY

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques

(2010) S. Kumar-Singh   GENES BRAIN AND BEHAVIOR

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

(2010) Margaret Fahnestock et al.   NEUROBIOLOGY OF AGING

Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing

(2010) L. Sarasa et al.   NEUROSCIENCE

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

The canine cognitive dysfunction rating scale (CCDR): A data-driven and ecologically relevant assessment tool

(2010) Hannah E. Salvin et al.   VETERINARY JOURNAL

Decreased cerebrospinal fluid Aβ42correlates with brain atrophy in cognitively normal elderly

(2009) Anne M. Fagan et al.   ANNALS OF NEUROLOGY

Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition

(2009) Naoto Oikawa et al.   BRAIN RESEARCH

Natural Non-Trasgenic Animal Models for Research in Alzheimers Disease

(2009) Manuel Sarasa et al.   Current Alzheimer Research

Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging

(2009) E. Head et al.   EXPERIMENTAL NEUROLOGY

Parenchymal and Vascular Lesions in Ageing Equine Brains: Histological and Immunohistochemical Studies

(2009) M.T. Capucchio et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Prevalence and risk factors of behavioural changes associated with age-related cognitive impairment in geriatric dogs

(2009) G. Azkona et al.   JOURNAL OF SMALL ANIMAL PRACTICE

Association between neurologic and cognitive dysfunction signs in a sample of aging dogs

(2009) L. Golini et al.   Journal of Veterinary Behavior-Clinical Applications and Research

Under diagnosis of canine cognitive dysfunction: A cross-sectional survey of older companion dogs

(2009) Hannah E. Salvin et al.   VETERINARY JOURNAL

Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines

(2008) Lori-Ann Christie et al.   AGE

Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease

(2008) Ahmadul Kadir et al.   ANNALS OF NEUROLOGY

Tauopathy with paired helical filaments in an aged chimpanzee

(2008) Rebecca F. Rosen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Two-Year Study with Fibrillar  -Amyloid (A ) Immunization in Aged Canines: Effects on Cognitive Function and Brain A 

(2008) E. Head et al.   JOURNAL OF NEUROSCIENCE

Dogs with canine counterpart of Alzheimer's disease lose noradrenergic neurons

(2008) Daniel Insua et al.   NEUROBIOLOGY OF AGING

Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study

(2008) O. L. Lopez et al.   NEUROLOGY

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease

(2006) Wycliffe O. Opii et al.   NEUROBIOLOGY OF AGING

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment

(2006) Christina T. Siwak-Tapp et al.   NEUROBIOLOGY OF AGING