Epithelial to Mesenchymal Transition in a Clinical Perspective

Epithelial to Mesenchymal Transition is Associated with Shorter Disease-Free Survival in Hepatocellular Carcinoma

(2014) Suguru Yamada et al.   ANNALS OF SURGICAL ONCOLOGY

Where cancer genomics should go next: a clinician's perspective

(2014) A. Rafii et al.   HUMAN MOLECULAR GENETICS

Cellules tumorales circulantes : pierre angulaire de la médecine personnalisée

(2014) A. Rafii et al.   JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION

Epithelial to mesenchymal transition correlates with tumor budding and predicts prognosis in esophageal squamous cell carcinoma

(2014) Yukiko Niwa et al.   JOURNAL OF SURGICAL ONCOLOGY

Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile

(2014) Raphael Lis et al.   Journal of Translational Medicine

Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC

(2014) Xiaolu Zhai et al.   MEDICAL ONCOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

(2014) John C. Morris et al.   PLoS One

BMP-7 blocks the effects of TGF-β-induced EMT in cholangiocarcinoma

(2014) Kassaporn Duangkumpha et al.   TUMOR BIOLOGY

Prognostic significance of the epithelial-to-mesenchymal transition markers e-cadherin, vimentin and twist in bladder cancer

(2014) Jun Zhao et al.   International Braz J Urol

Regulation of Metastasis by microRNAs in Ovarian Cancer

(2014) Yongchao Wang et al.   Frontiers in Oncology

Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

(2013) Yhun Yhong Sheen et al.   Biomolecules & Therapeutics

TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target

(2013) Sabrina Daniela da Silva et al.   CANCER

Tumor Cell Dissemination: Emerging Biological Insights from Animal Models and Cancer Patients

(2013) Yibin Kang et al.   CANCER CELL

The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms

(2013) Yue Teng et al.   CLINICAL & EXPERIMENTAL METASTASIS

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma

(2013) Mi Jung Kwon et al.   HUMAN PATHOLOGY

Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model

(2013) Cyril Touboul et al.   Journal of Translational Medicine

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Tumor metastasis: moving new biological insights into the clinic

(2013) Liling Wan et al.   NATURE MEDICINE

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

Multilayer control of the EMT master regulators

(2013) H Zheng et al.   ONCOGENE

Embryonic Stem Cells Markers SOX2, OCT4 and Nanog Expression and Their Correlations with Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma

(2013) Weiren Luo et al.   PLoS One

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

E-cadherin's dark side: Possible role in tumor progression

(2012) Fausto J. Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer

(2012) N. P. A. Devika Gunasinghe et al.   CANCER AND METASTASIS REVIEWS

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

TGF-β signaling and epithelial–mesenchymal transition in cancer progression

(2012) Yoko Katsuno et al.   CURRENT OPINION IN ONCOLOGY

Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer

(2012) Wen-Wei Chang et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Overexpression of epithelial-mesenchymal transition–related markers according to cell dedifferentiation: clinical implications as an independent predictor of poor prognosis in cholangiocarcinoma

(2012) Han Suk Ryu et al.   HUMAN PATHOLOGY

Insights into cancer metastasis from a clinicopathologic perspective: Epithelial-Mesenchymal Transition is not a necessary step

(2012) Michael Herman Chui   INTERNATIONAL JOURNAL OF CANCER

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non–Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy

(2012) Samir E. Witta et al.   JOURNAL OF CLINICAL ONCOLOGY

Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway

(2012) Hui-Chen Pai et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Gene expression analysis of matched ovarian primary tumors and peritoneal metastasis

(2012) Joel A Malek et al.   Journal of Translational Medicine

High co-expression of vascular endothelial growth factor receptor-1 and Snail is associated with poor prognosis after curative resection of hepatocellular carcinoma

(2012) Tao Li et al.   MEDICAL ONCOLOGY

Overexpression of ZEB2 in Peritumoral Liver Tissue Correlates with Favorable Survival after Curative Resection of Hepatocellular Carcinoma

(2012) Mu-Yan Cai et al.   PLoS One

A Cell-Based Small Molecule Screening Method for Identifying Inhibitors of Epithelial-Mesenchymal Transition in Carcinoma

(2012) Kian-Ngiap Chua et al.   PLoS One

Mesenchymal Cell Interaction with Ovarian Cancer Cells Triggers Pro-Metastatic Properties

(2012) Raphael Lis et al.   PLoS One

Role of the Microenvironment in Ovarian Cancer Stem Cell Maintenance

(2012) Jennifer Pasquier et al.   Biomed Research International

Salinomycin Selectively Targets ‘CD133+’ Cell Subpopulations and Decreases Malignant Traits in Colorectal Cancer Lines

(2011) Tao-Tao Dong et al.   ANNALS OF SURGICAL ONCOLOGY

Circulating Tumor Cells and Circulating Tumor DNA

(2011) Catherine Alix-Panabières et al.   Annual Review of Medicine

EW-7203, a novel small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor/activin receptor-like kinase-5, blocks TGF-β1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells

(2011) Chul-Yong Park et al.   CANCER SCIENCE

Vimentin in cancer and its potential as a molecular target for cancer therapy

(2011) Arun Satelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SNAI1 is Involved in the Proliferation and Migration of Glioblastoma Cells

(2011) Sung-Pil Han et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways

(2011) Olorunseun O. Ogunwobi et al.   CLINICAL & EXPERIMENTAL METASTASIS

Overexpression of ZEB2 at the Invasion Front of Colorectal Cancer Is an Independent Prognostic Marker and Regulates Tumor Invasion In Vitro

(2011) C. Kahlert et al.   CLINICAL CANCER RESEARCH

EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung

(2011) Chul-Yong Park et al.   EUROPEAN JOURNAL OF CANCER

Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis

(2011) Xiaonan Fu et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma

(2011) Hanning You et al.   HEPATOLOGY

Combination of epithelial-mesenchymal transition and cancer stem cell–like phenotypes has independent prognostic value in gastric cancer

(2011) Han Suk Ryu et al.   HUMAN PATHOLOGY

Biomarker Expression in Pelvic High-grade Serous Carcinoma

(2011) Martin Köbel et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer

(2011) Ling   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Identifying Inhibitors of Epithelial-Mesenchymal Transition by Connectivity Map–Based Systems Approach

(2011) Ajaya Kumar Reka et al.   Journal of Thoracic Oncology

Cancer theory faces doubts

(2011) Heidi Ledford   NATURE

A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer

(2011) A Bonnomet et al.   ONCOGENE

Copy Number Variation Analysis of Matched Ovarian Primary Tumors and Peritoneal Metastasis

(2011) Joel A. Malek et al.   PLoS One

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Concise Review: Cancer Stem Cells and Minimal Residual Disease

(2011) Gabriel Ghiaur et al.   STEM CELLS

Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma

(2010) Jongmin Kim et al.   CANCER SCIENCE

Oncologic trogocytosis with Hospicells induces the expression of N-cadherin by breast cancer cells

(2010) Poupot   INTERNATIONAL JOURNAL OF ONCOLOGY

Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study

(2010) Federico Cappuzzo et al.   LANCET ONCOLOGY

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

(2010) Svetlana A Mikheeva et al.   Molecular Cancer

Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies

(2010) Guy Lahat et al.   PLoS One

Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression

(2009) Kai-jie Wu et al.   ACTA PHARMACOLOGICA SINICA

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

(2009) T. Arumugam et al.   CANCER RESEARCH

Bone morphogenetic protein 7 induces mesenchymal-to-epithelial transition in melanoma cells, leading to inhibition of metastasis

(2009) Yi-Rang Na et al.   CANCER SCIENCE

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Overexpression of E-cadherin on Melanoma Cells Inhibits Chemokine-promoted Invasion Involving p190RhoGAP/p120ctn-dependent Inactivation of RhoA

(2009) Isabel Molina-Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of the role of Smad interacting protein 1 (SIP1) in glioma

(2009) Microgene Xia et al.   JOURNAL OF NEURO-ONCOLOGY

The epithelial-mesenchymal transition-inducing factor TWIST is an attractive target in advanced and/or metastatic bladder and prostate cancers

(2009) Hervé Wallerand et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway

(2008) Wen-Lei Zhuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transforming growth factor-β signaling: emerging stem cell target in metastatic breast cancer?

(2008) Antoinette R. Tan et al.   BREAST CANCER RESEARCH AND TREATMENT

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

(2008) D. Sarrio et al.   CANCER RESEARCH

Frzb, a Secreted Wnt Antagonist, Decreases Growth and Invasiveness of Fibrosarcoma Cells Associated with Inhibition of Met Signaling

(2008) Y. Guo et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition

(2008) J. Zavadil et al.   CANCER RESEARCH

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

(2008) A. J. Trimboli et al.   CANCER RESEARCH

Sensitivity to Epidermal Growth Factor Receptor Inhibitor Requires E-Cadherin Expression in Urothelial Carcinoma Cells

(2008) P. C. Black et al.   CLINICAL CANCER RESEARCH

Silibinin Inhibits Established Prostate Tumor Growth, Progression, Invasion, and Metastasis and Suppresses Tumor Angiogenesis and Epithelial-Mesenchymal Transition in Transgenic Adenocarcinoma of the Mouse Prostate Model Mice

(2008) R. P. Singh et al.   CLINICAL CANCER RESEARCH

SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway

(2008) Ming-Tzeung Chung et al.   GYNECOLOGIC ONCOLOGY

Cadherin switching

(2008) M. J. Wheelock et al.   JOURNAL OF CELL SCIENCE

Epithelial-to-Mesenchymal Transition Is Important to Metastasis, But Questions Remain

(2008) K. Garber   JNCI-Journal of the National Cancer Institute

Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway

(2008) Wenlei Zhuo et al.   LUNG CANCER

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas

(2008) Bo Zhai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice

(2007) Lorea Bueno et al.   EUROPEAN JOURNAL OF CANCER