Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer

Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity

(2020) Sara Verdura et al.   Aging-US

Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer

(2020) Prachya Kongtawelert et al.   MOLECULES

Non-coding RNA and immune-checkpoint inhibitors: friends or foes?

(2020) Dmitrii Shek et al.   Immunotherapy

(-)-Sativan Inhibits Tumor Development and Regulates miR-200c/PD-L1 in Triple Negative Breast Cancer Cells

(2020) Fu Peng et al.   Frontiers in Pharmacology

NF-κB and Its Role in Checkpoint Control

(2020) Annika C. Betzler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives

(2020) María Ángeles Ávila-Gálvez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer immunotherapy comes of age and looks for maturity

(2020) Amanda Finck et al.   Nature Communications

β-Catenin regulates tumor-derived PD-L1

(2020) Chuanhui Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genes Involved in the PD-L1 Pathway Might Associate with Radiosensitivity of Patients with Gastric Cancer

(2020) Zixuan Du et al.   Journal of Oncology

Upregulation of PD-L1 expression promotes epithelial-to-mesenchymal transition in sorafenib-resistant hepatocellular carcinoma cells

(2020) Gui-Li Xu et al.   Gastroenterology Report

Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer

(2019) Xiaoxia Jin et al.   Cancer Medicine

Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition

(2019) Yang Sun et al.   MOLECULES

Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas

(2019) Yoko Tsukita et al.   Molecular Cancer

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Checkpoint Blockade Strategies in the Treatment of Breast Cancer: Where We Are and Where We Are Heading

(2019) Jeremy Force et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Correction: RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

(2019) Sherene Loi et al.   CLINICAL CANCER RESEARCH

Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models

(2019) Heng Sheng Sow et al.   Cells

Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma

(2019) Gayathri Heenatigala Palliyage et al.   AAPS PHARMSCITECH

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

(2019) Yang Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression

(2019) Hwan Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol induced premature senescence and inhibited epithelial-mesenchymal transition of cancer cells via induction of tumor suppressor Rad9

(2019) Kuan-Yu Chen et al.   PLoS One

PD-L1 regulation by SDH5 via β-catenin/ZEB1 signaling

(2019) Zhan Tuo et al.   OncoImmunology

STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer

(2019) Zerdes et al.   Cancers

TOPK promotes epithelial-mesenchymal transition and invasion of breast cancer cells through upregulation of TBX3 in TGF-β1/Smad signaling

(2019) Young-Ju Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

The Role of Long Non-coding RNAs in Immunotherapy Resistance

(2019) Yuwen Zhou et al.   Frontiers in Oncology

Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion

(2019) Yuanyuan Jiang et al.   CANCER LETTERS

Curcumin rescues breast cells from epithelial‑mesenchymal transition and invasion induced by anti‑miR‑34a

(2019) Marcela Gallardo et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer

(2019) Annika Jögi et al.   PLoS One

PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation

(2018) Xin Yao Qiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

(2018) Chia-Wei Li et al.   CANCER CELL

Immunotherapy for pancreatic cancer: A long and hopeful journey

(2018) Jian-wei Xu et al.   CANCER LETTERS

New chalcone derivative exhibits antiproliferative potential by inducing G2/M cell cycle arrest, mitochondrial-mediated apoptosis and modulation of MAPK signalling pathway

(2018) Peter Takac et al.   CHEMICO-BIOLOGICAL INTERACTIONS

JAK2 and PD-L1 Amplification Enhance the Dynamic Expression of PD-L1 in Triple-negative Breast Cancer

(2018) Meixuan Chen et al.   Clinical Breast Cancer

Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells

(2018) Varun Sasidharan Nair et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hesperidin suppresses the migration and invasion of non-small cell lung cancer cells by inhibiting the SDF-1/CXCR-4 pathway

(2018) Rongmu Xia et al.   LIFE SCIENCES

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

(2018) Ioannis Zerdes et al.   ONCOGENE

Prognostic impact of programmed cell death ligand 1 (PD-L1) expression and its association with epithelial-mesenchymal transition in extrahepatic cholangiocarcinoma

(2018) Takashi Ueno et al.   Oncotarget

Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

(2018) Yiting Wang et al.   Frontiers in Pharmacology

Biomarkers for Clinical Benefit of Immune Checkpoint Inhibitor Treatment—A Review From the Melanoma Perspective and Beyond

