Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines

Amyloid-β Peptide and Oligomers in the Brain and Cerebrospinal Fluid of Aged Canines

(2017) Elizabeth Head et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial pathology

(2014) Wolfgang J Streit et al.   Acta Neuropathologica Communications

Pyroglutamate-Modified Amyloid-� Protein Demonstrates Similar Properties in an Alzheimer's Disease Familial Mutant Knock-In Mouse and Alzheimer's Disease Brain

(2013) Guoxin Wu et al.   Neurodegenerative Diseases

Immunolesion-induced loss of cholinergic projection neurones promotes β-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice

(2013) W. Härtig et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome

(2012) Line De Kimpe et al.   AGE

Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

(2012) Thomas J. Esparza et al.   ANNALS OF NEUROLOGY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Cognitive dysfunction in dogs: Pathologic neurodegeneration or just growing older?

(2012) Sara Bennett   VETERINARY JOURNAL

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

(2011) Maike Hartlage-Rübsamen et al.   ACTA NEUROPATHOLOGICA

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer’s Disease and the Brain of Aged Dogs with Cognitive Dysfunction

(2011) C.-H. Yu et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease

(2010) Adam P. Gunn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Concomitant detection of β-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice

(2010) Wolfgang Härtig et al.   JOURNAL OF CHEMICAL NEUROANATOMY

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Natural Non-Trasgenic Animal Models for Research in Alzheimers Disease

(2009) Manuel Sarasa et al.   Current Alzheimer Research

β-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog

(2009) Vanessa Bernedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

(2008) Dietmar Rudolf Thal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE

Dogs with canine counterpart of Alzheimer's disease lose noradrenergic neurons

(2008) Daniel Insua et al.   NEUROBIOLOGY OF AGING