(2018) Kristina Buder-Bakhaya et al.   Frontiers in Immunology

Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

(2018) Armando Cevenini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling

(2018) Justin Lucas et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells

(2018) Yue Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS promotes the expression of PD-L1 in gastric cancer cells through NF-κB activation

(2018) Hui Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Clinical Significance of Programmed Death-1 Ligand-1 Expression in Patients with Non-Small Cell Lung Cancer: A 5-year-follow-up Study

(2018) Yan-bin Chen et al.   TUMORI

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

(2018) Elizabeth Varghese et al.   Cancers

A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study

(2018) N. Martínez et al.   Clinical & Translational Oncology

Quality of life with talazoparib after platinum or multiple cytotoxic non-platinum regimens in patients with advanced breast cancer and germline BRCA1/2 mutations: patient-reported outcomes from the ABRAZO phase 2 trial

(2018) S.A. Hurvitz et al.   EUROPEAN JOURNAL OF CANCER

TGF-β Signaling and the Epithelial-Mesenchymal Transition during Palatal Fusion

(2018) Akira Nakajima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

(2018) Frederike Bensch et al.   NATURE MEDICINE

Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells

(2017) Rongmu Xia et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Liposomal curcumin and its application in cancer

(2017) Ting Feng et al.   International Journal of Nanomedicine

Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity

(2017) Zsófia Edit Pápay et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Molecular alterations in triple-negative breast cancer—the road to new treatment strategies

(2017) Carsten Denkert et al.   LANCET

New insights into the role of EMT in tumor immune escape

(2017) Stéphane Terry et al.   Molecular Oncology

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

(2017) Mark Robson et al.   NEW ENGLAND JOURNAL OF MEDICINE

NF-κB Is a Potential Molecular Drug Target in Triple-Negative Breast Cancers

(2017) Paola Poma et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

EMT, inflammation and metastasis

(2017) C. Theresa Vincent et al.   SEMINARS IN CANCER BIOLOGY

Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment

(2017) Manoj K. Pandey et al.   SEMINARS IN CANCER BIOLOGY

H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

(2017) Fei Peng et al.   Cell Death & Disease

Immunotherapy in Breast Cancer: the Emerging Role of PD-1 and PD-L1

(2017) François Bertucci et al.   Current Oncology Reports

A comprehensive review of the health perspectives of resveratrol

(2017) Abdur Rauf et al.   Food & Function

Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies

(2017) Michael Yousef et al.   Nutrients

Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway

(2017) Haneen Amawi et al.   Nutrients

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

(2017) Rosanna Mattera et al.   Nutrients

LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway

(2017) Qiong-Ni Zhu et al.   Oncotarget

Axl inhibition induces the antitumor immune response which can be further potentiated by PD-1 blockade in the mouse cancer models

(2017) Zhiqiang Guo et al.   Oncotarget

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways

(2017) Shengwei Liu et al.   Oncotarget

MiR-23a promotes TGF-β1-induced EMT and tumor metastasis in breast cancer cells by directly targeting CDH1 and activating Wnt/β-catenin signaling

(2017) Fei Ma et al.   Oncotarget

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

(2017) Xiaohui Yan et al.   Cell and Bioscience

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?

(2017) Zijun Y. Xu-Monette et al.   Frontiers in Immunology

Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer

(2017) Sushil Kumar et al.   OncoImmunology

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

(2017) Muhammad Zaeem Noman et al.   OncoImmunology

The immune system in cancer metastasis: friend or foe?

(2017) Louise M.E. Janssen et al.   Journal for ImmunoTherapy of Cancer

Significant Role of MUC1 in Development of Resistance to Currently Existing Anti-cancer Therapeutic Agents

(2017) Leila Farahmand et al.   CURRENT CANCER DRUG TARGETS

PARP inhibitors: the race is on

(2016) Jessica S Brown et al.   BRITISH JOURNAL OF CANCER

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

PD-L1-specific T cells

(2016) Shamaila Munir Ahmad et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells

(2016) Melanie R. Power Coombs et al.   CANCER LETTERS

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

The Basis of Oncoimmunology

(2016) A. Karolina Palucka et al.   CELL

Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer

(2016) Yuan Tang et al.   Clinical Breast Cancer

Lipid Based Nanosystems for Curcumin: Past, Present and Future

(2016) Aditya Nayak P. et al.   CURRENT PHARMACEUTICAL DESIGN

Spatholobus suberectusColumn Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway

(2016) Jia-Qi Sun et al.   Evidence-based Complementary and Alternative Medicine

MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2

(2016) Mengtao Ma et al.   International Journal of Biological Sciences

Curcumin and epithelial-mesenchymal transition in breast cancer cells transformed by low doses of radiation and estrogen

(2016) MARCELA GALLARDO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines

(2016) Marcela Gallardo et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Programmed Death-Ligand 1 Expression and Response to the Anti–Programmed Death 1 Antibody Pembrolizumab in Melanoma

(2016) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of natural polyphenols in cell signaling and cytoprotection against cancer development

(2016) Hanna Lewandowska et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial

(2016) Ian E Krop et al.   LANCET ONCOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms

(2016) Dona Sinha et al.   SEMINARS IN CANCER BIOLOGY

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma

(2016) Chan-Young Ock et al.   Oncotarget

Chemopreventive and immunomodulatory effects of Murraya koenigii aqueous extract on 4T1 breast cancer cell-challenged mice

(2015) Swee Keong Yeap et al.   BMC Complementary and Alternative Medicine

Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor

(2015) Kimberly Blackwell et al.   BREAST CANCER RESEARCH AND TREATMENT

IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer

(2015) K Abiko et al.   BRITISH JOURNAL OF CANCER

Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes

(2015) Ana Herrero et al.   CANCER CELL

Novel strategies for inhibiting PD-1 pathway-mediated immune suppression while simultaneously delivering activating signals to tumor-reactive T cells

(2015) Suzanne Ostrand-Rosenberg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse

(2015) Ning Zhang et al.   CELLULAR IMMUNOLOGY

Blood-Based Tests for Colorectal Cancer Screening: Do They Threaten the Survival of the FIT Test?

(2015) Robert S. Bresalier et al.   DIGESTIVE DISEASES AND SCIENCES

Protective effects of dendrosomal curcumin on an animal metastatic breast tumor

(2015) Baharak Farhangi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

(2015) Massimo Fantini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)

(2015) JING HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hesperidin Supplementation Modulates Inflammatory Responses Following Myocardial Infarction

(2015) F. Haidari et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma

(2015) Yiwei Wang et al.   MEDICAL ONCOLOGY

Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

(2015) Abdullah Alsuliman et al.   Molecular Cancer

Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair

(2015) Sunil K. Panigrahi et al.   NUCLEIC ACIDS RESEARCH

Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality

(2015) Ashok Kumar Grover et al.   Nutrition Journal

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis

(2015) M-F Pang et al.   ONCOGENE

Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways

(2015) Ratana Banjerdpongchai et al.   TUMOR BIOLOGY

FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

(2015) LaTonia Taliaferro-Smith et al.   Oncotarget

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells

(2015) Bàrbara Castellana et al.   Oncotarget

Epithelial to Mesenchymal Transition in a Clinical Perspective

(2015) Jennifer Pasquier et al.   Journal of Oncology

TGF-β1-Induced Epithelial–Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells

(2015) Joel Johansson et al.   Frontiers in Oncology

Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB

(2015) Kavitha Gowrishankar et al.   PLoS One

Targeting hypoxia at the forefront of anticancer immune responses

(2015) Muhammad Zaeem Noman et al.   OncoImmunology

hRAD9 functions as a tumor suppressor by inducing p21-dependent senescence and suppressing epithelial–mesenchymal transition through inhibition of Slug transcription

(2014) Fan-Chih Wen et al.   CARCINOGENESIS

Cell cycle progression in response to oxygen levels

(2014) Brian Ortmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selective JAK2 Inhibition Specifically Decreases Hodgkin Lymphoma and Mediastinal Large B-cell Lymphoma Growth In Vitro and In Vivo

(2014) Y. Hao et al.   CLINICAL CANCER RESEARCH

Human monocytes produce interferon-gamma upon stimulation with LPS

(2014) Marina D. Kraaij et al.   CYTOKINE

Hypoxia in the intestine or solid tumors: A beneficial or deleterious alarm signal?

(2014) Hussein Shehade et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt

(2014) Megan E. Harrison et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Dendritic cells with an increased PD-L1 by TGF-β induce T cell anergy for the cytotoxicity of hepatocellular carcinoma cells

(2014) Shasha Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by AP1-Dependent EpCAM Expression in MCF-7 Cells

(2014) Jiujiao Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

(2014) Matjaz Rokavec et al.   JOURNAL OF CLINICAL INVESTIGATION

An overview of clinical and commercial impact of drug delivery systems

(2014) Aaron C. Anselmo et al.   JOURNAL OF CONTROLLED RELEASE

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of P-Glycoprotein Alteration During Anticancer Treatment: Role in the Pharmacokinetic and Pharmacological Effects of Various Substrate Drugs

(2014) Takuro Kobori et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells

(2014) Gauri Deb et al.   MOLECULAR CARCINOGENESIS

A Pilot Study Comparing the Effect of Flaxseed, Aromatase Inhibitor, and the Combination on Breast Tumor Biomarkers

(2014) Susan E. McCann et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

PD-L1 Expression Is Increased in a Subset of Basal Type Breast Cancer Cells

(2014) Hatem Soliman et al.   PLoS One

Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop

(2014) Shravanti Mukherjee et al.   Stem Cell Research & Therapy

PD-L1 Expression in Triple-Negative Breast Cancer

(2014) E. A. Mittendorf et al.   Cancer Immunology Research

Oleuropein Induces Anti-metastatic Effects in Breast Cancer

(2013) Zeinab K. Hassan et al.   Asian Pacific Journal of Cancer Prevention

Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption

(2013) Hyunil Ha et al.   BMC Complementary and Alternative Medicine

Evaluating combinations of costimulatory antibody–ligand fusion proteins for targeted cancer immunotherapy

(2013) Nora Hornig et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance

(2013) Paraskevi Mallini et al.   CANCER TREATMENT REVIEWS

Molecular Pathways: PI3K Pathway Targets in Triple-Negative Breast Cancers

(2013) V. Gordon et al.   CLINICAL CANCER RESEARCH

Clinical impact of programmed cell death ligand 1 expression in colorectal cancer

(2013) Raoul A. Droeser et al.   EUROPEAN JOURNAL OF CANCER

Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer

(2013) Roberto Bei   Frontiers in Bioscience-Landmark

Resveratrol Sensitizes Tamoxifen in Antiestrogen-Resistant Breast Cancer Cells with Epithelial-Mesenchymal Transition Features

(2013) Xiao-Peng Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin Suppresses Doxorubicin-Induced Epithelial–Mesenchymal Transition via the Inhibition of TGF-β and PI3K/AKT Signaling Pathways in Triple-Negative Breast Cancer Cells

(2013) Wei-Chih Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacological modulation of beta-catenin and its applications in cancer therapy

(2013) Ravi Thakur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transcription Factor STAT3 As a Prognostic Marker and Therapeutic Target in Cancer

(2013) David A. Frank   JOURNAL OF CLINICAL ONCOLOGY

Characterization of Total Phenolic Constituents from the Stems of Spatholobus suberectus Using LC-DAD-MSn and Their Inhibitory Effect on Human Neutrophil Elastase Activity

(2013) Youwu Huang et al.   MOLECULES

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Flavanols from Japanese Quince (Chaenomeles Japonica) Fruit Inhibit Human Prostate and Breast Cancer Cell Line Invasiveness and Cause Favorable Changes inBax/Bcl-2mRNA Ratio

(2013) Urszula Lewandowska et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells

(2013) M K Asiedu et al.   ONCOGENE

Bioactivity-Guided Identification and Cell Signaling Technology to Delineate the Lactate Dehydrogenase A Inhibition Effects of Spatholobus suberectus on Breast Cancer

(2013) Zhiyu Wang et al.   PLoS One

Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients

(2013) Julie L. Ryan et al.   RADIATION RESEARCH

3,5,4′-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial–mesenchymal transition

(2013) Jie-Heng Tsai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Treating Breast Cancer in the 21st Century: Emerging Biological Therapies

(2013) Gabriel Tinoco et al.   Journal of Cancer

Biological Effects of Green Tea Capsule Supplementation in Pre-Surgery Postmenopausal Breast Cancer Patients

(2013) Steven S. Yu et al.   Frontiers in Oncology

Resveratrol and Its Analogues: Promising Antitumor Agents

(2012) Hai-Liang Zhu   Anti-Cancer Agents in Medicinal Chemistry

Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management

(2012) Vaqar Mustafa Adhami et al.   BIOCHEMICAL PHARMACOLOGY

mTOR Signaling in Cancer Cell Motility and Tumor Metastasis

(2012) Hongyu Zhou et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

(2012) Suzanne L Topalian et al.   CURRENT OPINION IN IMMUNOLOGY

In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells

(2012) Yuan-Chuen Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Risk of Lung Cancer Related to Dietary Intake of Flavonoids

(2012) Krista Yorita Christensen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

High ERK Protein Expression Levels Correlate with Shorter Survival in Triple-Negative Breast Cancer Patients

(2012) C. Bartholomeusz et al.   ONCOLOGIST

TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation

(2012) Jonas Fuxe et al.   SEMINARS IN CANCER BIOLOGY

Modulation of sweet responses of taste receptor cells

(2012) Ryusuke Yoshida et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model

(2011) Kevin Durgan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives

(2011) Chia-Jui Weng et al.   CANCER TREATMENT REVIEWS

Therapeutic targeting of B7-H1 in breast cancer

(2011) Amal Hasan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Programmed death-1 (PD-1)/PD-1 ligand pathway–mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders

(2011) Tomohiro Kozako et al.   HUMAN IMMUNOLOGY

IL-6-induced epithelial-mesenchymal transition promotes the generation of breast cancer stem-like cells analogous to mammosphere cultures

(2011) Yawei Yuan   INTERNATIONAL JOURNAL OF ONCOLOGY

The wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

(2011) Taj D. King et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

PI3K Pathway Mutations and PTEN Levels in Primary and Metastatic Breast Cancer

(2011) A. M. Gonzalez-Angulo et al.   MOLECULAR CANCER THERAPEUTICS

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

(2011) Berrin Özçelik et al.   PHARMACEUTICAL BIOLOGY

Antioxidant effects of curcumin in spinal cord injury in rats

(2011) Havva ŞAHİN KAVAKLI   Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery

Imaging of multidrug resistance in cancer

(2011) S. Dizdarevic et al.   CANCER IMAGING

Treatment of triple-negative metastatic breast cancer: toward individualized targeted treatments or chemosensitization?

(2010) N. Berrada et al.   ANNALS OF ONCOLOGY

Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer

(2010) Mathilde Bayet-Robert et al.   CANCER BIOLOGY & THERAPY

Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells

(2010) Ling Wang et al.   CANCER LETTERS

Management of breast cancer with targeted agents: importance of heterogenicity

(2010) Serena Di Cosimo et al.   Nature Reviews Clinical Oncology

Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy

(2010) Marta Rossi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

NF-ĸB and Bcl-3 Activation Are Prognostic in Metastatic Colorectal Cancer

(2010) Soham D. Puvvada et al.   ONCOLOGY

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

B7-H1 expression is regulated by MEK/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lymphoma

(2009) Ryo Yamamoto et al.   CANCER SCIENCE

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

Cytokines Involved in Interferon-γ Production by Human Macrophages

(2009) Cory M. Robinson et al.   Journal of Innate Immunity

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Hesperidin suppressed proliferations of both Human breast cancer and androgen-dependent prostate cancer cells

(2009) Choong Jae Lee et al.   PHYTOTHERAPY RESEARCH

AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression

(2008) Y.-X. Zhang et al.   CANCER RESEARCH

Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase

(2008) X.-W. Hu et al.   CARCINOGENESIS

Curcumin inhibits glucose production in isolated mice hepatocytes

(2008) Hideya Fujiwara et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Flavonoids and ovarian cancer risk: A case-control study in Italy

(2008) Marta Rossi et al.   INTERNATIONAL JOURNAL OF CANCER

Apigenin causes G2/M arrest associated with the modulation of p21Cip1 and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells

(2008) Eun Jeong Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients

(2008) T Kozako et al.   LEUKEMIA

Interaction of human PD-L1 and B7-1

(2008) Manish J. Butte et al.   MOLECULAR IMMUNOLOGY

Transcriptional regulation of cell polarity in EMT and cancer

(2008) G Moreno-Bueno et al.   ONCOGENE

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol inhibits heregulin-β1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells☆

(2007) F TANG et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY